Reflectionless tunneling in ballistic normal-metal--superconductor junctions

We investigate the phenomenon of reflectionless tunneling in ballistic normal-metal--superconductor (NS) structures, using a semiclassical formalism. It is shown that applied magnetic field and superconducting phase difference both impair the constructive interference leading to this effect, but in a qualitatively different way. This is manifested both in the conductance and in the shot noise properties of the system considered. Unlike diffusive systems, the features of the conductance are sharp, and enable fine spatial control of the current, as well as single channel manipulations. We discuss the possibility of conducting experiments in ballistic semiconductor-superconductor structures with smooth interfaces and some of the phenomena, specific to such structures, that could be measured. A general criterion for the barrier at NS interfaces, though large, to be effectively transparent to pair current is obtained.Comment: published versio

Measuring vertebrate telomeres: applications and limitations

Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic chromosomes that function in stabilizing chromosomal end integrity. In vivo studies of somatic tissue of mammals and birds have shown a correlation between telomere length and organismal age within species, and correlations between telomere shortening rate and lifespan among species. This result presents the tantalizing possibility that telomere length could be used to provide much needed information on age, ageing and survival in natural populations where longitudinal studies are lacking. Here we review methods available for measuring telomere length and discuss the potential uses and limitations of telomeres as age and ageing estimators in the fields of vertebrate ecology, evolution and conservation

A four‐component classification of uncertainties in biological invasions: implications for management

Although uncertainty is an integral part of any science, it raises doubts in public perception about scientific evidence, is exploited by denialists, and therefore potentially hinders the implementation of management actions. As a relatively young field of study, invasion science contains many uncertainties. This may explain why, despite international policies aimed at mitigating biological invasions, the implementation of national- and regional-scale measures to prevent or control alien species has done little to slow the increase in extent of invasions and the magnitude of impacts. Uncertainty is therefore a critical aspect of invasion science that should be addressed to enable the field to progress further. To improve how uncertainties in invasion science are captured and characterized, we propose a framework, which is also applicable to other applied research fields such as climate and conservation science, divided into four components: the need (1) to clearly circumscribe the phenomenon, (2) to measure and provide evidence for the phenomenon (i.e., confirmation), (3) to understand the mechanisms that cause the phenomenon, and (4) to understand the mechanisms through which the phenomenon results in consequences. We link these issues to three major types of uncertainty: linguistic, psychological, and epistemic. The application of this framework shows that the four components tend to be characterized by different types of uncertainty in invasion science.We explain how these uncertainties can be detrimental to the implementation of management measures and propose ways to reduce them. Since biological invasions are increasingly tightly embedded in complex socio-ecological systems, many problems associated with these uncertainties have convoluted solutions. They demand the consensus of many stakeholders to define and frame the dimensions of the phenomenon, and to decide on appropriate actions. While many of the uncertainties cannot be eliminated completely, we believe that using this framework to explicitly identify and communicate them will help to improve collaboration between researchers and managers, increase scientific, political, and public support for invasion research, and provide a stronger foundation for sustainable management strategies

Telomere lengths in human oocytes, cleavage stage embryos and blastocysts

Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase. When telomere length becomes critically short, cell senescence occurs. Telomere length therefore reflects both cellular ageing and capacity for division. We have measured telomere length in human germinal vesicle (GV) oocytes and pre-implantation embryos, by quantitative fluorescence in-situ hybridisation (Q-FISH), providing baseline data towards our hypothesis that telomere length is a marker of embryo quality. The numbers of fluorescent foci suggest that extensive clustering of telomeres occurs in mature GV stage oocytes, and in pre-implantation embryos. When calculating average telomere length by assuming that each signal presents one telomere, the calculated telomere length decreased from the oocyte to the cleavage stages, and increased between the cleavage stages and the blastocyst (11.12 vs 8.43 vs 12.22kb respectively, p<0.001). Other methods of calculation, based upon expected maximum and minimum numbers of telomeres, confirm that telomere length in blastocysts is significantly longer than cleavage stages. Individual blastomeres within an embryo showed substantial variation in calculated average telomere length. This study implies that telomere length changes according to the stage of pre-implantation embryo development

