Pseudo-Marginal MCMC for Parameter Estimation in α-Stable Distributions

The α-stable distribution is very useful for modelling data with extreme values and skewed behaviour. The distribution is governed by two key parameters, tail thickness and skewness, in addition to scale and location. Inferring these parameters is difficult due to the lack of a closed form expression of the probability density. We develop a Bayesian method, based on the pseudo-marginal MCMC approach, that requires only unbiased estimates of the intractable likelihood. To compute these estimates we build an adaptive importance sampler for a latentvariable-representation of the α-stable density. This representation has previously been used in the literature for conditional MCMC sampling of the parameters, and we compare our method with this approach.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.ifacol.2015.12.17

STABILITY OF ABNORMAL KARYOTYPES IN CELL CULTURE1

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dna replication patterns of canine chromosomes in vivo and in vitro

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Rapid Pathogen-Induced Apoptosis: A Mechanism Used by Dendritic Cells to Limit Intracellular Replication of Legionella pneumophila

Dendritic cells (DCs) are specialized phagocytes that internalize exogenous antigens and microbes at peripheral sites, and then migrate to lymphatic organs to display foreign peptides to naïve T cells. There are several examples where DCs have been shown to be more efficient at restricting the intracellular replication of pathogens compared to macrophages, a property that could prevent DCs from enhancing pathogen dissemination. To understand DC responses to pathogens, we investigated the mechanisms by which mouse DCs are able to restrict replication of the intracellular pathogen Legionella pneumophila. We show that both DCs and macrophages have the ability to interfere with L. pneumophila replication through a cell death pathway mediated by caspase-1 and Naip5. L. pneumophila that avoided Naip5-dependent responses, however, showed robust replication in macrophages but remained unable to replicate in DCs. Apoptotic cell death mediated by caspase-3 was found to occur much earlier in DCs following infection by L. pneumophila compared to macrophages infected similarly. Eliminating the pro-apoptotic proteins Bax and Bak or overproducing the anti-apoptotic protein Bcl-2 were both found to restore L. pneumophila replication in DCs. Thus, DCs have a microbial response pathway that rapidly activates apoptosis to limit pathogen replication

Coherent modulation of the sea-level annual cycle in the United States by Atlantic Rossby waves

Changes in the sea-level annual cycle (SLAC) can have profound impacts on coastal areas, including increased flooding risk and ecosystem alteration, yet little is known about the magnitude and drivers of such changes. Here we show, using novel Bayesian methods, that there are significant decadal fluctuations in the amplitude of the SLAC along the United States Gulf and Southeast coasts, including an extreme event in 2008–2009 that is likely (probability ≥68%) unprecedented in the tide-gauge record. Such fluctuations are coherent along the coast but decoupled from deep-ocean changes. Through the use of numerical and analytical ocean models, we show that the primary driver of these fluctuations involves incident Rossby waves that generate fast western-boundary waves. These Rossby waves project onto the basin-wide upper mid-ocean transport (top 1000 m) leading to a link with the SLAC, wherein larger SLAC amplitudes coincide with enhanced transport variability