Assessment of the performance of alternative aviation fuel in a modern air-spray combustor (MAC)

Recent concerns over energy security and environmental considerations have highlighted the importance of finding alternative aviation fuels. It is expected that coal and biomass derived fuels will fulfil a substantial part of these energy requirements. However, because of the physical and chemical difference in the composition of these fuels, there are potential problems associated with the efficiency and the emissions of the combustion process. Over the past 25 years Computational Fluid Dynamics (CFD) has become increasingly popular with the gas turbine industry as a design tool for establishing and optimising key parameters of systems prior to starting expensive trials. In this paper the performance of a typical aviation fuel, kerosene, an alternative aviation fuel, biofuel and a blend have been examined using CFD modelling. A good knowledge of the kinetics of the reaction of bio aviation fuels at both high and low temperature is necessary to perform reliable simulations of ignition, combustion and emissions in aero-engine. A novel detailed reaction mechanism was used to represent aviation fuel oxidation mechanism. The fuel combustion is calculated using a 3D commercial solver using a mixture fraction/pdf approach. Firstly, the study demonstrates that CFD predictions compare favourably with experimental data obtained by QinetiQ for a Modern Airspray Combustor (MAC) when used with traditional jet fuel (kerosene). Furthermore, the 3D CFD model has been refined to use the laminar flamelet model (LFM) approach that incorporates recently developed chemical reaction mechanisms for the bio-aviation fuel. This has enabled predictions for the bio-aviation fuel to be made. The impact of using the blended fuel has been shown to be very similar in performance to that of the 100% kerosene, confirming that aircraft running on 20% blended fuel should have no significant reduction in performance. It was also found that for the given operating conditions there is a significant reduction in performance when 100% biofuel if used. Additionally, interesting predictions were obtained, related to NOx emissions for the blend and 100% biofuel

IMECE2008-68772 ASSESMENT OF THE PERFORMANCE OF ALTERNATIVE AVIATION FUEL IN A MODERN AIR-SPRAY COMBUSTOR (MAC)

ABSTRACT Recent concerns over energy security and environmental considerations have highlighted the importance of finding alternative aviation fuels. It is expected that coal and biomass derived fuels will fulfil a substantial part of these energy requirements. However, because of the physical and chemical difference in the composition of these fuels, there are potential problems associated with the efficiency and the emissions of the combustion process. Over the past 25 years Computational Fluid Dynamics (CFD) has become increasingly popular with the gas turbine industry as a design tool for establishing and optimising key parameters of systems prior to starting expensive trials. In this paper the performance of a typical aviation fuel, kerosene, an alternative aviation fuel, biofuel and a blend have been examined using CFD modelling. A comprehensive understanding of the kinetics of the reaction for bio aviation fuels at both high and low temperature is necessary to perform reliable simulations of ignition, combustion and emissions in an aero-engine. A novel detailed reaction mechanism was used to represent the aviation fuel oxidation mechanism. The fuel combustion is calculated using a 3D commercial solver using a mixture fraction/pdf approach. Firstly, the study demonstrates that CFD predictions compare favourably with experimental data obtained by (MAC) when used with traditional jet fuel (kerosene). Furthermore, the 3D CFD model has been refined to use the laminar flamelet model (LFM) approach that incorporates recently developed chemical reaction mechanisms for the bioaviation fuel. This has enabled predictions for the bio-aviation fuel to be made. The impact of using the blended fuel has been shown to be very similar in performance to that of the 100% kerosene, confirming that aircraft running on 20% blended fuel should have no significant reduction in performance. It was also found that for the given operating conditions there is a significant reduction in performance when 100% biofuel is used. Additionally, interesting predictions were obtained, related to NO x emissions for the blend and 100% biofuel

Interactions in vivo between the Vif protein of HIV-1 and the precursor (Pr55GAG) of the virion nucleocapsid proteins

The abnormality of viral core structure seen in vif-defective HIV-1 grown in PBMCs has suggested a role for Vif in viral morphogenesis. Using an in vivo mammalian two-hybrid assay, the interaction between Vif and the precursor (Pr55GAG) of the virion nucleocapsid proteins has been analysed. This revealed the amino-terminal (aa 1–22) and central (aa 70–100) regions of Vif to be essential for its interaction with Pr55GAG, but deletion of the carboxy-terminal (aa 158–192) region of the protein had only a minor effect on its interaction. Initial deletion studies carried out on Pr55GAG showed that a 35-amino-acid region of the protein bridging the MA(p17)–CA(p24) junction was essential for its ability to interact with Vif. Site-directed mutagenesis of a conserved tryptophan (Trp21) near the amino terminus of Vif showed it to be important for the interaction with Pr55GAG. By contrast, mutagenesis of the highly conserved YLAL residues forming part of the BC-box motif, shown to be important in Vif promoting degradation of APOBEC3G/3F, had little or no effect on the Vif–Pr55GAG interaction

