On the structure and evolution of planets and their host stars −- effects of various heating mechanisms on the size of giant gas planets

It is already stated in the previous studies that the radius of the giant planets is affected by stellar irradiation. The confirmed relation between radius and incident flux depends on planetary mass intervals. In this study, we show that there is a single relation between radius and irradiated energy per gram per second ($l_-$), for all mass intervals. There is an extra increase in radius of planets if $l_-$ is higher than 1100 times energy received by the Earth ($l_\oplus$). This is likely due to dissociation of molecules. The tidal interaction as a heating mechanism is also considered and found that its maximum effect on the inflation of planets is about 15 per cent. We also compute age and heavy element abundances from the properties of host stars, given in the TEPCat catalogue (Southworth 2011). The metallicity given in the literature is as [Fe/H]. However, the most abundant element is oxygen, and there is a reverse relation between the observed abundances [Fe/H] and [O/Fe]. Therefore, we first compute [O/H] from [Fe/H] by using observed abundances, and then find heavy element abundance from [O/H]. We also develop a new method for age determination. Using the ages we find, we analyse variation of both radius and mass of the planets with respect to time, and estimate the initial mass of the planets from the relation we derive for the first time. According to our results, the highly irradiated gas giants lose 5 per cent of their mass in every 1 Gyr.Comment: 15 pages, 13 figures, 3 tables. Accepted by MNRA

Shapiro and parametric resonances in coupled Josephson junctions

The effect of microwave irradiation on the phase dynamics of intrinsic Josephson junctions in high temperature superconductors is investigated. We compare the current-voltage characteristics for a stack of coupled Josephson junctions under external irradiation calculated in the framework of CCJJ and CCJJ+DC models.Comment: 4 pages, Manuscript for Dubna-Nano 2012, submitted for Journal of Physics:Conference Serie

Investigating the biological properties of carbohydrate derived fulvic acid (CHD-FA) as a potential novel therapy for the management of oral biofilm infections.

Background: A number of oral diseases, including periodontitis, derive from microbial biofilms and are associated with increased antimicrobial resistance. Despite the widespread use of mouthwashes being used as adjunctive measures to control these biofilms, their prolonged use is not recommended due to various side effects. Therefore, alternative broad-spectrum antimicrobials that minimise these effects are highly sought after. Carbohydrate derived fulvic acid (CHD-FA) is an organic acid which has previously demonstrated to be microbiocidal against Candida albicans biofilms, therefore, the aims of this study were to evaluate the antibacterial activity of CHD-FA against orally derived biofilms and to investigate adjunctive biological effects.<p></p> Methods: Minimum inhibitory concentrations were evaluated for CHD-FA and chlorhexidine (CHX) against a range of oral bacteria using standardised microdilution testing for planktonic and sessile. Scanning electron microscopy was also employed to visualise changes in oral biofilms after antimicrobial treatment. Cytotoxicity of these compounds was assessed against oral epithelial cells, and the effect of CHD-FA on host inflammatory markers was assessed by measuring mRNA and protein expression.<p></p> Results: CHD-FA was highly active against all of the oral bacteria tested, including Porphyromonas gingivalis, with a sessile minimum inhibitory concentration of 0.5%. This concentration was shown to kill multi-species biofilms by approximately 90%, levels comparable to that of chlorhexidine (CHX). In a mammalian cell culture model, pretreatment of epithelial cells with buffered CHD-FA was shown to significantly down-regulate key inflammatory mediators, including interleukin-8 (IL-8), after stimulation with a multi-species biofilm.<p></p> Conclusions: Overall, CHD-FA was shown to possess broad-spectrum antibacterial activity, with a supplementary function of being able to down-regulate inflammation. These properties offer an attractive spectrum of function from a naturally derived compound, which could be used as an alternative topical treatment strategy for oral biofilm diseases. Further studies in vitro and in vivo are required to determine the precise mechanism by which CHD-FA modulates the host immune response.<p></p&gt

First Observation of PP-odd γ\gamma Asymmetry in Polarized Neutron Capture on Hydrogen

