Solar Intranetwork Magnetic Elements: bipolar flux appearance

The current study aims to quantify characteristic features of bipolar flux appearance of solar intranetwork (IN) magnetic elements. To attack such a problem, we use the Narrow-band Filter Imager (NFI) magnetograms from the Solar Optical Telescope (SOT) on board \emph{Hinode}; these data are from quiet and an enhanced network areas. Cluster emergence of mixed polarities and IN ephemeral regions (ERs) are the most conspicuous forms of bipolar flux appearance within the network. Each of the clusters is characterized by a few well-developed ERs that are partially or fully co-aligned in magnetic axis orientation. On average, the sampled IN ERs have total maximum unsigned flux of several 10^{17} Mx, separation of 3-4 arcsec, and a lifetime of 10-15 minutes. The smallest IN ERs have a maximum unsigned flux of several 10^{16} Mx, separations less than 1 arcsec, and lifetimes as short as 5 minutes. Most IN ERs exhibit a rotation of their magnetic axis of more than 10 degrees during flux emergence. Peculiar flux appearance, e.g., bipole shrinkage followed by growth or the reverse, is not unusual. A few examples show repeated shrinkage-growth or growth-shrinkage, like magnetic floats in the dynamic photosphere. The observed bipolar behavior seems to carry rich information on magneto-convection in the sub-photospheric layer.Comment: 26 pages, 14 figure

Considering patient values and treatment preferences enhances patient involvement in rectal cancer treatment decision making

Biological, physical and clinical aspects of cancer treatment with ionising radiatio

Satisfação e percepção do usuário do SUS sobre o serviço público de saúde Satisfaction and perception of SUS's users about public health care

A avaliação do grau de satisfação dos usuários do sistema de saúde é um importante indicador a ser considerado no planejamento das ações. O objetivo deste estudo foi avaliar o grau de satisfação de usuários dos serviços de saúde pública municipal quanto aos serviços utilizados. Este estudo tipo inquérito foi conduzido em cinco municípios do Estado de São Paulo. A amostra foi selecionada de forma estratificada e aleatória, sendo entrevistados 471 chefes de família ou respectivos cônjuges. Os dados qualitativos foram analisados pelo método de Análise de Conteúdo, e os dados quantitativos foram processados utilizando-se o software estatístico Epi Info. Dentre os usuários dos cinco municípios, 93,0% utilizam o serviço municipal de saúde. Para 72,0%, os serviços de saúde prestados estão resolvendo os problemas e necessidades da população. Com base no acesso ao atendimento, 57,6% da população queixaram-se da presença de filas para o atendimento. Mais da metade (69,5%) afirmou ter confiança na equipe de saúde; no entanto, muitos relatos demonstraram a carência de um atendimento humanizado. Em relação aos serviços de saúde, 61,7% classificaram-os como ótimo ou bom. Conclui-se que a maior parte dos usuários mostrou-se satisfeita com os serviços de saúde municipais, apesar da grande quantidade de queixas quanto ao atendimento, falta de humanização e acolhimento, deficiência de recursos físicos e materiais. A percepção do usuário é de extrema importância ao se dimensionar o reflexo das ações que vem sendo desenvolvidas no setor saúde, e serve como vetor de direcionamento e planejamento do serviço.<br>The assessment of the degree of users' satisfaction with the health system is an important indicator to be considered in planning actions. The aim of this study was to evaluate the degree of satisfaction of users of health services and municipal services to be used. This survey was conducted in five municipalities of São Paulo. The sample was selected at random, stratified, and interviewed 471 heads of households or their spouses. Qualitative data were analyzed using content analysis and quantitative data were processed using the statistical software Epi Info. Among the users of the five municipalities, 93.0% attended the public health care. To 72.0%, health services are solving the problems and needs of the population. Based on access to care, 57.6% of the population complained about the presence of queues for care. More than half (69.5%) said they had confidence in the health team, however, many reports demonstrated the lack of a humanized care. In relation to health services, 61.7% rated them as excellent or good. We conclude that most users are satisfied with the municipal health services, despite the large amount of complaints regarding care, lack of humanization and welcoming, lack of facilities. The user's perception is of utmost importance when scaling the result of actions that have been developed in the health sector, and serves as a vector of direction and planning service

Pattern recognition by pentraxins

Pentraxins are a family of evolutionarily conserved pattern-recognition proteins that are made up of five identical subunits. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver while PTX3 is produced in a variery oftissues during inflammation. The main functions of short pentraxins are to recognize a variery of pathogenic agents and then to either eliminate them or neutralize their harmful effects by utilizing the complement pathways and macrophages in the host. CRP binds to modified low-densiry lipoproteins, bacterial polysaccharides, apoptotic cells, and nuclear materials. By virtue of these recognition functions, CRP participates in the resolution ofcardiovascular, infectious, and autoimmune diseases. SAP recognizes carbohydrates, nuclear substances, and amyloid fibrils and thus participates in the resolution of infectious diseases, autoimmuniry, and amyloidosis. PTX3 interacts with several ligands, including growth factors, extracellular matrix component and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagoeytes. In addition, data in gene-targeted mice show that PTX3 is essential in female fertiliry, participating in the assembly of the cumulus oophorus extracellular matrix. PTX3 is therefore a nonredundant component ofthe humoral arm of innate immuniry as well as a tuner of inflammation. Thus, in conjunction with the other components ofinnate immuniry, the pentraxins use their pattern-recognition properry for the benefit of the host

Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome ODYSSEY OUTCOMES Trial

Cardiolog