Fed-batch control based upon the measurement of intracellular NADH

A series of experiments demonstrating that on-line measurements of intracellular NADH by culture fluorescence can be used to monitor and control the fermentation process are described. A distinct advantage of intercellular NADH measurements over other monitoring techniques such as pH and dissolved oxygen is that it directly measures real time events occurring within the cell rather than changes in the environment. When coupled with other measurement parameters, it can provide a finer degree of sophistication in process control

Multi-criteria analysis applied to multi-objective optimal pump scheduling in water systems

[EN] This work presents a multi-criteria-based approach to automatically select specific non-dominated solutions from a Pareto front previously obtained using multi-objective optimization to find optimal solutions for pump control in a water supply system. Optimal operation of pumps in these utilities is paramount to enable water companies to achieve energy efficiency in their systems. The Fuzzy Technique for Order of Preference by Similarity to Ideal Solution (FTOPSIS) is used to rank the Pareto solutions found by the non-dominated sorting genetic algorithm (NSGA-II) employed to solve the multi-objective problem. Various scenarios are evaluated under leakage uncertainty conditions, resulting in fuzzy solutions for the Pareto front. This paper shows the suitability of the approach for quasi real-world problems. In our case-study, the obtained solutions for scenarios including leakage represent the best trade-off among the optimal solutions, under some considered criteria, namely, operational cost, operational lack of service, pressure uniformity and network resilience. Potential future developments could include the use of clustering alternatives to evaluate the goodness of each solution under the considered evaluation criteria.Carpitella, S.; Brentan, BM.; Montalvo Arango, I.; Izquierdo Sebastián, J.; Certa, A. (2019). Multi-criteria analysis applied to multi-objective optimal pump scheduling in water systems. Water Science & Technology: Water Supply. 19(8):2338-2346. https://doi.org/10.2166/ws.2019.115S23382346198Ancău, M., & Caizar, C. (2010). The computation of Pareto-optimal set in multicriterial optimization of rapid prototyping processes. Computers & Industrial Engineering, 58(4), 696-708. doi:10.1016/j.cie.2010.01.015Aşchilean, I., Badea, G., Giurca, I., Naghiu, G. S., & Iloaie, F. G. (2017). Choosing the Optimal Technology to Rehabilitate the Pipes in Water Distribution Systems Using the AHP Method. Energy Procedia, 112, 19-26. doi:10.1016/j.egypro.2017.03.1109Brentan, B., Meirelles, G., Luvizotto, E., & Izquierdo, J. (2018). Joint Operation of Pressure-Reducing Valves and Pumps for Improving the Efficiency of Water Distribution Systems. Journal of Water Resources Planning and Management, 144(9), 04018055. doi:10.1061/(asce)wr.1943-5452.0000974Certa, A., Enea, M., Galante, G. M., & La Fata, C. M. (2017). ELECTRE TRI-based approach to the failure modes classification on the basis of risk parameters: An alternative to the risk priority number. Computers & Industrial Engineering, 108, 100-110. doi:10.1016/j.cie.2017.04.018Chen, C.-T. (2000). Extensions of the TOPSIS for group decision-making under fuzzy environment. Fuzzy Sets and Systems, 114(1), 1-9. doi:10.1016/s0165-0114(97)00377-1Cruz-Reyes, L., Fernandez, E., Sanchez, P., Coello Coello, C. A., & Gomez, C. (2017). Incorporation of implicit decision-maker preferences in multi-objective evolutionary optimization using a multi-criteria classification method. Applied Soft Computing, 50, 48-57. doi:10.1016/j.asoc.2016.10.037Farmani, R., Ingeduld, P., Savic, D., Walters, G., Svitak, Z., & Berka, J. (2007). Real-time modelling of a major water supply system. Proceedings of the Institution of Civil Engineers - Water Management, 160(2), 103-108. doi:10.1680/wama.2007.160.2.103Hadas, Y., & Nahum, O. E. (2016). Urban bus network of priority lanes: A combined multi-objective, multi-criteria and group decision-making approach. Transport Policy, 52, 186-196. doi:10.1016/j.tranpol.2016.08.006Hamdan, S., & Cheaitou, A. (2017). Supplier selection and order allocation with green criteria: An MCDM and multi-objective optimization approach. Computers & Operations Research, 81, 282-304. doi:10.1016/j.cor.2016.11.005Ho, W. (2008). Integrated analytic hierarchy process and its applications – A literature review. European Journal of Operational Research, 186(1), 211-228. doi:10.1016/j.ejor.2007.01.004Jowitt, P. W., & Germanopoulos, G. (1992). Optimal Pump Scheduling in Water‐Supply Networks. Journal of Water Resources Planning and Management, 118(4), 406-422. doi:10.1061/(asce)0733-9496(1992)118:4(406)Jowitt, P. W., & Xu, C. (1990). Optimal Valve Control in Water‐Distribution Networks. Journal of Water Resources Planning and Management, 116(4), 455-472. doi:10.1061/(asce)0733-9496(1990)116:4(455)Kurek, W., & Ostfeld, A. (2013). Multi-objective optimization of water quality, pumps operation, and storage sizing of water distribution systems. Journal of Environmental Management, 115, 189-197. doi:10.1016/j.jenvman.2012.11.030Lima, G. M., Luvizotto, E., & Brentan, B. M. (2017). Selection and location of Pumps as Turbines substituting pressure reducing valves. Renewable Energy, 109, 392-405. doi:10.1016/j.renene.2017.03.056Mala-Jetmarova, H., Sultanova, N., & Savic, D. (2017). Lost in optimisation of water distribution systems? A literature review of system operation. Environmental Modelling & Software, 93, 209-254. doi:10.1016/j.envsoft.2017.02.009Montalvo, I., Izquierdo, J., Pérez-García, R., & Herrera, M. (2014). Water Distribution System Computer-Aided Design by Agent Swarm Optimization. Computer-Aided Civil and Infrastructure Engineering, 29(6), 433-448. doi:10.1111/mice.12062Odan, F. K., Ribeiro Reis, L. F., & Kapelan, Z. (2015). Real-Time Multiobjective Optimization of Operation of Water Supply Systems. Journal of Water Resources Planning and Management, 141(9), 04015011. doi:10.1061/(asce)wr.1943-5452.0000515Ostfeld, A., Uber, J. G., Salomons, E., Berry, J. W., Hart, W. E., Phillips, C. A., … Walski, T. (2008). The Battle of the Water Sensor Networks (BWSN): A Design Challenge for Engineers and Algorithms. Journal of Water Resources Planning and Management, 134(6), 556-568. doi:10.1061/(asce)0733-9496(2008)134:6(556)Todini, E. (2000). Looped water distribution networks design using a resilience index based heuristic approach. Urban Water, 2(2), 115-122. doi:10.1016/s1462-0758(00)00049-2Zaidan, A. A., Zaidan, B. B., Al-Haiqi, A., Kiah, M. L. M., Hussain, M., & Abdulnabi, M. (2015). Evaluation and selection of open-source EMR software packages based on integrated AHP and TOPSIS. Journal of Biomedical Informatics, 53, 390-404. doi:10.1016/j.jbi.2014.11.012Żak, J., & Kruszyński, M. (2015). Application of AHP and ELECTRE III/IV Methods to Multiple Level, Multiple Criteria Evaluation of Urban Transportation Projects. Transportation Research Procedia, 10, 820-830. doi:10.1016/j.trpro.2015.09.03