We report the first observation of the parity-violating 2.2 MeV gamma-ray asymmetry $A^{np}_\gamma$ in neutron-proton capture using polarized cold neutrons incident on a liquid parahydrogen target at the Spallation Neutron Source at Oak Ridge National Laboratory. $A^{np}_\gamma$ isolates the $\Delta I=1$, \mbox{$^{3}S_{1}\rightarrow {^{3}P_{1}}$} component of the weak nucleon-nucleon interaction, which is dominated by pion exchange and can be directly related to a single coupling constant in either the DDH meson exchange model or pionless EFT. We measured $A^{np}_\gamma = [-3.0 \pm 1.4 (stat) \pm 0.2 (sys)]\times 10^{-8}$, which implies a DDH weak $\pi NN$ coupling of $h_{\pi}^{1} = [2.6 \pm 1.2(stat) \pm 0.2(sys)] \times 10^{-7}$ and a pionless EFT constant of $C^{^{3}S_{1}\rightarrow ^{3}P_{1}}/C_{0}=[-7.4 \pm 3.5 (stat) \pm 0.5 (sys)] \times 10^{-11}$ MeV$^{-1}$. We describe the experiment, data analysis, systematic uncertainties, and the implications of the result.Comment: 6 pages, 5 figure

Manifestation of Resonance-Related Chaos in Coupled Josephson Junctions

Chaotic features of systems of coupled Josephson junctions are studied. Manifestation of chaos in the temporal dependence of the electric charge, related to a parametric resonance, is demonstrated through the calculation of the maximal Lyapunov exponent, phase-charge and charge-charge Lissajous diagrams and correlation functions. The number of junctions in the stack strongly influences the fine structure in the current voltage characteristics and a strong proximity effect results from the nonperiodic boundary conditions. The observed resonance-related chaos exhibits intermittency over a range of conditions and parameters. General features of the system are analyzed by means of a linearized equation and the criteria for a breakpoint region with no chaos are obtained. Such criteria could clarify recent experimental observations of variations in the power output from intrinsic Josephson junctions in high temperature superconductors.Comment: 13 pages, 16 figure

Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease

Cataloged from PDF version of article.Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. © 2013 Elsevier B.V

Development of an in vitro periodontal biofilm model for assessing antimicrobial and host modulatory effects of bioactive molecules

Background: Inflammation within the oral cavity occurs due to dysregulation between microbial biofilms and the host response. Understanding how different oral hygiene products influence inflammatory properties is important for the development of new products. Therefore, creation of a robust host-pathogen biofilm platform capable of evaluating novel oral healthcare compounds is an attractive option. We therefore devised a multi-species biofilm co-culture model to evaluate the naturally derived polyphenol resveratrol (RSV) and gold standard chlorhexidine (CHX) with respect to anti-biofilm and anti-inflammatory properties.<p></p> Methods: An in vitro multi-species biofilm containing <i>S. mitis, F. nucleatum, P. Gingivalis</i> and <i>A. Actinomycetemcomitans</i> was created to represent a disease-associated biofilm and the oral epithelial cell in OKF6-TERT2. Cytotoxicity studies were performed using RSV and CHX. Multi-species biofilms were either treated with either molecule, or alternatively epithelial cells were treated with these prior to biofilm co-culture. Biofilm composition was evaluated and inflammatory responses quantified at a transcriptional and protein level.<p></p> Results: CHX was toxic to epithelial cells and multi-species biofilms at concentrations ranging from 0.01-0.2%. RSV did not effect multi-species biofilm composition, but was toxic to epithelial cells at concentrations greater than 0.01%. In co-culture, CHX-treated biofilms resulted in down regulation of the inflammatory chemokine IL-8 at both mRNA and protein level. RSV-treated epithelial cells in co-culture were down-regulated in the release of IL-8 protein, but not mRNA.<p></p> Conclusions: CHX possesses potent bactericidal properties, which may impact downstream inflammatory mediators. RSV does not appear to have bactericidal properties against multi-species biofilms, however it did appear to supress epithelial cells from releasing inflammatory mediators. This study demonstrates the potential to understand the mechanisms by which different oral hygiene products may influence gingival inflammation, thereby validating the use of a biofilm co-culture model.<p></p&gt

