1,053 research outputs found
Platelets Contribute to BBB Disruption Induced by HIV and Alcohol
The role of platelets in the neurological diseases that underlie cognitive impairment has attracted increasing attention in recent years. Multiple pathways in platelets contribute to host defenses, as well as to CNS function. In the current study, we hypothesize that the Blood Brain Barrier (BBB) is disrupted when exposed to platelets from patients with triple Co-morbidity (hazardous alcohol users+ HIV+ thrombocytopenia), compared to those with dual, single or no morbidity (HIV only, alcohol only or healthy controls)
R^4 counterterm and E7(7) symmetry in maximal supergravity
The coefficient of a potential R^4 counterterm in N=8 supergravity has been
shown previously to vanish in an explicit three-loop calculation. The R^4 term
respects N=8 supersymmetry; hence this result poses the question of whether
another symmetry could be responsible for the cancellation of the three-loop
divergence. In this article we investigate possible restrictions from the coset
symmetry E7(7)/SU(8), exploring the limits as a single scalar becomes soft, as
well as a double-soft scalar limit relation derived recently by Arkani-Hamed et
al. We implement these relations for the matrix elements of the R^4 term that
occurs in the low-energy expansion of closed-string tree-level amplitudes. We
find that the matrix elements of R^4 that we investigated all obey the
double-soft scalar limit relation, including certain
non-maximally-helicity-violating six-point amplitudes. However, the single-soft
limit does not vanish for this latter set of amplitudes, which suggests that
the E7(7) symmetry is broken by the R^4 term.Comment: 33 pages, typos corrected, published versio
Molecular Valves for Controlling Gas Phase Transport Made from Discrete Angstrom-Sized Pores in Graphene
An ability to precisely regulate the quantity and location of molecular flux
is of value in applications such as nanoscale 3D printing, catalysis, and
sensor design. Barrier materials containing pores with molecular dimensions
have previously been used to manipulate molecular compositions in the gas
phase, but have so far been unable to offer controlled gas transport through
individual pores. Here, we show that gas flux through discrete angstrom-sized
pores in monolayer graphene can be detected and then controlled using
nanometer-sized gold clusters, which are formed on the surface of the graphene
and can migrate and partially block a pore. In samples without gold clusters,
we observe stochastic switching of the magnitude of the gas permeance, which we
attribute to molecular rearrangements of the pore. Our molecular valves could
be used, for example, to develop unique approaches to molecular synthesis that
are based on the controllable switching of a molecular gas flux, reminiscent of
ion channels in biological cell membranes and solid state nanopores.Comment: to appear in Nature Nanotechnolog
Note on Bonus Relations for N=8 Supergravity Tree Amplitudes
We study the application of non-trivial relations between gravity tree
amplitudes, the bonus relations, to all tree-level amplitudes in N=8
supergravity. We show that the relations can be used to simplify explicit
formulae of supergravity tree amplitudes, by reducing the known form as a sum
of (n-2)! permutations obtained by solving on-shell recursion relations, to a
new form as a (n-3)!-permutation sum. We demonstrate the simplification by
explicit calculations of the next-to-maximally helicity violating (NMHV) and
next-to-next-to-maximally helicity violating (N^2MHV) amplitudes, and provide a
general pattern of bonus coefficients for all tree-level amplitudes.Comment: 21 pages, 9 figures; v2, minor changes, references adde
The S-Matrix in Twistor Space
The simplicity and hidden symmetries of (Super) Yang-Mills and (Super)Gravity
scattering amplitudes suggest the existence of a "weak-weak" dual formulation
in which these structures are made manifest at the expense of manifest
locality. We suggest that this dual description lives in (2,2) signature and is
naturally formulated in twistor space. We recast the BCFW recursion relations
in an on-shell form that begs to be transformed into twistor space. Our twistor
transformation is inspired by Witten's, but differs in treating twistor and
dual twistor variables more equally. In these variables the three and
four-point amplitudes are amazingly simple; the BCFW relations are represented
by diagrammatic rules that precisely define the "twistor diagrams" of Andrew
Hodges. The "Hodges diagrams" for Yang-Mills theory are disks and not trees;
they reveal striking connections between amplitudes and suggest a new form for
them in momentum space. We also obtain a twistorial formulation of gravity. All
tree amplitudes can be combined into an "S-Matrix" functional which is the
natural holographic observable in asymptotically flat space; the BCFW formula
turns into a quadratic equation for this "S-Matrix", providing a holographic
description of N=4 SYM and N=8 Supergravity at tree level. We explore loop
amplitudes in (2,2) signature and twistor space, beginning with a discussion of
IR behavior. We find that the natural pole prescription renders the amplitudes
well-defined and free of IR divergences. Loop amplitudes vanish for generic
momenta, and in twistor space are even simpler than their tree-level
counterparts! This further supports the idea that there exists a sharply
defined object corresponding to the S-Matrix in (2,2) signature, computed by a
dual theory naturally living in twistor space.Comment: V1: 46 pages + 23 figures. Less telegraphic abstract in the body of
the paper. V2: 49 pages + 24 figures. Largely expanded set of references
included. Some diagrammatic clarifications added, minor typo fixe
Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) involves considerable histological heterogeneity in terms of location and quality of the glomerular segmental lesions. The present study investigated the heterogeneity of segmental lesions in each variant of FSGS, determined by the Columbia classification, and its clinical relevance. All glomerular segmental lesions of 80 cases of primary FSGS were evaluated histologically based on location [tip (TIP), perihilar (PH), or not otherwise specified (NOS)], and quality (cellular or fibrous). Among the 1,299 glomeruli of the 80 biopsy specimens, 210 glomeruli (16.2%) had segmental lesions, comprising 57 (27%) cellular TIP, 4 (2%) fibrous TIP, 42 (20%) cellular NOS, 86 (41%) fibrous NOS, and 21 (10%) fibrous PH lesions. Each case was also classified into one of the five histological variants of the Columbia classification: collapsing (COL), TIP, cellular (CEL), PH, or NOS. Overlap of segmental lesions in different location categories was seen in the COL, TIP, and PH variants, and heterogeneity of quality was apparent in the COL and CEL variants. Histological findings of the CEL variant (endocapillary hypercellularity) were observed in nine of the 13 COL variants. Both location and quality correlated with disease duration, degree of proteinuria, and histological severity of global glomerular sclerosis and tubulo-interstitial lesions. These results demonstrated the histological heterogeneity of glomerular segmental lesions in all variants of the Columbia classification, except NOS. However, the fidelity of location and dominance of histological features were generally conserved in the TIP and PH variants. The COL and CEL variants warrant further investigation because of their overlapping histological findings and apparent histological heterogeneity in the glomerular segmental lesions
Supertwistor space for 6D maximal super Yang-Mills
6D maximal super Yang-Mills on-shell amplitudes are formulated in superspace
using 6 dimensional twistors. The 3,4,5-point tree amplitudes are obtained by
supersymmetrizing their bosonic counterparts and confirmed through the BCFW
construction. In contrast to 4D this superspace is non-chiral, reflecting the
fact that one cannot differentiate MHV from in 6D. Combined
with unitarity methods, this superspace should be useful for the study of
multi-loop D dimensional maximal super Yang-Mills and gravity amplitudes.
Furthermore, the non-chiral nature gives a natural framework for an off-shell
construction. We show this by matching our result with off-shell D=4 N=4 super
Yang-Mills amplitudes, expressed in projective superspace.Comment: 6 figures 28 pages. with better sign
Effect of microneedles on transdermal permeation enhancement of amlodipine
The present study aimed to investigate the effect of microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of amlodipine (AMLO). Two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PM) of 0.6 mm length were employed. In the case of PMs, arrays were applied thrice at different places within a 1.77-cm2 skin area (PM-3) to maintain the MN density closer to 0.6 mm ADM. Scaling analyses were done using dimensionless parameters like concentration of AMLO (Ct/Cs), thickness (h/L) and surface area of the skin (Sa/L2). Microinjection moulding technique was employed to fabricate PM. Histological studies revealed that the PM, owing to their geometry/design, formed wider and deeper microconduits when compared to ADM of similar length. Approximately 6.84- and 6.11-fold increase in the cumulative amount (48 h) of AMLO permeated was observed with 1.5 mm ADM and PM-3 treatments respectively, when compared to passive permeation amounts. Good correlations (R2 > 0.89) were observed between different dimensionless parameters with scaling analyses. The enhancement in AMLO permeation was found to be in the order of 1.5 mm ADM ≥ PM-3 > 1.2 mm ADM > 0.6 mm ADM ≥PM-1 > passive. The study suggests that MN application enhances the AMLO transdermal permeation and the geometrical parameters of MNs play an important role in the degree of such enhancement
Unraveling L_{n,k}: Grassmannian Kinematics
It was recently proposed that the leading singularities of the S-Matrix of N
= 4 super Yang-Mills theory arise as the residues of a contour integral over a
Grassmannian manifold, with space-time locality encoded through residue
theorems generalizing Cauchy's theorem to more than one variable. We provide a
method to identify the residue corresponding to any leading singularity, and we
carry this out very explicitly for all leading singularities at tree level and
one-loop. We also give several examples at higher loops, including all generic
two-loop leading singularities and an interesting four-loop object. As a
special case we consider a 12-pt N^4MHV leading singularity at two loops that
has a new kinematic structure involving double square roots. Our analysis
results in a simple picture for how the topological structure of loop graphs is
reflected in various substructures within the Grassmannian.Comment: 26+11 page
Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis
Many studies have implicated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-κB1 (Nfkb1) in inflammation and cancer. However, the regulatory potential for crosstalk between these two important transcription factors in inflammation and carcinogenesis has not been explored. To delineate conserved transcription factor-binding site signatures, we performed bioinformatic analyses on the promoter regions of human and murine Nrf2 and Nfkb1. We performed multiple sequence alignment of Nrf2 and Nfkb1 genes in five mammalian species – human, chimpanzee, dog, mouse and rat – to explore conserved biological features. We constructed a canonical regulatory network for concerted modulation of Nrf2 and Nfkb1 involving several members of the mitogen-activated protein kinase (MAPK) family and present a putative model for concerted modulation of Nrf2 and Nfkb1 in inflammation/carcinogenesis. Our results reflect potential for putative crosstalk between Nrf2 and Nfkb1 modulated through the MAPK cascade that may influence inflammation-associated etiopathogenesis of cancer. Taken together, the elucidation of potential relationships between Nrf2 and Nfkb1 may help to better understand transcriptional regulation, as well as transcription factor networks, associated with the etiopathogenesis of inflammation and cancer
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