The course of posterior antebrachial cutaneous nerve: Anatomical and sonographic study with a clinical implication

The course of the posterior antebrachial cutaneous nerve (PACN) was studied via ultrasound (US) and dissection. The aim of this study was to reveal the anatomical relationships of PACN with the surrounding structures along its pathway to identify possible critical points of compression. Nineteen cryopreserved cadaver body donor upper extremities were explored via US and further dissected. During US exploration, two reference points, in relation with the compression of the nerve, were marked using dye injection: (1) the point where the RN pierces the lateral intermuscular septum (LIMS) and (2) the point where the PACN pierces the deep fascia. Anatomical measurements referred to the lateral epicondyle (LE) were taken at these two points. Dissection confirmed the correct site of US-guided dye injection at 100% of points where the RN crossed the LIMS (10.5 cm from the LE) and was correctly injected at 74% of points where the PACN pierce the deep fascia (7.4 cm from the LE). There were variations in the course of the PACN, but it always divided from the RN as an only branch. Either ran close and parallel to the LIMS until the RN crossed the LIMS (84%) or clearly separated from the RN, 1 cm before it crossed the LIMS (16%). In 21% of cases, the PACN crossed the LIMS with the RN, while in the rest of the cases it always followed in the posterior compartment. A close relationship between PACN and LIMS, as well as triceps brachii muscle and deep fascia was observed. The US and anatomical study showed that the course of PACN maintains a close relationship with the LIMS and other connective tissues (such as the fascia and subcutaneous tissue) to be present in its pathology and treatment

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

Resultado clínico; Epitranscriptómica; GliomaClinical outcome; Epitranscriptomics; GliomaResultat clínic; Epitranscriptòmica; GliomaTumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of aberrant RNA modification landscapes in the so-called epitranscriptome. Here, we report that human glioma cells undergo DNA methylation-associated epigenetic silencing of NSUN5, a candidate RNA methyltransferase for 5-methylcytosine. In this setting, NSUN5 exhibits tumor-suppressor characteristics in vivo glioma models. We also found that NSUN5 loss generates an unmethylated status at the C3782 position of 28S rRNA that drives an overall depletion of protein synthesis, and leads to the emergence of an adaptive translational program for survival under conditions of cellular stress. Interestingly, NSUN5 epigenetic inactivation also renders these gliomas sensitive to bioactivatable substrates of the stress-related enzyme NQO1. Most importantly, NSUN5 epigenetic inactivation is a hallmark of glioma patients with long-term survival for this otherwise devastating disease.This work was supported by a European Research Council (ERC) Advanced Grant under the European Community’s Seventh Framework Program (FP7/2007-2013)/ERC Grant Agreement No. 268626—EPINORC project (to M. Esteller), the Ministerio de Economía y Competitividad (MINECO) under Grant No. SAF2014-55000-R (to M. Esteller) and the Instituto de Salud Carlos III (ISCIII), under the FIS PI16/01278 Project (to J. Seoane), the Integrated Project of Excellence no. PIE13/00022 (ONCOPROFILE) (to M. Esteller), CIBER 2016 CB16/12/00312 (CIBERONC) (to M. Esteller), co-financed by the European Development Regional Fund, ‘A way to achieve Europe’ ERDF, the AGAUR—Catalan Government (Project No. 2009SGR1315 and 2014SGR633) (to M. Esteller), the Cellex Foundation (to M. Esteller), Obra Social “La Caixa” (to M. Esteller), the CERCA Program and the Health and Science Departments of the Catalan Government (Generalitat de Catalunya) (to M. Esteller) and a grant from the National Health and Medical Research Council of Australia (APP1061551, to TP). M.W. Boudreau is a member of the NIH Chemistry-Biology Interface Training Program (T32-GM070421)

Elaboración de instrumento para diagnosticar las creencias y conocimientos de estudiantes de pedagogía básica sobre la matemática escolar, su aprendizaje y enseñanza

En el presente trabajo compartimos el desarrollo del Proyecto FONIDE FX11624, cuyo objetivo principal fue generar un instrumento válido capaz de identificar las creencias y conocimientos de estudiantes de Pedagogía básica sobre la matemática escolar, su enseñanza y aprendizaje al comienzo de su formación inicial. Por medio de una metodología mixta (entrevistas en profundidad para el apartado de creencias y validación de expertos para ítems de conocimiento), se logró construir la primera versión del instrumento, que fue aplicada a un total de 511 estudiantes de primer año de Pedagogía básica de un total de 14 universidades del país. Compartimos el proceso de elaboración del instrumento detallando el trabajo realizado para los ítems de creencias y de conocimiento y la composición final del instrumento como resultado de dicha validación

Spontaneous changes in brain striatal dopamine synthesis and storage dynamics ex vivo reveal end-product feedback-inhibition of tyrosine hydroxylase

