2,726 research outputs found
First Fruits of the Spitzer Space Telescope: Galactic and Solar System Studies
This article provides a brief overview of the Spitzer Space Telescope and
discusses its initial scientific results on galactic and solar system science.Comment: Review article to appear in slightly different format in Vol.44 of
Annual Reviews of Astronomy and Astrophysics, 200
Reducing Posterior Capsule Opacification by eliminating Myo/Nog cells through targeted drug delivery using 3DNA nanocarriers and the G8 antibody.
Investigating human audio-visual object perception with a combination of hypothesis-generating and hypothesis-testing fMRI analysis tools
Primate multisensory object perception involves distributed brain regions. To investigate the network character of these regions of the human brain, we applied data-driven group spatial independent component analysis (ICA) to a functional magnetic resonance imaging (fMRI) data set acquired during a passive audio-visual (AV) experiment with common object stimuli. We labeled three group-level independent component (IC) maps as auditory (A), visual (V), and AV, based on their spatial layouts and activation time courses. The overlap between these IC maps served as definition of a distributed network of multisensory candidate regions including superior temporal, ventral occipito-temporal, posterior parietal and prefrontal regions. During an independent second fMRI experiment, we explicitly tested their involvement in AV integration. Activations in nine out of these twelve regions met the max-criterion (A < AV > V) for multisensory integration. Comparison of this approach with a general linear model-based region-of-interest definition revealed its complementary value for multisensory neuroimaging. In conclusion, we estimated functional networks of uni- and multisensory functional connectivity from one dataset and validated their functional roles in an independent dataset. These findings demonstrate the particular value of ICA for multisensory neuroimaging research and using independent datasets to test hypotheses generated from a data-driven analysis
Phenomenological Consequences of sub-leading Terms in See-Saw Formulas
Several aspects of next-to-leading (NLO) order corrections to see-saw
formulas are discussed and phenomenologically relevant situations are
identified. We generalize the formalism to calculate the NLO terms developed
for the type I see-saw to variants like the inverse, double or linear see-saw,
i.e., to cases in which more than two mass scales are present. In the standard
type I case with very heavy fermion singlets the sub-leading terms are
negligible. However, effects in the percent regime are possible when
sub-matrices of the complete neutral fermion mass matrix obey a moderate
hierarchy, e.g. weak scale and TeV scale. Examples are cancellations of large
terms leading to small neutrino masses, or inverse see-saw scenarios. We
furthermore identify situations in which no NLO corrections to certain
observables arise, namely for mu-tau symmetry and cases with a vanishing
neutrino mass. Finally, we emphasize that the unavoidable unitarity violation
in see-saw scenarios with extra fermions can be calculated with the formalism
in a straightforward manner.Comment: 22 pages, matches published versio
Stochastic Modeling for the Expression of a Gene Regulated by Competing Transcription Factors
It is widely accepted that gene expression regulation is a stochastic event. The common approach for its computer simulation requires detailed information on the interactions of individual molecules, which is often not available for the analyses of biological experiments. As an alternative approach, we employed a more intuitive model to simulate the experimental result, the Markov-chain model, in which a gene is regulated by activators and repressors, which bind the same site in a mutually exclusive manner. Our stochastic simulation in the presence of both activators and repressors predicted a Hill-coefficient of the dose-response curve closer to the experimentally observed value than the calculated value based on the simple additive effects of activators alone and repressors alone. The simulation also reproduced the heterogeneity of gene expression levels among individual cells observed by Fluorescence Activated Cell Sorting analysis. Therefore, our approach may help to apply stochastic simulations to broader experimental data
Effectiveness of physiotherapy exercise following hip arthroplasty for osteoarthritis: a systematic review of clinical trials
Background: Physiotherapy has long been a routine component of patient rehabilitation following hip joint replacement. The purpose of this systematic review was to evaluate the effectiveness of physiotherapy exercise after discharge from hospital on function, walking, range of motion, quality of life and muscle strength, for osteoarthritic patients following elective primary total hip arthroplasty.
Methods: Design: Systematic review, using the Cochrane Collaboration Handbook for Systematic Reviews of Interventions and the Quorom Statement. Database searches: AMED, CINAHL, EMBASE, KingsFund, MEDLINE, Cochrane library (Cochrane reviews, Cochrane Central Register of Controlled Trials, DARE), PEDro, The Department of Health National
Research Register. Handsearches: Physiotherapy, Physical Therapy, Journal of Bone and Joint Surgery (Britain)
Conference Proceedings. No language restrictions were applied.
Selection: Trials comparing physiotherapy exercise versus usual/standard care, or comparing two types of relevant exercise physiotherapy, following discharge from hospital after elective primary total hip replacement for osteoarthritis were reviewed.
