Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

Hybrid nanomaterials based on inorganic nanoparticles and polymers are highly interesting structures since they combine synergistically the advantageous physical-chemical properties of both inorganic and polymeric components, providing superior functionality to the final material. These unique properties motivate the intensive study of these materials from a multidisciplinary view with the aim of finding novel applications in technological and biomedical fields. Choosing a specific synthetic methodology that allows for control over the surface composition and its architecture, enables not only the examination of the structure/property relationships, but, more importantly, the design of more efficient nanodevices for therapy and diagnosis in nanomedicine. The current review categorizes hybrid nanomaterials into three types of architectures: core-brush, hybrid nanogels, and core- shell. We focus on the analysis of the synthetic approaches that lead to the formation of each type of architecture. Furthermore, most recent advances in therapy and diagnosis applications and some inherent challenges of these materials are herein reviewed

Synthesis of Silver Nanostructures on Different Supports: From Nanoparticle Decoration to a Complete Shell Growth

Impact Factor (Clarivate): 2.6Fil: Macchione, Micaela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Macchione, Micaela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina.Fil: Macchione, Micaela A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.Fil: Moiraghi, Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Moiraghi, Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.Fil: Passarelli, Nicolas. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Passarelli, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.Fil: Coronado, Eduardo A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Coronado, Eduardo A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.Fil: Pérez, Manuel A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Pérez, Manuel A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.In this work, we investigate a complete strategy to obtain supported silver nanostructures (AgNSs) which can be used for different applications such as catalysis, optoelectronics, and biomedical devices. Given the poor wetting of silver on many support materials, the anchorage of silver nanoparticles (AgNPs) to the substrate (decoration) is achieved by employing an oxide precipitation-decomposition method. This protocol is optimized to obtain rapid and homogeneous decoration of AgNPs on different substrates such as silica, titania, and hydroxyapatite with a negligible production of free-standing silver nanoparticles. Going a step further, we have also studied the growth of AgNPs attached to silica spheres (SiO2NPs) using a seed-mediated growth strategy. The interplay of different processes like growth, corrosion, coalescence, and sintering determines the morphological features of the grown nanoparticles. Therefore, the substrate coverage and nanoparticle morphology can be qualitatively modified by varying the composition of the growth bath. The observed growth is consistent with a radial growth mechanism which, in most experimental conditions, allows for the production of anisotropic AgNSs onto silica surface. In addition, if the corrosion effects are minimized, the coalescence process of neighboring particles can lead to high surface coverages.info:eu-repo/semantics/publishedVersionFil: Macchione, Micaela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Macchione, Micaela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina.Fil: Macchione, Micaela A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.Fil: Moiraghi, Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Moiraghi, Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.Fil: Passarelli, Nicolas. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Passarelli, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.Fil: Coronado, Eduardo A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Coronado, Eduardo A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.Fil: Pérez, Manuel A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica, Argentina.Fil: Pérez, Manuel A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina

A large sample study of spin relaxation and magnetometric sensitivity of paraffin-coated Cs vapor cells

We have manufactured more than 250 nominally identical paraffin-coated Cs vapor cells (28mm inner diameter bulbs) for multi-channel atomic magnetometer applications. We describe our dedicated cell characterization apparatus. For each cell we have determined the intrinsic longitudinal, Γ 01, and transverse, Γ 02, relaxation rates. Our best cell shows Γ 01/2π≈0.5Hz, and Γ 02/2π≈2Hz. We find a strong correlation of both relaxation rates which we explain in terms of reservoir and spin exchange relaxation. For each cell we have determined the optimal combination of rf and laser powers which yield the highest sensitivity to magnetic field changes. Out of all produced cells, 90% are found to have magnetometric sensitivities in the range of 9to 30fT $\sqrt{\mathrm{Hz}}$ . Noise analysis shows that the magnetometers operated with such cells have a sensitivity close to the fundamental photon shot noise limi

Silver oxide particles/silver nanoparticles interconversion: Susceptibility of forward/backward reactions to the chemical environment at room temperature

The thermal stability of the silver oxide particles (Ag 2O)/ metallic silver nanoparticles (AgNPs) system in aqueous and gaseous environments is investigated with UV-Visible spectroscopy, TEM, SEM and DLS as characterisation techniques, and with calculations using electromagnetic theory. Thermal decomposition of aqueous Ag 2O colloids to produce AgNPs is conclusively demonstrated and used as a base reaction to produce clean AgNPs without any external reducing agent. Such a spontaneous character of Ag 2O decomposition in alkaline aqueous/water-enriched environments at room temperature makes the formation of silver oxide films on silver nanoparticles/nanostructures unlikely, keeping the silver surface oxide-free, a crucial feature in determining the silver catalytic and Raman enhancing properties. The synthetic suitability of this reaction to develop new routes to produce AgNPs is explored by analyzing the effect of temperature, complexing agents, and environment polarity on the AgNPs size/shape control. Thermal decomposition of Ag 2O colloids in aqueous/water-enriched environments offers the possibility to produce AgNPs at low cost, with easy, clean, safe and green chemistry procedures.Fil: Douglas Gallardo, Oscar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Moiraghi, Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Macchione, Micaela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Godoy, Jorge A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Perez, Manuel Alejo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Coronado, Eduardo A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Macagno, Vicente Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentin

Freezing-Tolerant Supramolecular Adhesives from Tannic Acid-Based Low-Transition-Temperature Mixtures

2 Year Impact Factor 2023: 9.6Fil: Mercadal, Pablo A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina.Fil: Mercadal, Pablo A. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias. Departamento de Recursos Naturales; Argentina.Fil: Mercadal, Pablo A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina.Fil: Montesinos, María del Mar. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.Fil: Montesinos, María del Mar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina.Fil: Macchione, Micaela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina.Fil: Macchione, Micaela A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina.Fil: Macchione, Micaela A. Universidad Nacional de Villa María. . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Villa María; Córdoba; Argentina.Fil: Dalosto, Sergio D. Universidad Nacional del Litoral. Instituto de Física del Litoral; Santa Fe; Argentina.Fil: Bierbrauer Karina L. Gobierno de la Provincia de Córdoba. Centro de Excelencia en Productos y Procesos de Córdoba, Pabellón CEPROCOR; Argentina.Fil: Bierbrauer Karina L. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Calderón, Marcelo. University of the Basque Country UPV/EHU. Faculty of Chemistry. POLYMAT, Applied Chemistry Department, San Sebastián; Spain.Fil: Calderón, Marcelo. IKERBASQUE, Basque Foundation for Science, Bilbao; Spain.Fil: González, Agustín. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina.Fil: González, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina.Fil: Picchio Matias L. University of the Basque Country UPV/EHU. Faculty of Chemistry. POLYMAT, Applied Chemistry Department, San Sebastián; Spain.Natural polyphenols like tannic acid (TA) have recently emerged as multifunctional building blocks for designing advanced materials. Herein, we show the benefits of having TA in a dynamic liquid state using low-transition-temperature mixtures (LTTMs) for developing freezing-tolerant glues. TA was combined with betaine or choline chloride to create LTTMs, which direct the self-assembly of guanosine into supramolecular viscoelastic materials with high adhesion. Molecular dynamics simulations showed that the structural properties of the material are linked to strong hydrogen bonding in TA–betaine and TA–choline chloride mixtures. Notably, long-term and repeatable adhesion was achieved even at −196 °C due to the binding ability of TA’s catechol and gallol units and the mixtures’ glass transition temperature. Additionally, the adhesives demonstrated injectability and low toxicity against fibroblasts in vitro. These traits reveal the potential of these systems as bioadhesives for tissue repair, opening new avenues for creating multifunctional soft materials with bioactive properties.info:eu-repo/semantics/publishedVersionFil: Mercadal, Pablo A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina.Fil: Mercadal, Pablo A. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias. Departamento de Recursos Naturales; Argentina.Fil: Mercadal, Pablo A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina.Fil: Montesinos, María del Mar. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.Fil: Montesinos, María del Mar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina.Fil: Macchione, Micaela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina.Fil: Macchione, Micaela A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina.Fil: Macchione, Micaela A. Universidad Nacional de Villa María. . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Villa María; Córdoba; Argentina.Fil: Dalosto, Sergio D. Universidad Nacional del Litoral. Instituto de Física del Litoral; Santa Fe; Argentina.Fil: Bierbrauer Karina L. Gobierno de la Provincia de Córdoba. Centro de Excelencia en Productos y Procesos de Córdoba, Pabellón CEPROCOR; Argentina.Fil: Bierbrauer Karina L. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Calderón, Marcelo. University of the Basque Country UPV/EHU. Faculty of Chemistry. POLYMAT, Applied Chemistry Department, San Sebastián; Spain.Fil: Calderón, Marcelo. IKERBASQUE, Basque Foundation for Science, Bilbao; Spain.Fil: González, Agustín. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina.Fil: González, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina.Fil: Picchio Matias L. University of the Basque Country UPV/EHU. Faculty of Chemistry. POLYMAT, Applied Chemistry Department, San Sebastián; Spain

A large sample study of spin relaxation and magnetometric sensitivity of paraffin-coated Cs vapor cells

