Satire on Politics and Government in Rag Darbari

Advertisement of removing impotency and piles on the street walls, Ganja smokers, Bhang Drinking, Beetle leaves chewing, pontification, misconception in family planning miscreants in society, National drink: Tea, Vote based politics, tyranny of police, over delay in public services and using public fund for personal trip all are the features of shivpalganj in UP. Shri Lal Shukla has carved a niche of all such realities in his work Rag Darbari—a Sahitya Academy Winning work. The current system in the biggest constituency UP in India is still unprogressive in removing corruption and other social evils. It is still struggling with malpractices which are generated to exploit the poor. The wrong propagation of Malaria abolition and finding dirt at the bus and railway stations are also comment able issues

Review of Malware Detection in Android Applications using Dynamic Analysis

Today Android has the biggest market share as compared to other operating system for smart phone. As users are continuously increasing day by day the Security is one of the main concerns for Smartphone users. As the features and power of Smartphone are increase, so that they has their vulnerability for attacks by Malwares. But the android is the operating system which is more secure than any other operating systems available for Smart phones. The Android operating system has very few restrictions for developers and it will increase the security risk for end users. In this paper we have reviewed android security model, application level security in android and its security issues

Micro Strip Patch Antenna Using Broadside Coupling

The prominent parameters of antenna are bandwidth and gain. For improving band width and gain there are many challenges for micro strip patch antenna. There are many designs for improving bandwidth and gain but there are some disadvantages of that design. The gain and bandwidth can be improved by using broadside coupling of patch. All designs are simulated with the help of HFSS software. Micro strip patch antenna used in mobile for communication purpose and also it is used in indoor and outdoor application for communication. DOI: 10.17762/ijritcc2321-8169.15010

Applying a novel combination of techniques to develop a predictive model for diabetes complications

© 2015 Sangi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Among the many related issues of diabetes management, its complications constitute the main part of the heavy burden of this disease. The aim of this paper is to develop a risk advisor model to predict the chances of diabetes complications according to the changes in risk factors. As the starting point, an inclusive list of (k) diabetes complications and (n) their correlated predisposing factors are derived from the existing endocrinology text books. A type of data meta-analysis has been done to extract and combine the numeric value of the relationships between these two. The whole n (risk factors) - k (complications) model was broken down into k different (n-1) relationships and these (n-1) dependencies were broken into n (1-1) models. Applying regression analysis (seven patterns) and artificial neural networks (ANN), we created models to show the (1-1) correspondence between factors and complications. Then all 1-1 models related to an individual complication were integrated using the naïve Bayes theorem. Finally, a Bayesian belief network was developed to show the influence of all risk factors and complications on each other. We assessed the predictive power of the 1-1 models by R2, F-ratio and adjusted R2 equations; sensitivity, specificity and positive predictive value were calculated to evaluate the final model using real patient data. The results suggest that the best fitted regression models outperform the predictive ability of an ANN model, as well as six other regression patterns for all 1-1 models

Adaptive High Beam Control in Vehicles using Image Processing

The numbers of accidents occurring in night are increasing day by day because of the improper illumination on the bended streets and also because of the blindness caused to the driver by high intensity beam coming from the front coming vehicle.With the end goal to give improved evening time security measures, this work means to plan and assemble a headlight by adjusting a traditional static headlamp by keeping in mindthe expenses and unwavering quality. Also, to switch the headlight to dipper when there’s a vehicle approaching from front reaches within a defined range

The aggregation of cytochrome C may be linked to its flexibility during refolding

Large-scale expression of biopharmaceutical proteins in cellular hosts results in production of large insoluble mass aggregates. In order to generate functional product, these aggregates require further processing through refolding with denaturant, a process in itself that can result in aggregation. Using a model folding protein, cytochrome C, we show how an increase in final denaturant concentration decreases the propensity of the protein to aggregate during refolding. Using polarised fluorescence anisotropy, we show how reduced levels of aggregation can be achieved by increasing the period of time the protein remains flexible during refolding, mediated through dilution ratios. This highlights the relationship between the flexibility of a protein and its propensity to aggregate. We attribute this behaviour to the preferential urea-residue interaction, over self-association between molecules

Millets - Neglected Cereal with High Potential in Health Benefits in Malnutrition

In a world grappling with malnutrition, millets emerge as unsung heroes, offering a beacon of hope for improved global health. This chapter delves into the treasure trove of millets, revealing their often-overlooked potential as a nutritional powerhouse. Millets, a diverse group of cereal grains, hold the promise of mitigating malnutrition on a global scale. Firstly, we explore the exceptional nutritional value of millets, demonstrating how they pack a punch with essential vitamins, minerals, and dietary fiber. A comparative analysis with other grains underscores their superiority in providing a balanced diet. We then uncover the diverse varieties of millets and their suitability for various regions and climates, making them an adaptable and sustainable choice for farmers worldwide. Millet farming techniques, including their resilience to adverse conditions, are discussed, shedding light on their role in food security. The health implications of millet consumption are another focus, revealing their potential in preventing chronic diseases and improving overall well-being. Case studies underscore the tangible impact of millet-based interventions on malnutrition reduction. However, challenges persist, such as limited awareness and policy support. Nonetheless, millets hold immense promise for enhancing global health and nutrition. This chapter advocates for the integration of millets into our diets, promoting sustainable agriculture, and addressing malnutrition's root causes. As we delve into the world of millets, we find not only a neglected cereal but a beacon of hope for a healthier, more sustainable future

Clinicopathological Profile and Surgical Treatment of Abdominal Tuberculosis: A Single Centre Experience in Northwestern Tanzania.

