EXTENDED ESSAY ON ORIENTALISM IN THE PAINTED VEIL BY WILLIAM SOMERSET MAUGHAM

In this paper, the writer discuss orientalism in William Somerset Maugham's The painted Veil. The purpose of the paper is to analyze how West describes the East and how the East looks at the West. The conflicts, the settings, and the characters in the novel are also shown in order to supporting the orientalism. It also discusses how the orientalism works in this novel and how the relation between the occident or the west and the orient or the east. In doing this research, the writer uses method of library research. The object of the paper is William Somerset Maugham's The painted Veil. The writer also uses postcolonial approach to help explain the issues in The Painted Veil. To investigate the issues, the writer uses orientalism theory by Edward Said.From the discussion in the paper the writer finds that there are some parts that show the British view towards Chinese. The orientalism in this novel is also shown in some parts such as the policy of British in China, the purpose of conquering China, and in comparison of The West religion and The East Religion

PENGARUH CELEBRITY ENDORSER, PESAN IKLAN TERHADAP KEPUTUSAN PEMBELIAN PRODUK LUWAK WHITE KOFFIEE DENGAN DAYA TARIK PRODUK SEBAGAI VARIABEL INTERVENING

The number of coffee connoisseurs is proven to continue to grow from various ages, from teenagers to the elderly. Luwak Coffee has just won 2 Top Brand 2017 awards in the White Coffee and Powder Coffee categories. Based on the 2017 Top Brand Index, it shows that the sales of White Koffi Luwak in 2017 reached 68.5% so it was stated that Luwak White Koffie reached the TOP. This study reflects the research of Luh Dwi Mariyanti, Gede Bayu Ranadhata, 2015, researching the Effect of Celebrity Endosers and Advertising Messages on Television on Purchasing Decisions on Walls Magnum Belgium Chocolate Ice Cream. But in this study the researchers examined again with different titles and different subjects, Luwak White Koffie and added another independent variable, namely the attractiveness of the product by using the Non-probability Sampling sampling technique, with the purposive sampling method. The results of statistical tests on the hypothesis the more attractive the celebrity endoser, the higher the attraction has the evidence strong enough to reject H0. The results of this empirical test prove that there is a significant influence between celebrity endoser variables on the Attraction, meaning that the more attractive the celebrity endoser, the higher the Attraction. The results of statistical tests on the hypothesis the more interesting the Advertising Message the more interesting the advertising message has enough strong evidence to reject H0. The results of this empirical test prove that there is a significant influence between the message variables on the Attraction, the more attractive the celebrity endoser, the higher the Attraction. The results of statistical testing of hypotheses the better Celebrity Endoser, the better the purchase decision has strong enough evidence to reject H0. The empirical test results prove a significant influence between the celebrity endoser variables on purchasing decisions, meaning that the better the celebrity endoser, the better the purchase decision. The results of statistical tests on the hypothesis the better the Advertising Message, the better the purchase decision has sufficient evidence to reject H0. The empirical test results prove a significant influence between the celebrity endoser variables on purchasing decisions. it means that the better the celebrity endoser, the better the purchase decision. The results of statistical tests on hypotheses the better the attraction, the better the purchase decision has sufficient evidence to reject H0. The empirical test results prove a significant influence between the celebrity endoser variables on purchasing decisions. it means that the better the celebrity endoser, the better the purchase decision. The results by testing the role data of Pull mediation variable towards celebrity endoser and purchasing decisions are explained in the figure above with t-score of 2.2787079 and p-value of 0.2268443. The results of the statistical data show that with a cur-off value t-Score ≥ 1.98 and a significance level ≤ 0.05, the Attraction is able to mediate celebrity endoser variables and purchasing decisions. Hypothesis test results show that celebrity endoser has an effect on attractiveness, so the mediating role of celebrity endoser is fully mediated. The results by testing the role data of Pull mediation variable on advertising messages and purchasing decisions are described in the figure above with t-Score 3.75131804 and p-Value 0.00017591. The results of the statistical data show that with a cut-off value of t-Score ≥ 1.98 and a significance level of ≤ 0.05, the Attraction is able to mediate the variable advertising messages and purchasing decisions. Hypothesis test results show that advertising messages affect the attractiveness, then the mediating role of advertising messages is fully mediated

Self-compacting Eco Concrete: Innovation of Fly Ash and Marble Waste as Environtmentally Friendly and High Quality Concrete Materials

