A new development cycle of the Statistical Toolkit

The Statistical Toolkit is an open source system specialized in the statistical comparison of distributions. It addresses requirements common to different experimental domains, such as simulation validation (e.g. comparison of experimental and simulated distributions), regression testing in the course of the software development process, and detector performance monitoring. Various sets of statistical tests have been added to the existing collection to deal with the one sample problem (i.e. the comparison of a data distribution to a function, including tests for normality, categorical analysis and the estimate of randomness). Improved algorithms and software design contribute to the robustness of the results. A simple user layer dealing with primitive data types facilitates the use of the toolkit both in standalone analyses and in large scale experiments.Comment: To be published in the Proc. of CHEP (Computing in High Energy Physics) 201

Herwig++ 2.0 Release Note

A new release of the Monte Carlo program Herwig++ (version 2.0) is now available. This is the first version of the program which can be used for hadron-hadron physics and includes the full simulation of both initial- and final-state QCD radiation.Comment: Source code and additional information available at http://hepforge.cedar.ac.uk/herwig

Molecular Phylogentic Analysis of Marine Polychaeta and Crassostrea rivularis

底栖生物在海洋生态系统中起着极其重要的作用，部分底栖生物也是重要的海洋经济物种。同时因为海洋底栖动物活动性小、地区性强，可以较好地反映水质和地质的污染状况，在海洋污染生物学指标中具有特别重要的意义。因此对底栖生物进行正确的分类和系统发育学研究是十分必要的。过去对底栖生物的分类主要根据形态来划分，但是随着科学的发展传统形态学越来越遇到一些难以克服的障碍，如趋同进化的问题。另外用形态特征定义一个分类阶元，就必须对标本的完整性、性别、生长阶段有严格的要求,因此对于一些特殊条件下取得的很难保持完整的形态的标本来说，进行形态学的鉴定尤其困难。现代分子生物学的发展。使我们可以利用核酸、蛋白质等生物大分子的...Marine benthos play a very important role in the ecology of marine environment. Lots of the animals are also important economic marine species. Meanwhile, because they are characterized as narrow active and special territory distribution, they can be used to indicate the quality of water and the polluted condition of sediments, which is an important part of the biologic indication of marine pollut...学位：理学硕士院系专业：生命科学学院生物学系_生物化学与分子生物学学号：20012605

Medicare for all

OBJECTIVES: Interferon (IFN) alpha is a key immunoregulatory cytokine secreted by activated plasmacytoid dendritic cells (PDC) that constitute less than 1% of leucocytes. IFNalpha plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Nevertheless, the natural IFNalpha inducers in SLE as well as the different IFNalpha secreting cell types are only partially characterised. METHODS: Chromatin was purified from calf thymus. Human peripheral blood mononuclear cells (PBMC), neutrophils and mouse bone marrow neutrophils were purified and cultured with different stimuli. IFNalpha production was estimated by flow cytometry, ELISA and a bioassay, and gene expression by quantitative real time PCR. Neutrophil activation and NETosis were analysed by flow cytometry, ELISA and confocal microscopy. RESULTS: Neutrophils produced a bioactive IFNalpha on stimulation with purified chromatin. IFNalpha secretion was observed with steady state neutrophils purified from 56 independent healthy individuals and autoimmune patients in response to free chromatin and not chromatin containing immune complexes. Chromatin induced IFNalpha secretion occurred independently of Toll-like receptor 9 (TLR9). Neutrophil priming by granulocyte-colony stimulating factor, granulocyte macrophage-colony stimulating factor or IFNalpha was not necessary but PBMC sustained IFNalpha secretion by neutrophils. PDC were 27 times more efficient than neutrophils but blood neutrophils were 100 times more frequent than PDC. Finally, neutrophil activation by chromatin was associated with NETosis and DNA sensor upregulation. CONCLUSIONS: Neutrophils have the capability of producing IFNalpha on selective triggering, and we identified a natural lupus stimulus involved, unveiling a new mechanism involved in SLE. Neutrophils represent another important source of IFNalpha and important targets for future therapies aimed at influencing IFNalpha levels

