In-flight calibration of STEREO-B/WAVES antenna system

The STEREO/WAVES (SWAVES) experiment on board the two STEREO spacecraft (Solar Terrestrial Relations Observatory) launched on 25 October 2006 is dedicated to the measurement of the radio spectrum at frequencies between a few kilohertz and 16 MHz. The SWAVES antenna system consists of 6 m long orthogonal monopoles designed to measure the electric component of the radio waves. With this configuration direction finding of radio sources and polarimetry (analysis of the polarization state) of incident radio waves is possible. For the evaluation of the SWAVES data the receiving properties of the antennas, distorted by the radiation coupling with the spacecraft body and other onboard devices, have to be known accurately. In the present context, these properties are described by the antenna effective length vectors. We present the results of an in-flight calibration of the SWAVES antennas using the observations of the nonthermal terrestrial auroral kilometric radiation (AKR) during STEREO roll maneuvers in an early stage of the mission. A least squares method combined with a genetic algorithm was applied to find the effective length vectors of the STEREO Behind (STEREO-B)/WAVES antennas in a quasi-static frequency range ($L_{antenna} \ll \lambda_{wave}$) which fit best to the model and observed AKR intensity profiles. The obtained results confirm the former SWAVES antenna analysis by rheometry and numerical simulations. A final set of antenna parameters is recommended as a basis for evaluations of the SWAVES data

The random phase approximation applied to ice

Standard density functionals without van der Waals interactions yield an unsatisfactory description of ice phases, specifically, high density phases occurring under pressure are too unstable compared to the common low density phase I$_h$ observed at ambient conditions. Although the description is improved by using functionals that include van der Waals interactions, the errors in relative volumes remain sizable. Here we assess the random phase approximation (RPA) for the correlation energy and compare our results to experimental data as well as diffusion Monte Carlo data for ice. The RPA yields a very balanced description for all considered phases, approaching the accuracy of diffusion Monte Carlo in relative energies and volumes. This opens a route towards a concise description of molecular water phases on surfaces and in cavities

Modified screen-printed carbon electrodes application for protein tumor markers determination

Screen-printed carbon electrodes were modified with gold nanoparticles bound with DNA-aptamers by two different methods. Aptamers can selectively bind protein tumor markers from the blood plasma. The electrodes were tested. Signals obtained via squire-wavy voltammetry from modified electrodes covered with blood plasma of the healthy donors and donors with lung cancer can be distinguished

A switch from α‐helical to β‐strand conformation during co‐translational protein folding

Cellular proteins begin to fold as they emerge from the ribosome.The folding landscape of nascent chains is not only shaped by theiramino acid sequence but also by the interactions with the ribo-some. Here, we combine biophysical methods with cryo-EM struc-ture determination to show that folding of aβ-barrel proteinbegins with formation of a dynamicα-helix inside the ribosome. Asthe growing peptide reaches the end of the tunnel, the N-terminalpart of the nascent chain refolds to aβ-hairpin structure thatremains dynamic until its release from the ribosome. Contactswith the ribosome and structure of the peptidyl transferase centerdepend on nascent chain conformation. These results indicate thatproteins may start out asα-helices inside the tunnel and switchinto their native folds only as they emerge from the ribosome.Moreover, the correlation of nascent chain conformations withreorientation of key residues of the ribosomal peptidyl-transferasecenter suggest that protein folding could modulate ribosome activity

Confronting the trans-Planckian question of inflationary cosmology with dissipative effects

We provide a class of QFTs which exhibit dissipation above a threshold energy, thereby breaking Lorentz invariance. Unitarity is preserved by coupling the fields to additional degrees of freedom (heavy fields) which introduce the rest frame. Using the Equivalence Principle, we define these theories in arbitrary curved spacetime. We then confront the trans-Planckian question of inflationary cosmology. When dissipation increases with the energy, the quantum field describing adiabatic perturbations is completely damped at the onset of inflation. However it still exists as a composite operator made with the additional fields. And when these are in their ground state, the standard power spectrum obtains if the threshold energy is much larger that the Hubble parameter. In fact, as the energy redshifts below the threshold, the composite operator behaves as if it were a free field endowed with standard vacuum fluctuations. The relationship between our models and the Brane World scenarios studied by Libanov and Rubakov displaying similar effects is discussed. The signatures of dissipation will be studied in a forthcoming paper.Comment: 30 pages, 1 Figure, to appear in CQ

Safety of the Intended Functionality Concept Integration into a Validation Tool Suite

Nowadays, the increasing complexity of Advanced Driver Assistance Systems (ADAS) and Automated Driving (AD) means that the industry must move towards a scenario-based approach to validation rather than relying on established technology-based methods. This new focus also requires the validation process to take into account Safety of the Intended Functionality (SOTIF), as many scenarios may trigger hazardous vehicle behaviour. Thus, this work demonstrates how the integration of the SOTIF process within an existing validation tool suite can be achieved. The necessary adaptations are explained with accompanying examples to aid comprehension of the approach