182 research outputs found
The state of Play with iPSCs and Spinal Cord Injury
The application of induced pluripotent stem cell (iPSC) technologies in cell based strategies, for the repair of the central nervous system (with particular focus on the spinal cord), is moving towards the potential use of clinical grade donor cells. The ability of iPSCs to generate donor neuronal, glial and astrocytic phenotypes for transplantation is highlighted here, and we review recent research using iPSCs in attempts to treat spinal cord injury in various animal models. Also discussed are issues relating to the production of clinical grade iPSCs, recent advances in transdifferentiation protocols for iPSC-derived donor cell populations, concerns about tumourogenicity, and whether iPSC technologies offer any advantages over previous donor cell candidates or tissues already in use as therapeutic tools in experimental spinal cord injury studies
Physica universalis juxta mentem Aristotelis... opus escripta [sic] a Michaele Craibinquel et anotata a R.P.M. Gabriele Ruiz. Anno D. MDCCLIII.
En lomo: "Ruiz. In Physicam universalem"Anotación en h. [1v]: "P. Montejaque"La foliación es posterior y faltan los fols. 128-129. Del párrafo 278 pasa al 286Moore acompaña una breve biografía del P. Gabriel Ruiz y anota acerca del manuscrito: "Letra clara. Abreviaturas no siempre congruentes. Mala ortografía"En ficha anterior de la Biblioteca la autoría se atribuía a Miguel Craywinckel, quien, según Moore, sólo fue el escribanoVéase también Caja C-37Incipit: "^ 1. Prooemium. Ipsius mundi visibilis machina inefabili artificio condita, mentis nostrae oculos rapit ad sui considerationem..." (fol. 1)Explicit: "... non est discontinuatum a suis compartibus, quia est continuative unitum suis partibus. Feriarum tempus labori inimicum pro otio quam opportunum veta ulterius progredi. Haec meta sit Physicae Generalis. Dum autem Physicam particularem, et metaphysicas lucubrationes vobis paramus, prospere avite, et Valete" (fol. 283)3081
Dynamical and Stationary Properties of On-line Learning from Finite Training Sets
The dynamical and stationary properties of on-line learning from finite
training sets are analysed using the cavity method. For large input dimensions,
we derive equations for the macroscopic parameters, namely, the student-teacher
correlation, the student-student autocorrelation and the learning force
uctuation. This enables us to provide analytical solutions to Adaline learning
as a benchmark. Theoretical predictions of training errors in transient and
stationary states are obtained by a Monte Carlo sampling procedure.
Generalization and training errors are found to agree with simulations. The
physical origin of the critical learning rate is presented. Comparison with
batch learning is discussed throughout the paper.Comment: 30 pages, 4 figure
A survey of phytoestrogenic activity in Kansas flint hills pastures
The botanical composition and basal
cover of three Kansas Flint Hills pastures
located in Butler and Chase counties was
surveyed to estimate the incidence of plant
species that contain appreciable levels of
estrogenic activity. Many-flowered scurfpea
and Ladino clover were the only plant species
classified as high in estrogenic activity.
Although significant estrogenic activity
existed in specific species, the willingness of
livestock to consume those species is unclear
Cluster Model of Decagonal Tilings
A relaxed version of Gummelt's covering rules for the aperiodic decagon is
considered, which produces certain random-tiling-type structures. These
structures are precisely characterized, along with their relationships to
various other random tiling ensembles. The relaxed covering rule has a natural
realization in terms of a vertex cluster in the Penrose pentagon tiling. Using
Monte Carlo simulations, it is shown that the structures obtained by maximizing
the density of this cluster are the same as those produced by the corresponding
covering rules. The entropy density of the covering ensemble is determined
using the entropic sampling algorithm. If the model is extended by an
additional coupling between neighboring clusters, perfectly ordered structures
are obtained, like those produced by Gummelt's perfect covering rules.Comment: 10 pages, 20 figures, RevTeX; minor changes; to be published in Phys.
Rev.
