Propuesta de comunicación en salud para abordar la problemática de la tuberculosis en el departamento de Sucre

No aplicaEn la propuesta se abordó la problemática de la tuberculosis en el departamento de Sucre y propuso una intervención para fortalecer la comunicación en salud en este contexto. Se destacó la importancia de una comunicación efectiva para prevenir, detectar y tratar la tuberculosis. Se propuso el uso del Modelo de Comunicación en Salud 4.0, que aprovecha las tecnologías digitales y las redes sociales, para promover la comunicación bidireccional y participativa entre los actores de salud y la comunidad. Los desafíos identificados incluyen la falta de acceso a la información, la desinformación y los estigmas asociados a la enfermedad. La intervención propuesta se enfoca en la difusión de mensajes claros, el uso de medios digitales, la capacitación de profesionales de salud y la participación activa de la comunidad. En resumen, se destaca la importancia de fortalecer la comunicación en salud para abordar la tuberculosis en Sucre y se propone una intervención basada en el Modelo de Comunicación en Salud 4.0.This study focuses on addressing the challenges of health communication related to tuberculosis in the Department of Sucre, Colombia. The aim is to develop an intervention proposal based on the principles of Health Communication 4.0. The proposal seeks to improve communication strategies, enhance access to accurate information, and combat misinformation and stigma associated with tuberculosis. The study highlights the importance of utilizing digital technologies, social media platforms, and clear messaging to reach a wider audience and promote community participation. Additionally, it emphasizes the need for training programs to enhance health communication skills among healthcare professionals and community members. The proposed intervention aims to create a comprehensive and effective communication framework to raise awareness, provide support, and facilitate the prevention and treatment of tuberculosis in the Department of Sucre

Manual para los maestros de escuelas de párvulos

Autor tomado de Palau, t. X, p. 130Las 12 p. finales contienen notaciones musicales, atribuidas por Palau al maestro José Bonill

Atributos del patrimonio cultural material para la potencialización del turismo cultural en Sincelejo para el año 2023 /

1.1 MB : 86 páginas ; tablasEste proyecto de investigación tiene como objetivo Analizar los atributos del patrimonio cultural material para la potencialización del turismo en Sincelejo. Del mismo modo se basó en diferentes concepciones relacionadas a este campo de estudio como son los autores Giménez (2005), quien define la teoría de los Atributos culturales, seguido Martorell (2017) citado en Alberca (2018), que hace referencia al turismo cultural, luego Fuentes et al (2019), el cual plantea la definición de las tradiciones y patrimonio entre otros que han resaltado sus aportes teóricos en la investigación, los cuales serán mencionados con su aporte en el marco de referencia. La investigación está enmarcada en el paradigma cualitativo, a través del método teoría fundamentada el cual es utilizado en las ciencias sociales que se encamina al estudio de datos y la generación de teorías a partir de la indagación y el análisis detallado de la información recopilada, esta se destaca por no ser una teoría preexistente, además es descriptiva y de campo, la fuente de información serán actores claves del sector cultural y turístico del departamento quienes son los encargados de la conservación y restauración del patrimonio cultural. Esta propuesta pretende dar a conocer los atributos del patrimonio cultural materiales de Sincelejo, logrando así un nuevo mercado turístico en el golfo del Morrosquillo. Esta propuesta es de gran apoyo para la comunidad sincelejana, debido a que presenta un beneficio económico, social y cultural por medio de estrategias que promuevan el turismo cultural en el departamento. El trabajo.The objective of this research project is to analyze the attributes of the material cultural heritage for the potentialization of tourism in Sincelejo. In the same way it was based on different conceptions related to this field of study such as the authors Giménez (2005) who defines the theory of Cultural Attributes, followed by Martorell (2017), who refers to cultural tourism, then Fuentes et al (2019), which raises the definition of traditions and heritage among others who have highlighted their theoretical contributions in the research, which will be mentioned with their contribution in the frame of reference. The research is framed in the qualitative paradigm, through the grounded theory method which is used in the social sciences that is directed to the study of data and the generation of theories from the inquiry and detailed analysis of the information collected, this stands out for not being a pre-existing theory, it is also descriptive and field, the source of information will be key actors of the cultural and tourism sector of the department who are responsible for the conservation and restoration of cultural heritage. This proposal intends to make known the attributes of the material cultural heritage of Sincelejo, thus achieving a new tourist market in the Gulf of Morrosquillo. This proposal is of great support for the community of Sincelejo, because it presents an economic, social and cultural benefit through strategies that promote cultural tourism in the department. El trabajo.PregradoAdministrador(a) de EmpresasTrabajo de grado(Administrador de Empresas) --Corporación Universitaria del Caribe. Facultad de Ciencias Económicas y Administrativas. Programa de Administración de Empresas. Sincelejo, 2023

Immunomodulatory role of vasoactive intestinal peptide and ghrelin in Oncorhynchus mykiss

Neuropeptides are a group of peptides derived from precursor proteins synthesized in neuronal and nonneuronal cells. The classical functions of neuropeptides have been extensively studied in mammals, including neuromodulation in the central nervous system, molecular signaling in the peripheral nervous system, and immunomodulation associated mainly with anti-inflammatory activity. In contrast, in teleosts, studies of the immunomodulatory function of these neuropeptides are limited. In Oncorhynchus mykiss, vasoactive intestinal peptide (VIP) mRNA sequences have not been cloned, and the role of VIP in modulating the immune system has not been studied. Furthermore, in relation to other neuropeptides with possible immunomodulatory function, such as ghrelin, there are also few studies. Therefore, in this work, we performed molecular cloning, identification, and phylogenetic analysis of three VIP precursor sequences (prepro-VIP1, VIP2 and VIP3) in rainbow trout. In addition, the immunomodulatory function of both neuropeptides was evaluated in an in vitro model using the VIP1 sequence identified in this work and a ghrelin sequence already studied in O. mykiss. The results suggest that the prepro-VIP2 sequence has the lowest percentage of identity with respect to the other homologous sequences and is more closely related to mammalian orthologous sequences. VIP1 induces significant expression of both pro-inflammatory (IFN-γ, IL-1β) and anti-inflammatory (IL-10 and TGF-β) cytokines, whereas ghrelin only induces significant expression of proinflammatory cytokines such as IL-6 and TNF-α

Use of S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy polyethylene glycol as an adjuvant improved protective immunity associated with a DNA vaccine encoding Cu,Zn superoxide dismutase of Brucella abortus in mice.

This study was conducted to evaluate the immunogenicity and protective efficacy of a DNA vaccine encoding Brucella abortus Cu,Zn superoxide dismutase (SOD) using the Toll-like receptor 2/6 agonist S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy polyethylene glycol (BPPcysMPEG) as an adjuvant. Intranasal coadministration of BPPcysMPEG with a plasmid carrying the SOD-encoding gene (pcDNA-SOD) into BALB/c mice elicited antigen-specific humoral and cellular immune responses. Humoral responses were characterized by the stimulation of IgG2a and IgG1 and by the presence of SOD-specific secretory IgA in nasal and bronchoalveolar lavage fluids. Furthermore, T-cell proliferative responses and increased production of gamma interferon were also observed upon splenocyte restimulation with recombinant SOD. Cytotoxic responses were also stimulated, as demonstrated by the lysis of RB51-SOD-infected J774.A1 macrophages by cells recovered from immunized mice. The pcDNA-SOD/BPPcysMPEG formulation induced improved protection against challenge with the virulent strain B. abortus 2308 in BALB/c mice over that provided by pcDNA-SOD, suggesting the potential of this vaccination strategy against Brucella infection