We have manufactured more than 250 nominally identical paraffin-coated Cs vapor cells (30 mm diameter bulbs) for multi-channel atomic magnetometer applications. We describe our dedicated cell characterization apparatus. For each cell we have determined the intrinsic longitudinal, \sGamma{01}, and transverse, \sGamma{02}, relaxation rates. Our best cell shows \sGamma{01}/2\pi\approx 0.5 Hz, and \sGamma{02}/2\pi\approx 2 Hz. We find a strong correlation of both relaxation rates which we explain in terms of reservoir and spin exchange relaxation. For each cell we have determined the optimal combination of rf and laser powers which yield the highest sensitivity to magnetic field changes. Out of all produced cells, 90% are found to have magnetometric sensitivities in the range of 9 to 30 fTHz. Noise analysis shows that the magnetometers operated with such cells have a sensitivity close to the fundamental photon shot noise limit

Experimental Setups for Single Event Effect Studies

Experimental setups are being prepared to test and to qualify electronic devices regarding their tolerance to Single Event Effect (SEE). A multiple test setup and a new beam line developed especially for SEE studies at the São Paulo 8 UD Pelletron accelerator were prepared. This accelerator produces proton beams and heavy ion beams up to 107Ag. A Super conducting Linear accelerator, which is under construction, may fulfill all of the European Space Agency requirements to qualify electronic components for SEE

Micronucleus formation induced by biomass burning particles derived from biomass burning induce high micronucleus frequency in Tradescantia pallida assay (TRAD-MN)

Manual harvesting is usually done after to sugar cane burning which is responsible for seasonal emission of air pollutants in Brazil and it is believed to be responsible for deleterious health effects in exposed populations. The mutagenic potential of sugar cane burning harvesting particulate and particle surrogates of residual oil fly ash (ROFA) were evaluated in assays measuring micronuclei (MN) in the pollen mother cells of Tradescantia pallida (TRAD-MN). Micronuclei frequencies in TRAD-MN to sugar cane burning residues (SCBR) at doses 0.3 and 0.03 mg/mL were respectively 2.18 ± 0.35 and 5.53 ± 1.04, whereas to ROFA from incinerator and ROFA from an electrostatic precipitator installed in one of the chimneys of a steel plant, MN frequencies were, respectively, 3.43 ± 0.7 and 4.90 ± 1.07. Significant differences were detected among the groups (p < 0.001), demonstrating that SCBR was at least as genotoxic as the fossil fuel derived particles. The results suggest that the burning process to harvest sugar cane should be better controlled. Keywords: pollution, burning particles, micronuclei, Tradescantia pallida . Partículas derivadas da queima de biomassa induzem alta frequência de micronúcleos no ensaio de Tradescantia pallida (TRAD-MN) Resumo A coleta de cana-de-açúcar manual é geralmente realizada após a queima, a qual é responsável pela emissão sazonal de poluentes atmosféricos no Brasil e acredita-se que este seja responsável pelos efeitos deletérios a saúde da população exposta. O potencial mutagênico da queima de cana-de-açúcar e partículas oriundas de resíduos em cinza de óleo queimado (ROFA) foi avaliado em ensaio que mede a freqüência de micronúcleos (MN) em células mãe de grão de pólen de Tradescantia pallida (TRAD-MN). A freqüência de TRAD-MN em resíduos de queima de cana de açúcar (SCBR) nas doses de 0.3 e 0,03mg/mL foi, respectivamente de 2,18 ± 0,35 e 5,53 ± 1,04, enquanto para ROFA de incinerador e ROFA de um precipitador eletrostático instalado em uma chaminé de uma indústria siderúrgica, a freqüência de MN foi, respectivamente, 3,43 ± 0,7 e 4,90 ± 1,07. Diferença significante foi observada entre os grupos (p<0,001), demonstrando que SCBR foi ao menos tão genotóxico quanto às partículas derivadas de combustíveis fósseis. Os resultados sugerem que o processo de queima de cana-de-açúcar no período da safra deveria ser mais bem controlado. Palavras-Chave: poluição, partículas de queimadas, micronúcleos, Tradescantia pallida

ESG: disentangling the governance pillar

This article is a perspective paper that provides a critical assessment of ESG's governance pillar. Specifically, we reflect on the implications of considering "governance" from a broader perspective, which combines corporate governance and the analysis of the governance mechanisms used by firms in the search for greater sustainability. We argue that such an enlarged panorama generates new discussions for the transition to more sustainable production and consumption systems. We also raise the question about the potential limitations of looking exclusively at governance efficiency as the basis for an effective discussion on ESG

ESG: disentangling the governance pillar

This article is a perspective paper that provides a critical assessment of ESG's governance pillar. Specifically, we reflect on the implications of considering "governance" from a broader perspective, which combines corporate governance and the analysis of the governance mechanisms used by firms in the search for greater sustainability. We argue that such an enlarged panorama generates new discussions for the transition to more sustainable production and consumption systems. We also raise the question about the potential limitations of looking exclusively at governance efficiency as the basis for an effective discussion on ESG