Effects of monoculture and polyculture farming in oil palm smallholdings on terrestrial arthropod diversity

Oil palm agriculture has become one of the economic mainstays for biodiversity-rich countries in the tropics. The conversion of native forests to oil palm monoculture plantation has caused unprecedented biodiversity loss in Southeast Asia. Little is known about the effects of oil palm polyculture farming on arthropod diversity. In this study, arthropods were sampled using pitfall traps at 120 sites in Peninsular Malaysia. We examined how arthropod biodiversity responded to different oil palm farming practices and local-scale vegetation structure characteristics. We found that the number of arthropod orders was significantly greater in polyculture than monoculture smallholdings. However, we did not detect a significant difference in arthropod order composition nor abundance between monoculture and polyculture practices. In situ habitat characteristics explained 16% of the variation in arthropod order richness, with key predictor variables including farming practice, height of oil palm stands, and number of immature palm. The findings of this study suggest that polyculture farming together with management for in situ habitat complexity may be a useful strategy in supporting biodiversity within in oil palm plantations

Factors Leading the Failure of ICT Project Management in the Public Sectors in Tanzania

The research study focuses on investigating the factors leading the failure of Information and Communication Technology (ICT) project management in the public sectors of Tanzania. The study utilizes a mixed-methods approach, combining both quantitative and qualitative data collection methods. The research includes a comprehensive literature review to identify factors associated with previous ICT project failures. Interviews and surveys are conducted with key stakeholders involved in ICT project management in Tanzania's public sectors. The findings highlight various factors contributing to the failure of ICT project management, including inadequate project planning and initiation, insufficient budget allocation, lack of skilled personnel, ineffective communication, and poor stakeholder engagement. Additionally, poor risk management strategies, organizational culture, political interference, and limited commitment from top management are identified as significant barriers to successful ICT project implementation. The implications of these findings emphasize the need for effective measures to address these challenges. Recommendations include improved project planning and initiation processes, increased budget allocation, enhanced human resource capabilities, and the establishment of effective communication channels. Creating a supportive organizational culture, minimizing political interference, and securing strong commitment from top management are also crucial to successful ICT project implementation in the public sectors of Tanzania. This research contributes valuable empirical evidence on the factors leading to ICT project management failure in Tanzania's public sectors. The findings can serve as a foundation for developing strategies and policies to promote successful ICT project implementation in similar contexts. Ultimately, addressing these challenges can lead to improved public service delivery and socio-economic development in the country

PENYULUHAN CARA PENGOLAHAN PANGAN YANG BAIK DI UKM KERUPUK KULIT IKAN

The implementation of good food processing methods (CPPB) in a production process, on the one hand, is often ignored by small business actors (SMEs), not carried out by fish skin cracker SMEs run by partners. On the other hand, the application of CPPB at every stage of the production process is a minimum standard for SMEs to ensure the quality of the food products produced is safe and fit for consumption. This service aims to provide counseling about CPPB to improve the quality of fish skin crackers products made by partners. Implementing the activity uses a Participatory Rural Appraisal (PRA) approach by involving a group of partners. Technical, operational activities consist of several stages, including (i) preparation for the implementing activities; (ii) counseling in the form of lectures and discussions; and (iii) success evaluation of the activity. The implementation of activities to increase understanding, knowledge, and awareness of the application of good food processing methods at each stage of the production process

Principles of genetic circuit design

Cells navigate environments, communicate and build complex patterns by initiating gene expression in response to specific signals. Engineers seek to harness this capability to program cells to perform tasks or create chemicals and materials that match the complexity seen in nature. This Review describes new tools that aid the construction of genetic circuits. Circuit dynamics can be influenced by the choice of regulators and changed with expression 'tuning knobs'. We collate the failure modes encountered when assembling circuits, quantify their impact on performance and review mitigation efforts. Finally, we discuss the constraints that arise from circuits having to operate within a living cell. Collectively, better tools, well-characterized parts and a comprehensive understanding of how to compose circuits are leading to a breakthrough in the ability to program living cells for advanced applications, from living therapeutics to the atomic manufacturing of functional materials.National Institute of General Medical Sciences (U.S.) (Grant P50 GM098792)National Institute of General Medical Sciences (U.S.) (Grant R01 GM095765)National Science Foundation (U.S.). Synthetic Biology Engineering Research Center (EEC0540879)Life Technologies, Inc. (A114510)National Science Foundation (U.S.). Graduate Research FellowshipUnited States. Office of Naval Research. Multidisciplinary University Research Initiative (Grant 4500000552

Gastroprotective activity and mechanisms of action of Bauhinia purpurea Linn (Leguminoseae) leaf methanol extract

Purpose: To determine the gastroprotective activity and mechanisms of protection of the methanol extract of Bauhinia purpurea leaves (MEBP) using ethanol-induced gastric ulcer model.Methods: Male Sprague Dawley rats (n = 6) were administered orally with 10 % DMSO, 100 mg/kg ranitidine or MEBP (50, 250 and 500 mg / kg) daily for 7 consecutive days prior to subjection to the ethanol-induced gastric ulcer assay. The mechanisms of gastroprotection were determined based on: i) antisecretory activity via pylorus ligation assay; ii) the role of nitric oxide (NO) and sulfhydryl group via pre-treatment of MEBP-treated rats with the respective N-nitro-L-arginine methyl ester (L-NAME) or carbenoxolone (CBX) followed by the ethanol-induced assay; and iii) antioxidant activity using superoxide anion radical scavenging assay and, oxygen radical absorbance capacity (ORAC) assay. Ranitidine (100 mg / kg) was used as the reference drug. .Results: MEBP exhibited a significant (p < 0.05) and dose-dependent gastroprotective activity against ethanol-induced gastric ulcer with ulcer formation ranging between 0 and 74 % (indicated by decrease in ulcer area from 21.3 to 5.5 mm2). The macroscopic observation was in line with the microscopic findings and further supported by the histological scores suggesting the antiulcer potential of MEBP. MEBP also significantly (p < 0.05) reduced volume gastric juice, as well as its free and total acidity while increasing its pH. Moreover, this activity was significantly (p < 0.05) modulated in the presence ofsulfhydryl group, but not NO. The extract also exhibited significant (p < 0.05) antioxidant activity.Conclusion: MEBP exerts gastroprotective activity partly via its antisecretory and antioxidant activities, as well as by modulation of sulfhydryl group, but not NO action.Keywords: Bauhinia purpurea, Gastroprotective activity, Gastric ulcer, Sulfhydryl group, Anti-secretory activity, Antioxidan

Modeling and Speed Control for Sensorless DC Motor BLDC Based on Real Time Experiement

This paper presents a modeling of the Brushless DC motor based on the system identification method. The input and output data were collected and simulated based on the real-time experiment. Taking a continues time form for the system model, a transfer function was selected in this work. The potentiometer has been used to send  Pulse Width Modulation (PWM) signals as input signal to the Brushless DC motor to determine the open-loop model of brushless DC motor (BLDC). LM2907 Tachometer attached with Brushless DC motor driver to measure the output speed. The input signal and measured output data were interfaced to plant by C code generation Matlab/Simulink through Arduino Mega controller. System identification toolbox was used for collecting data to obtain the estimates model. The best fit found for the system was 90.2%. The PID controller was developed to control the desired speed based on the given speed to demonstrate the feasibility of the given method.  &nbsp

ANTIBACTERIAL EFFICACY OF FIVE NATURAL ESSENTIAL OILS USED IN YEMEN: A COMPARATIVE STUDY

Background and objective: Due to the increasing resistance to synthetic antibiotics and preservatives, there is growing interest in exploring natural alternatives. This study aimed to evaluate the antibacterial potential of five commercially available essential oils in the Yemeni market Azadirachta indica (Neem), Moringa oleifera, Rosmarinus officinalis (Rosemary), Salvia officinalis, and Origanum majorana against selected Gram-positive and Gram-negative bacterial strains. Method: Agar diffusion was used to investigate the antibacterial activity of essential oils from five plants: Azadirachta indica (neem), Moringa oleifera, Rosmarinus officinalis (rosemary), Salvia officinalis, and Origanum majorana. Result:  Significant differences in the inhibitory effects of the plant oils of neem, Moringa oleifera, Rosmarinus officinalis, Salvia officinalis, and Origanum majorana against Gram-positive and Gram-negative bacteria were found during the antimicrobial screening process. Nearing the effectiveness of gentamicin (25 mm), Salvia officinalis and neem oils demonstrated the highest action against Gram-positive Staphylococcus aureus (22 mm and 20 mm inhibition zones, respectively). Rosmarinus officinalis, on the other hand, demonstrated a low level of efficacy (10 mm). Most oils were less effective against Gram-negative organisms, and E. coli showed resistance to all save Rosmarinus officinalis (12 mm). Conclusions: These results demonstrate the potential of oils produced from plants, especially Origanum majorana, neem, and Salvia officinalis, as antibacterial agents against Gram-negative bacteria highlights the need for more research into maximizing their use, either alone or in combination with other antibiotics, despite their encouraging efficacy against Gram-positive bacteria.                     Peer Review History: Received 9 April 2025;   Reviewed 14 May 2025; Accepted 20 June; Available online 15 July 2025 Academic Editor: Dr. Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, [email protected] Reviewers: Antonio José de Jesus Evangelista, Federal University of Ceará, UFC, Brazil, [email protected] Prof. Abdulwahab Ismail Al-kholani, Dean of Faculty of Dentistry at 21 September University, Yemen. [email protected]

