The interaction of the technical college and the employer: the prospects of social partnership

Социальное партнерство авторы статьи понимают как особый тип взаимодействия образовательного учреждения со всеми субъектами рынка труда, территориальными органами управления. Совершенно очевидно, что подготовить современного специалиста невозможно в отрыве от реального производства, без обеспечения возможности знакомиться и осваивать то оборудование и технологии, с которыми они встретятся, придя на предприятия.The authors of the article understand the social partnership as a special type of interaction of the educational institution with all subjects of the labor market, territorial authority aimed at maximizing the interests of all participants in this process. It is obvious that it is impossible to prepare a modern specialist in isolation from the real production without a guarantee of possibility to meet and master the equipment and technologies with which they’ll be working, coming to the company. At the college a system of social partnership was created, which is an integral part of the development of technical college

Features of the reaction of the kidney function of healthy rats to the intake of boric hydrocarbonate sodium mineral waters of varying quantitative macro- and micro-composition

The purpose of the work is a comparative assessment of the effect of boron hydrocarbonate sodium mineral waters with a varying quantitative and qualitative composition of macroelements and with different amounts of a bioactive element on the state of the urinary system of rats. Materials and methods. The work was performed on 81 white rats of the Wistar line of auto bred breeding, weighing 180-200 g. The rats were divided into four groups: group 1 - 21 intact rats served as controls; group 2 - 20 rats treated intragastrically with a soft probe MW "Polyana Ploskivskaya" at a dose of 1% of body weight daily, a course of 7 days; group 3 - 20 rats treated with MW "Polyana Kupel" according to the above method; group 4 - 20 rats treated with MW "Svalyava" according to the above process. Before removing the animals from the experiment, daily urine was collected from them; blood was also taken from the tail vein for biochemical studies. At autopsy, pieces of kidneys were taken for histological and histoenzymological studies (the activity of succinate dehydrogenase and lactate dehydrogenase was determined). Results. The histological studies showed no pathological changes in the kidneys were observed with the use of the studied boron MW. Still, there were structural changes, as well as an increase in the activity of redox enzymes. Changes in kidney function were unidirectional with using any of the investigated MW. Still, they had quantitative differences, which are less related to the amount of boron (in the form of orthoboric acid) in 1 liter of MW and more dependent on the osmolarity of the MW, the qualitative composition of macronutrients, and their ratio. Conclusion. We believe that osmolarity, as an integrated indicator of the state of the macronutrient component of MW, can be used to assess its effect on the structural and functional characteristics of the kidneys

АНАЛІЗ НЕСПРИЯТЛИВИХ ПОДІЙ ПІСЛЯ ІМУНІЗАЦІЇ ВАКЦИНАМИ ПРОТИ SARS CoV-2

Although the WHO-recommended coronavirus vaccines are safe and effective, vaccines provide new information to healthcare professionals about the extent and nature of adverse reactions to these drugs. The aim of the study is supplementing the available data on adverse reactions of vaccines on the example of the experience of vaccination of the teaching staff of the Cherkasy Medical Academy with vaccines COVISHIELD and COMIRNATY. Information for this study was collected retrospectively through a survey of 72 employees of the Cherkasy Medical Academy who were vaccinated with the COVISHIELD vaccine (first dose); 67 workers vaccinated with AstraZeneca (second dose); 54 workers who were vaccinated with COMIRNATY vaccine (first dose); 52 people vaccinated with this vaccine (second dose). The study confirmed that among the local side effects, the most common were pain at the injection site, among the systemic - fever, weakness, fatigue and drowsiness, headache, muscle pain, chills. Most of the side effects were most pronounced in young people, more often in women than in men.Although the WHO-recommended coronavirus vaccines are safe and effective, vaccines provide new information to healthcare professionals about the extent and nature of adverse reactions to these drugs. The aim of the study is supplementing the available data on adverse reactions of vaccines on the example of the experience of vaccination of the teaching staff of the Cherkasy Medical Academy with vaccines COVISHIELD and COMIRNATY. Information for this study was collected retrospectively through a survey of 72 employees of the Cherkasy Medical Academy who were vaccinated with the COVISHIELD vaccine (first dose); 67 workers vaccinated with AstraZeneca (second dose); 54 workers who were vaccinated with COMIRNATY vaccine (first dose); 52 people vaccinated with this vaccine (second dose). The study confirmed that among the local side effects, the most common were pain at the injection site, among the systemic - fever, weakness, fatigue and drowsiness, headache, muscle pain, chills. Most of the side effects were most pronounced in young people, more often in women than in men

Анализ инновационных технологий гидрогелей из уронатных полисахаридов и биодеградирующих пленок на их основе

