304 research outputs found
Electronic transport through a parallel--coupled triple quantum dot molecule: Fano resonances and bound states in the continuum
The electronic transport through a triple quantum dot molecule attached in
parallel to leads in presence of a magnetic flux is studied. Analytical
expressions of the linear conductance and density of states for the molecule in
equilibrium at zero temperature are obtained. As a consequence of quantum
interference, the conductance exhibits in general a Breit--Wigner and two Fano
resonances, the positions and widths of which are controlled by the magnetic
field. Every two flux quanta, there is an inversion of roles of the bonding and
antibonding states. For particular values of the magnetic flux and dot-lead
couplings, one or even both Fano resonances collapse and bound states in the
continuum (BIC's) are formed. The line broadenings of the molecular states are
examined as a function of the Aharonov--Bohm phase around the condition for the
formation of BIC's, finding resonances extremely narrow and robust against
variations of the magnetic field.Comment: 15 pages, 7 figure
Transport through a quantum wire with a side quantum-dot array
A noninteracting quantum-dot array side-coupled to a quantum wire is studied.
Transport through the quantum wire is investigated by using a noninteracting
Anderson tunneling Hamiltonian. The conductance at zero temperature develops an
oscillating band with resonances and antiresonances due to constructive and
destructive interference in the ballistic channel, respectively. Moreover, we
have found an odd-even parity in the system, whose conductance vanishes for an
odd number of quantum dots while becomes for an even number. We
established an explicit relation between this odd-even parity, and the
positions of the resonances and antiresonances of the conductivity with the
spectrum of the isolated QD arrayComment: 5 pages, 4 figures, submitted to PR
Ibuprofen-loaded calcium phosphate granules : combination of innovative characterization methods to relate mechanical strength to drug location
This paper studies the impact of the location of a drug substance on the physicochemical and mechanical properties of two types of calcium phosphate granules loaded with seven different contents of ibuprofen, ranging from 1.75% to 46%. These implantable agglomerates were produced by either low or high shear granulation. Unloaded Mi-Pro pellets presented higher sphericity and mechanical properties, but were slightly less porous than Kenwood granules (57.7% vs 61.2%). Nevertheless, the whole expected quantity of ibuprofen could be integrated into both types of granules. A combination of surface analysis, using near-infrared (NIR) spectroscopy coupling chemical imaging, and pellet porosity, by mercury intrusion measurements, allowed ibuprofen to be located. It was shown that, from 0% to 22% drug content, ibuprofen deposited simultaneously on the granule surface, as evidenced by the increase in surface NIR signal, and inside the pores, as highlighted by the decrease in pore volume. From 22%, porosity was almost filled, and additional drug substance coated the granule surfaces, leading to a large increase in the surface NIR signal. This coating was more regular for Mi-Pro pellets owing to their higher sphericity and greater surface deposition of drug substance. Unit crush tests using a microindenter revealed that ibuprofen loading enhanced the mechanical strength of granules, especially above 22% drug content, which was favorable to further application of the granules as a bone defect filler
Conductance and persistent current of a quantum ring coupled to a quantum wire under external fields
The electronic transport of a noninteracting quantum ring side-coupled to a
quantum wire is studied via a single-band tunneling tight-binding Hamiltonian.
We found that the system develops an oscillating band with antiresonances and
resonances arising from the hybridization of the quasibound levels of the ring
and the coupling to the quantum wire. The positions of the antiresonances
correspond exactly to the electronic spectrum of the isolated ring. Moreover,
for a uniform quantum ring the conductance and the persistent current density
were found to exhibit a particular odd-even parity related with the ring-order.
The effects of an in-plane electric field was also studied. This field shifts
the electronic spectrum and damps the amplitude of the persistent current
density. These features may be used to control externally the energy spectra
and the amplitude of the persistent current.Comment: Revised version, 7 pages and 9 figures. To appear in Phys. Rev.
Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study.
BACKGROUND AND AIMS: ENHANCE was a phase 3 study that evaluated efficacy and safety of seladelpar, a selective peroxisome proliferator-activated receptor-δ (PPAR) agonist, versus placebo in patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid (UDCA).
APPROACH AND RESULTS: Patients were randomized 1:1:1 to oral seladelpar 5 mg (n=89), 10 mg (n=89), placebo (n=87) daily (with UDCA, as appropriate). Primary end point was a composite biochemical response [alkaline phosphatase (ALP) < 1.67×upper limit of normal (ULN), ≥15% ALP decrease from baseline, and total bilirubin ≤ ULN] at month 12. Key secondary end points were ALP normalization at month 12 and change in pruritus numerical rating scale (NRS) at month 6 in patients with baseline score ≥4. Aminotransferases were assessed. ENHANCE was terminated early following an erroneous safety signal in a concurrent, NASH trial. While blinded, primary and secondary efficacy end points were amended to month 3. Significantly more patients receiving seladelpar met the primary end point (seladelpar 5 mg: 57.1%, 10 mg: 78.2%) versus placebo (12.5%) ( p < 0.0001). ALP normalization occurred in 5.4% ( p =0.08) and 27.3% ( p < 0.0001) of patients receiving 5 and 10 mg seladelpar, respectively, versus 0% receiving placebo. Seladelpar 10 mg significantly reduced mean pruritus NRS versus placebo [10 mg: -3.14 ( p =0.02); placebo: -1.55]. Alanine aminotransferase decreased significantly with seladelpar versus placebo [5 mg: 23.4% ( p =0.0008); 10 mg: 16.7% ( p =0.03); placebo: 4%]. There were no serious treatment-related adverse events.
CONCLUSIONS: Patients with primary biliary cholangitis (PBC) with inadequate response or intolerance to UDCA who were treated with seladelpar 10 mg had significant improvements in liver biochemistry and pruritus. Seladelpar appeared safe and well tolerated
Study of Spin and Decay-Plane Correlations of W Bosons in the e+e- -> W+W- Process at LEP
Data collected at LEP at centre-of-mass energies \sqrt(s) = 189 - 209 GeV are
used to study correlations of the spin of W bosons using e+e- -> W+W- -> lnqq~
events. Spin correlations are favoured by data, and found to agree with the
Standard Model predictions. In addition, correlations between the W-boson decay
planes are studied in e+e- -> W+W- -> lnqq~ and e+e- -> W+W- -> qq~qq~ events.
Decay-plane correlations, consistent with zero and with the Standard Model
predictions, are measured
Ultrarelativistic sources in nonlinear electrodynamics
The fields of rapidly moving sources are studied within nonlinear
electrodynamics by boosting the fields of sources at rest. As a consequence of
the ultrarelativistic limit the delta-like electromagnetic shock waves are
found. The character of the field within the shock depends on the theory of
nonlinear electrodynamics considered. In particular, we obtain the field of an
ultrarelativistic charge in the Born-Infeld theory.Comment: 10 pages, 3 figure
- …