Access and metro network convergence for flexible end-to-end network design

This paper reports on the architectural, protocol, physical layer, and integrated testbed demonstrations carried out by the DISCUS FP7 consortium in the area of access - metro network convergence. Our architecture modeling results show the vast potential for cost and power savings that node consolidation can bring. The architecture, however, also recognizes the limits of long-reach transmission for low-latency 5G services and proposes ways to address such shortcomings in future projects. The testbed results, which have been conducted end-to-end, across access - metro and core, and have targeted all the layers of the network from the application down to the physical layer, show the practical feasibility of the concepts proposed in the project

Signals for Vector Leptoquarks in Hadronic Collisions

We analyze systematically the signatures of vector leptoquarks in hadronic collisions. We examine their single and pair productions, as well as their effects on the production of lepton pairs. Our results indicate that a machine like the CERN Large Hadron Collider (LHC) will be able to unravel the existence of vector leptoquarks with masses up to the range of $2$--$3$ TeV.Comment: 15 pages and 5 figures (available upon request or through anonymous ftp), revtex3, IFUSP-P 108

Higher education segregation in Spain: Gender constructs and social background

The waning influence of ascriptive factors on occupational status has been related to the expansion of higher education systems and economic modernisation. The theory of Effectively Maintained Inequality observes that the horizontal stratification of university degrees is a strategy of social differentiation used mainly by the most advantaged social class to access the occupations that are better valued in the labour market. This article verifies the effectively maintained inequality theory by means of a statistical analysis of selected degrees, differentiated by gender and social class, carried out in a Spanish university during the period of expansion and consolidation of the higher education system. The results confirm the theory, but they are partially conditioned by the vertical stratification that alters the composition by gender of the contingent of students of less advantaged social class, in which women present a greater tendency to choose degrees that are less valued by the market

