8,854 research outputs found
Gas Chromaotography-Mass Spectrometry Analysis of Insecticidal Essential Oil Derived from Chinese Ainsliaea fragrans Champ ex Benth (Compositae)
Purpose: To investigate the chemical composition and insecticidal activity of the essential oil of the aerial parts of Ainsliaea fragrans against maize weevils (Sitophilus zeamais).Methods: The essential oil of A. fragrans aerial parts was obtained by hydrodistillation and analyzed by gas chromatography (GC) and gas chromaotography-mass spectrometry (GC-MS). Contact toxicity of the essential oil and its major constituents was determined by topical application against S. zeamais.Results: A total of 30 components of the essential oil were identified. The major constituents were myristicin (41.3 %), elemicine (11.9 %), cis-isosafrole (11.5 %), borneol (9.1 %) and caryophyllene (8.8 %). The essential oil of A. fragrans exhibited contact toxicity against S. zeamais with LC50 value of 50.7 μg/adult. Elemicine possessed the strongest contact toxicity (LC50 = 13.5 μg/adult) while cis-isosafrole, myristicin, caryophyllene and borneol had LC50 values of 31.2 μg/adult, 43.4 μg/adult, 57.9 μg/adult, and 98.4 μg/adult, respectively.Conclusion: The study indicates that the essential oil of A. fragrans aerial parts and its major constituents have a potential for development into natural insecticides for the control of grain storage insects.Keywords: Ainsliaea fragrans, Sitophilus zeamais, Contact toxicity, Elemicine, Essential oil, Grain storag
Tamoxifen accelerates the repair of demyelinated lesions in the central nervous system.
Enhancing central nervous system (CNS) myelin regeneration is recognized as an important strategy to ameliorate the devastating consequences of demyelinating diseases such as multiple sclerosis. Previous findings have indicated that myelin proteins, which accumulate following demyelination, inhibit remyelination by blocking the differentiation of rat oligodendrocyte progenitor cells (OPCs) via modulation of PKCα. We therefore screened drugs for their potential to overcome this differentiation block. From our screening, tamoxifen emerges as a potent inducer of OPC differentiation in vitro. We show that the effects of tamoxifen rely on modulation of the estrogen receptors ERα, ERβ, and GPR30. Furthermore, we demonstrate that administration of tamoxifen to demyelinated rats in vivo accelerates remyelination. Tamoxifen is a well-established drug and is thus a promising candidate for a drug to regenerate myelin, as it will not require extensive safety testing. In addition, Tamoxifen plays an important role in biomedical research as an activator of inducible genetic models. Our results highlight the importance of appropriate controls when using such models.This work was supported by grants from Wings for Life and the UK Multiple Sclerosis Society. M.R.N.K. holds an NIHR CL award and a Sir David and Isobel Walker fellowship. G.A.G. was supported by CONICYT (Becas Chile)
scholarship, and M.P.H. was supported by a Sir David and Isobel Walker studentship. Research in the author’s laboratory is supported by a core support grant from the Wellcome Trust and MRC to the Wellcome Trust Medical Research Council Cambridge Stem Cell Institut
Efficient and long-lived quantum memory with cold atoms inside a ring cavity
Quantum memories are regarded as one of the fundamental building blocks of
linear-optical quantum computation and long-distance quantum communication. A
long standing goal to realize scalable quantum information processing is to
build a long-lived and efficient quantum memory. There have been significant
efforts distributed towards this goal. However, either efficient but
short-lived or long-lived but inefficient quantum memories have been
demonstrated so far. Here we report a high-performance quantum memory in which
long lifetime and high retrieval efficiency meet for the first time. By placing
a ring cavity around an atomic ensemble, employing a pair of clock states,
creating a long-wavelength spin wave, and arranging the setup in the
gravitational direction, we realize a quantum memory with an intrinsic spin
wave to photon conversion efficiency of 73(2)% together with a storage lifetime
of 3.2(1) ms. This realization provides an essential tool towards scalable
linear-optical quantum information processing.Comment: 6 pages, 4 figure
Structural subnetwork evolution across the life-span: rich-club, feeder, seeder
The impact of developmental and aging processes on brain connectivity and the
connectome has been widely studied. Network theoretical measures and certain
topological principles are computed from the entire brain, however there is a
need to separate and understand the underlying subnetworks which contribute
towards these observed holistic connectomic alterations. One organizational
principle is the rich-club - a core subnetwork of brain regions that are
strongly connected, forming a high-cost, high-capacity backbone that is
critical for effective communication in the network. Investigations primarily
focus on its alterations with disease and age. Here, we present a systematic
analysis of not only the rich-club, but also other subnetworks derived from
this backbone - namely feeder and seeder subnetworks. Our analysis is applied
to structural connectomes in a normal cohort from a large, publicly available
lifespan study. We demonstrate changes in rich-club membership with age
alongside a shift in importance from 'peripheral' seeder to feeder subnetworks.
