Study of Mill Island ice core (East Antarctica): A sensitive site for high resolution ocean climate signals?

第2回極域科学シンポジウム　氷床コアセッション 11月16日（水） 国立極地研究所 2階大会議

Nuclear medicine practice in Japan: a report of the seventh nationwide survey in 2012

Objective The Subcommittee on the Survey of Nuclear Medical Practice in Japan has performed a nationwide survey of nuclear medicine practice every 5 years since 1982 to survey contemporary nuclear medicine practice and its changes over the years. Methods The subcommittee sent questionnaires, including the number and category of examinations as well as the kind and dose of the radiopharmaceuticals during the 30 days of June 2012, to all the nuclear medicine institutes. The total numbers for the year 2012 were then estimated. Results A total of 1,167 institutes responded to the survey, including the 14 in vitro assay institutes and 266 PET centers. The recovery rate was 92 %. The number of gamma cameras installed was 1,425 in total, with 9 % decrease in 5 years. Dual-head cameras and hybrid SPECT/CT scanners accounted for 84 and 10.5 %, respectively. The number of single-photon tracer studies in 2012 was 1.15 million which means decrease in 19 % in 5 years and 29 % in 10 years. All but cerebral perfusion study and sentinel lymphoscintigraphy have decreased. Bone scintigraphy was a leading examination (38.7 %), followed by cardiac studies (29.4 %) and cerebral perfusion study (18.5 %) in order. SPECT studies showed an increase from 42.3 to 47.2 %. PET centers have also increased from 212 to 295, as compared to the last survey. The 135 PET centers have installed one or two in-house cyclotrons. PET studies showed 25.5 % increase in 5 years, with oncology accounting for 96.3 %. 18F-FDG accounted for 98.2 % (505,990 examinations). PET examinations using 11C-methionine have been increasing, with 3,352 examinations in 2012. The number of new PET studies using 11C-PIB PET was 695. 131I-radioiodine targeted therapies showed an increase, including 3,644 patients (53.6 %) for thyroid cancer and 4,889 patients (17.9 %) for hyperthyroidism. Out-patient thyroid bed ablation therapy with 30 mCi of 131I accounted for 21.0 % of cancer patients. The number of admission rooms decreased from 158 to 135 in 5 years. In vitro radioassays have been declining continuously since 1992, with the number of studies of 9.0 million in 2012. Conclusions Single-photon examinations showed a continuous tendency toward a decline in the survey. In contrast, the number of hybrid SPECT/CT scanner examinations has increased. PET/CT study in the oncology field and radionuclide targeted therapy have steadily increased. © 2014 The Japanese Society of Nuclear Medicine

Impact of coastal East Antarctic ice rises on surface mass balance: insights from observations and modeling

About 20&thinsp;% of all snow accumulation in Antarctica occurs on the ice shelves. There, ice rises control the spatial surface mass balance (SMB) distribution by inducing snowfall variability and wind erosion due to their topography. Moreover these ice rises buttress the ice flow and represent ideal drilling locations for ice cores. In this study we assess the connection between snowfall variability and wind erosion to provide a better understanding of how ice rises impact SMB variability, how well this is captured in the regional atmospheric climate model RACMO2 and the implications of this SMB variability for ice rises as an ice core drilling site. By combining ground-penetrating radar (GPR) profiles from two ice rises in Dronning Maud Land with ice core dating, we reconstruct spatial and temporal SMB variations from 1983 to 2018 and compare the observed SMB with output from RACMO2 and SnowModel. Our results show snowfall-driven differences of up to 1.5 times higher SMB on the windward side of both ice rises than on the leeward side as well as a local erosion-driven minimum at the ice divide of the ice rises. RACMO2 captures the snowfall-driven differences but overestimates their magnitude, whereas the erosion on the peak can be reproduced by SnowModel with RACMO2 forcing. Observed temporal variability of the average SMBs, retrieved from the GPR data for four time intervals in the 1983&ndash;2018 range, are low at the peak of the easternmost ice rise (&sim;0.06&thinsp;mw.e.yr&minus;1), while they are higher (&sim;0.09&thinsp;mw.e.yr&minus;1) on the windward side of the ice rise. This implies that at the peak of the ice rise, higher snowfall, driven by orographic uplift, is balanced out by local erosion. As a consequence of this, the SMB recovered from the ice core matches the SMB from the GPR at the peak of the ice rise but not at the windward side of the ice rise, suggesting that the SMB signal is damped in the ice core.</p

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling via c-Myc. Mule also regulates protein levels of the receptor tyrosine kinase EphB3 by targeting it for proteasomal and lysosomal degradation. In the intestine, EphB/ephrinB interactions position cells along the crypt-villus axis and compartmentalize incipient colorectal tumors. Our study thus unveils an important new avenue by which Mule acts as an intestinal tumor suppressor by regulation of the intestinal stem cell niche

High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study

One view of sarcoidosis is that the term covers many different diseases. However, no classification framework exists for the future exploration of pathogenetic pathways, genetic or trigger predilections, patterns of lung function impairment, or treatment separations, or for the development of diagnostic algorithms or relevant outcome measures. We aimed to establish agreement on high-resolution CT (HRCT) phenotypic separations in sarcoidosis to anchor future CT research through a multinational two-round Delphi consensus process. Delphi participants included members of the Fleischner Society and the World Association of Sarcoidosis and other Granulomatous Disorders, as well as members' nominees. 146 individuals (98 chest physicians, 48 thoracic radiologists) from 28 countries took part, 144 of whom completed both Delphi rounds. After rating of 35 Delphi statements on a five-point Likert scale, consensus was achieved for 22 (63%) statements. There was 97% agreement on the existence of distinct HRCT phenotypes, with seven HRCT phenotypes that were categorised by participants as non-fibrotic or likely to be fibrotic. The international consensus reached in this Delphi exercise justifies the formulation of a CT classification as a basis for the possible definition of separate diseases. Further refinement of phenotypes with rapidly achievable CT studies is now needed to underpin the development of a formal classification of sarcoidosis

Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA