4,006 research outputs found
Statistical Pitfalls in Medical Research
In conducting and reporting of medical research, there are some common pitfalls in using statistical methodology which may result in invalid inferences being made. This paper is aimed to highlight to inexperienced statisticians or non-statistician some of the common statistical pitfalls encountered when using statistics to interpret data in medical research. We also comment on good practices to avoid these pitfalls. Malawi Medical Journal Vol. 20 (1) 2008 pp. 15-1
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Application of DIGE and mass spectrometry in the study of type 2 Diabetes Mellitus (T2DM) mouse models
Knowledge of the differences between the amounts and types of protein that are expressed in diseased compared to healthy subjects may give an understanding of the biological pathways that cause disease. This is the reasoning behind the presented protocol, which uses difference gel electrophoresis to discover up‐ or down‐regulated proteins between mice of different genotypes, or
of those fed on different diets, that may thus be prone to develop diabetes‐like phenotypes. Subsequent analysis of these proteins by tandem mass spectrometry typically facilitates their identification with a high degree of confidence
CISTO TRAUMÁTICO DA MANDÍBULA- RELATO DE CASO CLÍNICO
O cisto ósseo traumático é uma lesão não neoplásica que representa aproximadamente 1% de todos os cistos maxilares, acometendo as regiões de corpo e sínfise de mandíbula com maior freqüência. Sua etiologia é desconhecida, mas acredita-se que o trauma local seja fator relacionado ao seu desenvolvimento. Não há predileção por sexo e afeta mais jovens abaixo de 25 anos. O diagnóstico pode ser por radiografias de rotina que apresentam lesão radiolúcida, uniradicular, de crescimento lento, tamanho variável e limites definidos. O tratamento é cirúrgico com curetagem e punção
An Integrated Framework for the Quantification of Road Network Seismic Vulnerability and Accessibility to Critical Services
Road networks are regarded as the backbone of transportation systems, which play an
important role in the social and economic prosperity of societies. Due to this reason, it is crucial to
develop road networks with higher resiliency rates to operate normally during earthquake incidents.
In the last decades, the research that tackled the management of disasters for road networks gained
great attention, in particular by developing various seismic vulnerability assessment models. Most of
those models study a single criterion, e.g., physical damage of road assets, traffic disruption, and/or
functionality loss of the network without taking into consideration the combination of different
vulnerability criteria. The proposed framework is part of the global seismic vulnerability assessment
models that combine fragility functions and vulnerability indices, which is demonstrated by an
application in a road network in the city of Penang in Malaysia. In the first step, the fragility functions
are developed where their results are used to calculate the Seismic Vulnerability Index (SVI) for
roadways by weighting the main investigated parameters. This is followed by investigating the
Accessibility Index (AI) model that is employed to assess the accessibility of targeted districts within
the investigated area. Subsequently, an integrated approach is employed to generate the emergency
evacuation maps to critical service centres by referring to the correlations between vulnerability and
the accessibility rates. In conclusion, the results of this study integrate engineering judgment and
numerical models to create a comparative study for assessing the performance of road networks and
to validate the significance of an integrated seismic assessment on various critical societal sectors, such
as improving emergency accessibility and implementing better mitigation strategies for communities
living in disaster-prone areas.Ministry of Higher Education (MOHE) through Fundamental Research Grant Scheme (FRGS/1/2020/TK02/USM/02/1)
DALC: Distributed Automatic LSTM Customization for Fine-Grained Traffic Speed Prediction
Over the past decade, several approaches have been introduced for short-term
traffic prediction. However, providing fine-grained traffic prediction for
large-scale transportation networks where numerous detectors are geographically
deployed to collect traffic data is still an open issue. To address this issue,
in this paper, we formulate the problem of customizing an LSTM model for a
single detector into a finite Markov decision process and then introduce an
Automatic LSTM Customization (ALC) algorithm to automatically customize an LSTM
model for a single detector such that the corresponding prediction accuracy can
be as satisfactory as possible and the time consumption can be as low as
possible. Based on the ALC algorithm, we introduce a distributed approach
called Distributed Automatic LSTM Customization (DALC) to customize an LSTM
model for every detector in large-scale transportation networks. Our experiment
demonstrates that the DALC provides higher prediction accuracy than several
approaches provided by Apache Spark MLlib.Comment: 12 pages, 5 figures, the 34th International Conference on Advanced
Information Networking and Applications (AINA 2020), Springe
Human Angiostrongyliasis Outbreak in Dali, China
Angiostrongyliasis, caused by the rat lungworm Angiostrongylus cantonensis, is a potentially fatal food-borne disease. It is endemic in parts of Southeast Asia, the Pacific Islands, Australia, and the Caribbean. Outbreaks have become increasingly common in China due to the spread of efficient intermediate host snails, most notably Pomacea canaliculata. However, infections are difficult to detect since the disease has a rather long incubation period and few diagnostic clinical symptoms. Reliable diagnostic tests are not widely available. The described angiostrongyliasis epidemic in Dali, China lasted for eight months. Only 11 of a total of 33 suspected patients were clinically confirmed based on a set of diagnostic criteria. Our results demonstrate that the rapid and correct diagnosis of the index patient is crucial to adequately respond to an epidemic, and a set of standardized diagnostic procedures is needed to guide clinicians. Integrated control and management measures including health education, clinical guidelines and a hospital-based surveillance system, should be implemented in areas where snails are a popular food item
Superconductivity at the Border of Electron Localization and Itinerancy
The superconducting state of iron pnictides and chalcogenides exists at the
border of antiferromagnetic order. Consequently, these materials could provide
clues about the relationship between magnetism and unconventional
superconductivity. One explanation, motivated by the so-called bad-metal
behaviour of these materials, proposes that magnetism and superconductivity
develop out of quasi-localized magnetic moments which are generated by strong
electron-electron correlations. Another suggests that these phenomena are the
result of weakly interacting electron states that lie on nested Fermi surfaces.
Here we address the issue by comparing the newly discovered alkaline iron
selenide superconductors, which exhibit no Fermi-surface nesting, to their iron
pnictide counterparts. We show that the strong-coupling approach leads to
similar pairing amplitudes in these materials, despite their different Fermi
surfaces. We also find that the pairing amplitudes are largest at the boundary
between electronic localization and itinerancy, suggesting that new
superconductors might be found in materials with similar characteristics.Comment: Version of the published manuscript prior to final journal-editting.
Main text (23 pages, 4 figures) + Supplementary Information (14 pages, 7
figures, 3 tables). Calculation on the single-layer FeSe is added.
Enhancement of the pairing amplitude in the vicinity of the Mott transition
is highlighted. Published version is at
http://www.nature.com/ncomms/2013/131115/ncomms3783/full/ncomms3783.htm
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