Pengaruh Pekerjaan, Pendidikan, Penghasilan, Persepsi, dan Jumlah Anak dalam Keluarga terhadap Keberlangsungan Pendidikan Formal

The purpose of this study was determine to the influence of employment\u27s significant for education, income, perception of parents and the number of children in the family to the continuity of the formal education for children. The method used in this research is ex post facto with causal comparative studies. The results showed that the value of F-Multifariat for Wilk lambda at perception variable ( ) and the number of children variable ( ) has significance 0,05 so then Ho was rejected and Ha was accepted. This means there is no significant influence between the variable of job ( ), variable of education ( ) and variable of income ( ) to the continuity of the formal education for children

Synthesis of the Initial Scientific Results of the MIS Project (AND-1B Core), Victoria Land Basin, Antarctica

The ANDRILL Program successfully recovered a 1285 m-long succession of cyclic glacimarine sediment with interbedded volcanic deposits in its first season of drilling from the McMurdo Ice Shelf (MIS). The MIS AND-1B drill core represents the longest and most complete (98% recovery) geological record from the Antarctic continental margin to date, and will provide a key reference record of climate and ice-sheet variability through the Late Neogene. Here we present a synopsis of this Initial Science Report with emphasis on the potential of the record for improving our knowledge of Antarctica’s influence on global climate

Motor learning in unilateral cerebral palsy and the influence of corticospinal tract reorganization

Cerebral Palsy (CP) is a complex neurological disorder, characterized by congenital motor disability associated with behaviour, perception and cognition disorders. The sensorimotor impairments represent the main hallmark of the disease, significantly impacting the quality of life. So far, few studies have investigated motor learning abilities in CP and their association with the plastic reorganization of the motor system remains largely unknown. The present proof-of-principle study explored explicit motor sequence learning in children with unilateral CP and different patterns of motor system reorganization (bilateral, ipsilateral, contralateral). Children with unilateral CP, and a group of age-matched typically developing (TD) children, underwent a sequential finger tapping task, performed with the affected hand by children with CP and with the non-dominant hand by TD children. The pattern of corticospinal tract projections in hemiparetic patients was assessed by single-pulse Transcranial Magnetic Stimulation (TMS). Results showed the presence of finger dexterity impairments in children with unilateral CP presenting with a bilateral or an ipsilateral control of the affected (trained) hand, as compared to TD children. Conversely, motor sequence learning was impaired in unilateral CP with ipsilateral or contralateral corticospinal reorganization, but not in the case of a bilateral control of the paretic hand. These preliminary findings, although referred to small clinical samples, suggest that unilateral control of the paretic upper-limb, from the ipsilateral or the contralateral motor cortex, may not be sufficient to develop typical motor learning with the affected hand, which seems to require a bilateral representation in the motor cortex. This evidence has potential implications for fine motor skills rehabilitation in CP

Late Cenozoic Climate History of the Ross Embayment from the AND-1B Drill Hole: Culmination of Three Decades of Antarctic Margin Drilling

Because of the paucity of exposed rock, the direct physical record of Antarctic Cenozoic glacial history has become known only recently and then largely from offshore shelf basins through seismic surveys and drilling. The number of holes on the continental shelf has been small and largely confined to three areas (McMurdo Sound, Prydz Bay, and Antarctic Peninsula), but even in McMurdo Sound, where Oligocene and early Miocene strata are well cored, the late Cenozoic is poorly known and dated. The latest Antarctic geological drilling program, ANDRILL, successfully cored a 1285-m-long record of climate history spanning the last 13 m.y. from subsea-floor sediment beneath the McMurdo Ice Shelf (MIS), using drilling systems specially developed for operating through ice shelves. The cores provide the most complete Antarctic record to date of ice-sheet and climate fluctuations for this period of Earth’s history. The >60 cycles of advance and retreat of the grounded ice margin preserved in the AND-1B record the evolution of the Antarctic ice sheet since a profound global cooling step in deep-sea oxygen isotope records ~14 m.y.a. A feature of particular interest is a ~90-m-thick interval of diatomite deposited during the warm Pliocene and representing an extended period (~200,000 years) of locally open water, high phytoplankton productivity, and retreat of the glaciers on land

Neuronal Agrin Promotes Proliferation of Primary Human Myoblasts in an Age-Dependent Manner

