1,014 research outputs found
The relationship between EQ-5D, HAQ and pain in patients with rheumatoid arthritis: further validation and development of the limited dependent variable, mixture model approach
Objective
To provide robust estimates of EQ-5D as a function of the Health Assessment Questionnaire
(HAQ) and pain in patients with rheumatoid arthritis.
Method
Repeated observations of patients diagnosed with RA in a US observational cohort (n=100,398 observations) who provided data on HAQ, pain on a visual analogue scale and the EQ-5D questionnaire. We use a bespoke mixture modelling approach to appropriately reflect the characteristics of the EQ-5D instrument and compare this to results from linear regression.
Results
The addition of pain alongside HAQ as an explanatory variable substantially improves explanatory power. The preferred model is a four component mixture. Unlike the linear regression it exhibits very good fit to the data, does not suffer from problems of bias or predict values outside the feasible range.
Conclusions
It is appropriate to model the relationship between HAQ and EQ-5D but only if suitable statistical methods are applied. Linear models underestimate the QALY benefits, and therefore the cost effectiveness, of therapies. The bespoke mixture model approach outlined here overcomes this problem. The addition of pain as an explanatory variable greatly improves the estimates
Smoking and plasma fibrinogen, lipoprotein (a) and serotinin are markers for postoperative infrainguinal graft stenosis
Objectives:A number of systemic variables are associated with infrainguinal graft failure and also with experimental smooth muscle hyperplasia. Stenosis is the most common cause of infrainguinal graft thrombosis but it is not known if systemic variables are associated with stenosis.Design, materials and methods:In this study, clinical and serological factors were measured and correlated with stenosis development in 81 infrainguinal bypass grafts (52 vein, 29 PTFE; 28 with stenosis) in prospective (n = 46) and retrospective (n = 35) groups. Pre-existing stenosis was ecluded by perioperative graft assessment.Results:There was a significantly greater proportion of smokers in the patients who developed stenosis (11/18; 61%) compared with those who did not (6/28; 21%, p = 0.006; x2). Patients who developed stenosis also had significantly (Mann Whitney U-tests), higher circulating levels of [median (interquartile range)] fibrinogen (412.5 (356–484.5) vs. 339 (300–397.7) mg/100ml, p = 0.003), Lipoprotein (a) (0.20 (0.05–0.45) vs. 0.085 (0.05–0.23), g/l, p = 0.03) and 5-hydroxytryptamine (14.1 (6.6–45) vs. 4.41 (3–8.39) nmol/l, p = 0.005), than those without stenosis.By logistic regression, these associations were independent of graft material and whether grafts were studied prospectively or retrospectively.Conclusions:Smoking and plasma fibrinogen, Lp(a) and 5-hydroxytryptamine are markers for postoperative infrainguinal graft stenosis
Magnetic Anisotropy of Co2MnSn1−xSbx Thin Films Grown on GaAs (001)
Heusler alloy Co2MnSn1−xSbx (x = 0.0, 0.5, and 1.0) thin films were grown on GaAs (001) substrates using pulsed laser deposition techniques. Growth parameters have been determined that result in highly magnetically anisotropic, crystalline, and oriented (001) films. The angular dependences, relative to the GaAs (001) crystallographic directions, of the coercive field Hc(θ) and the remanence Mr(θ) were determined from angle dependent magneto-optic Kerr effect (MOKE) measurements. It was found that Hc(θ) revealed higher order symmetry contributions to the magnetic anisotropy than did Mr(θ). The Fourier analysis of rotational MOKE data was used to determine the symmetry contributions to the total anisotropy
Magnetic fields in cosmic particle acceleration sources
We review here some magnetic phenomena in astrophysical particle accelerators
associated with collisionless shocks in supernova remnants, radio galaxies and
clusters of galaxies. A specific feature is that the accelerated particles can
play an important role in magnetic field evolution in the objects. We discuss a
number of CR-driven, magnetic field amplification processes that are likely to
operate when diffusive shock acceleration (DSA) becomes efficient and
nonlinear. The turbulent magnetic fields produced by these processes determine
the maximum energies of accelerated particles and result in specific features
in the observed photon radiation of the sources. Equally important, magnetic
