Transcutaneous measurement of blood velocity profiles and flow

A comprehensive report is presented of the application of a pulsed ultrasound Doppler velocity meter for transcutaneous measurement of time varying velocity, velocity profiles, and instantaneous flow in arteries of anaesthetized dogs. The procedure used to provide direct velocity and flow calibration using the Doppler equation is outlined. Typical transcutaneous recordings obtained from the femoral artery, abdominal aorta, and carotid artery are illustrated. The results compare favourably with data obtained by invasive means such as electromagnetic cuff flowmeters. The possibility of high resolution, non-invasive haemodynamic measurements on dogs is demonstrated and the application to conscious human subjects suggeste

The Quasar Pair Q 1634+267 A, B and the Binary QSO vs. Dark Lens Hypotheses

Deep HST/NICMOS H (F160W) band observations of the z=1.96 quasar pair Q 1634+267A,B reveal no signs of a lens galaxy to a 1 sigma threshold of approximately 22.5 mag. The minimum luminosity for a normal lens galaxy would be a 6L_* galaxy at z > 0.5, which is 650 times greater than our detection threshold. Our observation constrains the infrared mass-to-light ratio of any putative, early-type, lens galaxy to (M/L)_H > 690h_65 (1200h_65) for Omega_0=0.1 (1.0) and H_0=65h_65 km/s/Mpc. We would expect to detect a galaxy somewhere in the field because of the very strong Mg II absorption lines at z=1.1262 in the Q 1634+267 A spectrum, but the HST H-band, I-band (F785LP) and V-band (F555W) images require that any associated galaxy be very under-luminous less than 0.1 L^*_H (1.0 L^*_I) if it lies within less than 40 h^{-1} (100 h^{-1}) kpc from Q 1634+267 A,B. While the large image separation (3.86 arcsec) and the lack of a lens galaxy strongly favor interpreting Q 1634+267A,B as a binary quasar system, the spectral similarity remains a puzzle. We estimate that at most 0.06% of randomly selected quasar pairs would have spectra as similar to each other as the spectra of Q 1634+267 A and B. Moreover, spectral similarities observed for the 14 quasar pairs are significantly greater than would be expected for an equivalent sample of randomly selected field quasars. Depending on how strictly we define similarity, we estimate that only 0.01--3% of randomly drawn samples of 14 quasar pairs would have as many similar pairs as the observational sample.Comment: 24 pages, including 4 figures, LaTex, ApJ accepted, comments from the editor included, minor editorial change

The templated growth of a chiral transition metal chalcogenide

We demonstrate that an intrinsically chiral, high Miller index surface of an achiral metal can be used to template the enantioselective growth of chiral transition metal chalcogenide films. Specifically, Cu(643)R can be used as a template for the enantioselective growth of a chiral copper telluride alloy surface. Beyond a critical alloy thickness the chiral influence of the Cu(643)R surface diminishes and an achiral surface forms. Our work demonstrates a new method of producing chiral transition metal chalcogenide surfaces, with potential applications in the study of structurally chiral topological insulators

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors.

PurposeImmune checkpoint blockade has improved outcomes across tumor types; little is known about the efficacy of these agents in rare tumors. We report the results of the (nonpancreatic) neuroendocrine neoplasm cohort of SWOG S1609 dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART).Patients and methodsWe performed a prospective, open-label, multicenter phase II clinical trial of ipilimumab plus nivolumab across multiple rare tumor cohorts, with the (nonpancreatic) neuroendocrine cohort reported here. Response assessment by grade was not prespecified. The primary endpoint was overall response rate [ORR; RECIST v1.1; complete response (CR) and partial response (PR)]; secondary endpoints included progression-free survival (PFS), overall survival (OS), stable disease >6 months, and toxicity.ResultsThirty-two eligible patients received therapy; 18 (56%) had high-grade disease. Most common primary sites were gastrointestinal (47%; N = 15) and lung (19%; N = 6). The overall ORR was 25% [95% confidence interval (CI) 13-64%; CR, 3%, N = 1; PR, 22%, N = 7]. Patients with high-grade neuroendocrine carcinoma had an ORR of 44% (8/18 patients) versus 0% in low/intermediate grade tumors (0/14 patients; P = 0.004). The 6-month PFS was 31% (95% CI, 19%-52%); median OS was 11 months (95% CI, 6-∞). The most common toxicities were hypothyroidism (31%), fatigue (28%), and nausea (28%), with alanine aminotransferase elevation (9%) as the most common grade 3/4 immune-related adverse event, and no grade 5 events.ConclusionsIpilimumab plus nivolumab demonstrated a 44% ORR in patients with nonpancreatic high-grade neuroendocrine carcinoma, with 0% ORR in low/intermediate grade disease

