Flavonoides como agentes quimiopreventivos y terapéuticos contra el cáncer de pulmón

The objective of the present review is to study the relationship between flavonoids and lung cancer, proposing that their regular consumption in Western diets could be beneficial for protecting patients against lung cancer.An extensive search of the scientific literature was performed in the following electronic specialized databases (PubMed central (PMC)-NBCI, Elsevier Journal, SciELO Spain, Scirus, Science Direct), including studies in animals, cells, and humans, in order to establish the effect of flavonoids in the prevention and development of lung cancer.Although in vitro and animal studies show the potential ability of flavonoids to act against different types of cancers, especially against lung cancers, the diverse results reported within epidemiological studies, together with the lack of experiments in humans, are the major factors in limiting making dietary recommendations based on scientific evidence for the management of patients with lung cancer. Therefore, the authors of the present study recommend following the dietary health practice guidelines which promotes the consumption of food enriched in flavonoids and reflects the current state of knowledge of an effective and appropriate diet in lung cancer patients

Magnetic illusion : transforming a magnetic object into another object by negative permeability

We theoretically predict and experimentally verify the illusion of transforming the magnetic signature of a 3D object into that of another arbitrary object. This is done by employing negative-permeability materials, which we demonstrate can be emulated by tailored sets of currents. The experimental transformation of the magnetic response of a ferromagnet into that of its antagonistic material, a superconductor, is presented to confirm the theory. The emulation of negative-permeability materials by currents provides a pathway for designing devices for controlling magnetic fields

De la Turismofobia a la Convivencia Turística: El Caso de Barcelona. Análisis Comparativo con Ámsterdam y Berlín

The phenomenon of tourism phobia and the problems of tourist coexistence are the subject matter, by means of a comparative analysis between the cities of Amsterdam, Barcelona and Berlin. The main objective of the study is to explain the tourism phobia phenomenon with the purpose of knowing the common characteristics that cause the appearance of problems of tourist coexistence. In order to be able to study this phenomenon, a statistical data search and informative articles analysis have been executed to point out the common characteristics and the problems of the tourist activity in this three cities. At the same time, interviews to personalities of the sector have been carried out, and include professionals from the public administration, associations, teachers and members of the private sector. This research has led us to consider that tourism phobia, etymologically speaking, gets away of the most common thoughts and opinions. All three cities present several problems of coexistence between tourists and residents which appear from the overcrowding of public spaces and as a result of a bad planning of the territory, causing discomfort among citizens. These problems have been understood as the hate to tourism by some industry players and the media

De la Turismofobia a la Convivencia Turística: El Caso de Barcelona. Análisis Comparativo con Ámsterdam y Berlín

The phenomenon of tourism phobia and the problems of tourist coexistence are the subject matter, by means of a comparative analysis between the cities of Amsterdam, Barcelona and Berlin. The main objective of the study is to explain the tourism phobia phenomenon with the purpose of knowing the common characteristics that cause the appearance of problems of tourist coexistence. In order to be able to study this phenomenon, a statistical data search and informative articles analysis have been executed to point out the common characteristics and the problems of the tourist activity in this three cities. At the same time, interviews to personalities of the sector have been carried out, and include professionals from the public administration, associations, teachers and members of the private sector. This research has led us to consider that tourism phobia, etymologically speaking, gets away of the most common thoughts and opinions. All three cities present several problems of coexistence between tourists and residents which appear from the overcrowding of public spaces and as a result of a bad planning of the territory, causing discomfort among citizens. These problems have been understood as the hate to tourism by some industry players and the media.El fenómeno de la turismofobia y los problemas de convivencia turística son el objeto de estudio del presente artículo, realizado en base a un análisis comparativo de las ciudades de Ámsterdam, Barcelona y Berlín. El objetivo principal es estudiar el concepto turismofobia con la finalidad de conocer las características comunes que provocan la aparición de varios problemas de convivencia turística.Para el estudio de la extensión del fenómeno se ha llevado a cabo una búsqueda de cifras y artículos divulgativos con el objetivo de definir los problemas provocados por la actividad turística en las tres ciudades. Paralelamente se han realizado entrevistas a 27 personalidades del sector, pertenecientes tanto a la administración pública como a asociaciones vecinales, al mundo académico y al sector privado.Los resultados llevan a considerar que la concepción del término turismofobia, teniendo en cuenta su significado etimológico, se aleja de las líneas más extendidas. Las tres ciudades presentan distintos problemas de convivencia entre turistas y residentes provocados, principalmente, por la masificación de los espacios públicos y por la mala planificación del entorno, hechos que causan malestar entre la ciudadanía y que ha sido entendido como odio al turismo tanto por diversos actores del sector como por los medios de comunicación

