The eclipsing bursting X-ray binary EXO 0748-676 revisited by XMM-Newton

The bright eclipsing and bursting low-mass X-ray binary EXO 0748-676 has been observed at several occasions by XMM-Newton during the initial calibration and performance verification (CAL/PV) phase. We present here the results obtained from observations with the EPIC cameras. Apart from several type-I X-ray bursts, the source shows a high degree of variability with the presence of soft flares. The wide energy coverage and high sensitivity of XMM-Newton allows for the first time a detailed description of the spectral variability. The source is found to be the superposition of a central (~2 10^8 cm) Comptonized emission, most probably a corona surrounding the inner edge of an accretion disk, associated with a more extended (~3 10^10 cm) thermal halo at a typical temperature of ~0.6 keV with an indication of non-solar abundances. Most of the variations of the source can be accounted for by a variable absorption affecting only the central comptonized component and reaching up to NH ~1.3 10^23 cm^{-2}. The characteristics of the surrounding halo are found compatible with an irradiated atmosphere of an accretion disc which intercepts the central emission due to the system high inclination.Comment: 6 pages, 4 figures, accepted for publication in A&A Letters, XMM special issu

Memory Effects in the Standard Model for Glasses

The standard model of glasses is an ensemble of two-level systems interacting with a thermal bath. The general origin of memory effects in this model is a quasi-stationary but non-equilibrium state of a single two-level system, which is realized due to a finite-rate cooling and very slow thermally activated relaxation. We show that single particle memory effects, such as negativity of the specific heat under reheating, vanish for a sufficiently disordered ensemble. In contrast, a disordered ensemble displays a collective memory effect [similar to that described by Kovacs for glassy polymers], where non-equilibrium features of the ensemble are monitored via a macroscopic observable. An experimental realization of the effect can be used to further assess the consistency of the model.Comment: 4 pages, 6 figure

Estimations for the Single Diffractive production of the Higgs boson at the Tevatron and the LHC

The single diffractive production of the standard model Higgs boson is computed using the diffractive factorization formalism, taking into account a parametrization for the Pomeron structure function provided by the H1 Collaboration. We compute the cross sections at next-to-leading order accuracy for the gluon fusion process, which includes QCD and electroweak corrections. The gap survival probability ($$) is also introduced to account for the rescattering corrections due to spectator particles present in the interaction, and to this end we compare two different models for the survival factor. The diffractive ratios are predicted for proton-proton collisions at the Tevatron and the LHC for the Higgs boson mass of $M_H$ = 120 GeV. Therefore, our results provide updated estimations for the diffractive ratios of the single diffractive production of the Higgs boson in the Tevatron and LHC kinematical regimes.Comment: 20 pages, 6 figures, 3 table

Short report: molecular markers associated with Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in the Democratic Republic of Congo.

Sulfadoxine-pyrimethamine (SP) is the first line antimalarial treatment in the Democratic Republic of Congo. Using polymerase chain reaction, we assessed the prevalence of mutations in the dihydrofolate reductase (dhfr) (codons 108, 51, 59) and dihydropteroate synthase (dhps) (codons 437, 540) genes of Plasmodium falciparum, which have been associated with resistance to pyrimethamine and sulfadoxine, respectively. Four hundred seventy-four patients were sampled in Kilwa (N = 138), Kisangani (N = 112), Boende (N = 106), and Basankusu (N = 118). The proportion of triple mutations dhfr varied between sites but was always > 50%. The proportion of dhps double mutations was < 20%, with some sites as low as 0.9%. A quintuple mutation was present in 12.8% (16/125) samples in Kilwa; 11.9% (13/109) in Kisangani, 2.9% (3/102) in Boende, and 0.9% (1/112) in Basankusu. These results suggest high resistance to pyrimethamine alone or combined with sulfadoxine. Adding artesunate to SP does not seem a valid alternative to the current monotherapy

Reducing the Number of Sputum Samples Examined and Thresholds for Positivity: An Opportunity to Optimise Smear Microscopy.

