Quand l'information échappe à ses créateurs : le cas de l'artificialisation des terres agricoles en Languedoc-Roussillon

International audienceThis article aims to describe how the quantification of a phenomenon in relation to a specific worldview spreads and is distorted. This project has been supported by a regional public authority in Languedoc-Roussillon (France), and consisted in the production of information so to quantify and qualify the farmland decrease due to urban sprawl. The paper is based on Latour's actor-network theory; it characterizes the process of enrolment, and the development of dissidences. Identifying contradictory logics and dissidences help questioning the complexity of ‘closing the black-box' regarding information production and of sensemaking between heterogeneous actants involved in a supposed-to-be public debate.Cet article vise à spécifier comment la quantification d'un phénomène fondée sur une certaine vision du monde se propage et se déforme. Ce projet a été porté par une direction déconcentrée de l'Etat soucieuse de l'emprise croissante du bâti sur les terres agricoles en Languedoc-Roussillon. Le cadre théorique mobilisé, la sociologie de la traduction, permet d'identifier les grandes étapes d'intéressement, d'enrôlement, ainsi que le développement de controverses. Les difficultés rencontrées interrogent sur la complexité de clôture de processus innovants s'agissant de production d'information et de co-construction de sens associant des actants hétérogènes impliqués dans des procédures de débat public

Image fusion performed with noncontrast computed tomography scans during endovascular aneurysm repair

We report two endovascular aneurysm repair procedures achieved under image fusion guidance accomplished with noncontrast injected preoperative computed tomography scans. Such use of this advanced imaging application reduces contrast media injection volume (respectively, 27 and 24 mL throughout the patients' hospital course). No changes in creatinine clearance occurred after the procedures. Contrast-enhanced ultrasound imaging confirmed technical success in both cases

BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues

The concept of oligomerization of G protein-coupled receptor (GPCR) opens new perspectives regarding physiological function regulation. The capacity of one GPCR to modify its binding and coupling properties by interacting with a second one can be at the origin of regulations unsuspected two decades ago. Although the concept is interesting, its validation at a physiological level is challenging and probably explains why receptor oligomerization is still controversial. Demonstrating direct interactions between two proteins is not trivial since few techniques present a spatial resolution allowing this precision. Resonance energy transfer (RET) strategies are actually the most convenient ones. During the last two decades, bioluminescent resonance energy transfer and time-resolved fluorescence resonance energy transfer (TR-FRET) have been widely used since they exhibit high signal-to-noise ratio. Most of the experiments based on GPCR labeling have been performed in cell lines and it has been shown that all GPCRs have the propensity to form homo- or hetero-oligomers. However, whether these data can be extrapolated to GPCRs expressed in native tissues and explain receptor functioning in real life, remains an open question. Native tissues impose different constraints since GPCR sequences cannot be modified. Recently, a fluorescent ligand-based GPCR labeling strategy combined to a TR-FRET approach has been successfully used to prove the existence of GPCR oligomerization in native tissues. Although the RET-based strategies are generally quite simple to implement, precautions have to be taken before concluding to the absence or the existence of specific interactions between receptors. For example, one should exclude the possibility of collision of receptors diffusing throughout the membrane leading to a specific FRET signal. The advantages and the limits of different approaches will be reviewed and the consequent perspectives discussed

SEOM clinical guidelines for pancreatic and biliary tract cancer (2020)

Chemotherapy; Radiotherapy; TreatmentQuimioterapia; Radioterapia; TratamientoQuimioteràpia; Radioteràpia; TractamentPancreatic cancer (PC) and biliary tract cancer (BTC) are both aggressive and highly fatal malignancies. Nowadays we have a profound knowledge about the molecular landscape of these neoplasms and this has allowed new therapeutic options. Surgery is the only potentially curative therapy in both cancers, but disease recurrence is frequent. In PC, adjuvant treatment with mFOLFIRINOX has improved overall survival (OS) and in BTC adjuvant treatment with capecitabine seems to improve OS and relapse-free survival. Concomitant radio-chemotherapy could also be considered following R1 surgery in both neoplasms. Neoadjuvant treatment represents the best option for achieving an R0 resection in borderline PC. Upfront systemic chemotherapy is the treatment of choice in unresectable locally advanced PC and BTC; then locoregional therapy could be considered after an initial period of at least 3–4 months of systemic chemotherapy. In metastatic PC, FOLFIRINOX or Gemcitabine plus nab-paclitaxel have improved OS compared with gemcitabine alone. In metastatic BTC, cisplatin plus gemcitabine constitute the standard treatment. Progress in the knowledge of molecular biology has enabled the identification of new targets for therapy with encouraging results that could in the future improve the survival and quality of life of patients with PC and BTC

Tailoring modal properties of inhibited-coupling guiding fibers by cladding modification

Understanding cladding properties is crucial for designing microstructured optical fibers. This is particularly acute for Inhibited-Coupling guiding fibers because of the reliance of their core guidance on the core and cladding mode-field overlap integral. Consequently, careful planning of the fiber cladding parameters allows obtaining fibers with optimized characteristics such as low loss and broad transmission bandwidth. In this manuscript, we report on how one can tailor the modal properties of hollow-core photonic crystal fibers by adequately modifying the fiber cladding. We show that the alteration of the position of the tubular fibers cladding tubes can alter the loss hierarchy of the modes in these fibers, and exhibit salient polarization propriety. In this context, we present two fibers with different cladding structures which favor propagation of higher order core modes \u2013 namely LP11 and LP21 modes. Additionally, we provide discussions on mode transformations in these fibers and show that one can obtain uncommon intensity and polarization profiles at the fiber output. This allows the fiber to act as a mode intensity and polarization shaper. We envisage this novel concept can be useful for a variety of applications such as hollow core fiber based atom optics, atom-surface physics, sensing and nonlinear optics

Water Condensation Zones around Main Sequence Stars

Understanding the set of conditions that allow rocky planets to have liquid water on their surface -- in the form of lakes, seas or oceans -- is a major scientific step to determine the fraction of planets potentially suitable for the emergence and development of life as we know it on Earth. This effort is also necessary to define and refine the so-called "Habitable Zone" (HZ) in order to guide the search for exoplanets likely to harbor remotely detectable life forms. Until now, most numerical climate studies on this topic have focused on the conditions necessary to maintain oceans, but not to form them in the first place. Here we use the three-dimensional Generic Planetary Climate Model (PCM), historically known as the LMD Generic Global Climate Model (GCM), to simulate water-dominated planetary atmospheres around different types of Main-Sequence stars. The simulations are designed to reproduce the conditions of early ocean formation on rocky planets due to the condensation of the primordial water reservoir at the end of the magma ocean phase. We show that the incoming stellar radiation (ISR) required to form oceans by condensation is always drastically lower than that required to vaporize oceans. We introduce a Water Condensation Limit, which lies at significantly lower ISR than the inner edge of the HZ calculated with three-dimensional numerical climate simulations. This difference is due to a behavior change of water clouds, from low-altitude dayside convective clouds to high-altitude nightside stratospheric clouds. Finally, we calculated transit spectra, emission spectra and thermal phase curves of TRAPPIST-1b, c and d with H2O-rich atmospheres, and compared them to CO2 atmospheres and bare rock simulations. We show using these observables that JWST has the capability to probe steam atmospheres on low-mass planets, and could possibly test the existence of nightside water clouds.Comment: Accepted for publication in Astronomy & Astrophysic

Patterning of educational attainment across inflammatory markers : Findings from a multi-cohort study

Background: Evidence suggests that the inflammatory reaction, an adaptive response triggered by a variety of harmful stimuli and conditions involved in the risk and development of many chronic diseases, is a potential pathway through which the socioeconomic environment is biologically embedded. Difficulty in interpreting the role of the inflammatory system in the embodiment dynamic arises because of heterogeneity across studies that use a limited but varied number of inflammatory markers. There is no consensus in the literature as to which inflammatory markers beyond the C-reactive protein and to a lesser extent interleukin 6 are related to the social environment. Accordingly, we aimed to investigate the association between educational attainment, and several markers of inflammation - C-reactive protein, fibrinogen, interleukin 6, interleukin 1 beta and tumor necrosis factor alpha- in 6 European cohort studies. Methods: Up to 17,470 participants from six European cohort studies with data on educational attainment, health behaviors and lifestyle factors, and at least two different inflammatory markers. Four sub-datasets were drawn with varying numbers of participants to allow pairwise comparison of the social patterning of C-reactive protein and any other inflammatory markers. To evaluate within each sub-dataset the importance of the context and cohort specificities, linear regression-based analyses were performed separately for each cohort and combined in a random effect meta-analysis to determine the relationship between educational attainment and inflammation. Results: We found that the magnitude of the relationship between educational attainment and five inflammatory biomarkers (C-reactive protein, fibrinogen, interleukin 6 and 1 beta and tumor necrosis factor alpha) was variable. By far the most socially patterned biomarker was C-reactive protein, followed by fibrinogen and to lesser extent interleukin 6, where a low educational attainment was associated with higher inflammation even after adjusting for health behaviours and body mass index. No association was found with interleukin 1 beta and tumor necrosis factor alpha. Conclusions: Our study suggests different educational patterning of inflammatory biomarkers. Further large-scale research is needed to explore social differences in the inflammatory cascade in greater detail and the extent to which these differences contribute to social inequalities in health.Peer reviewe