Multi-agent simulation of hydraulic transient equations in pressurized systems

Computational modeling pervades virtually every industrial process. By using numerical representations of the behavior of elements that constitute a system it is possible to obtain efficient and safe designs. Moreover, system operation can be better defined by using such models, thus enabling greater reliability and control. In this paper the use of agents to solve the equations describing fast transients in water networks is investigated. As the simulation of hydraulic transients in pressurized systems is a naturally distributed problem, the authors argue that a multi-agent based system is very suitable for the solution of this complex engineering phenomenon. A hybrid solution is built by deploying agents to work with sets of equations describing hydraulic transient behavior in pipeline systems. The details necessary to assemble a complete and lubricated machine to model the complex phenomenon of hydraulic transients in pressurized systems are described. This research develops a platform that constitutes an efficient and versatile tool of great interest for water supply managers when analyzing water hammer effects in their networks.Izquierdo Sebastián, J.; Montalvo Arango, I.; Pérez García, R.; Ayala Cabrera, D. (2015). Multi-agent simulation of hydraulic transient equations in pressurized systems. Journal of Computing in Civil Engineering. 04015071:1-14. doi:10.1061/(ASCE)CP.1943-5487.0000549S1140401507

Lightfastness assessment of Levantine rock art by means of microfading spectrometry