Constraints on the faint end of the quasar luminosity function at z~5 in the COSMOS field

We present the result of our low-luminosity quasar survey in the redshift range of 4.5 < z < 5.5 in the COSMOS field. Using the COSMOS photometric catalog, we selected 15 quasar candidates with 22 < i' < 24 at z~5, that are ~ 3 mag fainter than the SDSS quasars in the same redshift range. We obtained optical spectra for 14 of the 15 candidates using FOCAS on the Subaru Telescope and did not identify any low-luminosity type-1 quasars at z~5 while a low-luminosity type-2 quasar at z~5.07 was discovered. In order to constrain the faint end of the quasar luminosity function at z~5, we calculated the 1sigma confidence upper limits of the space density of type-1 quasars. As a result, the 1sigma confidence upper limits on the quasar space density are Phi< 1.33*10^{-7} Mpc^{-3} mag^{-1} for -24.52 < M_{1450} < -23.52 and Phi< 2.88*10^{-7} Mpc^{-3} mag^{-1} for -23.52 < M_{1450} < -22.52. The inferred 1sigma confidence upper limits of the space density are then used to provide constrains on the faint-end slope and the break absolute magnitude of the quasar luminosity function at z~5. We find that the quasar space density decreases gradually as a function of redshift at low luminosity (M_{1450} ~ -23), being similar to the trend found for quasars with high luminosity (M_{1450}<-26). This result is consistent with the so-called downsizing evolution of quasars seen at lower redshifts.Comment: 8 pages, 9 figures, 1 table, accepted for publication in Ap

The NICE-GUT trial protocol:A randomised, placebo controlled trial of oral nitazoxanide for the empiric treatment of acute gastroenteritis among Australian Aboriginal children

Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease. Randomised trials in other populations suggest nitazoxanide accelerates recovery for children with Giardia, amoebiasis, Cryptosporidium, Rotavirus and Norovirus gastroenteritis, as well as in cases where no enteropathogens are found. This double blind, 1:1 randomised, placebo controlled trial is investigating the impact of oral nitazoxanide on acute gastroenteritis in hospitalised Australian Aboriginal children aged 3 months to <5 years. Dosing is based on age-based dosing. The primary endpoint is the time to resolution of 'significant illness' defined as the time from randomisation to the time of clinical assessment as medically ready for discharge, or to the time of actual discharge from hospital, whichever occurs first. Secondary endpoints include duration of hospitalisation, symptom severity during the period of significant illness and following treatment, duration of rehydration and drug safety. Patients will be followed for medically significant events for 60 days. Analysis is based on Bayesian inference. Subgroup analysis will occur by pathogen type (bacteria, virus or parasite), rotavirus vaccination status, age and illness severity. Ethics approval has been granted by the Central Australian Human Research Ethics Committee (HREC-14-221) and the Human Research Ethics Committee of the Northern Territory Department of Health and Menzies School of Health Research (HREC2014-2172). Study investigators will ensure that the trial is conducted in accordance with the principles of the Declaration of Helsinki. Individual participant consent will be obtained. Results will be disseminated via peer-reviewed publication. ACTRN12614000381684

Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis

Bone morphogenetic protein (BMP) family members, including BMP2, BMP4, and BMP7, are expressed throughout limb development. BMPs have been implicated in early limb patterning as well as in the process of skeletogenesis. However, due to complications associated with early embryonic lethality, particularly for Bmp2 and Bmp4, and with functional redundancy among BMP molecules, it has been difficult to decipher the specific roles of these BMP molecules during different stages of limb development. To circumvent these issues, we have constructed a series of mouse strains lacking one or more of these BMPs, using conditional alleles in the case of Bmp2 and Bmp4 to remove them specifically from the limb bud mesenchyme. Contrary to earlier suggestions, our results indicate that BMPs neither act as secondary signals downstream of Sonic Hedghog (SHH) in patterning the anteroposterior axis nor as signals from the interdigital mesenchyme in specifying digit identity. We do find that a threshold level of BMP signaling is required for the onset of chondrogenesis, and hence some chondrogenic condensations fail to form in limbs deficient in both BMP2 and BMP4. However, in the condensations that do form, subsequent chondrogenic differentiation proceeds normally even in the absence of BMP2 and BMP7 or BMP2 and BMP4. In contrast, we find that the loss of both BMP2 and BMP4 results in a severe impairment of osteogenesis

