A Review on Advanced Decision Trees for Efficient & Effective k-NN Classification

K Nearest Neighbor (KNN) strategy is a notable classification strategy in data mining and estimations in light of its direct execution and colossal arrangement execution. In any case, it is outlandish for ordinary KNN strategies to select settled k esteem to all tests. Past courses of action assign different k esteems to different test tests by the cross endorsement strategy however are typically tedious. This work proposes new KNN strategies, first is a KTree strategy to learn unique k esteems for different test or new cases, by including a training arrange in the KNN classification. This work additionally proposes a change rendition of KTree technique called K*Tree to speed its test organize by putting additional data of the training tests in the leaf node of KTree, for example, the training tests situated in the leaf node, their KNNs, and the closest neighbor of these KNNs. K*Tree, which empowers to lead KNN arrangement utilizing a subset of the training tests in the leaf node instead of all training tests utilized in the recently KNN techniques. This really reduces the cost of test organize

Review Paper on Answers Selection and Recommendation in Community Question Answers System

Nowadays, question answering system is more convenient for the users, users ask question online and then they will get the answer of that question, but as browsing is primary need for each an individual, the number of users ask question and system will provide answer but the computation time increased as well as waiting time increased and same type of questions are asked by different users, system need to give same answers repeatedly to different users. To avoid this we propose PLANE technique which may quantitatively rank answer candidates from the relevant question pool. If users ask any question, then system provide answers in ranking form, then system recommend highest rank answer to the user. We proposing expert recommendation system, an expert will provide answer of the question which is asked by the user and we also implement sentence level clustering technique in which a single question have multiple answers, system provide most suitable answer to the question which is asked by the user

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion

Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles

A Research Agenda to Underpin Malaria Eradication

Pedro Alonso and colleagues introduce the Malaria Eradication Research Agenda (malERA) initiative and the set of articles published in this PLoS Medicine Supplement that distill the research questions key to malaria eradication

Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?

In this review we discuss recent progress in the development, testing, and clinical evaluation of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has been made in TB vaccine research and development: from a pipeline virtually empty of new TB candidate vaccines in the early 1990s, to an era in which a dozen novel TB vaccine candidates have been and are being evaluated in human clinical trials. In addition, innovative approaches are being pursued to further improve existing vaccines, as well as discover new ones. Thus, there is good reason for optimism in the field of TB vaccines that it will be possible to develop better vaccines than BCG, which is still the only vaccine available against TB

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease