Note about a second "evidence" for a WIMP annual modulation

This note, with its five questions, is intended to contribute to a clarification about a claimed "evidence" by the DAMA group of an annual modulation of the counting rate of a Dark Matter NaI(Tl) detector as due to a neutralino (SUSY-LSP) Dark Matter candidate.Comment: LaTex, 3 pages, 2 figure

On Quantum Algorithms

Quantum computers use the quantum interference of different computational paths to enhance correct outcomes and suppress erroneous outcomes of computations. In effect, they follow the same logical paradigm as (multi-particle) interferometers. We show how most known quantum algorithms, including quantum algorithms for factorising and counting, may be cast in this manner. Quantum searching is described as inducing a desired relative phase between two eigenvectors to yield constructive interference on the sought elements and destructive interference on the remaining terms.Comment: 15 pages, 8 figure

Efficient discrete-time simulations of continuous-time quantum query algorithms

The continuous-time query model is a variant of the discrete query model in which queries can be interleaved with known operations (called "driving operations") continuously in time. Interesting algorithms have been discovered in this model, such as an algorithm for evaluating nand trees more efficiently than any classical algorithm. Subsequent work has shown that there also exists an efficient algorithm for nand trees in the discrete query model; however, there is no efficient conversion known for continuous-time query algorithms for arbitrary problems. We show that any quantum algorithm in the continuous-time query model whose total query time is T can be simulated by a quantum algorithm in the discrete query model that makes O[T log(T) / log(log(T))] queries. This is the first upper bound that is independent of the driving operations (i.e., it holds even if the norm of the driving Hamiltonian is very large). A corollary is that any lower bound of T queries for a problem in the discrete-time query model immediately carries over to a lower bound of \Omega[T log(log(T))/log (T)] in the continuous-time query model.Comment: 12 pages, 6 fig

Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players?

Introduction: Non-alcoholic fatty liver disease (NAFLD), considered the leading cause of chronic liver disease in children, can often progress from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH). It is clear that obesity is one of the main risk factors involved in NAFLD pathogenesis, even if specific mechanisms have yet to be elucidated. We investigated the distribution of intestinal bifidobacteria and lactobacilli in the stools of four groups of children: obese, obese with NAFL, obese with NASH, and healthy, age-matched controls (CTRLs). Material and methods: Sixty-one obese, NAFL and NASH children and 54 CTRLs were enrolled in the study. Anthropometric and metabolic parameters were measured for all subjects. All children with suspected NASH underwent liver biopsy. Bifidobacteria and lactobacilli were analysed in children’s faecal samples, during a broader, 16S rRNA-based pyrosequencing analysis of the gut microbiome. Results: Three Bifidobacterium spp. (Bifidobacterium longum, Bifidobacterium bifidum, and Bifidobacterium adolescentis) and five Lactobacillus spp. (L. zeae, L. vaginalis, L. brevis, L. ruminis, and L. mucosae) frequently recurred in metagenomic analyses. Lactobacillus spp. increased in NAFL, NASH, or obese children compared to CTRLs. Particularly, L. mucosae was significantly higher in obese (p = 0.02426), NAFLD (p = 0.01313) and NASH (p = 0.01079) than in CTRLs. In contrast, Bifidobacterium spp. were more abundant in CTRLs, suggesting a protective and beneficial role of these microorganisms against the aforementioned diseases. Conclusions: Bifidobacteria seem to have a protective role against the development of NAFLD and obesity, highlighting their possible use in developing novel, targeted and effective probiotics

Drosophila Importin-α2 Is Involved in Synapse, Axon and Muscle Development

Nuclear import is required for communication between the cytoplasm and the nucleus and to enact lasting changes in gene transcription following stimuli. Binding to an Importin-α molecule in the cytoplasm is often required to mediate nuclear entry of a signaling protein. As multiple isoforms of Importin-α exist, some may be responsible for the entry of distinct cargoes rather than general nuclear import. Indeed, in neuronal systems, Importin-α isoforms can mediate very specific processes such as axonal tiling and communication of an injury signal. To study nuclear import during development, we examined the expression and function of Importin-α2 in Drosophila melanogaster. We found that Importin-α2 was expressed in the nervous system where it was required for normal active zone density at the NMJ and axonal commissure formation in the central nervous system. Other aspects of synaptic morphology at the NMJ and the localization of other synaptic markers appeared normal in importin-α2 mutants. Importin-α2 also functioned in development of the body wall musculature. Mutants in importin-α2 exhibited errors in muscle patterning and organization that could be alleviated by restoring muscle expression of Importin-α2. Thus, Importin-α2 is needed for some processes in the development of both the nervous system and the larval musculature

Future large-scale water-Cherenkov detector

MEMPHYS (MEgaton Mass PHYSics) is a proposed large-scale water-Cherenkov experiment to be performed deep underground. It is dedicated to nucleon decay searches and the detection of neutrinos from supernovae, solar, and atmospheric neutrinos, as well as neutrinos from a future beam to measure the CP violating phase in the leptonic sector and the mass hierarchy. This paper provides an overview of the latest studies on the expected performance of MEMPHYS in view of detailed estimates of its physics reach, mainly concerning neutrino beams

How the reliability of external competences shapes the modularization strategies of industrialized construction firms

Firms modularize as they move into industrialized construction. Prior research highlights the importance of their modularization strategies, arguing that firms can either build the competence for modularization internally or can source them externally. To understand what shapes a firm’s choice to use external competences in its modularization strategy, we studied three leading construction firms. In this multiple case study, Alpha, Beta and Gamma are leaders in Asian markets, using reinforced concrete solutions in high-rise industrialized construction. Where external competences are available, our analyses show the work firms do to make them reliable and that their choice to use external competences is shaped by their reliability. Alpha modularized in a context with little available external competences, so it built new competences in-house; Beta chose to use the externally available manufacturing and assembly competences, using standards, remote monitoring and control of product architectures to make them reliable for their use in modularization; Gamma had available competences in the external context and initially sought to use them, but reliability concerns led to it modularizing by acquiring the firms to bring these competences in-house. Our contribution is to show how ensuring the reliability of external competences shapes modularization strategies. Further, we have identified actions that firms can adopt to make external competences reliable through: (1) use of international standards, (2) quality control procedures, (3) control of product architectures, and 4) acquisition of external competences. We provide implications for practitioners and policy makers seeking to transition to industrialized construction; and discuss new areas for research