Crop Updates 2002 - Pulse Research and Industry Development in Western Australia

This session covers seventy one papers from different authors: 1. 2001 PULSE INDUSTRY HIGHLIGHTS CONTRIBUTORS BACKGROUND 2001 REGIONAL ROUNDUP 2. Northern Agricultural Region, M. Harries, Department of Agriculture 3. Central Agricultural Region, R. French and I. Pritchard, Department of Agriculture 4. Great Southern and Lakes, N. Brandon, N. Runciman and S. White, Department of Agriculture 5. Esperance Mallee, M. Seymour, Department of Agriculture PULSE PRODUCTION AGRONOMY AND GENETIC IMPROVEMENT 6. Faba bean, P. White, Department of Agriculture 7. Germplasm evaluation, P. White, M. Seymour and M. Harries, Department of Agriculture 8. Variety evaluation, P. White, M. Harries, N. Brandon and M. Seymour, Department of Agriculture 9. Sowing rate and time of sowing, P. White, N. Brandon, M. Seymour and M. Harries, Department of Agriculture 10.Use of granular inoculum in the Great Southern, N. Brandon1, J. Howieson2 and R. Yates2 1Department of Agriculture, 2Centre for Rhizobium Studies, Murdoch University 11.Tolerance to post emergent herbicides, M. Seymour and M. Harries, Department of Agriculture 12.Herbicide tolerance of new varieties, H. Dhammu and T. Piper, Department of Agriculture Desi chickpea 13. Breeding highlights, T. Khan, Department of Agriculture 14. Variety evaluation, T. Khan and K. Regan, Department of Agriculture 15. Effect of genotype and environment on seed quality, N. Suizu1 and D. Diepeveen2 1School of Public Health, Curtin University of Technology 2Department of Agriculture 16. Seed discolouration, C. Veitch and P. White, Department of Agriculture 17. Foliar application on N increases seed yield and seed protein under terminal drought, J. Palta1,2, A. Nandwal3 and N. Turner1,2 , 1CSIRO Plant Industry, 2CLIMA, the University of Western Australia, 3Department of Botany, Haryana Agric University, Hisar, India 18. Tolerance to chilling at flowering, H. Clarke, CLIMA, The University of Western Australia 19. Molecular studies of ascochyta blight disease in chickpea, G. Dwyer1, H. Loo1, T. Khan2, K. Siddique3, M. Bellgard1 and M. Jones1 ,1WA State Agricultural Biotechnology Centre and Centre for Bioinformatics and Biological Computing, Murdoch University, 2Department of Agriculture, 3CLIMA, The University of Western Australia 20. Effect of row spacing and sowing rate on seed yield, G. Riethmuller and B. MacLeod, Department of Agriculture 21. Herbicide tolerance on marginal soil types, H. Dhammu and T. Piper, Department of Agriculture 22. Kabuli chickpea, K. Regan, Department of Agriculture 23. Variety and germplasm evaluation, T. Khan and K. Regan, Department of Agriculture 24. Premium quality kabuli chickpea development in the ORIA, K. Siddique1, K. Regan2, R. Shackles2 and P. Smith2 , 1 CLIMA, The University of Western Australia, 2Department of Agriculture 25. Evaluation of ascochylta resistant germplasm from Syria and Turkey, K. Siddique1, C. Francis1 and K. Regan2, 1CLIMA, University of Western Australia 2Department of Agriculture Field pea 26. Breeding highlights, T. Khan Department of Agriculture 27. Variety evaluation, T. Khan Department of Agriculture 28. Comparing the phosphorus requirement of field pea and wheat, M. Bolland and P. White, Department of Agriculture 29. Tolerance of field pea to post emergent herbicides, M. Seymour and N. Brandon, Department of Agriculture 30. Response of new varieties to herbicides, H. Dhammu and T. Piper, Department of Agriculture 31. Lentil, K. Regan, Department of Agriculture 32. Variety evaluation, K. Regan, N. Brandon, M. Harries and M. Seymour, Department of Agriculture 33. Interstate evaluation of advanced breeding lines developed in WA, K. Regan1, K. Siddique2 and M. Materne3, 1Department of Agriculture, 2CLIMA, University of Western Australia, 3Victorian Institute for Dryland Agriculture, Agriculture Victoria 34. Evaluation of germplasm from overseas and local