Необходимость проведения микционной цистоуретрографии для оценки взрослых кандидатов на трансплантацию почки

Objective. While international guidelines necessitate Voiding Cystourethrogram (VCUG) for pediatric patients, it is unnecessary for the evaluation of adult patients without urological disorders as renal transplant candidates. The objective of this study was to evaluate the results of adult candidates who underwent VCUG before transplantation and to demonstrate the necessity for this imaging. Methods. A retrospective study of the data of 1265 adult candidates who underwent VCUG before transplantation at our center, was undertaken. VUR, the presence of Postvoiding residual urine (PVR) (>100 ml), Low bladder capacity (LBC) (<100 ml), and urethral pathologies were evaluated with VCUG. Results. The mean age was 42.3 ± 1.3. The mean dialysis period was 27.8 ± 4.2 months. According to the VCUG results, 19.2% of the patients had pathological findings. On the other hand, the rate of urological disorders was only 5.1%, according to end-stage renal disease (ESRD) etiologies. VCUG outcomes indicated bilateral high-grade reflux in native kidneys in 4.4% (n = 56) of the candidates, unilateral high-grade reflux in 4.1% (n = 52), bilateral low grade reflux in 2.1% (n = 26), unilateral low-grade reflux in 2.4% (n = 30), and reflux in rejected transplanted kidney in 2.3% (n = 29). In addition, significant LBC was noted in 4.8% (n = 61), significant PVR in 1.1% (n = 14), and urethral stricture in 0.5% (n = 6) of the candidates. Conclusion. VCUG should be considered as a part of routine evaluation in adult renal transplant recipient candidates as well as in pediatric candidates, even if their ESRD etiologies are not due to urological disorders.В то время как во всех международных протоколах при подготовке к трансплантации почки в педиатрической практике потенциальным реципиентам предписано обязательно проводить микционную цисто уретрографию (МЦУГ), нет никаких указаний относительно этого перед проведением трансплантации почки взрослым пациентам без урологических нарушений. Цель: оценить результативность МЦУГ, проведенной перед трансплантацией взрослым пациентам, и необходимость использования этого метода визуализации перед операцией. Материалы и методы. Было проведено ретроспективное исследова ние данных 1265 взрослых реципиентов почки, которым выполняли МЦУГ перед трансплантацией в нашем центре. С помощью МЦУГ оценивали наличие и степень пузырно-мочеточникового рефлюкса (ПМР), остаточный объем мочи после мочеиспускания (PVR) (>100 мл), емкость мочевого пузыря (низ кая емкость мочевого пузыря <100 мл) и патологию мочеиспускательного канала. Результаты. Средний возраст пациентов составил 42,3 ± 1,3 года. В среднем пациенты находились на диализе 27,8 ± 4,2 ме сяца. По результатам МЦУГ у 19,2% пациентов были обнаружены патологические изменения. С другой стороны, урологические нарушения были причиной терминальной почечной недостаточности (ТПН) всего в 5,1% случаев. По результатам МЦУГ были выявлены двусторонний ПМР тяжелой степени в нативных почках у 4,4% (n = 56) потенциальных реципиентов, односторонний ПМР тяжелой степени – у 4,1% (n = 52), двусторонний ПМР легкой степени – в 2,1% (n = 26), односторонний ПМР легкой степени тяжести – у 2,4% (n = 30) и рефлюкс в трансплантат почки при его отторжении – у 2,3% (n = 29). Кроме того, обнаружено значительное снижение емкости мочевого пузыря у 4,8% (n = 61), значительное сниже ние PVR – у 1,1% (n = 14) и стриктура уретры – у 0,5% (n = 6) потенциальных реципиентов. Заключение. Следует рассмотреть целесообразность включения в повседневную клиническую практику МЦУГ для оценки функционального состояния мочевыводящих путей взрослых потенциальных реципиентов перед трансплантацией почки, а также реципиентов-детей, даже если ТПН не обусловлена урологическими заболеваниями

A Novel Multimodal Biometric Authentication System Using Machine Learning and Blockchain

Secure user authentication has become an important issue in modern society as in many consumer applications, especially financial transactions, it is extremely important to prove the identity of the user. In this context, biometric authentication methods that rely on physical and behavioural characteristics have been proposed as an alternative for convolutional systems that rely on simple passwords, Personal Identification Number or tokens. However, in real-world applications, authentication systems that involve a single biometric faced many issues, especially lack accuracy and noisy data, which boost the research community to create multibiometric systems that involve a variety of biometrics. Those systems provide better performance and higher accuracy compared to other authentication methods. However, most of them are inconvenient and requires complex interactions from the user. Thus, in this paper, we present a multimodal authentication system that relies on machine learning and blockchain, intending to provide a more reliable, transparent, and convenient authentication mechanism. The proposed system combines tow important biometrics: fingerprint and face with age, and gender features. The supervised learning algorithm Decision Tree has been used to combine the results of the biometrics verification process and produce a confidence level related to the user. The initial experimental results show the efficiency and robustness of the proposed systems

The necessity of voiding cystourethrogram for the evaluation of recipient candidates in adult renal transplantation