Stability and BPS branes
We define the concept of Pi-stability, a generalization of mu-stability of
vector bundles, and argue that it characterizes N=1 supersymmetric brane
configurations and BPS states in very general string theory compactifications
with N=2 supersymmetry in four dimensions.Comment: harvmac, 18 p
Evaluation of Ralgro® on pasture and subsequent feedlot performance and carcass merit of mexican crossbred steers
A pasture/feedlot field study was conducted
to evaluate the effects of a single
Ralgro® implant during the stocker phase on
steer grazing performance and subsequent
feedlot performance and carcass merit. A
total of 2,764 steers of Mexican origin averaging
449 lb were assembled in Texas and
shipped to Kansas, where they grazed on
three intensively-early-stocked Flint Hills
pastures. At initial processing, the steers
were individually weighed and randomly
assigned to either a non-implanted control
group or a Ralgro implant group. Ralgro
steers gained more (23 lb; P<0.01) than
controls during the 82- to 93-day grazing
phase. Following the grazing phase, all steers
were shipped to a commercial feedlot in
southwestern Kansas where steers from each
pasture were individually weighed and given
a single Component E-S® implant. Immediately
after processing, steers from each
pasture were sorted into either a light- or
heavy-weight pen, regardless of pasture
implant treatment, resulting in six feedlot
pens. Days on feed ranged from 127 to 197.
Control steers gained faster (P<0.01) during
the feedlot phase; however, Ralgro steers had
higher cumulative weight gains across the
combined pasture and feedlot phases
(P<0.01) and averaged three fewer days on
feed (P<0.05). There were no significant
differences for marbling, fat thickness, ribeye
area, KPH fat, or yield grade. Ralgro
steers had lower (P<0.05) quality grades
because of a higher incidence (P<0.001) of
steers with B and C carcass maturities
The spectrum of BPS branes on a noncompact Calabi-Yau
We begin the study of the spectrum of BPS branes and its variation on lines
of marginal stability on O_P^2(-3), a Calabi-Yau ALE space asymptotic to
C^3/Z_3. We show how to get the complete spectrum near the large volume limit
and near the orbifold point, and find a striking similarity between the
descriptions of holomorphic bundles and BPS branes in these two limits. We use
these results to develop a general picture of the spectrum. We also suggest a
generalization of some of the ideas to the quintic Calabi-Yau.Comment: harvmac, 45 pp. (v2: added references
Nonlinear effects in resonant layers in solar and space plasmas
The present paper reviews recent advances in the theory of nonlinear driven
magnetohydrodynamic (MHD) waves in slow and Alfven resonant layers. Simple
estimations show that in the vicinity of resonant positions the amplitude of
variables can grow over the threshold where linear descriptions are valid.
Using the method of matched asymptotic expansions, governing equations of
dynamics inside the dissipative layer and jump conditions across the
dissipative layers are derived. These relations are essential when studying the
efficiency of resonant absorption. Nonlinearity in dissipative layers can
generate new effects, such as mean flows, which can have serious implications
on the stability and efficiency of the resonance
The acute transcriptional response to resistance exercise: impact of age and contraction mode
Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We used transcriptomics to compare age-related molecular responses to acute CON and ECC exercise. Eight young (21±1 y) and eight older (70±1 y) exercise-naïve male volunteers had vastus lateralis biopsies collected at baseline and 5 h post unilateral CON and contralateral ECC exercise. RNA was subjected to next-generation sequencing and differentially expressed (DE) genes tested for pathway enrichment using Gene Ontology (GO). The young transcriptional response to CON and ECC was highly similar and older adults displayed moderate contraction-specific profiles, with no GO enrichment. Age-specific responses to ECC revealed 104 DE genes unique to young, and 170 DE genes in older muscle, with no GO enrichment. Following CON, 15 DE genes were young muscle-specific, whereas older muscle uniquely expressed 147 up-regulated genes enriched for cell adhesion and blood vessel development, and 28 down-regulated genes involved in mitochondrial respiration, amino acid and lipid metabolism. Thus, older age is associated with contraction-specific regulation often without clear functional relevance, perhaps reflecting a degree of stochastic age-related dysregulation.This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.CSD was funded by a doctoral training studentship from Bournemouth University. This work was generously supported by the Wellcome Trust Institutional Strategic Support Award (WT105618MA). RMA is generously supported by the Wellcome Trust Institutional Strategic Support Award (WT105618MA) and an EPSRC/BBSRC Innovation Fellowship (EP/S001352/1). We acknowledge the Medical Research Council [grant number MR/P021220/1] [grant number MR/K00414X/1] and Arthritis Research UK [grant number 19891] as part of the MRC-ARUK Centre for Musculoskeletal Ageing Research awarded to the Universities of Nottingham and Birmingham, and the National Institute for Health Research, Nottingham Biomedical Research Centre. This work was supported by the Biotechnology and Biological Sciences Research Council [grant number BB/N015894/1]. This work was supported by a grant from the Swedish Research Council for Sport Science (dnr 2016/125 and dnr 2017/143). C.R.G.W is supported by the Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership [BB/J014400/1; BB/M009122/1].Published versio
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