projects, K. Regan1, J. Clements2, K.H.M. Siddique2 and C. Francis21Department of Agriculture, 2CLIMA, University of Western Australia 35. Evaluation of breeding lines developed in WA, K. Regan1, J. Clements2, K.H.M. Siddique2 and C. Francis21Department of Agriculture, 2CLIMA, University of Western Australia 36. Productivity and yield stability in Australia and Nepal, C. Hanbury, K. Siddique and C. Francis, CLIMA, the University of Western Australia Vetch 37. Germplasm evaluation, M. Seymour1, R. Matic2 and M. Tate3, 1Department of Agriculture, 2South Australian Research and Development Institute, 3University of Adelaide, Waite Campus 38. Tolerance of common vetch to post emergent herbicides, M. Seymour and N. Brandon, Department of Agriculture Narbon bean 39. Removing narbon bean from wheat, M. Seymour, Department of Agriculture 40. Tolerance to low rates of Roundup and Sprayseed, M. Seymour, Department of Agriculture 41. Lathyrus development, C. Hanbury, CLIMA, the University of Western Australia 42. Poultry feeding trials, C. Hanbury1 and B. Hughes2 ,1CLIMA, the University of Western Australia,2Pig and Poultry Production Institute, South Australia Pulse Species 43. Species time of sowing, B. French, Department of Agriculture 44. High value pulses in the Great Southern, N. Brandon and N. Runciman, Department of Agriculture 45. Time of Harvest for improved seed yields of pulses, G. Riethmuller and B. French, Department of Agriculture 46. Phosphate acquisition efficiency of pulse crops, P. Rees, Plant Biology, Faculty of Natural and Agricultural Sciences UWA DEMONSTRATION OF PULSES IN THE FARMING SYSTEM 47. Howzat desi chickpea in the northern region, M. Harries, Department of Agriculture 48. Field pea harvest losses in the Great Southern and Esperance region, N. Brandon and M. Seymour, Department of Agriculture 49. Timing of crop topping in field pea, N. Brandon and G. Riethmuller, Department of Agriculture DISEASE AND PEST MANAGEMENT 50. Ascochyta blight of chickpea, B. MacLeod, M. Harries and N. Brandon, Department of Agriculture 51. Evaluation of Australian management packages, 52. Screening foliar fungicides 53. Row spacing and row spraying 54. Ascochyta management package for 2002, B. MacLeod, Department of Agriculture 55. Epidemiology of aschochyta and botrytis disease of pulses, J. Galloway and B. MacLeod, Department of Agriculture 56. Ascochyta blight of chickpea 57. Black spot of field pea 58. Ascochyta blight of faba bean 59. Ascochyta blight of lentil 60. Botrytis grey mould of chickpea 61. Black spot spread: Disease models are based in reality, J. Galloway, Department of Agriculture 62. Black spot spread: Scaling-up field data to simulate ‘Bakers farm’, M. Salam, J. Galloway, A. Diggle and B. MacLeod, Department of Agriculture 63. Pulse disease diagnostics, N. Burges and D. Wright, Department of Agriculture Viruses in pulses 64. Incidence of virus diseases in chickpea, J. Hawkes1, D. Thackray1 and R. Jones1,2, 1CLIMA, The University of Western Australia 2Department of Agriculture Insect pests 65. Risk assessment of aphid feeding damage on pulses, O. Edwards, J. Ridsdill-Smith, and R. Horbury, CSIRO Entomology 66. Optimum spray timing to control aphid feeding damage of faba bean, F. Berlandier, Department of Agriculture 67. Incorporation of pea weevil resistance into a field pea variety, O. Byrne1 and D. Hardie2, 1CLIMA, The University of Western Australia, 2Department of Agriculture 68. Screening wild chickpea species for resistance to Helicoverpa, T. Ridsdill-Smith1 and H. Sharma2,1CSIRO, Entomology, 2ICRISAT, Hyderabad 69. Field strategies to manage the evolution of pea weevil resistance in transgenic field pea, M. de Sousa Majer1, R. Roush2, D. Hardie3, R. Morton4 and T. Higgins4, 1Curtin University of Technology, 2Waite Campus, University of Adelaide, 3Department of Agriculture, 4CSIRO Plant Industry, Canberra 70. ACKNOWLEDGMENTS 71. Appendix 1: Summary of previous result

Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw.