The development of construction in Indonesia is increasing every year, the data shows that Indonesia is the largest market of construction services in ASEAN with value of 267 billion US dollars (Kompas.com 2015). This leads to the increasing need of construction materials such as concrete. With this condition, it will harm the environment because the concrete mix materials are found in nature such as cement and sand. From the problem, the researchers innovate concrete material from fly ash and marble waste with Self Compacting Concrete method. The purpose of this innovation was to produce high quality, economical and environmentally friendly concrete with Self Compacting Concrete (SCC) method. The researchers conducted V-funnel test, L.Box test, Slump Flow test and compressive strength of concrete. From the data obtained, V-funnel test on concrete was able to flow in 4 sec, L.Box had a concrete surface comparison of 1 cm, Slump Flow test had diameter of 85 cm on concrete with FC quality number 1, and the result of compressive strength of concrete was 34-45 Mpa with a preliminary design of 35 Mpa, but this result was obtained at the age of 7 days and it would get stronger at the age requirement of 28 days. The price of concrete in the market was currently IDR 1,100,000-/m3, while the SCC concrete with additional material of fly ash and marble waste was obtained the price of IDR 792,156,-/m3. So, it could save the time of 21 days and save the cost of IDR 307,800,-. Fly ash served as a replacement of cement by 30%, while marble was the replacement of aggregate to obtain maximum quality of concrete so that the concrete had called environmentally friendly. By this innovation, it can be obtained timesaving, low cost estimation, high compressive strength and environmentally friendly concrete.

Pelatihan Instagram Bisnis Pengusaha Muda Desa Tumbrep Kabupaten Batang

This service activity related to Instagram business training for young entrepreneurs was carried out in Tumbrep Village, Bandar District, Batang Regency. The purpose of this service is to provide additional knowledge for young entrepreneurs who use a digital approach in carrying out their business activities, especially Instagram. The methods used are observation and interviews, presentation of material or lectures, focus group discussions and technical training, exhibitions or MSME bazaars. At first, the young entrepreneurs from Tumbrep Village still managed personal Instagram accounts for personal and business activities. In addition, the results of posting photos are still not conceptualized. Through community service activities, participants are invited to take advantage of Instagram for business and edit product photos to be posted. The conclusion from this service is that managing Instagram accounts for business activities requires special concepts and techniques. The training conducted by the service team who has this competence is really needed by the young entrepreneurs of Tumbrep Village.

Biomarker discovery and redundancy reduction towards classification using a multi-factorial MALDI-TOF MS T2DM mouse model dataset

Diabetes like many diseases and biological processes is not mono-causal. On the one hand multifactorial studies with complex experimental design are required for its comprehensive analysis. On the other hand, the data from these studies often include a substantial amount of redundancy such as proteins that are typically represented by a multitude of peptides. Coping simultaneously with both complexities (experimental and technological) makes data analysis a challenge for Bioinformatics

Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat

Background: Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic compound. Olvanil has potent anti-hyperalgesic effects in several experimental models of chronic pain. Here we report the inhibitory effects of olvanil on nociceptive processing using cultured dorsal root ganglion (DRG) neurons and compare the effects of capsaicin and olvanil on thermal nociceptive processing in vivo; potential contributions of the cannabinoid CB1 receptor to olvanil’s anti-hyperalgesic effects were also investigated. Methods: A hot plate analgesia meter was used to evaluate the anti-nociceptive effects of olvanil on capsaicin-induced thermal hyperalgesia and the role played by CB1 receptors in mediating these effects. Single cell calcium imaging studies of DRG neurons were employed to determine the desensitizing effects of olvanil on capsaicin-evoked calcium responses. Statistical analysis used Student’s t test or one way ANOVA followed by Dunnett’s post-hoctest as appropriate. Results: Both olvanil (100 nM) and capsaicin (100 nM) produced significant increases in intracellular calcium concentrations [Ca2+]I in cultured DRG neurons. Olvanil was able to des ensitise TRPV1 responses to further capsaicin exposure more effectively than capsaicin. Intra plantar injection of capsaicin (0.1, 0.3 and 1μg) produced a robust TRPV1-dependant thermal hyperalgesia in rats, whilst olvanil (0.1, 0.3 and 1μg) produced no hyperalgesia, emphasizing its lack of pungency. The highest dose of olvanil significantly reduced the hyperalgesic effects of capsaicin in vivo. Intraplantar injection of the selective cannabinoid CB1 receptor antagonist rimonabant (1μg) altered neither capsaicin-induced thermal hyperalgesia nor the desensitizing properties of olvanil, indicating a lack of involvement of CB1receptors. Conclusions: Olvanil is effective in reducing capsaicin-induced thermal hyperalgesia, probably via directly desensitizingTRPV1 channels in a CB 1 receptor-independent fashion. The results presented clearly support the potential for olvanil in the development of new topical analgesic preparations for treating chronic pain conditions while avoiding the unwanted side effects of capsaicin treatments

Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy

Background A reliable system for grading operative difficulty of laparoscopic cholecystectomy would standardise description of findings and reporting of outcomes. The aim of this study was to validate a difficulty grading system (Nassar scale), testing its applicability and consistency in two large prospective datasets. Methods Patient and disease-related variables and 30-day outcomes were identified in two prospective cholecystectomy databases: the multi-centre prospective cohort of 8820 patients from the recent CholeS Study and the single-surgeon series containing 4089 patients. Operative data and patient outcomes were correlated with Nassar operative difficultly scale, using Kendall’s tau for dichotomous variables, or Jonckheere–Terpstra tests for continuous variables. A ROC curve analysis was performed, to quantify the predictive accuracy of the scale for each outcome, with continuous outcomes dichotomised, prior to analysis. Results A higher operative difficulty grade was consistently associated with worse outcomes for the patients in both the reference and CholeS cohorts. The median length of stay increased from 0 to 4 days, and the 30-day complication rate from 7.6 to 24.4% as the difficulty grade increased from 1 to 4/5 (both p < 0.001). In the CholeS cohort, a higher difficulty grade was found to be most strongly associated with conversion to open and 30-day mortality (AUROC = 0.903, 0.822, respectively). On multivariable analysis, the Nassar operative difficultly scale was found to be a significant independent predictor of operative duration, conversion to open surgery, 30-day complications and 30-day reintervention (all p < 0.001). Conclusion We have shown that an operative difficulty scale can standardise the description of operative findings by multiple grades of surgeons to facilitate audit, training assessment and research. It provides a tool for reporting operative findings, disease severity and technical difficulty and can be utilised in future research to reliably compare outcomes according to case mix and intra-operative difficulty

Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes

<p>Abstract</p> <p>Background</p> <p>Escalating trends of obesity and associated type 2 diabetes (T2D) has prompted an increase in the use of alternative and complementary functional foods. <it>Momordica charantia </it>or bitter melon (BM) that is traditionally used to treat diabetes and complications has been demonstrated to alleviate hyperglycemia as well as reduce adiposity in rodents. However, its effects on human adipocytes remain unknown. The objective of our study was to investigate the effects of BM juice (BMJ) on lipid accumulation and adipocyte differentiation transcription factors in primary human differentiating preadipocytes and adipocytes.</p> <p>Methods</p> <p>Commercially available cryopreserved primary human preadipocytes were treated with and without BMJ during and after differentiation. Cytotoxicity, lipid accumulation, and adipogenic genes mRNA expression was measured by commercial enzymatic assay kits and semi-quantitative RT-PCR (RT-PCR).</p> <p>Results</p> <p>Preadipocytes treated with varying concentrations of BMJ during differentiation demonstrated significant reduction in lipid content with a concomitant reduction in mRNA expression of adipocyte transcription factors such as, peroxisome proliferator-associated receptor γ (PPARγ) and sterol regulatory element-binding protein 1c (SREBP-1c) and adipocytokine, resistin. Similarly, adipocytes treated with BMJ for 48 h demonstrated reduced lipid content, perilipin mRNA expression, and increased lipolysis as measured by the release of glycerol.</p> <p>Conclusion</p> <p>Our data suggests that BMJ is a potent inhibitor of lipogenesis and stimulator of lipolysis activity in human adipocytes. BMJ may therefore prove to be an effective complementary or alternative therapy to reduce adipogenesis in humans.</p

A pilot study to evaluate the effect of Taeumjowi-tang on obesity in Korean adults: study protocol for a randomised, double-blind, placebo-controlled, multicentre trial

<p>Abstract</p> <p>Background</p> <p>Obesity, which is described as excessive or abnormal body fat, increases the risk of diet-related diseases. In Korea and around the world, the prevalence of obesity has grown annually from 1998 to 2008. This growth has continued despite various therapeutic efforts. The discovery of new and alternative treatments for obesity should be considered an important priority. Taeumjowi-tang (TJ001), a traditional Korean medicinal extract consisting of eight herbs, is a widely used herbal remedy for obesity in Korea. However, the efficacy and safety of TJ001 have not been fully investigated in a clinical trial. The purpose of this pilot study is to estimate obesity-related parameters and to assess the efficacy and safety of TJ001.</p> <p>Methods</p> <p>Our study is a randomised, double-blind, placebo-controlled, multicentre clinical trial of Taeumjowi-tang (TJ001). For this study, we will recruit obese Korean patients of both sexes, ages 18 to 65 years, from four university hospitals. A total of 104 subjects will be recruited. The participants will receive either 7 g of TJ001 or a placebo three times daily for 12 weeks. The primary end point will be the rate of subjects who lose at least 5% of their baseline body weight. The secondary end points will be changes in body weight, body mass index, waist circumference, hip circumference, waist/hip circumference ratio, lipid profiles, body fat composition, blood pressure, fasting glucose concentration, C-reactive protein and questionnaires related to the quality of life. The outcomes will be measured every 4 weeks. The study period will be 12 weeks and will include a total of five visits with each subject (at screening and at 0, 4, 8 and 12 weeks).</p> <p>Conclusions</p> <p>The results of our study will inform various estimates of TJ001 and will serve as the basis for a larger-scale trial. This study will assess the efficacy and safety of TJ001 as an alternative herbal remedy for obesity.</p> <p>Trial registration</p> <p>Current Controlled Trials <a href="http://www.controlled-trials.com/ISRCTN87153759">ISRCTN87153759</a></p