Tailoring magnetic fields in inaccessible regions

Controlling magnetism, essential for a wide range of technologies, is impaired by the impossibility of generating a maximum of magnetic field in free space. Here, we propose a strategy based on negative permeability to overcome this stringent limitation. We experimentally demonstrate that an active magnetic metamaterial can emulate the field of a straight current wire at a distance. Our strategy leads to an unprecedented focusing of magnetic fields in empty space and enables the remote cancellation of magnetic sources, opening an avenue for manipulating magnetic fields in inaccessible regions

Liver transcriptome profile in pigs with extreme phenotypes of intramuscular fatty acid composition

Abstract Background New advances in high-throughput technologies have allowed for the massive analysis of genomic data, providing new opportunities for the characterization of the transcriptome architectures. Recent studies in pigs have employed RNA-Seq to explore the transcriptome of different tissues in a reduced number of animals. The main goal of this study was the identification of differentially-expressed genes in the liver of Iberian x Landrace crossbred pigs showing extreme phenotypes for intramuscular fatty acid composition using RNA-Seq. Results The liver transcriptomes of two female groups (H and L) with phenotypically extreme intramuscular fatty acid composition were sequenced using RNA-Seq. A total of 146 and 180 unannotated protein-coding genes were identified in intergenic regions for the L and H groups, respectively. In addition, a range of 5.8 to 7.3% of repetitive elements was found, with SINEs being the most abundant elements. The expression in liver of 186 (L) and 270 (H) lncRNAs was also detected. The higher reproducibility of the RNA-Seq data was validated by RT-qPCR and porcine expression microarrays, therefore showing a strong correlation between RT-qPCR and RNA-Seq data (ranking from 0.79 to 0.96), as well as between microarrays and RNA-Seq (r=0.72). A differential expression analysis between H and L animals identified 55 genes differentially-expressed between groups. Pathways analysis revealed that these genes belong to biological functions, canonical pathways and three gene networks related to lipid and fatty acid metabolism. In concordance with the phenotypic classification, the pathways analysis inferred that linolenic and arachidonic acids metabolism was altered between extreme individuals. In addition, a connection was observed among the top three networks, hence suggesting that these genes are interconnected and play an important role in lipid and fatty acid metabolism. Conclusions In the present study RNA-Seq was used as a tool to explore the liver transcriptome of pigs with extreme phenotypes for intramuscular fatty acid composition. The differential gene expression analysis showed potential gene networks which affect lipid and fatty acid metabolism. These results may help in the design of selection strategies to improve the sensorial and nutritional quality of pork meat.This work was funded by MICINN projects AGL2008-04818-C03/GAN and AGL2011-29821-C02 (Ministerio de Economía y Competitividad), and by the Innovation Consolider-Ingenio 2010 Program (CSD2007-00036, Centre for Research in Agrigenomics). Y. Ramayo-Caldas was funded by a FPU PhD grant from the Spanish Ministerio de Educación (AP2008-01450), J. Corominas was funded by a FPI PhD grant from the Spanish Ministerio de Educación (BES-2009-018223), A. Esteve-Codina is recipient of a FPI PhD fellowship from the Ministerio de Educación (BES-2008-005772), Spain.Peer Reviewe

Gut microbiota resilience in horse athletes following holidays out to pasture

Elite horse athletes that live in individual boxes and train and compete for hours experience longterm physical and mental stress that compromises animal welfare and alters the gut microbiota. We therefore assessed if a temporary period out to pasture with conspecifics could improve animal welfare and in turn, favorably affect intestinal microbiota composition. A total of 27 athletes were monitored before and after a period of 1.5 months out to pasture, and their fecal microbiota and behavior profiles were compared to those of 18 horses kept in individual boxes. The overall diversity and microbiota composition of pasture and control individuals were temporally similar, suggesting resilience to environmental challenges. However, pasture exposure induced an increase in Ruminococcus and Coprococcus that lasted 1-month after the return to individual boxes, which may have promoted beneficial effects on health and welfare. Associations between the gut microbiota composition and behavior indicating poor welfare were established. Furthermore, withdrawn behavior was associated with the relative abundances of Lachnospiraceae AC2044 group and Clostridiales family XIII. Both accommodate a large part of butyrate-producing bacterial genera. While we cannot infer causality within this study, arguably, these findings suggest that management practices maintained over a longer period of time may moderate the behavior link to the gut ecosystem beyond its resilience potential

Publisher Correction: Unraveling the effects of the gut microbiota composition and function on horse endurance physiology

Correction de l'article DOI: 10.1038/s41598-019-46118-