From a master to a laywoman : a feminine manual of self-help

This article analyzes master Joan's Tròtula, a late fourteenth-century Catalan text on women's health addressed to an infanta of Aragon which survives in one late fourteenth-century manuscript. It presents a hypothesis regarding its genre, its composition and use at the Catalan-Aragonese Court, and its later fortuna. It considers how Master Joan inscribed in the text a conception of women's medical needs, while also defininglay women's involvement in maintaining their health

Reseñas

Esther RUBIO HERRÁEZ ; Mileva EINSTEIN-MARIC, ¿Por qué en la sombra

Poder académico versus autoridad femenina : la Facultad de Medicina de París contra Jacoba Félicié (1322 )

Este artículo analiza el juicio que la Facultad de Medicina de París incoó contra Jacoba Félicié en 1322. Partiendo de las narrativas de sus pacientes, intenta interpretar la práctica médica de Jacoba y la naturaleza específica de la relación establecida con sus pacientes. Para identificar y describir esta relación, utilizamos una distinción básica entre poder y autoridad

A faint companion around CrA-9: protoplanet or obscured binary?

Understanding how giant planets form requires observational input from directly imaged protoplanets. We used VLT/NACO and VLT/SPHERE to search for companions in the transition disc of 2MASS J19005804-3645048 (hereafter CrA-9), an accreting M0.75 dwarf with an estimated age of 1-2 Myr. We found a faint point source at $\sim$0.7'' separation from CrA-9 ($\sim$108 au projected separation). Our 3-epoch astrometry rejects a fixed background star with a $5\sigma$ significance. The near-IR absolute magnitudes of the object point towards a planetary-mass companion. However, our analysis of the 1.0-3.8$\mu$m spectrum extracted for the companion suggests it is a young M5.5 dwarf, based on both the 1.13-$\mu$m Na index and comparison with templates of the Montreal Spectral Library. The observed spectrum is best reproduced with high effective temperature ($3057^{+119}_{-36}$K) BT-DUSTY and BT-SETTL models, but the corresponding photometric radius required to match the measured flux is only $0.60^{+0.01}_{-0.04}$ Jovian radius. We discuss possible explanations to reconcile our measurements, including an M-dwarf companion obscured by an edge-on circum-secondary disc or the shock-heated part of the photosphere of an accreting protoplanet. Follow-up observations covering a larger wavelength range and/or at finer spectral resolution are required to discriminate these two scenarios.Comment: 24 pages, 14 figures, 4 tables, to be published in MNRA

Crystallization and Preliminary Analysis of Crystals of the 24-Meric Hemocyanin of the Emperor Scorpion (Pandinus imperator)

Hemocyanins are giant oxygen transport proteins found in the hemolymph of several invertebrate phyla. They constitute giant multimeric molecules whose size range up to that of cell organelles such as ribosomes or even small viruses. Oxygen is reversibly bound by hemocyanins at binuclear copper centers. Subunit interactions within the multisubunit hemocyanin complex lead to diverse allosteric effects such as the highest cooperativity for oxygen binding found in nature. Crystal structures of a native hemocyanin oligomer larger than a hexameric substructure have not been published until now. We report for the first time growth and preliminary analysis of crystals of the 24-meric hemocyanin (MW = 1.8 MDa) of emperor scorpion (Pandinus imperator), which diffract to a resolution of 6.5 Å. The crystals are monoclinc with space group C 1 2 1 and cell dimensions a = 311.61 Å, b = 246.58 Å and c = 251.10 Å (α = 90.00°, β = 90.02°, γ = 90.00°). The asymmetric unit contains one molecule of the 24-meric hemocyanin and the solvent content of the crystals is 56%. A preliminary analysis of the hemocyanin structure reveals that emperor scorpion hemocyanin crystallizes in the same oxygenated conformation, which is also present in solution as previously shown by cryo-EM reconstruction and small angle x-ray scattering experiments

Viscum album Exerts Anti-Inflammatory Effect by Selectively Inhibiting Cytokine-Induced Expression of Cyclooxygenase-2

Viscum album (VA) preparations are extensively used as complementary therapy in cancer and are shown to exert anti-tumor activities which involve the cytotoxic properties, induction of apoptosis, inhibition of angiogenesis and several other immunomodulatory mechanisms. In addition to their application in cancer therapy, VA preparations have also been successfully utilized in the treatment of several inflammatory pathologies. Owing to the intricate association of inflammation and cancer and in view of the fact that several anti-tumor phytotherapeutics also exert a potent anti-inflammatory effect, we hypothesized that VA exerts an anti-inflammatory effect that is responsible for its therapeutic benefit. Since, inflammatory cytokine-induced cyclo-oxygenase-2 (COX-2) and prostaglandin E2 (PGE2) play a critical role in the pathogenesis of inflammatory diseases, we investigated the anti-inflammatory effect of VA on regulation of cyclo-oxygenase expression and PGE2 biosynthesis by using human lung adenocarcinoma cells (A549 cells) as a model. A549 cells were stimulated with IL-1β and treated with VA preparation (VA Qu Spez) for 18 hours. PGE2 was analysed in the culture supernatants by enzyme immunoassay. Expression of COX-2 and COX-1 proteins was analyzed by immunoblotting and the expression of COX-2 mRNA was assessed by semi-quantitative RT-PCR. We found that VA Qu Spez inhibit the secretion of IL-1β-induced PGE2 in a dose-dependent manner. Further, we also show that this inhibitory action was associated with a reduced expression of COX-2 without modulating the COX-1 expression. Together these results demonstrate a novel anti-inflammatory mechanism of action of VA preparations wherein VA exerts an anti-inflammatory effect by inhibiting cytokine-induced PGE2 via selective inhibition of COX-2