Altres ajuts: acord transformatiu CRUE-CSICAltres ajuts: , The Michael J. Fox Foundation (ID15291), "la Caixa" Foundation (ID 100010434), under the agreement LCF/PR/HR17/52150003Synaptic events are important to define treatment strategies for brain disorders. In the present paper, freshly obtained rat brain striatal minces were incubated under different times and conditions to determine dopamine biosynthesis, storage, and tyrosine hydroxylase phosphorylation. Remarkably, we found that endogenous dopamine spontaneously accumulated during tissue incubation at 37 °C ex vivo while dopamine synthesis simultaneously decreased. We analyzed whether these changes in brain dopamine biosynthesis and storage were linked to dopamine feedback inhibition of its synthesis-limiting enzyme tyrosine hydroxylase. The aromatic-l-amino-acid decarboxylase inhibitor NSD-1015 prevented both effects. As expected, dopamine accumulation was increased with l-DOPA addition or VMAT2-overexpression, and dopamine synthesis decreased further with added dopamine, the VMAT2 inhibitor tetrabenazine or D2 auto-receptor activation with quinpirole, accordingly to the known synaptic effects of these treatments. Phosphorylation activation and inhibition of tyrosine hydroxylase on Ser31 and Ser40 with okadaic acid, Sp-cAMP and PD98059 also exerted the expected effects. However, no clear-cut association was found between dopamine feedback inhibition of its own biosynthesis and changes of tyrosine hydroxylase phosphorylation, assessed by Western blot and mass spectrometry. The later technique also revealed a new Thr30 phosphorylation in rat tyrosine hydroxylase. Our methodological assessment of brain dopamine synthesis and storage dynamics ex vivo could be applied to predict the in vivo effects of pharmacological interventions in animal models of dopamine-related disorders

Duration of Sleep, Perception of Hunger and Satiety and Weight Gain during Pregnancy

Objective: To determine whether the duration and interruption of sleep, perception of hunger-satiety influence the excessive weight gain in Mexican pregnant women. Materials and Methods: Cross-sectional design, with 305 pregnant women, recruited in a primary care clinic. The duration of sleep was evaluated by interview and a hunger and satiety perception scale was used. Weight was obtained before and during pregnancy. The linear regression model was used to analyze the data. Results: The average number of hours that pregnant women slept was 9.04 hours per night, 83% interrupted sleep and 16.7% gained excessive gestational weight. The pre-gestational body mass index and sleep interruption explained the gestational weight gain. Conclusion: Intervening in factors that influence the interruption of sleep in pregnant women can contribute to prevent excessive weight gain and prevent maternal and child complications

Generalized Regression Neural Networks with Application in Neutron Spectrometry

The aim of this research was to apply a generalized regression neural network (GRNN) to predict neutron spectrum using the rates count coming from a Bonner spheres system as the only piece of information. In the training and testing stages, a data set of 251 different types of neutron spectra, taken from the International Atomic Energy Agency compilation, were used. Fifty-one predicted spectra were analyzed at testing stage. Training and testing of GRNN were carried out in the MATLAB environment by means of a scientific and technological tool designed based on GRNN technology, which is capable of solving the neutron spectrometry problem with high performance and generalization capability. This computational tool automates the pre-processing of information, the training and testing stages, the statistical analysis, and the post-processing of the information. In this work, the performance of feed-forward backpropagation neural networks (FFBPNN) and GRNN was compared in the solution of the neutron spectrometry problem. From the results obtained, it can be observed that despite very similar results, GRNN performs better than FFBPNN because the former could be used as an alternative procedure in neutron spectrum unfolding methodologies with high performance and accuracy

Interactive translation prediction versus conventional post-editing in practice: a study with the CasMaCat workbench

