917 research outputs found
A systematic review of physical activity promotion strategies
This article was first published in:British Journal of Sports Medicine:1996:30:84-89We have reviewed randomised controlled trials of physical activity promotion to provide recent and reliable information on the effectiveness of physical activity promotion. Computerised databases and references of references were searched. Experts were contacted and asked for information about existing work. Studies assessed were randomised controlled trials of healthy, free living, adult subjects, where exercise behaviour was the dependent variable. Eleven trials were identified. No United Kingdom based studies were found. Interventions that encourage walking and do not require attendance at a facility are most likely to lead to sustainable increases in overall physical activity. Brisk walking has the greatest potential for increasing overall activity levels of a sedentary population and meeting current public health recommendations. The small number of trials limits the strength of any conclusions and highlights the need for more research
Morse theory of the moment map for representations of quivers
The results of this paper concern the Morse theory of the norm-square of the
moment map on the space of representations of a quiver. We show that the
gradient flow of this function converges, and that the Morse stratification
induced by the gradient flow co-incides with the Harder-Narasimhan
stratification from algebraic geometry. Moreover, the limit of the gradient
flow is isomorphic to the graded object of the
Harder-Narasimhan-Jordan-H\"older filtration associated to the initial
conditions for the flow. With a view towards applications to Nakajima quiver
varieties we construct explicit local co-ordinates around the Morse strata and
(under a technical hypothesis on the stability parameter) describe the negative
normal space to the critical sets. Finally, we observe that the usual Kirwan
surjectivity theorems in rational cohomology and integral K-theory carry over
to this non-compact setting, and that these theorems generalize to certain
equivariant contexts.Comment: 48 pages, small revisions from previous version based on referee's
comments. To appear in Geometriae Dedicat
Is there an association between airborne and surface microbes in the critical care environment?
BackgroundThere are few data and no accepted standards for air quality in the intensive care unit (ICU). Any relationship between airborne pathogens and hospital-acquired infection (HAI) risk in the ICU remains unknown.AimFirst, to correlate environmental contamination of air and surfaces in the ICU; second, to examine any association between environmental contamination and ICU-acquired staphylococcal infection.MethodsPatients, air, and surfaces were screened on 10 sampling days in a mechanically ventilated 10-bed ICU for a 10-month period. Near-patient hand-touch sites (N = 500) and air (N = 80) were screened for total colony count and Staphylococcus aureus. Air counts were compared with surface counts according to proposed standards for air and surface bioburden. Patients were monitored for ICU-acquired staphylococcal infection throughout.FindingsOverall, 235 of 500 (47%) surfaces failed the standard for aerobic counts (≤2.5 cfu/cm2). Half of passive air samples (20/40: 50%) failed the ‘index of microbial air’ contamination (2 cfu/9 cm plate/h), and 15/40 (37.5%) active air samples failed the clean air standard
CCD BV and 2MASS photometric study of the open cluster NGC 1513
We present CCD BV and JHK 2MASS photometric data for the open cluster
NGC 1513. We observed 609 stars in the direction of the cluster up to a
limiting magnitude of mag. The star count method shows that the
centre of the cluster lies at ,
and its angular size is arcmin.