Abdominal tuberculosis continues to be a major public health problem worldwide and poses diagnostic and therapeutic challenges to general surgeons practicing in resource-limited countries. This study was conducted to describe the clinicopathological profile and outcome of surgical treatment of abdominal tuberculosis in our setting and compare with what is described in literature. A prospective descriptive study of patients who presented with abdominal tuberculosis was conducted at Bugando Medical Centre (BMC) in northwestern Tanzania from January 2006 to February 2012. Ethical approval to conduct the study was obtained from relevant authorities. Statistical data analysis was performed using SPSS version 17.0. Out of 256 patients enrolled in the study, males outnumbered females. The median age was 28 years (range = 16-68 years). The majority of patients (77.3%) had primary abdominal tuberculosis. A total of 127 (49.6%) patients presented with intestinal obstruction, 106 (41.4%) with peritonitis, 17 (6.6%) with abdominal masses and 6 (2.3%) patients with multiple fistulae in ano. Forty-eight (18.8%) patients were HIV positive. A total of 212 (82.8%) patients underwent surgical treatment for abdominal tuberculosis. Bands /adhesions (58.5%) were the most common operative findings. Ileo-caecal region was the most common bowel involved in 122 (57.5%) patients. Release of adhesions and bands was the most frequent surgical procedure performed in 58.5% of cases. Complication and mortality rates were 29.7% and 18.8% respectively. The overall median length of hospital stay was 32 days and was significantly longer in patients with complications (p < 0.001). Advanced age (age ≥ 65 years), co-morbid illness, late presentation, HIV positivity and CD4+ count < 200 cells/μl were statistically significantly associated with mortality (p < 0.0001). The follow up of patients were generally poor as only 37.5% of patients were available for follow up at twelve months after discharge. Abdominal tuberculosis constitutes a major public health problem in our environment and presents a diagnostic challenge requiring a high index of clinical suspicion. Early diagnosis, early anti-tuberculous therapy and surgical treatment of the associated complications are essential for survival

An Important Role for Syndecan-1 in Herpes Simplex Virus Type-1 Induced Cell-to-Cell Fusion and Virus Spread

Herpes simplex virus type-1 (HSV-1) is a common human pathogen that relies heavily on cell-to-cell spread for establishing a lifelong latent infection. Molecular aspects of HSV-1 entry into host cells have been well studied; however, the molecular details of the spread of the virus from cell-to-cell remain poorly understood. In the past, the role of heparan sulfate proteoglycans (HSPG) during HSV-1 infection has focused solely on the role of HS chains as an attachment receptor for the virus, while the core protein has been assumed to perform a passive role of only carrying the HS chains. Likewise, very little is known about the involvement of any specific HSPGs in HSV-1 lifecycle. Here we demonstrate that a HSPG, syndecan-1, plays an important role in HSV-1 induced membrane fusion and cell-to-cell spread. Interestingly, the functions of syndecan-1 in fusion and spread are independent of the presence of HS on the core protein. Using a mutant CHO-K1 cell line that lacks all glycosaminoglycans (GAGs) on its surface (CHO-745) we demonstrate that the core protein of syndecan-1 possesses the ability to modulate membrane fusion and viral spread. Altogether, we identify a new role for syndecan-1 in HSV-1 pathogenesis and demonstrate HS-independent functions of its core protein in viral spread

A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita

© The Author(s). 2018Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops. Pasteuria penetrans is a hyperparasitic bacterium capable of suppressing the nematode reproduction, and represents a typical coevolved pathogen-hyperparasite system. Attachment of Pasteuria endospores to the cuticle of second-stage nematode juveniles is the first and pivotal step in the bacterial infection. RNA-Seq was used to understand the early transcriptional response of the root-knot nematode at 8 h post Pasteuria endospore attachment. Results: A total of 52,485 transcripts were assembled from the high quality (HQ) reads, out of which 582 transcripts were found differentially expressed in the Pasteuria endospore encumbered J2 s, of which 229 were up-regulated and 353 were down-regulated. Pasteuria infection caused a suppression of the protein synthesis machinery of the nematode. Several of the differentially expressed transcripts were putatively involved in nematode innate immunity, signaling, stress responses, endospore attachment process and post-attachment behavioral modification of the juveniles. The expression profiles of fifteen selected transcripts were validated to be true by the qRT PCR. RNAi based silencing of transcripts coding for fructose bisphosphate aldolase and glucosyl transferase caused a reduction in endospore attachment as compared to the controls, whereas, silencing of aspartic protease and ubiquitin coding transcripts resulted in higher incidence of endospore attachment on the nematode cuticle. Conclusions: Here we provide evidence of an early transcriptional response by the nematode upon infection by Pasteuria prior to root invasion. We found that adhesion of Pasteuria endospores to the cuticle induced a down-regulated protein response in the nematode. In addition, we show that fructose bisphosphate aldolase, glucosyl transferase, aspartic protease and ubiquitin coding transcripts are involved in modulating the endospore attachment on the nematode cuticle. Our results add new and significant information to the existing knowledge on early molecular interaction between M. incognita and P. penetrans.Peer reviewedFinal Published versio