Clinical features and prognostic factors of 245 Portuguese patients hospitalized with COVID-19

Introduction Since the declaration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in March 2020, Portugal was considered a role model with regards to the first COVID-19 wave. However, a third wave started in 2021 started, turning the country into the worst in the world regarding new infections and death rate per capita in the last weeks of January 2021. No significant data regarding the country's first wave of hospitalized patients have been published. Those data may help understand the differences over time regarding patients and the clinical approach to them. Herein, we present data of COVID-19 patients hospitalized at the main tertiary hospital of the second-most affected county at the time and identify risk factors associated with disease progression and outcomes. Materials and methods We performed a prospective observational study of patients admitted with COVID-19 to a central hospital between March 20 and June 1, 2020. The primary endpoint of this study was 30-day mortality or the need for ventilatory support and the secondary outcomes were both outcomes individually. Results 245 patients were included, with a median age of 79 years, 52% males. Hypertension (n = 172) and dyslipidemia (n = 114) were the most frequent comorbidities. Half of the patients (n = 121) were treated with hydroxychloroquine. The primary outcome occurred in 114 patients; mortality at 30 days was 35%. Age (OR 1.05; 1.02-1.07) and active cancer (OR 3.89; 1.43-10.57) were associated with the primary outcome, with dyslipidemia being protective (OR 0.46; 0.25-0.80). Treatment with hydroxychloroquine or lopinavir/ritonavir was not associated with the main outcome. Patients who had been symptomatic for more than 7 days had lower mortality (OR 0.23; 0.09-0.63). Discussion In the present study, age and cancer were associated with higher mortality, as noted in prior articles. The population had a higher median age than reported in previous studies, which may explain the increased mortality. The protective association of dyslipidemia was not previously described. This association was not related to statin intake. Conclusion The reported high mortality of COVID-19 is rarely seen in other infectious diseases. Our elderly population probably reflects more reliably the incidence of COVID-19 in European countries with constricted age pyramids.publishe

As capitanias hereditárias no mapa de Luís Teixeira

By means of the known map of Luís Teixeira, we analyze the evolution of the hereditary captaincies in their first 50 years. It was found that this map, despite its historical and cartographic value, has several mistakes and inconsistencies. There are errors with regard to the border lines, donatories and historical events. From the cartographic point of view, as other maps of the time, it is quite accurate in latitude but not in longitude. With regard to the dating, task made mainly by the examination of the names of the donatories, it can be said that coexist data from different times and the best explanation for this is that the author collected the most data in 1574 and then updated some information in 1586, but not all. To examine this question, we made an analysis of the evolution of these territories, whose information are dispersed. And this propitiated rectify some knowledge; by example the fact that the Bahia captaincy, in the first years, be constituted only by the city of Salvador; and about the categorization of village or cities, that is not made in the base of the greater or lesser size or importance, but by the fact of be created by the donatory or by the crown. These mistakes may perhaps be explained by the character of the map, similar to some roteiros of the time, and show in a practical way an interesting lesson, yet known theoretically: a map, no matter how beautiful and how historical it is, it can not be considered as an accurate portrayal of the reality or as a photography of the time: as any historical document, should be read carefully and with critical sense.Partindo do conhecido mapa de Luís Teixeira, apresenta-se a evolução das capitanias hereditárias nos primeiros 50 anos. Constatou-se que esse mapa, apesar de seu valor histórico e cartográfico, possui diversos equívocos e inconsistências. Há enganos com relação às linhas divisórias, aos donatários e aos acontecimentos. Do ponto de vista cartográfico, como outros mapas da época, ele é suficientemente acurado em latitude, mas pouco em longitude. Com relação à datação, feita principalmente examinando-se os nomes dos donatários, pode-se dizer que coexistem dados de diferentes épocas, e a melhor explicação é de que o autor coletou dados numa época (1574) e depois atualizou algumas informações (1586), mas não todas. Para examinar essa questão, foi feita uma breve análise das vicissitudes desses territórios, cujas informações se encontram dispersas. Isso permitiu retificar alguns conhecimentos, como, por exemplo, o fato de a Capitania da Bahia, nos primeiros anos, ser formada unicamente pela cidade de Salvador, e que a categorização em vilas ou cidades não se dá pelo maior ou menor tamanho ou importância, mas pelo fato de serem criadas ou pelo donatário ou pela coroa. Esses enganos talvez possam ser explicados pelo caráter do mapa, comparável a alguns "roteiros" da época, e podem mostrar de forma concreta uma interessante lição já conhecida teoricamente: um mapa, por mais belo e histórico que seja, e por mais louvado que tenha sido, não pode ser considerado simploriamente como um retrato fiel da realidade, uma fotografia da época: como qualquer documento histórico, deve ser lido com cuidado e sentido crítico

Etude expérimentale de la combustion d'un mélange méthane-air hétérogène globalement pauvre

POITIERS-BU Sciences (861942102) / SudocSudocFranceF

Laminar burning velocities and Markstein numbers of syngas-air mixtures

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