Pemanfaatan Tepung Daun Talas Terfermentasi Kapang Trichoderma viride Sebagai Bahan Alternatif Dalam Formulasi Pakan Ikan Lele (Clarias gariepinus)

Ikan lele adalah ikan yang banyak dibudidayakan oleh pembudidaya. Dalam budidaya kualitas pakan sangat diperhatikan, terutama kandungan gizinya.Selama ini gizi protein pakan ikan tinggi diperoleh dari tepung ikan, akan tetapi harganya kurang ekonomis. Maka tepung ikan disubstitusi oleh tepung daun talas yang harganya ekonomis, akan tetapi serat kasar yang dikandung 17 % sedangkan kebutuhan ikan lele akan serat kasar berkisar 3-10 %. Oleh karena itu, tepung daun talas perlu difermentasi dengan Trichoderma viride untuk menurunkan serat kasarnya dan dapat menunjang pertumbuhan ikan lele. Penggunaan bahan baku lokal tepung daun talas terfermentasi diharapkan dapat menjadi alternatif dalam formulasi pakan ikan lele. Penelitian ini dilakukan di Laboratorium Ilmu Teknologi Perikanan Divisi Perekayasaan Hasil Perikanan Fakultas Perikanan Universitas Brawijaya dengan tujuan untuk mendapatkan waktu fermentasi yang optimal dalam proses fermentasi tepung daun talas dan memperoleh dosis tepung daun talas hasil fermentasi yang dapat dimanfaatkan dalam formula pakan ikan lele. Jenis bahan fermentasi yang digunakan adalah Trichoderma viride yang diperoleh dari Laboratorium Pusat Peneitian Biologi (LIPI). Proses fermentasi dilakukan selama 5,7 dan 9 hari, dengan dosis 3% dan diinkubasi pada suhu ruang (300C) untuk memperoleh hasil fermentasi terbaik. Rancangan percobaan yang digunakan adalah rancangan acak lengkap dengan lima perlakuan dan tiga ulangan berdasarkan kandungan pakan percobaan dengan iso protein 30,22% dan iso energi 3.600 kkal/kg. Lima perlakuan substitusi tepung daun talas terfermentasi terhadap tepung ikan yang berbeda, meliputi perlakuan A (0%), B (5%), C (10%), D (15%) dan E (20%). Pada uji coba biologis pakan percobaan, bobot rata-rata benih ikan lele yang digunakan yaitu bobot 5-9 gram selama 30 hari. Paremeter utama yang diamati meliputi kelulushidupan (survival rate), laju pertumbuhan spesifik (specific growth rate), rasio konversi pakan (feed convertion ratio), rasio efisiensi protein (protein efficiency ratio), retensi protein, retensi energi dan daya cerna nutrien. Hasil penelitian tahap 1 diperoleh lama fermentasi tepung daun talas dengan Trichoderma viride terbaik dalam menurunkan serat kasar yaitu selama 7 hari. Dengan hasil proksimat protein 22,07 %, lemak 7,13 %, abu 11,34 %, serat kasar 6,88 %, selulosa 16,88 %, aktivitas enzim selulase 3,03 IU/ml, glukosa 0,54 % dan nilai asam amino esensial (histidine 0,31, threonine 0,11, arginine 0,57, methionine 0,48, valine 0,64, phenyalanine 0,65, isoleucine 0,53, leucine 0,86 dan lysine 0,98). Hasil penelitian tahap 2 menunjukkan bahwa penggunaan protein tepung daun talas (Colocasia esculenta L.) terfermentasi Trichoderma viride untuk mensubstitusi protein tepung ikan dalam formulasi pakan ikan lele (Clarias gariepinus) adalah 20 % untuk laju pertumbuhan spesifik 1,85%BB/hari; rasio konversi pakan 1,42%; rasio efisiensi protein 2,19%; retensi protein 29,73%, retensi energi 19,82%; untuk daya cerna protein 79,64% dan daya cerna energi 59,05%