field amplification by the CR currents and pressure anisotropies may affect the
shocked gas temperatures and compression, both in the shock precursor and in
the downstream flow, if the shock is an efficient CR accelerator. Strong
fluctuations of the magnetic field on scales above the radiation formation
length in the shock vicinity result in intermittent structures observable in
synchrotron emission images. Resonant and non-resonant CR streaming
instabilities in the shock precursor can generate mesoscale magnetic fields
with scale-sizes comparable to supernova remnants and even superbubbles. This
opens the possibility that magnetic fields in the earliest galaxies were
produced by the first generation Population III supernova remnants and by
clustered supernovae in star forming regions.Comment: 30 pages, Space Science Review
Parsimonious genotype by environment interaction covariance models for cassava (Manihot esculenta)
Open Access Journal; Published online: 21 Sep 2022The assessment of cassava clones across multiple environments is often carried out at the uniform yield trial, a late evaluation stage, before variety release. This is to assess the differential response of the varieties across the testing environments, a phenomenon referred to as genotype-by-environment interaction (GEI). This phenomenon is considered a critical challenge confronted by plant breeders in developing crop varieties. This study used the data from variety trials established as randomized complete block design (RCBD) in three replicates across 11 locations in different agro-ecological zones in Nigeria over four cropping seasons
(2016–2017, 2017–2018, 2018–2019, and 2019–2020). We evaluated a total of 96 varieties, including five checks, across 48 trials. We exploited the intricate pattern of GEI by fitting variance–covariance structure models on fresh root yield. The goodness-of-fit statistics revealed that the factor analytic model of order 3 (FA3) is the most parsimonious model based on Akaike Information Criterion (AIC). The three-factor loadings from the FA3 model explained, on average across the 27 environments, 53.5% [FA (1)], 14.0% [FA (2)], and 11.5% [FA (3)] of the genetic effect, and altogether accounted for 79.0% of total genetic variability. The association of factor loadings with weather covariates using partial least squares regression
(PLSR) revealed that minimum temperature, precipitation and relative humidity are weather conditions influencing the genotypic response across the testing environments in the southern region and maximum temperature, wind speed, and temperature range for those in the northern region of Nigeria. We conclude that the FA3 model identified the common latent factors to dissect and account for complex interaction in multi-environment field trials, and the PLSR is an effective approach for describing GEI variability in the context of multi-environment trials where external environmental covariables are included in modeling
Exploring genotype by environment interaction on cassava yield and yield related traits using classical statistical methods
Open Access Journal; Published online: 18 Jul 2022Variety advancement decisions for root quality and yield-related traits in cassava are complex due to the variable patterns of genotype-by-environment interactions (GEI). Therefore, studies focused on the dissection of the existing patterns of GEI using linear-bilinear models such as Finlay-Wilkinson (FW), additive main effect and multiplicative interaction (AMMI), and genotype and genotype-by-environment (GGE) interaction models are critical in defining the target population of environments (TPEs) for future testing, selection, and advancement. This study assessed 36 elite cassava clones in 11 locations over three cropping seasons in the cassava breeding program of IITA based in Nigeria to quantify the GEI effects for root quality and yield-related traits. Genetic correlation coefficients and heritability estimates among environments found mostly intermediate to high values indicating high correlations with the major TPE. There was a differential clonal ranking among the environments indicating the existence of GEI as also revealed by the likelihood ratio test (LRT), which further confirmed the statistical model with the heterogeneity of error variances across the environments fit better. For all fitted models, we found the main effects of environment, genotype, and interaction