The amniote jaw complex is a remarkable amalgamation of derivatives from distinct embryonic cell lineages. During development, the cells in these lineages experience concerted movements, migrations, and signaling interactions that take them from their initial origins to their final destinations and imbue their derivatives with aspects of form including their axial orientation, anatomical identity, size, and shape. Perturbations along the way can produce defects and disease, but also generate the variation necessary for jaw evolution and adaptation. We focus on molecular and cellular mechanisms that regulate form in the amniote jaw complex, and that enable structural and functional integration. Special emphasis is placed on the role of cranial neural crest mesenchyme (NCM) during the species-specific patterning of bone, cartilage, tendon, muscle, and other jaw tissues. We also address the effects of biomechanical forces during jaw development and discuss ways in which certain molecular and cellular responses add adaptive and evolutionary plasticity to jaw morphology. Overall, we highlight how variation in molecular and cellular programs can promote the phenomenal diversity and functional morphology achieved during amniote jaw evolution or lead to the range of jaw defects and disease that affect the human condition

Crop Updates 2005 - Lupins and Pulses

This session covers sixty five papers from different authors: 1. 2004 LUPIN AND PULSE INDUSTRY HIGHLIGHTS, Peter White Department of Agriculture 2. BACKGROUND, Peter White Department of Agriculture 2004 REGIONAL ROUNDUP 3. Northern Agricultural Region, Martin Harries, Department of Agriculture 4. Central Agricultural Region, Ian Pritchard, Department of Agriculture 5. Great Southern and Lakes, Rodger Beermier, Department of Agriculture 6. Esperance Port Zone, Mark Seymour, Department of Agriculture, and David Syme, The Grain Pool of WA LUPIN AND PULSE PRODUCTION AGRONOMY AND GENETIC IMPROVEMENT 7. Lupin, Martin Harries, Department of Agriculture 8. Narrow-leafed lupin breeding, Bevan Buirchell, Department of Agriculture 9. Yellow lupin breeding in Western Australia, Kedar Adhikari, Mark Sweetingham and Bevan Buirchell, Department of Agriculture 10. WALAB2000 - First Anthracnose resistant albus lupins, Kedar Adhikari, Bevan Buirchell, MarkSweetingham and Geoff Thomas, Department of Agriculture 11. Improving lupin grain quality and yield through genetic manipulation of key physiological traits, Jon Clements1 and Bevan Buirchell2,1CLIMA, The University of Western Australia 2Department of Agriculture 12. Lupin alkaloids in four Australian species, Shao Fang Wang, Chemistry Centre (WA), CLIMA, The University of Western Australia 13. Improving lupin tolerance to herbicides of metribuzin, isoxaflutole and carfentrazone-ethyl, Ping Si1, Mark Sweetingham12, Bevan Buirchell12, David Bowran2 and Huaan Yang12 , 1CLIMA, The University of Western Australia, 2Department of Agriculture 14. Combined cultural and shielded sprayer herbicide application for weed management, Martin Harries and Mike Baker Department of Agriculture 15. Field testing of lupin seed of various sources with and without post maturity, pre harvest rain for field establishment, Martin Harries, Wayne Parker, Mike Baker, Department of Agriculture 16. Lupin seed rate by wide row spacing, Martin Harries, Bob French, Damien Owen D’arcy, Department of Agriculture 17. How environment influences row spacing response in lupins, Bob French, Department of Agriculture 18. The effect of wider row spacing on lupin architecture, growth and nutrient uptake dynamics, Bill Bowden and Craig Scanlan, Department of Agriculture 19. Fertiliser placement and application rate in wide rows, Martin Harries, Damien Owen D’arcy, Department of Agriculture 20. The pros and cons of cowing lupins in ‘wide’ rows, Wayne Parker, Bob French and Martin Harries, Department of Agriculture 21. Investigation into the influence of row orientation in lupin crops, Jeff Russell1 and Angie Roe2, 1Department of Agriculture, 2Farm Focus Consultants 22. Making the most of Mandelup, Greg Shea and Chris Matthews, Department of Agriculture 23. The effect of wild radish density and lupin cultivars on their competition at Merredin, Shahab Pathan, Abul Hashem and