Phenomenological constraints on SUSY SU(5) GUTs with non-universal gaugino masses

We study phenomenological aspects of supersymmetric SU(5) grand unified theories with non-universal gaugino masses. For large tan beta, we investigate constraints from the requirement of successful electroweak symmetry breaking, the positivity of stau mass squared and the b to s gamma decay rate. In the allowed region, the nature of the lightest supersymmetric particle is determined. Examples of mass spectra are given. We also calculate loop corrections to the bottom mass due to superpartners.Comment: 10 pages, 2 figures (8 eps files), uses REVTeX. Replaced to match the version to be published in PRD: minor corrections and addition

A Measurement of B Meson Production and Lifetime Using D`− Events in Z0 Decays

A study of B meson decays into D l- X final states is presented. In these events, neutral and charged D mesons originate predominantly from B+ and B0 decays, respectively. The dilution of this correlation due to D** production has been taken into account. From 263700 hadronic Z0 decays collected in 1991 with the DELPHI detector at the LEP collider, 92 D0 --> K- pi+, 35 D+ --> K- pi+ pi+ and 61 D*+ --> D0 pi+ followed by D0 --> K- pi+ or D0 --> K- pi+ pi+ pi-, are found with an associated lepton of the same charge as the kaon. From the D0 l- and D*+ l-, the probability f(d) that a b quark hadronizes into a B- (or B0BAR),meson is found to be 0.44 +/-0.08 +/-0.09, corresponding to a total (B(s) + LAMBDA(b)) hadronization fraction of 0.12(-0.12)+0.24 .By reconstructing the energy of each B meson, the b quark fragmentation is directly measured for the first time. The mean value of the B meson energy fraction is: [X(E)(B)] = 0.695+/-0.015(stat.)+/-0.029(syst.) Reconstructing D-lepton vertices, the following B life-times are measured: tau(B) = 1.27(-0.18)+0.22(stat.)+/-0.15(syst.) ps, where bBAR --> D0 l- X, tau(B) = 1.18(-0.27)+0.39(stat.)+/-0.15(syst.) ps, where BBAR --> D+ l- X, T(B) = 1.19(-0.19)+0.25(stat.)+/-0.15(syst.) ps where BBAR --> D*+ l- X, and an average tau(B) = 1.23(-0.13)+0.14(stat.)+/-0.15(syst.) ps is found. Allowing for decays into D** l- vBAR, the B+ and B0 lifetimes are: tau(B+)= 1.30(0.29)+0.33(stat.)+/-0.15(syst. exp.) +/-0.05(syst. D**) ps, tau(B0)= 1.17(-0.23)+0.29(stat.)+/-0.15(syst. exp.) +/-0.05 (syst. D**) ps, tau(B+)/tau(B0) = 1.11(0.39)+0.51(stat.)+/-0.05(syst. exp.) +/-0.10(syst. D**) ps

Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography

Selective separation of enantiomers is a substantial challenge for the pharmaceutical industry. Chromatography on chiral stationary phases is the standard method, but at a very high cost for industrial-scale purification owing to the high cost of the chiral stationary phases. Typically, these materials are poorly robust, expensive to manufacture and often too specific for a single desired substrate, lacking desirable versatility across different chiral analytes. Here we disclose a porous, robust homochiral metal-organic framework (MOF), TAMOF-1, built from copper(II) and an affordable linker prepared from natural L-histidine. TAMOF-1 has shown to be able to separate a variety of model racemic mixtures, including drugs, in a wide range of solvents of different polarity, outperforming several commercial chiral columns for HPLC separations. Although not exploited in the present article, it is worthy to mention that the preparation of this new material is scalable to the multikilogram scale, opening unprecedented possibilities for low-energy chiral separation at the industrial scale

Measurement of the triple-gluon vertex from 4-JET events at LEP

From the combined data of 1990 and 1991 of the DELPHI experiment at LEP, 13057 4-jet events are obtained and used for determining the contribution of the triple-gluon vertex. The relevant variables are the generalized Nachtmann Reiter angle theta(NR)* and the opening angle of the two least energetic jets. A fit to their two-dimensional distribution yields C(A)/C(F)=2.12+/-0.35 and N(C)/N(A)=0.46+/-0.19, where C(A)/C(F) is the ratio of the coupling strength of the triple-gluon vertex to that of gluon bremsstrahlung from quarks, and N(C)/N(A), the ratio of the number of quark colours to the number of gluons. This constitutes a convincing model-independent proof of the existence of the triple-gluon vertex, since its contribution is directly proportional to C(A)/C(F). The results are in agreement with the values expected from QCD: C(A)/C(F)=2.25, and N(C)/N(A)=3/8

New insights into the neolithisation process in southwest Europe according to spatial density analysis from calibrated radiocarbon dates

The agricultural way of life spreads throughout Europe via two main routes: the Danube corridor and the Mediterranean basin. Current archaeological literature describes the arrival to the Western Mediterranean as a rapid process which involves both demic and cultural models, and in this regard, the dispersal movement has been investigated using mathematical models, where the key factors are time and space. In this work, we have created a compilation of all available radiocarbon dates for the whole of Iberia, in order to draw a chronological series of maps to illustrate temporal and spatial patterns in the neolithisation process. The maps were prepared by calculating the calibrated 14C date probability density curves, as a proxy to show the spatial dynamics of the last hunter-gatherers and first farmers. Several scholars have pointed out problems linked with the variability of samples, such as the overrepresentation of some sites, the degree of regional research, the nature of the dated samples and above all the archaeological context, but we are confident that the selected dates, after applying some filters and statistical protocols, constitute a good way to approach settlement spatial patterns in Iberia at the time of the neolithisation process

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when = 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution

Evaluation of cytotoxic and mitodepressive activity of aqueous extracts from thirteen Argentine medicinal plants

Trece especies de plantas vasculares usadas en la medicina popular argentina, fueron estudiadas para evaluar las actividades citotóxicas y mitodepresivas de sus extractos acuosos a diferentes concentraciones usando los tests de Artemia salina y Allium. No se observó actividad citotóxica de los extractos analizados con el test de Artemia salina y, en relación a los parámetros macroscópicos de toxicidad general, todas las especies mostraron correlaciones negativas aunque no significativas entre la longitud media de las raíces y la concentración del extracto y el test de Allium. La frecuencia de las anormalidades macroscópicas de las raíces mostró correlaciones negativas en todas las especies analizadas siendo la mayoría, estadísticamente significativas, indicando un efecto de la concentración. En casi todas las muestras ensayadas, se observaron efectos de tipo C-mitótico ya que el Indice Mitótico disminuyó en tanto que las anormalidades mitóticas se incrementaron con las concentraciones crecientes de los extractos. En ningún caso se observó actividad clastogénica significativa.Thirteen vascular plant species used in argentine folk medicine were studied in order to evaluate the cytotoxic and mitodepressive activity of their aqueous extracts at different concentrations, using both the Artemia salina Test and the Allium Test. No cytotoxic activity was observed for analyzed extracts with the Artemia salina Test, and in relation to macroscopic parameters of general toxicity, all species exhibited negative albeit non-significant correlations between average root length and extract concentration in the Allium Test. Frequency of root macroscopic abnormalities and average root length showed significant or highly significant negative correlations in all but two of the analyzed species which nevertheless exhibited comparable negative trends, indicating a concentration effect. In almost all assayed samples a Cmitotic effects of the extracts was observed since the mitotic index decreased and mitotic abnormalities increased with increasing extract concentrations. Clastogenic activity was not found in the analyzed extracts.Colegio de Farmacéuticos de la Provincia de Buenos Aire