Outcomes of Operatively Treated Acute Knee Dislocations

Knee dislocation is a complex and rare injury often presenting in the context of high velocity trauma. The aim of this study is to establish the subjective outcomes of surgically treated knee dislocations. A total of 20 knees dislocations treated by open repair were reviewed. Their progress and outcomes were assessed by using a modified Lysholm score questionnaire. Data was obtained on patient demographics, details of injury, investigation, treatment, rehabilitation, 24 months objective outcome and subjective outcomes. Six patients had a vascular deficit and six had neurological deficits. The median range of motion was 0°-100°. Patients with an initially lower pre-injury level of function were able to return an activity level comparable to their pre-injury status. 22% of competitive athletes retuned to competitive sports. 38% of patients undertaking heavy activity returned to comparable pre-injury level of activity and 67% of patients undertaking moderate level of activity before injury returned to a comparable level after repair. 68% regularly had problems running, 70% problem squatting, 40% swelling and 42% problem with stairs. Most patients however did not have locking of the knee or problems with knees giving way. Patients pain scores decreased over time to an acceptable level. Despite the severity of the injury, majority of patients achieved a satisfactory outcome, although none of the patients reached the same level of function as before the injury. 80% of the patients were satisfied with their outcome. All dissatisfied patients suffered postoperative complications

Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors

Kashif Rahim,1 Muhammad Shan,2 Ihtisham Ul Haq,3– 5 Muhammad Naveed Nawaz,2 Sajida Maryam,3,4 Mansour S Alturki,6 Abdulaziz H Al Khzem,6 Kamel Metwally,7 Simona Cavalu,8 Saleh F Alqifari,9 Galal Yahya10 1School of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, People’s Republic of China; 2Department of Microbiology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Punjab, Pakistan; 3Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, Gliwice, Poland; 4Joint Doctoral School, Silesian University of Technology, Gliwice, 44-100, Poland; 5Programa de Pós-graduação em Inovação Tecnológica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil; 6Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, 34212, Saudi Arabia; 7Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia; 8Faculty of Medicine and Pharmacy, University of Oradea, Oradea, 410073, Romania; 9Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia; 10Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Al Sharqia, 44519, EgyptCorrespondence: Kashif Rahim, School of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, People’s Republic of China, Email [email protected] Saleh F Alqifari, Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia, Email [email protected]: DPP4 (Dipeptidyl-peptidase 4) a versatile protease, emerges as a prominent player in soluble and membrane-bound forms. Its heightened expression has been intimately linked to the initiation and severity of diverse autoimmune diseases, spanning rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (SSc), inflammatory bowel disease, autoimmune diabetes, and even SARS-CoV-2 infection. Operating as a co-stimulator of T cell activity, DPP4 propels T cell proliferation by binding adenosine deaminase (ADA), thereby augmenting the breakdown of adenosine—an influential inhibitor of T cell proliferation. However, the discovery of a wide range of DPP4 inhibitors has shown promise in alleviating these diseases’ signs, symptoms, and severity. The available DPP4 inhibitors have demonstrated significant effectiveness in blocking DPP4 activity. Based on the characterization of their binding mechanisms, three distinct groups of DPP4 inhibitors have been identified: saxagliptin, alogliptin, and sitagliptin, each representing a different class. Elevated levels of angiotensin-converting enzyme 2 (ACE2) expression are associated with producing various coronavirus peptidases. With its anti-inflammatory properties, Sitagliptin may assist COVID-19 patients in preventing and managing cytokine storms. This comprehensive review delves into the burgeoning realm of DPP4 inhibitors as therapeutic interventions for diverse autoimmune diseases. With a discerning focus on their efficacy, the investigation sheds light on their remarkable capacity to alleviate the burdensome signs and symptoms intricately linked to these conditions.Keywords: autoimmune diseases, DPP4 inhibitors, inflammatory disorders, MERS-CoV, diabetes mellitus, COVID-1