Powder Compaction: Compression Properties of Cellulose Ethers

Effective development of matrix tablets requires a comprehensive understanding of different raw material attributes and their impact on process parameters. Cellulose ethers (CE) are the most commonly used pharmaceutical excipients in the fabrication of hydrophilic matrices. The innate good compression and binding properties of CE enable matrices to be prepared using economical direct compression (DC) techniques. However, DC is sensitive to raw material attributes, thus, impacting the compaction process. This article critically reviews prior knowledge on the mechanism of powder compaction and the compression properties of cellulose ethers, giving timely insight into new developments in this field

Electrospun Oxygen Scavenging Films of Poly(3-hydroxybutyrate) Containing Palladium Nanoparticles for Active Packaging Applications

[EN] This paper reports on the development and characterization of oxygen scavenging films made of poly(3-hydroxybutyrate) (PHB) containing palladium nanoparticles (PdNPs) prepared by electrospinning followed by annealing treatment at 160 degrees C. The PdNPs were modified with the intention to optimize their dispersion and distribution in PHB by means of two different surfactants permitted for food contact applications, i.e., hexadecyltrimethylammonium bromide (CTAB) and tetraethyl orthosilicate (TEOS). Analysis of the morphology and characterization of the chemical, thermal, mechanical, and water and limonene vapor barrier properties and the oxygen scavenging capacity of the various PHB materials were carried out. From the results, it was seen that a better dispersion and distribution was obtained using CTAB as the dispersing aid. As a result, the PHB/PdNP nanocomposites containing CTAB provided also the best oxygen scavenging performance. These films offer a significant potential as new active coating or interlayer systems for application in the design of novel active food packaging structures.This research has received funding from the Spanish Ministry of Economy and Competitiveness (MINECO, project AGL2015-63855-C2-1-R) and the EU H2020 project YPACK (reference number 773872). A.C. and S.T.-G. would like to thank the Brazilian Council for Scientific and Technological Development (CNPq) and MINECO for her predoctoral grant (205955/2014-2) and his Juan de la Cierva contract (IJCI-2016-29675), respectively.Cherpinski, A.; Gozutok, M.; Turkoglu Sasmazel, H.; Torres-Giner, S.; Lagaron, JM. (2018). Electrospun Oxygen Scavenging Films of Poly(3-hydroxybutyrate) Containing Palladium Nanoparticles for Active Packaging Applications. Nanomaterials. 8(7):1-19. https://doi.org/10.3390/nano8070469S11987Puglia, D., Fortunati, E., D’Amico, D. A., Manfredi, L. B., Cyras, V. P., & Kenny, J. M. (2014). 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Determination and evaluation of some physicochernical parameters in the Dardanelles (Canakkale Strait, Turkey) using multiple probe system and geographic information system

The Dardanelles (Canakkale Strait) is a water passage connecting the Aegean Sea and Sea of Marmara. The average depth of the Dardanelles is 60 m; the deepest part reaches more than 100 m. Environmental parameters such as temperature, pH, salinity, dissolved oxygen and total dissolved solids were measured at different depths in the Dardanelles. The sampling period was between December 2002 and March 2003. All the data was measured by a YSI 6600 Model Multiple Probe System. Also, a Geographic Information System was used to create a tabular and spatial database, with the aim of integrating the physicochemical properties in the Dardanelles. Temperature and salinity profiles by the Geographic Information System showed that there was stratification and formation of two different water masses in the Dardanelles. The measurements showed that lower layer waters (> 20 m) are saltier than upper layer waters of the Dardanelles. Therefore, the lower layer waters also hold higher values for total dissolved solids. Although the temperature and salinity characteristics of the Dardanelles are specific due to its topographic structure and some fresh water discharges, the stratification in the Dardanelles is generally similar to other parts of the Turkish Strait System (Bosphorus and Sea of Marmara) because of large salinity differences between the Aegean and Black Sea