The article is devoted to the analysis of the state and dynamics of scientific developments in the field of creating products for life and health, based on hydrogels from uronate polysaccharides (HUP). The article is reflected the results of the global scientific research monitoring and their changes in the field of technologies for the creation and use of HUP. The results of a retrospective analysis of existing technologies based on poorly studied in the field of food technologies uronic acids, as glucuronic, idouronic, hyaluronic were presented. The study showed, that nowadays the industry of products with their content is acquiring market traits, although it has insufficient scientific substantiation. Development segments with widely used uronate polysaccharides – pectins and alginates – according to the types of hydrogels (swollen hydrogel, cross-linked hydrogel, xerogel) were developed. The article presents examples and identified the required properties of substances intended for immobilization or encapsulation in the hydrogel matrix of uronate polysaccharides. The basic principles of uronate polysaccharides crosslinking chains in the hydrogel phase are determined. Possible methods of biologically active substances (BAS) retention in the matrix of uronate polysaccharides to reduce the risk of premature oxidation, destruction, decomposition, decomposition, evaporation were described. The search for information allowed us to identify key technological areas for the development of scientific research on the creation and use of HUP to improve people's lives and health. The archives of the world's leading publications in the field of food chemistry, biotechnology, food engineering, chemistry of new materials, food polymers and hydrocolloids were analyzed. The authors used in their work the resources of the Science Direct search system, which made it possible to determine the most promising and modern lines of development of HUP technologies and products based on them. The analysis of technologies has shown that existing innovative technologies are formed on “basic” technologies for producing solutions of high-molecular compounds under various conditions. Active modernization is carried out in the direction of creating products with immobilized biologically active substances, as well as in attempts to compose a composition with other polysaccharides and/or peptide components. The article notes that existing technologies allow developing other technologies with the help of which it is possible to expand the field of HUP application.Статья посвящена анализу состояния и динамике научных разработок в области создания продуктов для жизни и здоровья на основе гидрогелей из уронатных полисахаридов (ГУП). В статье отражены результаты мониторинга мировых научных исследований и их изменений в области технологий создания и применения ГУП. Авторы представили результаты ретроспективного анализа существующих технологий на основе малоизученых в области пищевых технологий уроновых кислот: глюкуроновая, идоуроновая, гиалуроновая. Исследование показало, что на сегодня индустрия продуктов с их содержанием приобретает вполне рыночные черты, хотя и имеет недостаточно полное научное обоснование. Сформированы сегменты разработок с широко используемыми уронатными полисахаридами - пектинами и альгинатами – по видам гидрогелей (гидрогель набухший, гидрогель сшитый, ксерогель). В статье представлены примеры и выявлены требуемые свойства веществ, предназначенных для иммобилизации или инкапсуляции в матрицу гидрогеля из уронатных полисахаридов. Определены основные принципы сшивания цепочек уронатных полисахаридов в фазе гидрогеля. Описаны возможные способы удержания биологически активных веществ (БАВ) в матрице уронатных полисахаридов для снижения риска преждевременного окисления, деструкции, разложения, распада, испарения. Поиск информации позволил определить ключевые технологические области развития научных исследований по созданию и применению ГУП для улучшения жизни и здоровья людей. Проанализированы архивы ведущих мировых изданий в области пищевой химии, биотехнологии, пищевой инженерии, химии новых материалов, пищевых полимеров и гидроколлоидов. Авторы использовали в работе ресурсы поисковой системы Science Direct, что позволило определить наиболее перспективные и современные направления развития технологий ГУП и продуктов на их основе. Анализ технологий показал, что существующие инновационные технологии сформированы на “базисных” технологиях получения растворов высокомолекулярных соединений при различных условиях. Активная модернизация проводится в направлении создания продуктов с иммобилизированными БАВ, а также в попытках составить композицию с другими полисахаридами и/или пептидными составляющими. В работе отмечается, что существующие технологии позволяют развивать другие технологии, с помощью которых возможно расширить сферы применения ГУП

Contribution of some immunological and metabolic factors to formation of piglets’ post-vaccination immunity

The role and responsibility of natural resistance factors, protein and lipid metabolism in the formation of piglets post-vaccination immunity against circovirus is researched. Blood was taken for tests before and on the 15th, 40th and 70th day after the vaccination. The sampled blood was analyzed to determine immunological and biochemical parameters. It was revealed that before vaccination, 31.46% of the studied samples have a positive reaction in ELISA; their number increases to 67.80–71.16% on the 40th and 70th days after vaccination.In the blood of piglets, especially on the 40th and 70th day after the vaccination, the total count of leukocytes, monocytes and lymphocytes increases by 1.21; 2.28 times and 1.48 times, but neutrophils reduced by 1.74 times along with the phagocytic properties activation. The anabolic directivity of protein metabolism is defined by the synthesis of globulin proteins. At the same time albumin-synthesizing activity in a liver decreased and “cytolysis reaction” of hepatocytes was detected. In the lipid profile of piglets’ blood, the content of LDL‑cholesterol increased by 1.44 times, while that of triglycerides decreased by 2.64 times. X‑ray spectral analysis revealed the correlation between the formation of post-vaccination immunity and two factors: the factor of the principal component (PC) 1, which is predominantly associated with indicators of natural resistance, and PC2, which is associated with metabolism indicators. The research results show that in order to increase the efficiency of formation of post-vaccination immunity in piglets, it is necessary to combine vaccination with hepatoprotective drugs

Iconics in the training of engineers as an innovative component

The paper proposes the inclusion in the educational process of training engineers discipline «iconics» as a visual modeling courseВ статье предлагается включение в образовательные процессы подготовки инженеров дисциплины «Иконика» в качестве визуально-моделирующего курс