This is the peer reviewed version of the following article: del Hoyo-Meléndez JM, Carrión-Ruiz B, Riutort-Mayol G, Lerma JL. Lightfastness assessment of Levantine rock art by means of microfading spectrometry. Color Res Appl. 2019;44:547 555, which has been published in final form at https://doi.org/10.1002/col.22372. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.[EN] The documentation of archeological sites requires the adoption of non-destructive techniques to safeguard the unique legacy coming from prehistoric periods. This article tackles the assessment of lightfastness properties on a rock art site to deter- mine the behavior of motif's color deterioration over time in Remi¿gia Cave, Castello¿n (Spain), which is considered part of a UNESCO World Heritage Site. The measurements were performed using a microfade testing device to analyze the spectral characteristics and the aging properties of the colorant system and various substrates on site. Two scenarios have been identified depending on whether the lightness (L*) parameter of the rocky substrate changes or not in relation with the painted motifs. If the substrate remains stable without any change, red motifs con- taining iron oxide pigments will become more visible. If the substrate becomes lighter, the pigments will experience similar changes. Therefore, the contrast between paintings and support will be considerably enhanced.The authors also would like to thank the Generalitat Valenciana for providing access to the site during the measurement campaigns. Fruitful comments from the Spanish archeologists Prof. Valentín Villaverde and Dra. Esther López-Montalvo are also gratefully acknowledged. The authors acknowledge the research project HAR2014-59873-R from the Spanish Ministerio de Economía y Competitividad for providing financial support.Del Hoyo-Meléndez, JM.; Carrión-Ruiz, B.; Riutort-Mayol, G.; Lerma, JL. (2019). Lightfastness assessment of Levantine rock art by means of microfading spectrometry. Color Research & Application. 44(4):547-555. https://doi.org/10.1002/col.22372S547555444Vileikis, O., Cesaro, G., Santana Quintero, M., van Balen, K., Paolini, A., & Vafadari, A. (2012). Documentation in World Heritage conservation. Journal of Cultural Heritage Management and Sustainable Development, 2(2), 130-152. doi:10.1108/20441261211273635Management Planning for Archaelogical Sites 2002 The Getty Conservation Institute Los Angeles G Palumbo Threats and challenges to the archaeological heritage in the Mediterranean 3 12ICOMOS. ICOMOS World Report 2000 on Monuments and Sites in Danger; 2000.https://www.icomos.org/risk/world_report/2000/risk2000.htm. Accessed October 25 2017.Giesen, M. J., Ung, A., Warke, P. A., Christgen, B., Mazel, A. D., & Graham, D. W. (2014). Condition assessment and preservation of open-air rock art panels during environmental change. Journal of Cultural Heritage, 15(1), 49-56. doi:10.1016/j.culher.2013.01.013Díez-Herrero, A., Gutiérrez-Pérez, I., Lario, J., Cañaveras, J. C., Benavente, D., Sánchez-Moral, S., & Alonso-Azcárate, J. (2009). Analysis of potential direct insolation as a degradation factor of cave paintings in Villar del Humo, Cuenca, Central Spain. Geoarchaeology, 24(4), 450-465. doi:10.1002/gea.20274López-Montalvo, E., Villaverde, V., Roldán, C., Murcia, S., & Badal, E. (2014). An approximation to the study of black pigments in Cova Remigia (Castellón, Spain). Technical and cultural assessments of the use of carbon-based black pigments in Spanish Levantine Rock Art. Journal of Archaeological Science, 52, 535-545. doi:10.1016/j.jas.2014.09.017Hernanz, A., Ruiz-López, J. F., Gavira-Vallejo, J. M., Martin, S., & Gavrilenko, E. (2010). Raman microscopy of prehistoric rock paintings from the Hoz de Vicente, Minglanilla, Cuenca, Spain. Journal of Raman Spectroscopy, 41(11), 1394-1399. doi:10.1002/jrs.2582Domingo, I., Villaverde, V., López-Montalvo, E., Lerma, J. L., & Cabrelles, M. (2013). Latest developments in rock art recording: towards an integral documentation of Levantine rock art sites combining 2D and 3D recording techniques. Journal of Archaeological Science, 40(4), 1879-1889. doi:10.1016/j.jas.2012.11.024Iturbe, A., Cachero, R., Cañal, D., & Martos, A. (2018). Digitalización de cuevas con arte paleolítico parietal de Bizkaia. Análisis científico y divulgación mediante nuevas técnicas de visualización. Virtual Archaeology Review, 9(18), 57. doi:10.4995/var.2018.7579Carrión-Ruiz, B., Blanco-Pons, S., & Lerma, J. L. (2016). DIGITAL IMAGE ANALYSIS OF THE VISIBLE REGION THROUGH SIMULATION OF ROCK ART PAINTINGS. Proceedings of the ARQUEOLÓGICA 2.0 8th International Congress on Archaeology, Computer Graphics, Cultural Heritage and Innovation. doi:10.4995/arqueologica8.2016.3560Fredlund, G., & Sundstrom, L. (2007). Digital infra-red photography for recording painted rock art. Antiquity, 81(313), 733-742. doi:10.1017/s0003598x00095697Cerrillo-Cuenca, E., & Sepúlveda, M. (2015). An assessment of methods for the digital enhancement of rock paintings: the rock art from the precordillera of Arica (Chile) as a case study. Journal of Archaeological Science, 55, 197-208. doi:10.1016/j.jas.2015.01.006Robert, E., Petrognani, S., & Lesvignes, E. (2016). Applications of digital photography in the study of Paleolithic cave art. Journal of Archaeological Science: Reports, 10, 847-858. doi:10.1016/j.jasrep.2016.07.026López-Menchero Bendicho, V. M., Marchante Ortega, Á., Vincent, M., Cárdenas Martín-Buitrago, Á. J., & Onrubia Pintado, J. (2017). Uso combinado de la fotografía digital nocturna y de la fotogrametría en los procesos de documentación de petroglifos: el caso de Alcázar de San Juan (Ciudad Real, España). Virtual Archaeology Review, 8(17), 64. doi:10.4995/var.2017.6820Molada-Tebar, A., Lerma, J. L., & Marqués-Mateu, Á. (2017). Camera characterization for improving color archaeological documentation. Color Research & Application, 43(1), 47-57. doi:10.1002/col.22152Del Hoyo-Meléndez, J. M., Lerma, J. L., López-Montalvo, E., & Villaverde, V. (2015). Documenting the light sensitivity of Spanish Levantine rock art paintings. ISPRS Annals of Photogrammetry, Remote Sensing and Spatial Information Sciences, II-5/W3, 53-59. doi:10.5194/isprsannals-ii-5-w3-53-2015Whitmore, P. M., Bailie, C., & Connors, S. A. (2000). Micro-fading tests to predict the result of exhibition: progress and prospects. Studies in Conservation, 45(sup1), 200-205. doi:10.1179/sic.2000.45.supplement-1.200Whitmore, P. M., Pan, X., & Bailie, C. (1999). Predicting the Fading of Objects: Identification of Fugitive Colorants through Direct Nondestructive Lightfastness Measurements. Journal of the American Institute for Conservation, 38(3), 395. doi:10.2307/3179999Ford, B. (2011). Non-destructive microfade testing at the National Museum of Australia. AICCM Bulletin, 32(1), 54-64. doi:10.1179/bac.2011.32.1.008Del Hoyo-Meléndez, J. M., & Mecklenburg, M. F. (2010). A survey on the light-fastness properties of organic-based Alaska Native artifacts. Journal of Cultural Heritage, 11(4), 493-499. doi:10.1016/j.culher.2010.01.004Conservation of Ancient Sites on the Silk Road 2010 The Getty Conservation Institute The Getty. Los Angeles JR Druzik Evaluating the light sensitivity of paints in selected wall paintings at the Mogao Grottoes: caves 217 98 and 85 457 463López-Montalvo, E., Roldán, C., Badal, E., Murcia-Mascarós, S., & Villaverde, V. (2017). Identification of plant cells in black pigments of prehistoric Spanish Levantine rock art by means of a multi-analytical approach. A new method for social identity materialization using chaîne opératoire. PLOS ONE, 12(2), e0172225. doi:10.1371/journal.pone.0172225Roldán, C., Murcia-Mascarós, S., Ferrero, J., Villaverde, V., López, E., Domingo, I., … Guillem, P. M. (2010). Application of field portable EDXRF spectrometry to analysis of pigments of Levantine rock art. X-Ray Spectrometry, 39(3), 243-250. doi:10.1002/xrs.1254Roldán García, C., Villaverde Bonilla, V., Ródenas Marín, I., & Murcia Mascarós, S. (2016). A Unique Collection of Palaeolithic Painted Portable Art: Characterization of Red and Yellow Pigments from the Parpalló Cave (Spain). PLOS ONE, 11(10), e0163565. doi:10.1371/journal.pone.0163565Łojewski, T., Thomas, J., Gołąb, R., Kawałko, J., & Łojewska, J. (2011). Note: Light ageing with simultaneous colorimetry via fibre optics reflection spectrometry. 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Signal and Backgrounds for the Single Production of Scalar and Vector Leptoquarks at the LHC