Dissipative Electron Transport through Andreev Interferometers

We consider the conductance of an Andreev interferometer, i.e., a hybrid structure where a dissipative current flows through a mesoscopic normal (N) sample in contact with two superconducting (S) "mirrors". Giant conductance oscillations are predicted if the superconducting phase difference $\phi$ is varied. Conductance maxima appear when $\phi$ is on odd multiple of $\pi$ due to a bunching at the Fermi energy of quasiparticle energy levels formed by Andreev reflections at the N-S boundaries. For a ballistic normal sample the oscillation amplitude is giant and proportional to the number of open transverse modes. We estimate using both analytical and numerical methods how scattering and mode mixing --- which tend to lift the level degeneracy at the Fermi energy --- effect the giant oscillations. These are shown to survive in a diffusive sample at temperatures much smaller than the Thouless temperature provided there are potential barriers between the sample and the normal electron reservoirs. Our results are in good agreement with previous work on conductance oscillations of diffusive samples, which we propose can be understood in terms of a Feynman path integral description of quasiparticle trajectories.Comment: 24 pages, revtex, 12 figures in eps forma

Genetic origins of honey bees (Apis mellifera) on Kangaroo Island and Norfolk Island (Australia) and the Kingdom of Tonga

International audienceAbstractWe examine the origin of honey bee (Apis mellifera) populations in Kangaroo Island (Australia), Norfolk Island (Australia) and the Kingdom of Tonga using a highly polymorphic mitochondrial DNA region and a panel of 37 single nucleotide polymorphisms that assigns ancestry to three evolutionary lineages: Eastern Europe, Western Europe and Africa. We also examine inbreeding coefficients and genetic variation using microsatellites and mitochondrial sequencing. The honey bees of Kangaroo Island have a high proportion of Eastern European ancestry (90.2%), consistent with claims that they are of the subspecies A. m. ligustica. The honey bees of Norfolk Island also had a majority of ancestry from Eastern Europe (73.1%) with some contribution from Western Europe (21.2%). The honey bees of Tonga are mainly of Western European (70.3%) origin with some Eastern European ancestry (27.4%). Despite the suspected severe bottlenecks experienced by these island population, inbreeding coefficients were low

The prevalence and incidence of mental ill-health in adults with autism and intellectual disabilities

The prevalence, and incidence, of mental ill-health in adults with intellectual disabilities and autism were compared with the whole population with intellectual disabilities, and with controls, matched individually for age, gender, ability-level, and Down syndrome. Although the adults with autism had a higher point prevalence of problem behaviours compared with the whole adult population with intellectual disabilities, compared with individually matched controls there was no difference in prevalence, or incidence of either problem behaviours or other mental ill-health. Adults with autism who had problem behaviours were less likely to recover over a two-year period than were their matched controls. Apparent differences in rates of mental ill-health are accounted for by factors other than autism, including Down syndrome and ability level

Phase coherent transport in hybrid superconducting structures: the case of d-wave superconductors

We examine the effect of d-wave symmetry on zero bias anomalies in normal-superconducting tunnel junctions and phase-periodic conductances in Andreev interferometers. In the presence of d-wave pairing, zero-bias anomalies are suppressed compared with the s-wave case. For Andreev interferometers with aligned islands, the phase-periodic conductance is insensistive to the nature of the pairing, whereas for non-aligned islands, the nature of the zero-phase extremum is reversed.Comment: 10 Pages, Revtex. 11 postscript figures available on reques

Responses to the publication of the American Psychiatric Association’s DSM 5

The idea and practice of ‘diagnosis’ in psychiatry has always been controversial. Controversy came to a head in the period preceding and immediately after publication of the latest version of the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders, DSM-5. There was widespread international discussion and debate not only in scholarly journals but in mainstream and social media, and to the formation of International DSM Response Committee and an International Summit on Psychiatric Diagnosis. This article documents that process and outlines the issues that provoked, and continue to provoke most controversy, from the (admittedly personal) perspective of those involved. It ends with suggestions of alternatives to diagnosis, which avoid some of these problems and outlines how these are being taken forward. The next ten years are likely to see significant change