Bob French, Department of Agriculture 24. The potential of pearl lupin (Lupinus mutabilis) for southern Australia, Jon Clements1, Mark Sweetingham2, Bevan Buirchell2, Sofia Sipsas2, Geoff Thomas2, John Quealy1, Roger Jones2, Clive Francis1, Colin Smith2 and Gordon Francis1, 1CLIMA, University of Western Australia 2Department of Agriculture 25. Field pea, Mark Seymour, Department of Agriculture 26. Breeding highlights, Tanveer. Khan and Bob French, Department of Agriculture 27. Variety evaluation, Tanveer Khan, Kerry Regan, Jenny Garlinge and Rod Hunter, Department of Agriculture 28. Large scale field pea variety trials, Martin Harries, Department of Agriculture 29. Kaspa demonstrations, Rodger Beermier, Mark Seymour, Ian Pritchard, Graham Mussell, Department of Agriculture 30. Field pea harvesting demonstration at Merredin, Glen Riethmuller, Greg Shea and Bob French, Department of Agriculture 31. Does Kaspa respond differently to disease, fungicides, time of sowing or seed rate, Mark Seymour, Department of Agriculture 32. Field pea response to foliar Manganese in mallee district, Mark Seymour, Department of Agriculture 33. Kaspa harvesting observations 2004, Mark Seymour, Ian Pritchard, Glen Riethmuller, Department of Agriculture 34. ‘Blackspot Manager’ for understanding blackspot of peas and ascochyta blight management, Moin Salam and Jean Galloway, Department of Agriculture 35. 250,000 ha of field pea in WA – Is it sustainable? Larn McMurray1 and Mark Seymour2, 1South Australian Research and Development Institute, 2Department of Agriculture 36. Desi chickpea, Wayne Parker, Department of Agriculture 37. Breeding highlights, Tanveer Khan1,2 and Kadambot Siddique2,1Department of Agriculture, 2CLIMA, The University of Western Australia 38. Variety evaluation, Tanveer Khan, Kerry Regan, Jenny Garlinge and Rod Hunter, Department of Agriculture 39. Large scale variety testing of desi chickpeas, Martin Harries, Greg Shea, Mike Baker, Dirranie Kirby, Department of Agriculture 40. Desi variety chickpea trial, Martin Harries and Murray Blyth, Department of Agriculture 41. Seeding rates and row spacing of chickpea desi, Martin Harries, MurrayBlyth, Damien Owen D’arcy, Department of Agriculture 42. Molecular characterisation of chickpea wild relatives, Fucheng Shan, Heather Clarke and Kadambot Siddique, CLIMA, The University of Western Australia 43. Plant phosphorus status has a limited influence on the concentration of phosphorus-mobilising carboxylates in the rhizosphere of chickpea, Madeleine Wouterlood, Hans Lambers and Erik Veneklaas, The University of Western Australia 44. Kabuli chickpea, Kerry Regan, Department of Agriculture, and CLIMA, The University of Western Australia 45. ‘Kimberly Large’ A high quality and high yielding new variety for the Ord River Irrigation Area, Kerry Regan1,2, Kadambot Siddique2, Peter White1,2, Peter Smith1 and Gae Plunkett1,1Department of Agriculture, 2CLIMA, University of Western Australia 46. Development of ascochyta resistant and high quality varieties for Australia, Kadambot Siddique1, Kerry Regan1,2, Tim Pope1 and Mike Baker2, 1CLIMA, The University of Western Australia 2Department of Agriculture 47. Towards double haploids in chickpeas and field pea, Janine Croser, Julia Wilson and Kadambot Siddique, CLIMA, The University of Western Australia 48. Crossing chickpea with wild Cicer relatives to introduce resistance to disease and tolerance to environmental stress, Heather Clarke and Kadambot Siddique, CLIMA, The University of Western Australia 49. Faba bean, Peter White, Department of Agriculture 50. Germplasm evaluation, Peter White1,2, Kerry Regan1,2, Tim Pope2, Martin Harries1, Mark Seymour1, Rodger Beermier1 and Leanne Young1, 1Department of Agriculture, 2CLIMA, The University of Western Australia 51. Lentil, Kerry Regan, Department of Agriculture, and CLIMA, The University of Western Australia 52. Variety and germplasm evaluation, Kerry Regan1,2, Tim Pope2, Leanne Young1, Martin Harries1, Murray Blyth1 and Michael Materne3, 1Department of Agriculture, 2CLIMA, University of Western Australia, 3Department of Primary Industries, Victoria 53. Lathyrus species, Kadambot Siddique1, Kerry Regan2, and Colin Hanbury2, 1CLIMA, the University of Western Australia, 2Department of Agricultur