SETTING: Urban health clinic, Nairobi. OBJECTIVE: To evaluate the impact on tuberculosis (TB) case detection and laboratory workload of reducing the number of sputum smears examined and thresholds for diagnosing positive smears and positive cases. DESIGN: In this prospective study, three Ziehl-Neelsen stained sputum smears from consecutive pulmonary TB suspects were examined blind. The standard approach (A), > or = 2 positive smears out of 3, using a cut-off of 10 acid-fast bacilli (AFB)/100 high-power fields (HPF), was compared with approaches B, > or = 2 positive smears (> or = 4 AFB/100 HPF) out of 3, one of which is > or = 10 AFB/100 HPF; C, > or = 2 positive smears (> or = 4 AFB/100 HPF) out of 3; D, > or = 1 positive smear (> or = 10 AFB/100 HPF) out of 2; and E, > or = 1 positive smear (> or = 4 AFB/100 HPF) out of 2. The microscopy gold standard was detection of at least one positive smear (> or = 4 AFB/100 HPF) out of 3. RESULTS: Among 644 TB suspects, the alternative approaches detected from 114 (17.7%) (approach B) to 123 cases (19.1%) (approach E) compared to 105 cases (16.3%) for approach A (P < 0.005). Sensitivity ranged between 82.0% (105/128) for A and 96.1% (123/128) for E. The single positive smear approaches reduced the number of smears by 36% compared to approach A. CONCLUSION: Reducing the number of specimens and the positivity threshold to define a positive case increased the sensitivity of microscopy and reduced laboratory workload

Added value of bleach sedimentation microscopy for diagnosis of tuberculosis: a cost-effectiveness study.

SETTING: Bleach sedimentation is a method used to increase the diagnostic yield of sputum microscopy for countries with a high prevalence of human immunodeficiency virus (HIV) infection and limited resources. OBJECTIVES: To compare the relative cost-effectiveness of different microscopy approaches in diagnosing tuberculosis (TB) in Kenya. METHODS: An analytical decision tree model including cost and effectiveness measures of 10 combinations of direct (D) and overnight bleach (B) sedimentation microscopy was constructed. Data were drawn from the evaluation of the bleach sedimentation method on two specimens (first on the spot [1] and second morning [2]) from 644 TB suspects in a peripheral health clinic. Incremental cost per smear-positive detected case was measured. Costs included human resources and materials using a micro-costing evaluation. RESULTS: All bleach-based microscopy approaches detected significantly more cases (between 23.3% for B1 and 25.9% for B1+B2) than the conventional D1+D2 approach (21.0%). Cost per tested case ranged between respectively euro 2.7 and euro 4.5 for B1 and B1+D2+B2. B1 and B1+B2 were the most cost-effective approaches. D1+B2 and D1+B1 were good alternatives to avoid using approaches exclusively based on bleach sedimentation microscopy. CONCLUSIONS: Among several effective microscopy approaches used, including sodium hypochlorite sedimentation, only some resulted in a limited increase in the laboratory workload and would be most suitable for programmatic implementation

The method of Gaussian weighted trajectories. V. On the 1GB procedure for polyatomic processes

In recent years, many chemical reactions have been studied by means of the quasi-classical trajectory (QCT) method within the Gaussian binning (GB) procedure. The latter consists in "quantizing" the final vibrational actions in Bohr spirit by putting strong emphasis on the trajectories reaching the products with vibrational actions close to integer values. A major drawback of this procedure is that if N is the number of product vibrational modes, the amount of trajectories necessary to converge the calculations is ~ 10^N larger than with the standard QCT method. Applying it to polyatomic processes is thus problematic. In a recent paper, however, Czako and Bowman propose to quantize the total vibrational energy instead of the vibrational actions [G. Czako and J. M. Bowman, J. Chem. Phys., 131, 244302 (2009)], a procedure called 1GB here. The calculations are then only ~ 10 times more time-consuming than with the standard QCT method, allowing thereby for considerable numerical saving. In this paper, we propose some theoretical arguments supporting the 1GB procedure and check its validity on model test cases as well as the prototype four-atom reaction OH+D_2 -> HOD+D

On the Parameterized Complexity of Red-Blue Points Separation

We study the following geometric separation problem: Given a set R of red points and a set B of blue points in the plane, find a minimum-size set of lines that separate R from B. We show that, in its full generality, parameterized by the number of lines k in the solution, the problem is unlikely to be solvable significantly faster than the bruteforce nO(k) -time algorithm, where n is the total number of points. Indeed, we show that an algorithm running in time f(k)nᵒ(k/log k) , for any computable function f, would disprove ETH. Our reduction crucially relies on selecting lines from a set with a large number of different slopes (i.e., this number is not a function of k). Conjecturing that the problem variant where the lines are required to be axis-parallel is FPT in the number of lines, we show the following preliminary result. Separating R from B with a minimum-size set of axis-parallel lines is FPT in the size of either set, and can be solved in time O∗(9|B|) (assuming that B is the smaller set)