The optical and near-infrared two-colour diagrams reveal the colour excesses in
the direction of the cluster as , and
mag. These results are consistent with normal
interstellar extinction values. Optical and near-infrared Zero Age
Main-Sequences (ZAMS) provided an average distance modulus of
mag, which can be translated into a distance of
pc. Finally, using Padova isochrones we determined the metallicity
and age of the cluster as ( dex) and
, respectively.Comment: 15 pages, 12 figures and 4 tables, accepted for publication in
Astrophysics & Space Scienc
The structure and dynamics of young star clusters: King 16, NGC 1931, NGC 637 and NGC 189
In this paper, using 2MASS photometry, we study the structural and dynamical
properties of four young star clusters viz. King 16, NGC 1931, NGC 637 and NGC
189. For the clusters King 16, NGC 1931, NGC 637 and NGC 189, we obtain the
limiting radii of 7', 12', 6' and 5' which correspond to linear radii of 3.6
pc, 8.85 pc, 3.96 pc and 2.8 pc respectively. The reddening values
obtained for the clusters are 0.85, 0.65--0.85, 0.6 and 0.53 and their true
distances are 1786 pc, 3062 pc, 2270 pc and 912 pc respectively. Ages of the
clusters are 6 Myr, 4 Myr, 4 Myr and 10 Myr respectively. We compare their
structures, luminosity functions and mass functions () to the parameter to study the star
formation process and the dynamical evolution of these clusters. We find that,
for our sample, mass seggregation is observed in clusters or their cores only
when the ages of the clusters are comparable to their relaxation times (). These results suggest mass seggregation due to dynamical effects. The
values of , which characterise the overall mass functions for the
clusters are 0.96 0.11, 1.16 0.18, 0.55 0.14 and 0.66
0.31 respectively. The change in as a function of radius is a good
indicator of the dynamical state of clusters.Comment: Accepted for publication in Astrophysics & Space Scienc
Efficacy of novel recombinant fowlpox vaccine against recent Mexican H7N3 highly pathogenic avian influenza virus
Since 2012, H7N3 highly pathogenic avian influenza (HPAI) has produced negative economic and animal welfare impacts on poultry in central Mexico. In the present study, chickens were vaccinated with two different recombinant fowlpox virus vaccines (rFPV-H7/3002 with 2015 H7 hemagglutinin [HA] gene insert, and rFPV-H7/2155 with 2002 H7 HA gene insert), and were then challenged three weeks later with H7N3 HPAI virus (A/chicken/Jalisco/CPA-37905/2015). The rFPV-H7/3002 vaccine conferred 100% protection against mortality and morbidity, and significantly reduced virus shed titers from the respiratory and gastrointestinal tracts. In contrast, 100% of sham and rFPV-H7/2155 vaccinated birds shed virus at higher titers and died within 4 days. Pre- (15/20) and post- (20/20) challenge serum of birds vaccinated with rFPV-H7/3002 had antibodies detectable by hemagglutination inhibition (HI) assay using challenge virus antigen. However, only a few birds (3/20) in the rFPV-H7/2155 vaccinated group had antibodies that reacted against the challenge strain but all birds had antibodies that reacted against the homologous vaccine antigen (A/turkey/Virginia/SEP-66/2002) (20/20). One possible explanation for differences in vaccines efficacy is the antigenic drift between circulating viruses and vaccines. Molecular analysis demonstrated that the Mexican H7N3 strains have continued to rapidly evolve since 2012. In addition, we identified in silico three potential new N-glycosylation sites on the globular head of the H7 HA of A/chicken/Jalisco/CPA-37905/2015 challenge virus, which were absent in 2012 H7N3 outbreak virus. Our results suggested that mutations in the HA antigenic sites including increased glycosylation sites, accumulated in the new circulating Mexican H7 HPAIV strains, altered the recognition of neutralizing antibodies from the older vaccine strain rFPV-H7/2155. Therefore, the protective efficacy of novel rFPV-H7/3002 against recent outbreak Mexican H7N3 HPAIV confirms the importance of frequent updating of vaccines seed strains for long-term effective control of H7 HPAI virus
Efficient Resolution of Anisotropic Structures
We highlight some recent new delevelopments concerning the sparse
representation of possibly high-dimensional functions exhibiting strong
anisotropic features and low regularity in isotropic Sobolev or Besov scales.
