Hypersonic blunt body computations including real gas effects

The recently developed second-order explicit and implicit total variation diminishing (TVD) shock-capturing methods of the Harten and Yee, Yee, and van Leer types in conjunction with a generalized Roe's approximate Riemann solver of Vinokur and the generalized flux-vector splittings of Vinokur and Montagne for two-dimensional hypersonic real gas flows are studied. A previous study on one-dimensional unsteady problems indicated that these schemes produce good shock-capturing capability and that the state equation does not have a large effect on the general behavior of these methods for a wide range of flow conditions for equilibrium air. The objective of this paper is to investigate the applicability and shock resolution of these schemes for two-dimensional steady-state hypersonic blunt body flows. The main contribution of this paper is to identify some of the elements and parameters which can affect the convergence rate for high Mach numbers or real gases but have negligible effect for low Mach number cases for steady-state inviscid blunt body flows

Frozen spatial chaos induced by boundaries

We show that rather simple but non-trivial boundary conditions could induce the appearance of spatial chaos (that is stationary, stable, but spatially disordered configurations) in extended dynamical systems with very simple dynamics. We exemplify the phenomenon with a nonlinear reaction-diffusion equation in a two-dimensional undulated domain. Concepts from the theory of dynamical systems, and a transverse-single-mode approximation are used to describe the spatially chaotic structures.Comment: 9 pages, 6 figures, submitted for publication; for related work visit http://www.imedea.uib.es/~victo

High- Resolution Shock-Capturing Schemes for Inviscid and Viscous Hypersonic Flows

A class of high-resolution implicit total variation diminishing (TVD) type algorithms suitable for transonic multidimensional Euler and Navier-Stokes equations has been extended to hypersonic computations. The improved conservative shock-capturing schemes are spatially second- and third-order and are fully implicit. They can be first- or second-order accurate in time and are suitable for either steady or unsteady calculations. Enhancement of stability and convergence rate for hypersonic flows is discussed. With the proper choice of the temporal discretization and implicit linearization, these schemes are fairly efficient and accurate for very complex two-dimensional hypersonic in viscid and viscous shock interactions. This study is complemented by a variety of steady and unsteady viscous and inviscid hypersonic blunt body flow computations. Due to the inherent stiffness of viscous flow problems, numerical experiments indicated that the convergence rate is in general slower for viscous flows than for inviscid steady flows

Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity

The receptor tyrosine kinase Met and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas the deregulation of Met signaling is associated with tumorigenesis. While ligand-activated Met promotes survival, caspase-dependent generation of the p40 Met fragment leads to apoptosis induction – hallmark of the dependence receptor. Although the survival signaling pathways induced by Met are well described, the pro-apoptotic signaling pathways are unknown. We show that, although p40 Met contains the entire kinase domain, it accelerates apoptosis independently of kinase activity. In cell cultures undergoing apoptosis, the fragment shows a mitochondrial localization, required for p40 Met-induced cell death. Fulminant hepatic failure induced in mice leads to the generation of p40 Met localized also in the mitochondria, demonstrating caspase cleavage of Met in vivo. According to its localization, the fragment induces mitochondrial permeabilization, which is inhibited by Bak silencing and Bcl-xL overexpression. Moreover, Met silencing delays mitochondrial permeabilization induced by an apoptotic treatment. Thus, the Met-dependence receptor in addition to its well-known role in survival signaling mediated by its kinase activity, also participates in the intrinsic apoptosis pathway through the generation of p40 Met – a caspase-dependent fragment of Met implicated in the mitochondrial permeabilization process

Comprehensive study of phase transitions in relaxational systems with field-dependent coefficients

We present a comprehensive study of phase transitions in single-field systems that relax to a non-equilibrium global steady state. The mechanism we focus on is not the so-called Stratonovich drift combined with collective effects, but is instead similar to the one associated with noise-induced transitions a la Horsthemke-Lefever in zero-dimensional systems. As a consequence, the noise interpretation (e.g., Ito vs Stratonvich) merely shifts the phase boundaries. With the help of a mean-field approximation, we present a broad qualitative picture of the various phase diagrams that can be found in these systems. To complement the theoretical analysis we present numerical simulations that confirm the findings of the mean-field theory

Chaos induced coherence in two independent food chains

Coherence evolution of two food web models can be obtained under the stirring effect of chaotic advection. Each food web model sustains a three--level trophic system composed of interacting predators, consumers and vegetation. These populations compete for a common limiting resource in open flows with chaotic advection dynamics. Here we show that two species (the top--predators) of different colonies chaotically advected by a jet--like flow can synchronize their evolution even without migration interaction. The evolution is charaterized as a phase synchronization. The phase differences (determined through the Hilbert transform) of the variables representing those species show a coherent evolution.Comment: 5 pages, 5 eps figures. Accepted for publication in Phys. Rev.

Forecasting the SST space-time variability of the Alboran Sea with genetic algorithms

We propose a nonlinear ocean forecasting technique based on a combination of genetic algorithms and empirical orthogonal function (EOF) analysis. The method is used to forecast the space-time variability of the sea surface temperature (SST) in the Alboran Sea. The genetic algorithm finds the equations that best describe the behaviour of the different temporal amplitude functions in the EOF decomposition and, therefore, enables global forecasting of the future time-variability.Comment: 15 pages, 3 figures; latex compiled with agums.st

Improvement of radiology requisition

AbstractPurposeInadequate or incomplete information on radiology requisitions may have a substantial impact on the radiological process. This study aimed to evaluate the impact of standardization and computerization of radiology requisitions on the quality of provided data, satisfaction of hospital staff and access time.MethodsThe impact of requisition support was assessed at each step of the improvement process for inpatients: before (Step 1), after standardization (Step 2) and after computerization of radiology requisition (Step 3). The quality of information provided was assessed by proportion of missing data on MRI and CT requisitions. Satisfaction was assessed by an anonymous auto-questionnaire filled by ordering physicians, radiologists and radiology technicians. Access time was prospectively assessed.ResultsStandardization of radiology requisition resulted in a significant drop in proportion of missing data. Computerization of radiology requisition, based on the single standardized radiology requisition, further improved the quality of information reported on radiology requisitions. The median access time was significantly improved (from 5 to 3days) for the largest provider of CT requisitions.ConclusionsStandardization and computerization have a synergistic effect on the overall quality improvement. Moreover, the computerized provider order entry enables traceability of information, makes communication between radiologists and ordering physicians easier and improves examination planning