Outcomes: Functional activities of daily living, walking, quality of life, muscle strength and range of hip joint
motion. Trial quality was extensively evaluated. Narrative synthesis plus meta-analytic summaries were performed to summarise the data.
Results: 8 trials were identified. Trial quality was mixed. Generally poor trial quality, quantity and diversity prevented explanatory meta-analyses. The results were synthesised and meta-analytic summaries were used where possible to provide a formal summary of results. Results indicate that physiotherapy exercise after discharge following total hip replacement has the potential to benefit patients.
Conclusion: Insufficient evidence exists to establish the effectiveness of physiotherapy exercise following primary hip replacement for osteoarthritis. Further well designed trials are required to determine the value of post discharge exercise following this increasingly common surgical procedure
Mach's Principle and the Origin of Inertia
The current status of Mach's principle is discussed within the context of
general relativity. The inertial properties of a particle are determined by its
mass and spin, since these characterize the irreducible unitary representations
of the inhomogeneous Lorentz group. The origin of the inertia of mass and
intrinsic spin are discussed and the inertia of intrinsic spin is studied via
the coupling of intrinsic spin with rotation. The implications of spin-rotation
coupling and the possibility of history dependence and nonlocality in
relativistic physics are briefly mentioned.Comment: 14 pages. Dedicated to Carl Brans in honor of his 80th birthday. To
appear in the Brans Festschrift; v2: typo corrected, published in: At the
Frontier of Spacetime, edited by T. Asselmeyer-Maluga (Springer, 2016),
Chapter 10, pp. 177-18
Infrared composition of the Large Magellanic Cloud
The evolution of galaxies and the history of star formation in the Universe
are among the most important topics in today's astrophysics. Especially, the
role of small, irregular galaxies in the star-formation history of the Universe
is not yet clear. Using the data from the AKARI IRC survey of the Large
Magellanic Cloud at 3.2, 7, 11, 15, and 24 {\mu}m wavelengths, i.e., at the
mid- and near-infrared, we have constructed a multiwavelength catalog
containing data from a cross-correlation with a number of other databases at
different wavelengths. We present the separation of different classes of stars
in the LMC in color-color, and color-magnitude, diagrams, and analyze their
contribution to the total LMC flux, related to point sources at different
infrared wavelengths
Quantum Discord and entropic measures of quantum correlations: Optimization and behavior in finite spin chains
We discuss a generalization of the conditional entropy and one-way
information deficit in quantum systems, based on general entropic forms. The
formalism allows to consider simple entropic forms for which a closed
evaluation of the associated optimization problem in qudit-qubit systems is
shown to become feasible, allowing to approximate that of the quantum discord.
As application, we examine quantum correlations of spin pairs in the exact
ground state of finite spin chains in a magnetic field through the quantum
discord and information deficit. While these quantities show a similar
behavior, their optimizing measurements exhibit significant differences, which
can be understood and predicted through the previous approximations. The
remarkable behavior of these quantities in the vicinity of transverse and
non-transverse factorizing fields is also discussed.Comment: 10 pages, 3 figure
Detection of coronary artery stenoses by contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography.
Background-Multislice spiral computed tomography (MSCT) with retrospectively ECG-gated image reconstruction permits coronary artery visualization. We investigated the method's ability to identify high-grade coronary artery stenoses and occlusions. Methods and Results-A total of 64 consecutive patients were studied by MSCT (4ϫ1 mm cross-sections, 500-ms rotation, table feed 1.5 mm/rotation, intravenous contrast agent, retrospectively ECG-gated image reconstruction). All coronary arteries and side branches with a luminal diameter Ն2.0 mm were assessed concerning evaluability and the presence of high-grade stenoses (Ͼ70% diameter stenosis) or occlusions. Results were compared with quantitative coronary angiography. Of 256 coronary arteries (left main, left anterior descending, left circumflex and right coronary artery, including their respective side branches), 174 could be evaluated (68%). In 19 patients (30%), all arteries were evaluable. Artifacts caused by coronary motion were the most frequent reason for unevaluable arteries. Overall, 32 of 58 high-grade stenoses and occlusions were detected by MSCT (58%). In evaluable arteries, 32 of 35 lesions were detected, and the absence of stenosis was correctly identified in 117 of 139 arteries (sensitivity, 91%; specificity, 84%). If analysis was extended to all stenoses with Ͼ50% diameter reduction, sensitivity was 85% (40 of 47) and specificity was 76% (96 of 127). Conclusions-MSCT with retrospective ECG gating permits the detection of coronary artery stenoses with high accuracy if image quality is sufficient, but its clinical use may presently be limited due to degraded image quality in a substantial number of cases, mainly due to rapid coronary motion
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