Telemetric monitoring of fetal blood pressure and heart rate in the freely moving pregnant sheep: a feasibility study

Remote telemetric monitoring of fetal haemodynamics in pregnant sheep would allow unrestricted animal movement, minimize suffering and distress, and improve animal welfare, while enhancing the quality of data collected. This may also be useful in clinical practice following fetal surgery. Using an open fetal surgical technique at approximately two-thirds of gestation, we implanted the catheter of a D70-PCTP haemodynamic telemetric device (Data Sciences International, Tilburg, The Netherlands) into the carotid artery of the fetal sheep (n ¼ 4). The attached transmitter was secured to the posterior aspect of the maternal anterior abdominal wall. Two receivers, with a range of 1 m each, were sited in an 11 m2 sheep enclosure to maximize animal freedom while allowing continuous monitoring of the ewe. The receivers were connected by cable to a nearby computer. In the first two procedures, both fetuses died eight and 12 days after surgery, and the catheter tip was observed to be lying in the bicarotid trunk. In the next two procedures the catheter tip was threaded further upstream from the insertion point, in an attempt to reach the fetal aorta, and both fetuses survived until the scheduled postmortem examination at the end of pregnancy. After catheter implantation, fetal blood pressure (BP) and heart rate (HR) were successfully recorded continuously for seven days and then hourly per day for a further three weeks. The fetal BP and HR values were in the normal range for healthy sheep fetuses.PublishedN/

Justi?a : entre a colis?o de direitos fundamentais e pondera??o

Submitted by Setor de Tratamento da Informa??o - BC/PUCRS ([email protected]) on 2016-05-25T12:23:20Z No. of bitstreams: 1 DIS_LOURDES_PASA_ALBRECHT_COMPLETO.pdf: 1048720 bytes, checksum: 97aef1a1c1d89e22709a6364d497153c (MD5)Made available in DSpace on 2016-05-25T12:23:20Z (GMT). No. of bitstreams: 1 DIS_LOURDES_PASA_ALBRECHT_COMPLETO.pdf: 1048720 bytes, checksum: 97aef1a1c1d89e22709a6364d497153c (MD5) Previous issue date: 2016-03-23Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPqThis research has as its objective the demonstration that a concrete case of a fundamental legal rights collision decided by the weighting factor can be justified by the rationality. Rationality weighting is anchored on the reasons established by rules of general practice arguments and specifically on the legal argumentation, rationally linking argumentation and the authority endowed decision. It is intended to expose the problem of a rational legal argument rules non-observation and the own rules of weighing in its application to decide the fundamental legal rights collision cases. This practice of judicial decision can become vulnerable to realization of justice in the concrete case.Esta investiga??o tem por objetivo mostrar que um caso concreto de colis?o de direitos fundamentais decidido por meio da pondera??o pode ser fundamentado racionalmente. A racionalidade da pondera??o est? ancorada nas raz?es estabelecidas por regras da argumenta??o pr?tica geral e especificamente da argumenta??o jur?dica, vinculando racionalmente argumenta??o e decis?o dotada de autoridade. O que se pretende expor ? o problema da inobserv?ncia das regras de argumenta??o jur?dica racional e das regras pr?prias da pondera??o na sua aplica??o para decidir os casos de colis?o de direitos fundamentais. Essa pr?tica de decis?o judicial pode tornar vulner?vel a realiza??o da justi?a no caso concreto