Our results show a refinement within the rich-club structure (increase in
transitivity and betweenness centrality), as well as increased efficiency in
the feeder subnetwork and decreased measures of network integration and
segregation in the seeder subnetwork. These results demonstrate the different
developmental patterns when analyzing the connectome stratified according to
its rich-club and the potential of utilizing this subnetwork analysis to reveal
the evolution of brain architectural alterations across the life-span
Brain penetrant LRRK2 inhibitor
This is the author accepted manuscript. The final version is available from ACS via the DOI in this record. Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. Here, we report that a 2-anilino-4-methylamino-5- chloropyrimidine, HG-10-102-01 (4), is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant. Compound 4 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in cells and is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse brain following intraperitoneal delivery of doses as low as 50 mg/kg. © 2012 American Chemical Society.NIHMedical Research CouncilMichael J Fox foundation for Parkinson’s disease researchPharmaceutical companies supporting the DSTT (AstraZeneca, Boehringer-Ingelheim, GlaxoSmithKline, Merck KgaA and Pfizer
Full-field implementation of a perfect eavesdropper on a quantum cryptography system
Quantum key distribution (QKD) allows two remote parties to grow a shared
secret key. Its security is founded on the principles of quantum mechanics, but
in reality it significantly relies on the physical implementation.
Technological imperfections of QKD systems have been previously explored, but
no attack on an established QKD connection has been realized so far. Here we
show the first full-field implementation of a complete attack on a running QKD
connection. An installed eavesdropper obtains the entire 'secret' key, while
none of the parameters monitored by the legitimate parties indicate a security
breach. This confirms that non-idealities in physical implementations of QKD
can be fully practically exploitable, and must be given increased scrutiny if
quantum cryptography is to become highly secure.Comment: Revised after editorial and peer-review feedback. This version is
published in Nat. Commun. 8 pages, 6 figures, 1 tabl
Bench-to-bedside review : targeting antioxidants to mitochondria in sepsis
Peer reviewedPublisher PD
Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication. The ATP and its derivatives function as a 'danger signal' in the most primitive forms of life. Purinoceptors are extraordinarily widely distributed in all cell types and tissues and they are involved in the regulation of an even more extraordinary number of biological processes. In addition to fast purinergic signalling in neurotransmission, neuromodulation and secretion, there is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body. In this article, we focus on the latter in the immune/defence system, in stratified epithelia in visceral organs and skin, embryological development, bone formation and resorption, as well as in cancer. Cell Death and Disease (2010) 1, e9; doi:10.1038/cddis.2009.11; published online 14 January 201
Geospatial information infrastructures
Manual of Digital Earth / Editors: Huadong Guo, Michael F. Goodchild, Alessandro Annoni .- Springer, 2020 .- ISBN: 978-981-32-9915-3Geospatial information infrastructures (GIIs) provide the technological, semantic,organizationalandlegalstructurethatallowforthediscovery,sharing,and use of geospatial information (GI). In this chapter, we introduce the overall concept and surrounding notions such as geographic information systems (GIS) and spatial datainfrastructures(SDI).WeoutlinethehistoryofGIIsintermsoftheorganizational andtechnologicaldevelopmentsaswellasthecurrentstate-of-art,andreflectonsome of the central challenges and possible future trajectories. We focus on the tension betweenincreasedneedsforstandardizationandtheever-acceleratingtechnological changes. We conclude that GIIs evolved as a strong underpinning contribution to implementation of the Digital Earth vision. In the future, these infrastructures are challengedtobecomeflexibleandrobustenoughtoabsorbandembracetechnological transformationsandtheaccompanyingsocietalandorganizationalimplications.With this contribution, we present the reader a comprehensive overview of the field and a solid basis for reflections about future developments
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