2,968 research outputs found
A derivative formula for the free energy function
We consider bond percolation on the lattice. Let be the
number of open clusters in . It is well known that converges to the free energy function at the zero field.
In this paper, we show that converges to
.Comment: 8 pages 1 figur
Processing, microstructure and mechanical properties of bimodal size SiCp reinforced AZ31B magnesium matrix composites
AbstractThe bimodal size SiC particulates (SiCp) reinforced magnesium matrix composites with different ratios of micron SiCp and nano SiCp (M-SiCp:N-SiCp = 14.5:0.5, 14:1, and 13.5:1.5) were prepared by semisolid stirring assisted ultrasonic vibration method. The AZ31B alloy and all as-cast SiCp/AZ31B composites were extruded at 350 °C with the ratio of 12:1. Microstructural characterization of the extruded M14 + N1 (M-SiCp:N-SiCp = 14:1) composite revealed the uniform distribution of bimodal size SiCp and significant grain refinement. Optical Microscopy(OM) observation showed that, compared with the M14.5 + N0.5 (M-SiCp:N-SiCp = 14.5:0.5) composite, there are more recrystallized grains in M14 + N1 (M-SiCp:N-SiCp = 14:1) and M13.5 + N1.5 (M-SiCp:N-SiCp = 13.5:1.5) composites, but in comparison to the M13.5 + N1.5 composite, the average grain size of the M14 + N1 composite is slightly decreased. The evaluation of mechanical properties indicated that the yield strength and ultimate tensile strength of the M14 + N1 composite were obviously increased compared with other composites
Evaluating the use of covariance-based structural equation modelling with reflective measurement in organizational and management research : a review and recommendations for best practice
Covariance‐based structural equation modelling (CB‐SEM) with reflective measurement has been a popular data analysis tool in organizational and management research. Extensive studies and guidelines have been published on what constitutes its best practice. What is much less known is the extent to which CB‐SEM users in organizational and management research comprehend and adhere to the standards and principles behind this advanced analytical technique. In this study, we first devised an evaluation scheme to assess the quality of CB‐SEM performed in a study, and then utilized this scheme to examine 144 CB‐SEM studies published in 12 top organizational and management journals between 2011 and 2016. The evaluation of the published studies revealed a pressing need for more systematic and standardized approaches to planning, conducting and reporting CB‐SEM studies. We discussed the implication of the findings for future work
Dual-acting stapled peptides target both HIV-1 entry and assembly
Background:
Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD) of the HIV-1 capsid (CA) protein with an improved affinity (Kd ~ 1 μM) compared to CAI (Kd ~ 15 μM). NYAD-1 disrupts the formation of both immature- and mature-like virus particles in in vitro and cell-based assembly assays. In addition, it displays potent anti-HIV-1 activity in cell culture against a range of laboratory-adapted and primary HIV-1 isolates.<p></p>
Results:
In this report, we expanded the study to i,i + 7 hydrocarbon-stapled peptides to delineate their mechanism of action and antiviral activity. We identified three potent inhibitors, NYAD-36, -66 and -67, which showed strong binding to CA in NMR and isothermal titration calorimetry (ITC) studies and disrupted the formation of mature-like particles. They showed typical α-helical structures and penetrated cells; however, the cell penetration was not as efficient as observed with the i,i + 4 peptides. Unlike NYAD-1, the i,i + 7 peptides did not have any effect on virus release; however, they impaired Gag precursor processing. HIV-1 particles produced in the presence of these peptides displayed impaired infectivity. Consistent with an effect on virus entry, selection for viral resistance led to the emergence of two mutations in the gp120 subunit of the viral envelope (Env) glycoprotein, V120Q and A327P, located in the conserved region 1 (C1) and the base of the V3 loop, respectively.<p></p>
Conclusion:
The i,i + 7 stapled peptides derived from CAI unexpectedly target both CA and the V3 loop of gp120. This dual-targeted activity is dependent on their ability to penetrate cells as well as their net charge. This mechanistic revelation will be useful in further modifying these peptides as potent anti-HIV-1 agents.<p></p>
Modular Invariance and Characteristic Numbers
We show that a general miraculous cancellation formula, the divisibility of
certain characteristic numbers and some other topologiclal results are con-
sequences of the modular invariance of elliptic operators on loop spaces.
Previously we have shown that modular invariance also implies the rigidity of
many elliptic operators on loop spaces.Comment: 14 page
Contact resistance in graphene-based devices
We report a systematic study of the contact resistance present at the
interface between a metal (Ti) and graphene layers of different, known
thickness. By comparing devices fabricated on 11 graphene flakes we demonstrate
that the contact resistance is quantitatively the same for single-, bi-, and
tri-layer graphene (), and is in all cases
independent of gate voltage and temperature. We argue that the observed
behavior is due to charge transfer from the metal, causing the Fermi level in
the graphene region under the contacts to shift far away from the charge
neutrality point
Some Relations between Twisted K-theory and E8 Gauge Theory
Recently, Diaconescu, Moore and Witten provided a nontrivial link between
K-theory and M-theory, by deriving the partition function of the Ramond-Ramond
fields of Type IIA string theory from an E8 gauge theory in eleven dimensions.
We give some relations between twisted K-theory and M-theory by adapting the
method of Diaconescu-Moore-Witten and Moore-Saulina. In particular, we
construct the twisted K-theory torus which defines the partition function, and
also discuss the problem from the E8 loop group picture, in which the
Dixmier-Douady class is the Neveu-Schwarz field. In the process of doing this,
we encounter some mathematics that is new to the physics literature. In
particular, the eta differential form, which is the generalization of the eta
invariant, arises naturally in this context. We conclude with several open
problems in mathematics and string theory.Comment: 23 pages, latex2e, corrected minor errors and typos in published
versio
Thermal stability of sputter-deposited 330 austenitic stainless-steel thin films with nanoscale growth twins
We have explored the thermal stability of nanoscale growth twins in sputter-deposited 330 stainless-steel (SS) films by vacuum annealing up to 500 °C. In spite of an average twin spacing of only 4 nm in the as-deposited films, no detectable variation in the twin spacing or orientation of twin interfaces was observed after annealing. An increase in the average columnar grain size was observed after annealing. The hardness of 330 SS films increases after annealing, from 7 GPa for as-deposited films to around 8 GPa for annealed films, while the electrical resistivity decreases slightly after annealing. The changes in mechanical and electrical properties after annealing are interpreted in terms of the corresponding changes in the residual stress and microstructure of the films
Anisotropic Superparamagnetism of Monodispersive Cobalt-Platinum Nanocrystals
Based on the high-temperature organometallic route (Sun et al. Science 287,
1989 (2000)), we have synthesized powders containing CoPt_3 single crystals
with mean diameters of 3.3(2) nm and 6.0(2) nm and small log-normal widths
sigma=0.15(1). In the entire temperature range from 5 K to 400 K, the
zero-field cooled susceptibility chi(T) displays significant deviations from
ideal superparamagnetism. Approaching the Curie temperature of 450(10) K, the
deviations arise from the (mean-field) type reduction of the ferromagnetic
moments, while below the blocking temperature T_b, chi(T) is suppressed by the
presence of energy barriers, the distributions of which scale with the particle
volumes obtained from transmission electron microscopy (TEM). This indication
for volume anisotropy is supported by scaling analyses of the shape of the
magnetic absorption chi''(T,omega) which reveal distribution functions for the
barriers being also consistent with the volume distributions observed by TEM.
Above 200 K, the magnetization isotherms M(H,T) display Langevin behavior
providing 2.5(1) mu_B per CoPt_3 in agreement with reports on bulk and thin
film CoPt_3. The non-Langevin shape of the magnetization curves at lower
temperatures is for the first time interpreted as anisotropic
superparamagnetism by taking into account an anisotropy energy of the
nanoparticles E_A(T). Using the magnitude and temperature variation of E_A(T),
the mean energy barriers and 'unphysical' small switching times of the
particles obtained from the analyses of chi''(T,omega) are explained. Below T_b
hysteresis loops appear and are quantitatively described by a blocking model,
which also ignores particle interactions, but takes the size distributions from
TEM and the conventional field dependence of E_A into account.Comment: 12 pages with 10 figures and 1 table. Version accepted for
publication in Phys. Rev. B . Two-column layou
Invasive Rosa rugosa populations outperform native populations, but some populations have greater invasive potential than others
Increased performance of invasive plant species in their introduced range vs. their native range has been previously documented. However, performance differences among invasive populations have rarely been explored, despite this information being central to understanding the evolution of invasiveness as well as being a useful basis to inform management of invasive species. To examine variation in performance among populations of Rosa rugosa in its introduced range, and whether introduced populations perform better than native populations, we quantified growth and reproductive traits in five invasive populations in northwest Europe and two native and declining populations in China. Overall, we found that the introduced R. rugosa populations we sampled performed significantly better than the sampled native populations for growth and reproductive traits (2 to 4 fold increase). However, there was significant variation for most traits among the five invasive populations, demonstrating that some introduced populations we sampled were more successful invaders than others. Our findings provide a useful foundation for management of invasive R. rugosa in Europe, and support the recent call for more intra-species research in invasive species biology.Shuping Zhang, Maike Isermann, Wenhao Gan, Martin Bree
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