Objective. While international guidelines necessitate Voiding Cystourethrogram (VCUG) for pediatric patients, it is unnecessary for the evaluation of adult patients without urological disorders as renal transplant candidates. The objective of this study was to evaluate the results of adult candidates who underwent VCUG before transplantation and to demonstrate the necessity for this imaging. Methods. A retrospective study of the data of 1265 adult candidates who underwent VCUG before transplantation at our center, was undertaken. VUR, the presence of Postvoiding residual urine (PVR) (>100 ml), Low bladder capacity (LBC) (<100 ml), and urethral pathologies were evaluated with VCUG. Results. The mean age was 42.3 ± 1.3. The mean dialysis period was 27.8 ± 4.2 months. According to the VCUG results, 19.2% of the patients had pathological findings. On the other hand, the rate of urological disorders was only 5.1%, according to end-stage renal disease (ESRD) etiologies. VCUG outcomes indicated bilateral high-grade reflux in native kidneys in 4.4% (n = 56) of the candidates, unilateral high-grade reflux in 4.1% (n = 52), bilateral low grade reflux in 2.1% (n = 26), unilateral low-grade reflux in 2.4% (n = 30), and reflux in rejected transplanted kidney in 2.3% (n = 29). In addition, significant LBC was noted in 4.8% (n = 61), significant PVR in 1.1% (n = 14), and urethral stricture in 0.5% (n = 6) of the candidates. Conclusion. VCUG should be considered as a part of routine evaluation in adult renal transplant recipient candidates as well as in pediatric candidates, even if their ESRD etiologies are not due to urological disorders

Evaluation of the optimal sampling approach for HPV genotyping in circumcised heterosexual men with genital warts

Background: Human papillomavirus (HPV) causes a serious socioeconomic burden globally. However, there is currently no consensus on the optimal sampling method for HPVDNA genotyping in circumcised heterosexual men. This study aimed to determine the diagnostic efficacy of 6 different anatomic sampling sites in HPV DNA polymerase chain reaction (PCR) testing of circumcised heterosexual men with genital warts. Methods: The study included circumcised heterosexual men who presented to our clinic with complaints of genital warts. Swab samples were obtained from the penile shaft (PS), scrotum, coronal sulcus (CS), and external urethral meatus (EUM). First-void urine (FVU) and genital wart biopsy (GWB) were also tested for HPV DNA by PCR. Results: A total of 32 patients (mean age: 36.9 ± 6.9 years) were included. None of the six samples studied was sufficient on its own to reveal all HPV types detected in a patient. When the samples were analyzed individually, GWB detected an average of 49.5% of total HPV types in a patient. This rate was 50.5% for PS, 40.4% for CS, 31.6% for scrotum, 26.3% for EUM, and 15.8% for FVU samples. The detection rate increased to 75.8% with combined testing of GWB and PS samples, 83.2% with GWB/PS/CS, 90.5% with GWB/PS/CS/scrotum, and 98.9% with GWB/PS/CS/scrotum/EUM samples. Conclusion: No single anatomic region or sample type can detect all HPV types present in circumcised heterosexual men by PCR assay. The detection rate approaches 99% when wart biopsy is combined with swab sampling of the penile shaft, coronal sulcus, scrotum, and external urethral meatus. © 2023 Japanese Society of Chemotherapy and The Japanese Association for Infectious Disease

Studies on shading system in sweet cherries (Prunus avium L.) to prevent double fruit formation under subtropical climatic conditions

In this study, the performances of cherries grown under subtropical conditions and the effects of shading systems on the prevention of double fruit formation were investigated. The experiments were carried out at Pozmer Agricultural Research and Application Center in Adana (50 m a.s.l.) during 2006-2008. 'Na-1', 'Early Van Compact', 'Bing Spur', 'Lapins' and 'Cristobalina' cherry cultivars fruited earlier and had good yielding, however double fruiting especially in 'Na-1' cherry cultivar seemed to be a serious problem under warm climatic conditions. The shading system was applied to reduce the high temperature affect to double fruit formation. Shading system with 55% of light transmission reduced air temperature about 1.9-3.1°C compared to the full exposure. As a result of temperature reduction, double pistil formation was also reduced to 60.89 and 27.81%. The temperatures over 30°C affected the promotion of double fruit formation during the physiological bud differentiation period at the beginning of June while morphological differentiation period of cherries will be initiated on 20th June and continued until the end of July to the beginning of August

Preparation of magnetite nanoparticle and fatty acid incorporated poly(methacrylic acid-ethyl acrylate) nanowebs via electrospinning for magnetic hyperthermia application

Magnetic hyperthermia has been arising as a promising approach for treatment of cancer. When magnetic nanoparticles (MNPs) are locally injected through cancerous tissues and subjected to an appropriate alternating magnetic field, they generate heat due to the rotation of the nanomagnets, causing the destruction of the cancer cells. For repeated applications of magnetic hyperthermia, it is highly preferred to keep the temperature constant at about 41-46 degrees C while preventing the leakage of MNPs, to minimize secondary effects on surrounding healthy tissues. In our study, we produced novel nanowebs provided with magnetic and thermal buffering properties by encapsulating MNPs and Lauric Acid in poly(methyl ethyl acrylate) matrix via uniaxial electrospinning. For the oleic acid functionalized magnetic nanoparticles, the magnetization for the corresponding nanowebs is higher by a factor of two for all concentrations than the ones with non-functionalized magnetic nanoparticles, indicating a more effective integration of the functionalized nanoparticles through the nanoweb. The heat absorption and release capacities of the nanowebs, incorporated with 1.25-2.50 % functionalized MNPs, vary between 70-75 Jg(-1) at 40-48 degrees C. They also demonstrate thermal cycling ability and thermal stability