Neuronal agrin, a heparan sulphate proteoglycan secreted by the -motor neurons, promotes the formation and maintenance of the neuromuscular junction by binding to Lrp4 and activating muscle-specific kinase (MuSK). Neuronal agrin also promotes myogenesis by enhancing differentiation and maturation of myotubes, but its effect on proliferating human myoblasts, which are often considered to be unresponsive to agrin, remains unclear. Using primary human myoblasts, we determined that neuronal agrin induced transient dephosphorylation of ERK1/2, while c-Abl, STAT3, and focal adhesion kinase were unresponsive. Gene silencing of Lrp4 and MuSK markedly reduced the BrdU incorporation, suggesting the functional importance of the Lrp4/MuSK complex for myoblast proliferation. Acute and chronic treatments with neuronal agrin increased the proliferation of human myoblasts in old donors, but they did not affect the proliferation of myoblasts in young donors. The C-terminal fragment of agrin which lacks the Lrp4-binding site and cannot activate MuSK had a similar age-dependent effect, indicating that the age-dependent signalling pathways activated by neuronal agrin involve the Lrp4/MuSK receptor complex as well as an Lrp4/MuSK-independent pathway which remained unknown. Collectively, our results highlight an age-dependent role for neuronal agrin in promoting the proliferation of human myoblasts

Risk perception and vulnerability of value: a study in the context of commercial property sector

© 2016 The Author(s). Published by Vilnius Gediminas Technical University (VGTU) Press, and Taylor & Francis. The research was developed linking the impact of flood risk on utility, desirability and marketability related to vulnerability of commercial property value. Likert style questionnaire survey was conducted to obtain data from flood affected and un-affected respondents across different designated flood risk zones on key business and perception variables among two groups of business property holders in England. The responses were analysed through a spatial vulnerability model to illustrate the distribution of the vulnerability of value of properties among flood plain business holders on a GIS platform. Majority of respondents perceived that utility of properties may be hampered by flooding and subsequently have an impact on value for property at risk. Those with flood experience gave greater weight to their specific business needs such as the prime location and expected income level than those without flood experience. The implication of the study lies in understanding that flood risk perceptions can shape actions of people at risk towards future increase in resilience having strategic impact on value of property saleability in the future

Sedimentology and stratigraphy of the ANDRILL McMurdo Ice Shelf (AND-1B) core

During the 2006-2007 austral summer, the ANDRILL McMurdo Ice Shelf Project recovered a core 1285 m long (AND-1B) from Windless Bight in McMurdo Sound. This core contains a range of lithologies, including both siliciclastic and volcanic diamictites, sandstones and mudstones; diatomites; and volcanic ash/tuff and one phonolitic lava flow. This sequence has been subdivided into eight lithostratigraphic units and 25 subunits, based on lithological abundances. Eleven lithofacies have been identified, ranging from open marine diatomites and mudstones to turbidites to ice-proximal massive and stratified diamictites. More than 50 glacimarine sequences have been recognized, bounded by glacial surfaces of erosion. Three distinct stacking patterns are present, showing evidence of glacial advance/retreat/advance with varying degrees of preservation. Carbonate and pyrite are the dominant secondary phases in the core. The pyrite overprint is especially notable in volcanic sediments below ~400 mbsf, where it often obscures stratification and sediment texture

Sedimentology and stratigraphy of the ANDRILL McMurdo Ice Shelf (AND-1B) core

During the 2006-2007 austral summer, the ANDRILL McMurdo Ice Shelf Project recovered a core 1285 m long (AND-1B) from Windless Bight in McMurdo Sound. This core contains a range of lithologies, including both siliciclastic and volcanic diamictites, sandstones and mudstones; diatomites; and volcanic ash/tuff and one phonolitic lava flow. This sequence has been subdivided into eight lithostratigraphic units and 25 subunits, based on lithological abundances. Eleven lithofacies have been identified, ranging from open marine diatomites and mudstones to turbidites to ice-proximal massive and stratified diamictites. More than 50 glacimarine sequences have been recognized, bounded by glacial surfaces of erosion. Three distinct stacking patterns are present, showing evidence of glacial advance/retreat/advance with varying degrees of preservation. Carbonate and pyrite are the dominant secondary phases in the core. The pyrite overprint is especially notable in volcanic sediments below ~400 mbsf, where it often obscures stratification and sediment texture

Tissue and serum immune response in chronic hepatitis C with mild histological lesions

The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy and has been suggested to involve a complex balance between cytokines with pro and anti-inflammatory activity. We investigated the expression of inflammatory cells and cytokines in the liver and serum of 51 chronically HCV infected patients and compared them to data from two sets of normal controls: 51 healthy blood donors and 33 liver biopsies of healthy liver donors. We also assessed the relationship between selected cytokines and cell populations in hepatic compartments and the disease stage. Compared with controls, hepatitis C patients had a greater expression of portal TNF-α, TGF-β and CD4+ and acinar IFN-γ, TNF-α, IL-1β and IL-4, as well as a higher serum concentration of IL-2, IL-10 and TGF-β. Significant positive correlations were found between portal CD4+ and TNF-α, portal CD8+ and TGF-β, portal CD45+RO and TNF-α, acinar CD45+RO and IFN-γ and acinar CD57+ and TGF-β. In conclusion, we have shown that (i) in this sample of predominantly mild disease, the immune response was associated with a pro-inflammatory response pattern, (ii) CD4+ T-lymphocytes played a major role in orchestrating the immune response and (iii) these events primarily took place in the portal space.FAPES