Evaluation of physicians' professional performance: An iterative development and validation study of multisource feedback instruments

Contains fulltext : 107798.pdf (publisher's version ) (Open Access)BACKGROUND: There is a global need to assess physicians' professional performance in actual clinical practice. Valid and reliable instruments are necessary to support these efforts. This study focuses on the reliability and validity, the influences of some sociodemographic biasing factors, associations between self and other evaluations, and the number of evaluations needed for reliable assessment of a physician based on the three instruments used for the multisource assessment of physicians' professional performance in the Netherlands. METHODS: This observational validation study of three instruments underlying multisource feedback (MSF) was set in 26 non-academic hospitals in the Netherlands. In total, 146 hospital-based physicians took part in the study. Each physician's professional performance was assessed by peers (physician colleagues), co-workers (including nurses, secretary assistants and other healthcare professionals) and patients. Physicians also completed a self-evaluation. Ratings of 864 peers, 894 co-workers and 1960 patients on MSF were available. We used principal components analysis and methods of classical test theory to evaluate the factor structure, reliability and validity of instruments. We used Pearson's correlation coefficient and linear mixed models to address other objectives. RESULTS: The peer, co-worker and patient instruments respectively had six factors, three factors and one factor with high internal consistencies (Cronbach's alpha 0.95 - 0.96). It appeared that only 2 percent of variance in the mean ratings could be attributed to biasing factors. Self-ratings were not correlated with peer, co-worker or patient ratings. However, ratings of peers, co-workers and patients were correlated. Five peer evaluations, five co-worker evaluations and 11 patient evaluations are required to achieve reliable results (reliability coefficient >/= 0.70). CONCLUSIONS: The study demonstrated that the three MSF instruments produced reliable and valid data for evaluating physicians' professional performance in the Netherlands. Scores from peers, co-workers and patients were not correlated with self-evaluations. Future research should examine improvement of performance when using MSF

Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2

C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of TH1 and TH-17 cellular responses. Fungal recognition by dectin-1 on human dendritic cells engages the CARD9-Bcl10-Malt1 module to activate NF-κB. Here we demonstrate that Malt1 recruitment is pivotal to TH-17 immunity by selective activation of NF-κB subunit c-Rel, which induces expression of TH-17-polarizing cytokines IL-1β and IL-23p19. Malt1 inhibition abrogates c-Rel activation and TH-17 immunity to Candida species. We found that Malt1-mediated activation of c-Rel is similarly essential to induction of TH-17-polarizing cytokines by dectin-2. Whereas dectin-1 activates all NF-κB subunits, dectin-2 selectively activates c-Rel, signifying a specialized TH-17-enhancing function for dectin-2 in anti-fungal immunity by human dendritic cells. Thus, dectin-1 and dectin-2 control adaptive TH-17 immunity to fungi via Malt1-dependent activation of c-Rel

Periconceptional bread intakes indicate New Zealand's proposed mandatory folic acid fortification program may be outdated: results from a postpartum survey

Abstract Background In September 2009, a folic acid fortification mandate (135 μg/100 g bread) was to be implemented in New Zealand. However, due to political and manufacturer objection, fortification was deferred until May 2012. Based on estimates of bread consumption derived from a 1997 nationally representative survey, this program was intended to deliver a mean additional intake of 140 μg folic acid/d to women of childbearing age. Little is known about current bread consumption patterns in this target group. The aim of this study was to assess bread consumption among women prior to and during pregnancy with the intent to estimate periconceptional folic acid intakes that would be derived from bread if mandatory fortification were implemented as currently proposed. Methods A retrospective survey of 723 postpartum women in hospitals and birthing centres across New Zealand was conducted using a self-administered questionnaire on bread intake prior to and during pregnancy and maternal socio-demographic and obstetric characteristics. Results Median bread intake before conception (2 slices/d) was below that of previous data upon which the current fortification proposal was modeled (3-4 slices/d). If mandatory fortification is implemented as proposed, only 31% (95% CI = 24%-37%) of childbearing-age women would attain an additional folic acid intake of ≥ 140 μg/d, with a mean of 119 μg/d (95% CI = 107 μg/d-130 μg/d). Based on these data, a fortification level of 160 μg/100 g bread is required to achieve the targeted mean of 140 μg folic acid/d. Nonetheless, under the current proposal additional folic acid intakes would be greatest among the least advantaged segments of the target population: Pacific and indigenous Māori ethnic groups; those with increased parity, lower income and education; younger and single mothers; and women with unplanned pregnancies. Subgroups predicted to derive less than adequate folic acid intakes from the proposed policy were women of Asian descent and those with a postgraduate education. Conclusions This study provides insight on the ability of a fortification policy to benefit the groups at highest risk of poor folate intakes in a population. However, bread consumption among the target group of childbearing women appears to have declined since the data used in previous dietary modeling were collected. Thus, it seems prudent to re-model dietary folic acid intakes based on more recent national survey data prior to the implementation of a mandatory folic acid fortification policy.</p