372 research outputs found
Major adverse kidney events in pediatric continuous kidney replacement therapy
IMPORTANCE: Continuous kidney replacement therapy (CKRT) is increasingly used in youths with critical illness, but little is known about longer-term outcomes, such as persistent kidney dysfunction, continued need for dialysis, or death.
OBJECTIVE: To characterize the incidence and risk factors, including liberation patterns, associated with major adverse kidney events 90 days after CKRT initiation (MAKE-90) in children, adolescents, and young adults.
DESIGN, SETTING, AND PARTICIPANTS: This international, multicenter cohort study was conducted among patients aged 0 to 25 years from The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) registry treated with CKRT for acute kidney injury or fluid overload from 2015 to 2021. Exclusion criteria were dialysis dependence, concurrent extracorporeal membrane oxygenation use, or receipt of CKRT for a different indication. Data were analyzed from May 2 to December 14, 2023.
EXPOSURE: Patient clinical characteristics and CKRT parameters were assessed. CKRT liberation was classified as successful, reinstituted, or not attempted. Successful liberation was defined as the first attempt at CKRT liberation resulting in 72 hours or more without return to dialysis within 28 days of CKRT initiation.
MAIN OUTCOMES AND MEASURES: MAKE-90, including death or persistent kidney dysfunction (dialysis dependence or ≥25% decline in estimated glomerular filtration rate from baseline), were assessed.
RESULTS: Among 969 patients treated with CKRT (529 males [54.6%]; median [IQR] age, 8.8 [1.7-15.0] years), 630 patients (65.0%) developed MAKE-90. On multivariable analysis, cardiac comorbidity (adjusted odds ratio [aOR], 1.60; 95% CI, 1.08-2.37), longer duration of intensive care unit admission before CKRT initiation (aOR for 6 days vs 1 day, 1.07; 95% CI, 1.02-1.13), and liberation pattern were associated with MAKE-90. In this analysis, patients who successfully liberated from CKRT within 28 days had lower odds of MAKE-90 compared with patients in whom liberation was attempted and failed (aOR, 0.32; 95% CI, 0.22-0.48) and patients without a liberation attempt (aOR, 0.02; 95% CI, 0.01-0.04).
CONCLUSIONS AND RELEVANCE: In this study, MAKE-90 occurred in almost two-thirds of the population and patient-level risk factors associated with MAKE-90 included cardiac comorbidity, time to CKRT initiation, and liberation patterns. These findings highlight the high incidence of adverse outcomes in this population and suggest that future prospective studies are needed to better understand liberation patterns and practices
Consensus-based recommendations on priority activities to address acute kidney injury in children: A modified Delphi consensus statement
Importance: Increasing evidence indicates that acute kidney injury (AKI) occurs frequently in children and young adults and is associated with poor short-term and long-term outcomes. Guidance is required to focus efforts related to expansion of pediatric AKI knowledge.
Objective: To develop expert-driven pediatric specific recommendations on needed AKI research, education, practice, and advocacy.
Evidence Review: At the 26th Acute Disease Quality Initiative meeting conducted in November 2021 by 47 multiprofessional international experts in general pediatrics, nephrology, and critical care, the panel focused on 6 areas: (1) epidemiology; (2) diagnostics; (3) fluid overload; (4) kidney support therapies; (5) biology, pharmacology, and nutrition; and (6) education and advocacy. An objective scientific review and distillation of literature through September 2021 was performed of (1) epidemiology, (2) risk assessment and diagnosis, (3) fluid assessment, (4) kidney support and extracorporeal therapies, (5) pathobiology, nutrition, and pharmacology, and (6) education and advocacy. Using an established modified Delphi process based on existing data, workgroups derived consensus statements with recommendations.
Findings: The meeting developed 12 consensus statements and 29 research recommendations. Principal suggestions were to address gaps of knowledge by including data from varying socioeconomic groups, broadening definition of AKI phenotypes, adjudicating fluid balance by disease severity, integrating biopathology of child growth and development, and partnering with families and communities in AKI advocacy.
Conclusions and Relevance: Existing evidence across observational study supports further efforts to increase knowledge related to AKI in childhood. Significant gaps of knowledge may be addressed by focused efforts
Disordered loops in the two-dimensional antiferromagnetic spin-fermion model
The spin-fermion model has long been used to describe the quantum-critical
behavior of 2d electron systems near an antiferromagnetic (AFM) instability.
