6,585 research outputs found
Studies on the RF Deflectors for CTF3
The bunch train compression scheme for the CLIC Test Facility CTF3 relies on the feasibility of fast RF deflectors. They are essentially RF cavities or TW sections working on transverse. deflecting mode. The most demanding issues in the deflector design are those related to the beam dynamics, including the beam loading effects on the fundamental deflecting mode, while the efficiency required by the CTF3 parameters can be met by already existing structures. The analysis of the beam dynamics, which addresses the deflector design is reported in this paper, and different structures representing possible solutions are compared
The SMILING project : prevention of falls by a mechatronic training device
Ageing is characterized by functional changes that can create gait and balance disturbances, which are the main risk factors of falling. Elderly people at risk of falling can be considered to be suffering from an involuntary motor behaviour that restricts their participation in society. One method to overcome such a situation is to activate a new learning process to train for real life tasks, which represents innovation. The SMILING system is intended to challenge the elderly to solve new problems in real time by inducing variable environments that need active response and problem solving. Variable environments induced by perturbations will weaken stiff motor behaviour(s), induce flexibility and thus enable effective training and improve mobility in real life environments. The SMILING solution provides a changeable yet safe environment that needs active response and problem solving by the user. It consists of a wearable non-invasive computer-controlled system that applies chaotic perturbations to the lower extremities during walking through small alterations of the height and slope of weight-bearing surfaces. The complete system consists of 3 modules: i) a complete walking analysis system; ii) a pair of motorised training shoes; iii) a user friendly portable control unit
Commissioning Status of the CTF3 Delay Loop
The CLIC Test Facility CTF3, built at CERN by an international collaboration, aims at demonstrating the linear collider by 2010. In particular, one of the main goals is to study the generation of high-current electron pulses by interleaving bunch trains in delay lines and rings using transverse RF deflectors. This will be done in the 42 m long delay loop, built under the responsibility of INFN/LNF, and the 84 m long combiner ring that will follow it. The delay loop installation was completed and its commissioning started at the end of 2005. In this paper the commissioning results are presented, including the first tests of beam recombination
Flood damage data analysis: towards an improvement of data quality and usability
The European project IDEA (Improving Damage assessments to Enhance cost-benefit Analyses) is a response to the limited reliability of data currently used to support cost-benefit analyses for natural hazards mitigation; in particular, an improvement of both damage data quality and procedures to collect and manage them is pursued by the project. A comprehensive understanding of (i) how disaster data are presently collected and stored, (ii) main reasons for data collection, (iii) possible uses of collected data, and (iv) stakeholders involved in data collection and management is the first step to improve the present quality, reliability and usability of data. To this aim, several case studies were analysed in the project referring to different hazards, countries and spatial scale. The analysis brought, for each case study, to (i) the characterisation of data owners, data collectors, and data users, and (ii) a critical analysis of damage data in terms of their comprehensiveness in reproducing observed impacts, data sources, formats and level of detail. This paper discusses results obtained for the floods that hit the Umbria Region (Central Italy) in 2012 and 2013, as emblematic of the different case studies analysed in the project. First, the methodological approach followed in the analysis is disclosed. Then, results are presented. Finally, their implication for the project objective are discussed
Second-order -regularity in nonlinear elliptic problems
A second-order regularity theory is developed for solutions to a class of
quasilinear elliptic equations in divergence form, including the -Laplace
equation, with merely square-integrable right-hand side. Our results amount to
the existence and square integrability of the weak derivatives of the nonlinear
expression of the gradient under the divergence operator. This provides a
nonlinear counterpart of the classical -coercivity theory for linear
problems, which is missing in the existing literature. Both local and global
estimates are established. The latter apply to solutions to either Dirichlet or
Neumann boundary value problems. Minimal regularity on the boundary of the
domain is required. If the domain is convex, no regularity of its boundary is
needed at all
Proposal for taking data with the KLOE-2 detector at the DANE collider upgraded in energy
This document reviews the physics program of the KLOE-2 detector at
DANE upgraded in energy and provides a simple solution to run the
collider above the -peak (up to 2, possibly 2.5 GeV). It is shown how a
precise measurement of the multihadronic cross section in the energy region up
to 2 (possibly 2.5) GeV would have a major impact on the tests of the Standard
Model through a precise determination of the anomalous magnetic moment of the
muon and the effective fine-structure constant at the scale. With a
luminosity of about cms, DANE upgraded in energy
can perform a scan in the region from 1 to 2.5 GeV in one year by collecting an
integrated luminosity of 20 pb (corresponding to a few days of data
taking) for single point, assuming an energy step of 25 MeV. A few years of
data taking in this region would provide important tests of QCD and effective
theories by physics with open thresholds for pseudo-scalar (like
the ), scalar (, etc...) and axial-vector (, etc...)
mesons; vector-mesons spectroscopy and baryon form factors; tests of CVC and
searches for exotics. In the final part of the document a technical solution
for the energy upgrade of DANE is proposed.Comment: 19 pages, 8 figure
Recurrent Modification of a Conserved Cis-Regulatory Element Underlies Fruit Fly Pigmentation Diversity
The development of morphological traits occurs through the collective action of networks of genes connected at the level of gene expression. As any node in a network may be a target of evolutionary change, the recurrent targeting of the same node would indicate that the path of evolution is biased for the relevant trait and network. Although examples of parallel evolution have implicated recurrent modification of the same gene and cis-regulatory element (CRE), little is known about the mutational and molecular paths of parallel CRE evolution. In Drosophila melanogaster fruit flies, the Bric-à-brac (Bab) transcription factors control the development of a suite of sexually dimorphic traits on the posterior abdomen. Female-specific Bab expression is regulated by the dimorphic element, a CRE that possesses direct inputs from body plan (ABD-B) and sex-determination (DSX) transcription factors. Here, we find that the recurrent evolutionary modification of this CRE underlies both intraspecific and interspecific variation in female pigmentation in the melanogaster species group. By reconstructing the sequence and regulatory activity of the ancestral Drosophila melanogaster dimorphic element, we demonstrate that a handful of mutations were sufficient to create independent CRE alleles with differing activities. Moreover, intraspecific and interspecific dimorphic element evolution proceeded with little to no alterations to the known body plan and sex-determination regulatory linkages. Collectively, our findings represent an example where the paths of evolution appear biased to a specific CRE, and drastic changes in function were accompanied by deep conservation of key regulatory linkages. © 2013 Rogers et al
Change in Markers of Bone Metabolism with Chemotherapy for Advanced Prostate Cancer: Interleukin-6 Response Is a Potential Early Indicator of Response to Therapy
Men with androgen-independent prostate cancer (AIPC) frequently have bone metastasis. The effects of chemotherapy on markers of bone metabolism have not been well characterized. We conducted a prospective study of patients with AIPC randomized in the first cycle to receive either docetaxel/estramustine or zoledronic acid, a bisphosphonate, to inhibit osteoclastic activity. Here we report the effects of therapy on markers of bone metabolism in these patients following the first cycle of therapy. Serum levels of several indices of bone remodeling were evaluated using commercial enzyme-linked immunosorbent assays. Changes in markers of bone metabolism were compared in patients receiving initial chemotherapy versus bisphosphonate. There was no significant difference in median change in any of the measured bone markers in patients given zoledronic acid when compared to chemotherapy. When comparing responders to nonresponders, overall interleukin-6 (IL-6) decreased by 35% in prostate-specific antigen responders; whereas, IL-6 levels increased by 76% in nonresponders (p = 0.03). Elevated IL-6 levels and reductions in IL-6 levels early in treatment may reflect ultimate clinical response to docetaxel-based regimens.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78145/1/jir.2008.0024.pd
Bose-Einstein Correlations in e+e- to W+W- at 172 and 183 GeV
Bose-Einstein correlations between like-charge pions are studied in hadronic
final states produced by e+e- annihilations at center-of-mass energies of 172
and 183 GeV. Three event samples are studied, each dominated by one of the
processes W+W- to qqlnu, W+W- to qqqq, or (Z/g)* to qq. After demonstrating the
existence of Bose-Einstein correlations in W decays, an attempt is made to
determine Bose-Einstein correlations for pions originating from the same W
boson and from different W bosons, as well as for pions from (Z/g)* to qq
events. The following results are obtained for the individual chaoticity
parameters lambda assuming a common source radius R: lambda_same = 0.63 +- 0.19
+- 0.14, lambda_diff = 0.22 +- 0.53 +- 0.14, lambda_Z = 0.47 +- 0.11 +- 0.08, R
= 0.92 +- 0.09 +- 0.09. In each case, the first error is statistical and the
second is systematic. At the current level of statistical precision it is not
established whether Bose-Einstein correlations, between pions from different W
bosons exist or not.Comment: 24 pages, LaTeX, including 6 eps figures, submitted to European
Physical Journal
W+W- production and triple gauge boson couplings at LEP energies up to 183 GeV
A study of W-pair production in e+e- annihilations at Lep2 is presented,
based on 877 W+W- candidates corresponding to an integrated luminosity of 57
pb-1 at sqrt(s) = 183 GeV. Assuming that the angular distributions of the
W-pair production and decay, as well as their branching fractions, are
described by the Standard Model, the W-pair production cross-section is
measured to be 15.43 +- 0.61 (stat.) +- 0.26 (syst.) pb. Assuming lepton
universality and combining with our results from lower centre-of-mass energies,
the W branching fraction to hadrons is determined to be 67.9 +- 1.2 (stat.) +-
0.5 (syst.)%. The number of W-pair candidates and the angular distributions for
each final state (qqlnu,qqqq,lnulnu) are used to determine the triple gauge
boson couplings. After combining these values with our results from lower
centre-of-mass energies we obtain D(kappa_g)=0.11+0.52-0.37,
D(g^z_1)=0.01+0.13-0.12 and lambda=-0.10+0.13-0.12, where the errors include
both statistical and systematic uncertainties and each coupling is determined
setting the other two couplings to the Standard Model value. The fraction of W
bosons produced with a longitudinal polarisation is measured to be
0.242+-0.091(stat.)+-0.023(syst.). All these measurements are consistent with
the Standard Model expectations.Comment: 48 pages, LaTeX, including 13 eps or ps figures, submitted to
European Physical Journal
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