Fuzzy Human Reliability Analysis: Applications and Contributions Review

The applications and contributions of fuzzy set theory to human reliability analysis (HRA) are reassessed. The main contribution of fuzzy mathematics relies on its ability to represent vague information. Many HRA authors have made contributions developing new models, introducing fuzzy quantification methodologies. Conversely, others have drawn on fuzzy techniques or methodologies for quantifying already existing models. Fuzzy contributions improve HRA in five main aspects: (1) uncertainty treatment, (2) expert judgment data treatment, (3) fuzzy fault trees, (4) performance shaping factors, and (5) human behaviour model. Finally, recent fuzzy applications and new trends in fuzzy HRA are herein discussed

Latent failures on biodiesel plants

The process to obtain biodiesel is simple, however it is a chemical process in which toxic and flammable substances are used or variables like temperature or pressure should be controlled to avoid any kind of incident. Literature report accidents where most human errors are related to the confidence of operators by this simplicity. Much of these accidents are influenced by a number of factors involved constituting latent failures. This paper presents a summary of latent failures identified on biodiesel plants and a description of their causes and the accepted practices to eliminate them.Fil: Rivera, Selva S.. Universidad Nacional de Cuyo. Facultad de Ingenieria. Instituto de Capacitación Especial y Desarrollo de Ingeniería Asistida Por Computadora; ArgentinaFil: Núñez Mc Leod, Jorge Eduardo. Universidad Nacional de Cuyo. Facultad de Ingenieria. Instituto de Capacitación Especial y Desarrollo de Ingeniería Asistida Por Computadora; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Calvo Olivares, Romina Daniela. Universidad Nacional de Cuyo. Facultad de Ingenieria. Instituto de Capacitación Especial y Desarrollo de Ingeniería Asistida Por Computadora; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza; Argentin

The effects of exposure to a rotating environment /10 rpm/ on four aviators for a period of twelve days

Motion sickness studies of aviators exposed to rotating environment - Aerospace medicin

Scientific Objectives of Einstein Telescope

The advanced interferometer network will herald a new era in observational astronomy. There is a very strong science case to go beyond the advanced detector network and build detectors that operate in a frequency range from 1 Hz-10 kHz, with sensitivity a factor ten better in amplitude. Such detectors will be able to probe a range of topics in nuclear physics, astronomy, cosmology and fundamental physics, providing insights into many unsolved problems in these areas.Comment: 18 pages, 4 figures, Plenary talk given at Amaldi Meeting, July 201

A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics

Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented the microattribution approach to assess the pharmacogenomic biomarkers allelic spectrum in 18 European populations, mostly from developing European countries, by analyzing 1,931 pharmacogenomics biomarkers in 231 genes. Our data show significant interpopulation pharmacogenomic biomarker allele frequency differences, particularly in 7 clinically actionable pharmacogenomic biomarkers in 7 European populations, affecting drug efficacy and/or toxicity of 51 medication treatment modalities. These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned. Also, our data demonstrate notable differences in predicted genotype-based warfarin dosing among these populations. Our findings can be exploited not only to develop guidelines for medical prioritization, but most importantly to facilitate integration of pharmacogenomics and to support pre-emptive pharmacogenomic testing. This may subsequently contribute towards significant cost-savings in the overall healthcare expenditure in the participating countries, where pharmacogenomics implementation proves to be cost-effective