Death and dying in hospitals from the nurses perspectives

Department of Nursing 3FM CUÚstav ošetřovatelství 3. LF UKThird Faculty of Medicine3. lékařská fakult

End-of-waste Criteria for Copper and Copper Alloy Scrap: Technical Proposals

This report is the JRC-IPTS contribution to the development of the end-of-waste criteria for copper and copper alloy scrap in accordance with Article 6 of Directive 2008/98/EC of the European Parliament and of the Council on waste (the Waste Framework Directive). This report includes a possible set of end-of-waste criteria and shows how the proposals were developed based on a comprehensive techno-economic analysis of copper and copper alloy recycling and an analysis of the economic, environmental and legal impacts when copper scrap cease to be wastes. The purpose of end-of-waste criteria is to avoid confusion about the waste definition and to clarify when certain waste that has undergone recovery ceases to be waste. Recycling should be supported by creating legal certainty and an equal level playing field and by removing unnecessary administrative burdens. The end-of-waste criteria should provide a high level of environmental protection and an environmental and economic benefit.JRC.DDG.J.6-Sustainable production and consumptio

Technicko-ekonomická analýza pro zpracování odpadních produktů hutní výroby

Import 20/04/2006Prezenční výpůjčkaVŠB - Technická univerzita Ostrava. Fakulta hornicko-geologická. Institut ekonomiky a systémů řízení (545

Cyanine–flavonol hybrids as NIR-light activatable carbon monoxide donors in methanol and aqueous solutions

Here we report on carbon monoxide-photoreleasable compounds (photoCORMs) that combine heptamethine cyanine and flavonol chromophores and are activated upon irradiation with near-infrared light. Excellent CO-release yields and uncaging cross sections in aqueous solutions, enhanced water solubilities thanks to polar substituents or a host-guest approach using cucurbit[7]uril are demonstrated. The hybrids display outstanding biocompatibility and diverse, structure-dependent cell penetrability and internalization

Highly efficient affinity anchoring of gold nanoparticles on chitosan nanofibers via dialdehyde cellulose for reusable catalytic devices

Polysaccharides are often utilized as reducing and stabilizing agents and as support in the synthesis of gold nanoparticles (AuNPs). However, using approaches like spin coating or dip coating, AuNPs are generally bound to the support only by weak interactions, which can lead to decreased stability of the composite. Here, a two-stage approach for the preparation of composites with covalently anchored AuNPs is proposed. First, 5 nm AuNPs with high catalytic activity for the reduction of 4-nitrophenol (TOF = 15.8 min−1) were synthesized and stabilized using fully oxidized and solubilized 2,3-dialdehyde cellulose (DAC). Next, the carbonyl groups in the shell of prepared nanoparticles were used to tether AuNPs to chitosan nanofibers with quantitative efficacy in a process that we termed “affinity anchoring”. Schiff bases formed during this process were subsequently reduced to secondary amines by borohydride, which greatly improved the stability of the composite in the broad pH range from 3 to 9. The catalytic efficacy of the resulting composite is demonstrated using a model catalytic device, showing high stability, fast conversion rates, and direct reusability. © 2023 Elsevier LtdDKRVO, (RP/CPS/2022/007); Tomas Bata University in Zlin, TBU, (IGA/CPS/2023/006); Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Grantová Agentura České Republiky, GA ČR, (23-07361S); Masarykova Univerzita, MU, (MUNI/A/1298/2022

Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?

Study provides an in-depth analysis of the structure-function relationship of polysaccharide anticancer drug carriers and points out benefits and potential drawbacks of differences in polysaccharide glycosidic bonding, branching and drug binding mode of the carriers. Cellulose, dextrin, dextran and hyaluronic acid have been regioselectively oxidized to respective dicarboxylated derivatives, allowing them to directly conjugate cisplatin, while preserving their major structural features intact. The structure of source polysaccharide has crucial impact on conjugation effectiveness, carrier capacity, drug release rates, in vitro cytotoxicity and cellular uptake. For example, while branched structure of dextrin-based carrier partially counter the undesirable initial burst release, it also attenuates the cellular uptake and the cytotoxicity of carried drug. Linear polysaccharides containing β-(1→4) glycosidic bonds and oxidized at C2 and C3 (cellulose and hyaluronate) have the best overall combination of structural features for improved drug delivery applications including potentiation of the cisplatin efficacy towards malignances. © 2021 Elsevier LtdMinistry of Education, Youth and Sports of the Czech Republic - DKRVO [RP/CPS/2020/006]; project Advanced Functional Nanorobots [CZ.02.1.01/0.0/0.0/15_003/0000444]; internal grant for specific research from TBU in Zlin [IGA/CPS/2020/003]; Faculty of Medicine MU Brno; Ministry of Education, Youth and Sports of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic [LM2018127]; project "e-Infrastruktura CZ" (e-INFRA) within the program Projects of Large Research, Development and Innovations Infrastructures [LM2018140]CZ.02.1.01/0.0/0.0/15_003/0000444, RP/CPS/2020/006; LM2018127; IGA/CPS/2020/003; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT: LM201814