Gel mobility shift scanning of pectin-inducible promoter from Penicillium griseoroseum reveals the involvement of a CCAAT element in the expression of a polygalacturonase gene

Previous reports have described pgg2, a polygalacturonase-encoding gene of Penicillium griseoroseum, as an attractive model for transcriptional regulation studies, due to its high expression throughout several in vitro growth conditions, even in the presence of non-inducing sugars such as sucrose. A search for regulatory motifs in the 5' upstream regulatory sequence of pgg2 identified a putative CCAAT box that could justify this expression profile. This element, located 270 bp upstream of the translational start codon, was tested as binding target for regulatory proteins. Analysis of a 170 bp promoter fragment by electrophoretic mobility shift assay (EMSA) with nuclear extracts prepared from mycelia grown in pectin-containing culture medium revealed a high mobility complex that was subsequently confirmed by analyzing it with a double-stranded oligonucleotide spanning the CCAAT motif. A substitution in the core sequence for GTAGG partially abolished the formation of specific complexes, showing the involvement of the CCAAT box in the regulation of the polygalacturonase gene studied

Design of an electronic voting system using A blockchain network

Design of a scalable electronic voting system, which, based on a generic model designed for this application called voting cell, guarantees the integrity of the information through the use of a private network Blockchain. For the validation of the system, the implementation of a cell was carried out, for which fifty voters and three voting options were enabled. The stored data was intentionally modified to corroborate the error correction method used by the block chain networks and thus ensure the integrity of the voting system results

Heavy Flavours in Collider Experiments

Current issues in the studies of Heavy Flavours in colliders are described with particular emphasis on experiments in which the UK is involved. Results on charm production at HERA are examined and compared to those at the Tevatron. B production rates at the Tevatron as well as the status of B lifetimes and mixing in the LEP collaborations and at the Tevatron are highlighted. The measurement of sin2beta from CDF is described as well as the most recent results on top physics at the Tevatron

GeantV: Results from the prototype of concurrent vector particle transport simulation in HEP

Full detector simulation was among the largest CPU consumer in all CERN experiment software stacks for the first two runs of the Large Hadron Collider (LHC). In the early 2010's, the projections were that simulation demands would scale linearly with luminosity increase, compensated only partially by an increase of computing resources. The extension of fast simulation approaches to more use cases, covering a larger fraction of the simulation budget, is only part of the solution due to intrinsic precision limitations. The remainder corresponds to speeding-up the simulation software by several factors, which is out of reach using simple optimizations on the current code base. In this context, the GeantV R&D project was launched, aiming to redesign the legacy particle transport codes in order to make them benefit from fine-grained parallelism features such as vectorization, but also from increased code and data locality. This paper presents extensively the results and achievements of this R&D, as well as the conclusions and lessons learnt from the beta prototype.Comment: 34 pages, 26 figures, 24 table

CAP interacts with cytoskeletal proteins and regulates adhesion‐mediated ERK activation and motility

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102140/1/emboj7601406-sup-0001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102140/2/emboj7601406.pd

Offloading electromagnetic shower transport to GPUs

Making general particle transport simulation for high-energy physics (HEP) single-instruction-multiple-thread (SIMT) friendly, to take advantage of accelerator hardware, is an important alternative for boosting the throughput of simulation applications. To date, this challenge is not yet resolved, due to difficulties in mapping the complexity of Geant4 components and workflow to the massive parallelism features exposed by graphics processing units (GPU). The AdePT project is one of the R\&D initiatives tackling this limitation and exploring GPUs as potential accelerators for offloading some part of the CPU simulation workload. Our main target is to implement a complete electromagnetic shower demonstrator working on the GPU. The project is the first to create a full prototype of a realistic electron, positron, and gamma electromagnetic shower simulation on GPU, implemented as either a standalone application or as an extension of the standard Geant4 CPU workflow. Our prototype currently provides a platform to explore many optimisations and different approaches. We present the most recent results and initial conclusions of our work, using both a standalone GPU performance analysis and a first implementation of a hybrid workflow based on Geant4 on the CPU and AdePT on the GPU.Comment: 8 pages, 4 figures, 20th International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT 2021), to be published in Journal of Physics: Conference Series, editor Andrei Gheat