Specifically, we focus on the solution of transport equations which exhibit
propagation of singularities where, additionally, high-dimensionality enters
when the convection field, and hence the solutions, depend on parameters
varying over some compact set. Important constituents of our approach are
directionally adaptive discretization concepts motivated by compactly supported
shearlet systems, and well-conditioned stable variational formulations that
support trial spaces with anisotropic refinements with arbitrary
directionalities. We prove that they provide tight error-residual relations
which are used to contrive rigorously founded adaptive refinement schemes which
converge in . Moreover, in the context of parameter dependent problems we
discuss two approaches serving different purposes and working under different
regularity assumptions. For frequent query problems, making essential use of
the novel well-conditioned variational formulations, a new Reduced Basis Method
is outlined which exhibits a certain rate-optimal performance for indefinite,
unsymmetric or singularly perturbed problems. For the radiative transfer
problem with scattering a sparse tensor method is presented which mitigates or
even overcomes the curse of dimensionality under suitable (so far still
isotropic) regularity assumptions. Numerical examples for both methods
illustrate the theoretical findings
Accuracy of the electronic health record’s problem list in describing multimorbidity in patients with heart failure in the emergency department
Patients with heart failure (HF) often suffer from multimorbidity. Rapid assessment of multimorbidity is important for minimizing the risk of harmful drug-disease and drug-drug interactions. We assessed the accuracy of using the electronic health record (EHR) problem list to identify comorbid conditions among patients with chronic HF in the emergency department (ED). A retrospective chart review study was performed on a random sample of 200 patients age ≥65 years with a diagnosis of HF presenting to an academic ED in 2019. We assessed participant chronic conditions using: (1) structured chart review (gold standard) and (2) an EHR-based algorithm using the problem list. Chronic conditions were classified into 37 disease domains using the Agency for Healthcare Research Quality’s Elixhauser Comorbidity Software. For each disease domain, we report the sensitivity, specificity, positive predictive value, and negative predictive of using an EHR-based algorithm. We calculated the intra-class correlation coefficient (ICC) to assess overall agreement on Elixhauser domain count between chart review and problem list. Patients with HF had a mean of 5.4 chronic conditions (SD 2.1) in the chart review and a mean of 4.1 chronic conditions (SD 2.1) in the EHR-based problem list. The five most prevalent domains were uncomplicated hypertension (90%), obesity (42%), chronic pulmonary disease (38%), deficiency anemias (33%), and diabetes with chronic complications (30.5%). The positive predictive value and negative predictive value of using the EHR-based problem list was greater than 90% for 24/37 and 32/37 disease domains, respectively. The EHR-based problem list correctly identified 3.7 domains per patient and misclassified 2.0 domains per patient. Overall, the ICC in comparing Elixhauser domain count was 0.77 (95% CI: 0.71-0.82). The EHR-based problem list captures multimorbidity with moderate-to-good accuracy in patient with HF in the ED
The transformative potential of international service-learning at a university with a Christian foundation in the UK
This article draws upon the findings of a study at Liverpool Hope University (LHU) into the transformative nature of International Service-Learning (ISL) experiences for student participants. This research is concerned with the implications of these findings for professional practice, in particular how ISL is constructed in Higher Education policy and practice. Recognising the problematic nature of this endeavor, this article responds to a call for discussion around pedagogical approaches underpinning counter-cultural and critical service programmes aligned with the radical principles of the Catholic social teaching. This study is grounded in a holistic conceptualisation of transformative learning that demands looking beyond an epistemological process that involves shifts in worldview and habits of mind to an ontological process that accounts for changes to our being in the world. It investigated how LHU students describe their ongoing experience of ISL and explored the conditions for learning and the associated transformative processes and outcomes in this context. Data analysis involved phenomenological description, constant comparative thematic analysis followed by a critical, hermeneutical analysis. This article will explicate the themes of moral and spiritual learning that emerged as part of a broader framework. In particular, it was found that the development of authentic relationships between travelling companions, accompanying tutors and partners overseas is central to learning that is reciprocated and provides a model of the transformative process in this context. This article concludes that this presents a pedagogical approach grounded in social justice that enables ISL to reach its transformative potential
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