We perform a detailed analysis of the potentiality of the CERN Large Hadron Collider to study the single production of leptoquarks via $pp \to e^\pm q\to$ leptoquark $\to e^\pm q$, with $e^\pm$ generated by the splitting of photons radiated by the protons. Working with the most general $SU(2)_L \otimes U(1)_Y$ invariant effective lagrangian for scalar and vector leptoquarks, we analyze in detail the leptoquark signals and backgrounds that lead to a final state containing an $e^\pm$ and a hard jet with approximately balanced transverse momenta. Our results indicate that the LHC will be able to discover leptoquarks with masses up to 2--3 TeV, depending on their type, for Yukawa couplings of the order of the electromagnetic one.Comment: Revtex, 23 pages, 11 postscript files. Uses axodraw.sty (included) and epsfig.sty. Typos corrected. To be published in Phys. Rev.

A Human Development Framework for CO2 Reductions

Although developing countries are called to participate in CO2 emission reduction efforts to avoid dangerous climate change, the implications of proposed reduction schemes in human development standards of developing countries remain a matter of debate. We show the existence of a positive and time-dependent correlation between the Human Development Index (HDI) and per capita CO2 emissions from fossil fuel combustion. Employing this empirical relation, extrapolating the HDI, and using three population scenarios, the cumulative CO2 emissions necessary for developing countries to achieve particular HDI thresholds are assessed following a Development As Usual approach (DAU). If current demographic and development trends are maintained, we estimate that by 2050 around 85% of the world's population will live in countries with high HDI (above 0.8). In particular, 300Gt of cumulative CO2 emissions between 2000 and 2050 are estimated to be necessary for the development of 104 developing countries in the year 2000. This value represents between 20% to 30% of previously calculated CO2 budgets limiting global warming to 2{\deg}C. These constraints and results are incorporated into a CO2 reduction framework involving four domains of climate action for individual countries. The framework reserves a fair emission path for developing countries to proceed with their development by indexing country-dependent reduction rates proportional to the HDI in order to preserve the 2{\deg}C target after a particular development threshold is reached. Under this approach, global cumulative emissions by 2050 are estimated to range from 850 up to 1100Gt of CO2. These values are within the uncertainty range of emissions to limit global temperatures to 2{\deg}C.Comment: 14 pages, 7 figures, 1 tabl

Signal and Backgrounds for Leptoquarks at the LHC II: Vector Leptoquarks

We perform a detailed analyses of the CERN Large Hadron Collider (LHC) capability to discover first generation vector leptoquarks through their pair production. We study the leptoquark signals and backgrounds that give rise to final states containing a pair e+e- and jets. Our results show that the LHC will be able to discover vector leptoquarks with masses up to 1.3-2.1 TeV depending on their couplings to fermions and gluons.Comment: 18 pages, 3 figures, REVTe