significant for all observed traits except for dry matter content whose GEI sensitivity was marginally significant as found using the FW model. We identified TMS14F1297P0019 and TMEB419 as two topmost stable clones with a sensitivity values of 0.63 and 0.66 respectively using the FW model. However, GGE and AMMI stability value in conjunction with genotype selection index revealed that IITA-TMS-IBA000070 and TMS14F1036P0007 were the top-ranking clones combining both stability and yield performance measures. The AMMI-2 model clustered the testing environments into 6 mega-environments based on winning genotypes for fresh root yield. Alternatively, we identified 3 clusters of testing environments based on genotypic BLUPs derived from the random GEI component
Galaxy Clusters as Reservoirs of Heavy Dark Matter and High-Energy Cosmic Rays: Constraints from Neutrino Observations
Galaxy Clusters (GCs) are the largest reservoirs of both dark matter and
cosmic rays (CRs). Dark matter self-annihilation can lead to a high luminosity
in gamma rays and neutrinos, enhanced by a strong degree of clustering in dark
matter substructures. Hadronic CR interactions can also lead to a high
luminosity in gamma rays and neutrinos, enhanced by the confinement of CRs from
cluster accretion/merger shocks and active galactic nuclei. We show that
IceCube/KM3Net observations of high-energy neutrinos can probe the nature of
GCs and the separate dark matter and CR emission processes, taking into account
how the results depend on the still-substantial uncertainties. Neutrino
observations are relevant at high energies, especially at >10 TeV. Our results
should be useful for improving experimental searches for high-energy neutrino
emission. Neutrino telescopes are sensitive to extended sources formed by dark
matter substructures and CRs distributed over large scales. Recent observations
by Fermi and imaging atmospheric Cherenkov telescopes have placed interesting
constraints on the gamma-ray emission from GCs. We also provide calculations of
the gamma-ray fluxes, taking into account electromagnetic cascades inside GCs,
which can be important for injections at sufficiently high energies. This also
allows us to extend previous gamma-ray constraints to very high dark matter
masses and significant CR injections at very high energies. Using both
neutrinos and gamma rays, which can lead to comparable constraints, will allow
more complete understandings of GCs. Neutrinos are essential for some dark
matter annihilation channels, and for hadronic instead of electronic CRs. Our
results suggest that the multi-messenger observations of GCs will be able to
give useful constraints on specific models of dark matter and CRs. [Abstract
abridged.]Comment: 31 pages, 20 figures, 1 table, accepted for publication in JCAP,
references and discussions adde
The Formation of Cosmic Structures in a Light Gravitino Dominated Universe
We analyse the formation of cosmic structures in models where the dark matter
is dominated by light gravitinos with mass of eV -- 1 keV, as predicted
by gauge-mediated supersymmetry (SUSY) breaking models. After evaluating the
number of degrees of freedom at the gravitinos decoupling (), we compute
the transfer function for matter fluctuations and show that gravitinos behave
like warm dark matter (WDM) with free-streaming scale comparable to the galaxy
mass scale. We consider different low-density variants of the WDM model, both
with and without cosmological constant, and compare the predictions on the
abundances of neutral hydrogen within high-redshift damped Ly-- systems
and on the number density of local galaxy clusters with the corresponding
observational constraints. We find that none of the models satisfies both
constraints at the same time, unless a rather small value (\mincir
0.4) and a rather large Hubble parameter (\magcir 0.9) is assumed.
Furthermore, in a model with warm + hot dark matter, with hot component
provided by massive neutrinos, the strong suppression of fluctuation on scales
of \sim 1\hm precludes the formation of high-redshift objects, when the
low-- cluster abundance is required. We conclude that all different variants
of a light gravitino DM dominated model show strong difficulties for what
concerns cosmic structure formation.
This gives a severe cosmological constraint on the gauge-mediated SUSY
breaking scheme.Comment: 28 pages,Latex, submitted for publication to Phys.Rev.
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