[EN] We conducted a field trial in computer-assisted professional translation to compare interactive translation prediction (ITP) against conventional post-editing (PE) of machine translation (MT) output. In contrast to the conventional PE set-up, where an MT system first produces a static translation hypothesis that is then edited by a professional (hence "post-editing"), ITP constantly updates the translation hypothesis in real time in response to user edits. Our study involved nine professional translators and four reviewers working with the web-based CasMaCat workbench. Various new interactive features aiming to assist the post-editor/translator were also tested in this trial. Our results show that even with little training, ITP can be as productive as conventional PE in terms of the total time required to produce the final translation. Moreover, translation editors working with ITP require fewer key strokes to arrive at the final version of their translation.This work was supported by the European Union’s 7th Framework Programme (FP7/2007–2013) under grant agreement No 287576 (CasMaCat ).Sanchis Trilles, G.; Alabau, V.; Buck, C.; Carl, M.; Casacuberta Nolla, F.; Garcia Martinez, MM.; Germann, U.... (2014). Interactive translation prediction versus conventional post-editing in practice: a study with the CasMaCat workbench. Machine Translation. 28(3-4):217-235. https://doi.org/10.1007/s10590-014-9157-9S217235283-4Alabau V, Leiva LA, Ortiz-Martínez D, Casacuberta F (2012) User evaluation of interactive machine translation systems. In: Proceedings of the 16th Annual Conference of the European Association for Machine Translation, pp 20–23Alabau V, Buck C, Carl M, Casacuberta F, García-Martínez M, Germann U, González-Rubio J, Hill R, Koehn P, Leiva L, Mesa-Lao B, Ortiz-Martínez D, Saint-Amand H, Sanchis-Trilles G, Tsoukala C (2014) Casmacat: A computer-assisted translation workbench. In: Proceedings of the 14th Conference of the European Chapter of the Association for Computational Linguistics, pp 25–28Alves F, Vale D (2009) Probing the unit of translation in time: aspects of the design and development of a web application for storing, annotating, and querying translation process data. Across Lang Cultures 10(2):251–273Bach N, Huang F, Al-Onaizan Y (2011) Goodness: A method for measuring machine translation confidence. In: Proceedings of the Annual Meeting of the Association for Computational Linguistics, pp 211–219Barrachina S, Bender O, Casacuberta F, Civera J, Cubel E, Khadivi S, Lagarda AL, Ney H, Tomás J, Vidal E, Vilar JM (2009) Statistical approaches to computer-assisted translation. Comput Linguist 35(1):3–28Brown PF, Della Pietra SA, Della Pietra VJ (1993) The mathematics of statistical machine translation: parameter estimation. Comput Linguist 19(2):263–311Callison-Burch C, Koehn P, Monz C, Post M, Soricut R, Specia L (2012) Findings of the 2012 workshop on statistical machine translation. In: Proceedings of the Seventh Workshop on Statistical Machine Translation, pp 10–51Carl M (2012a) The CRITT TPR-DB 1.0: A database for empirical human translation process research. In: Proceedings of the AMTA 2012 Workshop on Post-Editing Technology and Practice, pp 1–10Carl M (2012b) Translog-II: a program for recording user activity data for empirical reading and writing research. In: Proceedings of the Eighth International Conference on Language Resources and Evaluation, pp 4108–4112Carl M (2014) Produkt- und Prozesseinheiten in der CRITT Translation Process Research Database. In: Ahrens B (ed) Translationswissenschaftliches Kolloquium III: Beiträge zur Übersetzungs- und Dolmetschwissenschaft (Köln/Germersheim). Peter Lang, Frankfurt am Main, pp 247–266Carl M, Kay M (2011) Gazing and typing activities during translation : a comparative study of translation units of professional and student translators. Meta 56(4):952–975Doherty S, O’Brien S, Carl M (2010) Eye tracking as an MT evaluation technique. Mach Transl 24(1):1–13Elming J, Carl M, Balling LW (2014) Investigating user behaviour in post-editing and translation using the Casmacat workbench. In: O’Brien S, Winther Balling L, Carl M, Simard M, Specia L (eds) Post-editing of machine translation: processes and applications. Cambridge Scholar Publishing, Newcastle upon Tyne, pp 147–169Federico M, Cattelan A, Trombetti M (2012) Measuring user productivity in machine translation enhanced computer assisted translation. In: Proceedings of the Tenth Biennial Conference of the Association for Machine Translation in the AmericasFlournoy R, Duran C (2009) Machine translation and document localization at adobe: From pilot to production. In: Proceedings of MT Summit XIIGreen S, Heer J, Manning CD (2013) The efficacy of human post-editing for language translation. In: Proceedings of SIGCHI Conference on Human Factors in Computing Systems, pp 439–448Guerberof A (2009) Productivity and quality in mt post-editing. In: Proceedings of MT Summit XII-Workshop: Beyond Translation Memories: New Tools for Translators MTGuerberof A (2012) Productivity and quality in the post-editing of outputs from translation memories and machine translation. 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Kineticomechanistic study of the redox pH cycling processes occurring on a robust water-soluble cyanido-bridged mixed-valence {CoIII/FeII}2 square

A kineticomechanistic study of reversible electron-transfer processes undergone by the water-soluble, cyanido-bridged mixed-valence [{CoIII{(Me)2(μ-ET)cyclen}}2{(μ-NC)2FeII(CN)4}2]2- square has been carried out. The oxidation reaction consists of a two-step process with the participation of a solvent-assisted outer-sphere complex, as a result of the establishment of hydrogen bonds that involve the oxo groups of the oxidant (peroxodisulfate) and the terminal cyanido ligands of the tetrametallic square. The formally endergonic reduction reaction of the fully oxidized ([{CoIII{(Me)2(μ-ET)cyclen}}2{(μ-NC)2FeIII(CN)4}2]) core by water, producing hydrogen peroxide from water even at low pH values, is also a two-step process. Each one of these processes requires a set of two preequilibria involving the association of OH- and its subsequent deprotonation by a further OH- anion. The structure of the square compound in its fully protonated form has also been determined by X-ray diffraction and shows the existence of strong hydrogen-bonding interactions, in agreement with the rather high basicity of the terminal cyanido ligands. Likewise, density functional theory calculations on the tetrametallic complex showed zones with negative electrostatic potential around the FeII centers of the square that would account for the establishment of the hydrogen bonds found in the solid state. Spectroelectrochemistry experiments demonstrated the singular stability of the {CoIII/FeII}2 2- complex, as well as that of their partially, {Co2 III/FeIIIFeII}-, and fully, {CoIII/FeIII}2, oxidized counterparts because no hysteresis was observed in these measurements.