49 research outputs found

    Physics Opportunities with the 12 GeV Upgrade at Jefferson Lab

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    This white paper summarizes the scientific opportunities for utilization of the upgraded 12 GeV Continuous Electron Beam Accelerator Facility (CEBAF) and associated experimental equipment at Jefferson Lab. It is based on the 52 proposals recommended for approval by the Jefferson Lab Program Advisory Committee.The upgraded facility will enable a new experimental program with substantial discovery potential to address important topics in nuclear, hadronic, and electroweak physics.Comment: 64 page

    Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

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    Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes

    Pion and Kaon multiplicities in heavy quark jets from e+e− annihilation at 29 GeV

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    Polymorphism: an evaluation of the potential risk to the quality of drug products from the FarmĂĄcia Popular Rede PrĂłpria

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    Morphology of the turkey vagina with and without an egg mass in the uterus

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    In this study we examined the gross anatomy of the uterus and vagina in turkeys in egg production. With no uterine egg mass, removal of the tunica serosa that enclosed the uterus revealed deep periodic in-folding of the muscularis transversely circumscribing the sac-like segment. When the connective tissue embracing the neutral buffered formalin fixed vagina was completely teased free, the exposed tubular segment was shaped as a counter-clockwise spiral or as a series of angular, random bends. The uterovaginal junction was flush with the uterine mucosa or projected slightly into the uterine lumen. With a uterine egg mass, the deep in-foldings of the uterus were abolished. The only alteration to the morphology of the vagina was that the uterovaginal junction appeared dilated and pressed into its juncture with the uterus. Whether an egg mass was present or not, uterovaginal junction folds that projected into the uterus possessed sperm storage tubules. An egg mass in the uterus compressed the uterovaginal junction folds, and its mucosa became contiguous with the uterine mucosa. Finally, from an evolutionary perspective, in the turkey and possibly other species possessing a nonintromittent phallus, vaginal pleomorphism may have been driven primarily by the need to accommodate the overall length of the vagina in a limited abdominal space and to a lesser extent on sexual selection

    Palladium-Carbon σ-Bonded Complexes

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