Recently, the standard procedure to integrate out the fermions to obtain an
effective action for spin waves has been questioned in the clean case. We show
that in the presence of disorder, the single fermion loops display two
crossover scales: upon lowering the energy, the singularities of the clean
fermionic loops are first cut off, but below a second scale new singularities
arise that lead again to marginal scaling. In addition, impurity lines between
different fermion loops generate new relevant couplings which dominate at low
energies. We outline a non-linear sigma model formulation of the single-loop
problem, which allows to control the higher singularities and provides an
effective model in terms of low-energy diffusive as well as spin modes.Comment: 22 pages, 8 figure
Pulsed extraction of ionization from helium buffer gas
The migration of intense ionization created in helium buffer gas under the
influence of applied electric fields is considered. First the chemical
evolution of the ionization created by fast heavy-ion beams is described.
Straight forward estimates of the lifetimes for charge exchange indicate a
clear suppression of charge exchange during ion migration in low pressure
helium. Then self-consistent calculations of the migration of the ions in the
electric field of a gas-filled cell at the National Superconducting Cyclotron
Laboratory (NSCL) using a Particle-In-Cell computer code are presented. The
results of the calculations are compared to measurements of the extracted ion
current caused by beam pulses injected into the NSCL gas cell.Comment: Accepted for pubilication in Nucl. Instrum. Meth. B, 14 pages, 8
figure
Singular Structure and Enhanced Friedel Oscillations in the Two-Dimensional Electron Gas
We calculate the leading order corrections (in ) to the static
polarization , with dynamically screened interactions, for the
two-dimensional electron gas. The corresponding diagrams all exhibit singular
logarithmic behavior in their derivatives at and provide significant
enhancement to the proper polarization particularly at low densities. At a
density of , the contribution from the leading order {\em fluctuational}
diagrams exceeds both the zeroth order (Lindhard) response and the self-energy
and exchange contributions. We comment on the importance of these diagrams in
two-dimensions and make comparisons to an equivalent three-dimensional electron
gas; we also consider the impact these finding have on computed
to all orders in perturbation theory
Direct mass measurements beyond the proton drip-line
First on-line mass measurements were performed at the SHIPTRAP Penning trap
mass spectrometer. The masses of 18 neutron-deficient isotopes in the
terbium-to-thulium region produced in fusion-evaporation reactions were
determined with relative uncertainties of about , nine of them
for the first time. Four nuclides (Ho and Tm) were
found to be proton-unbound. The implication of the results on the location of
the proton drip-line is discussed by analyzing the one-proton separation
energies
Exact integral equation for the renormalized Fermi surface
The true Fermi surface of a fermionic many-body system can be viewed as a
fixed point manifold of the renormalization group (RG). Within the framework of
the exact functional RG we show that the fixed point condition implies an exact
integral equation for the counterterm which is needed for a self-consistent
calculation of the Fermi surface. In the simplest approximation, our integral
equation reduces to the self-consistent Hartree-Fock equation for the
counterterm.Comment: 5 pages, 1 figur
Renormalized perturbation theory for Fermi systems: Fermi surface deformation and superconductivity in the two-dimensional Hubbard model
Divergencies appearing in perturbation expansions of interacting many-body
systems can often be removed by expanding around a suitably chosen renormalized
(instead of the non-interacting) Hamiltonian. We describe such a renormalized
perturbation expansion for interacting Fermi systems, which treats Fermi
surface shifts and superconductivity with an arbitrary gap function via
additive counterterms. The expansion is formulated explicitly for the Hubbard
model to second order in the interaction. Numerical soutions of the
self-consistency condition determining the Fermi surface and the gap function
are calculated for the two-dimensional case. For the repulsive Hubbard model
close to half-filling we find a superconducting state with d-wave symmetry, as
expected. For Fermi levels close to the van Hove singularity a Pomeranchuk
instability leads to Fermi surfaces with broken square lattice symmetry, whose
topology can be closed or open. For the attractive Hubbard model the second
order calculation yeilds s-wave superconductivity with a weakly momentum
dependent gap, whose size is reduced compared to the mean-field result.Comment: 18 pages incl. 6 figure
Programs and processes for advancing pediatric acute kidney support therapy in hospitalized and critically ill children: A report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
Pediatric acute kidney support therapy (paKST) programs aim to reliably provide safe, effective, and timely extracorporeal supportive care for acutely and critically ill pediatric patients with acute kidney injury (AKI), fluid and electrolyte derangements, and/or toxin accumulation with a goal of improving both hospital-based and lifelong outcomes. Little is known about optimal ways to configure paKST teams and programs, pediatric-specific aspects of delivering high-quality paKST, strategies for transitioning from acute continuous modes of paKST to facilitate rehabilitation, or providing effective short- and long-term follow-up. As part of the 26th Acute Disease Quality Initiative Conference, the first to focus on a pediatric population, we summarize here the current state of knowledge in paKST programs and technology, identify key knowledge gaps in the field, and propose a framework for current best practices and future research in paKST
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