4,902 research outputs found
Role of Intracardiac Echocardiography (ICE) in Transcatheter Occlusion of Atrial Septal Defects
The SUSY seesaw model and lepton-flavor violation at a future electron-positron linear collider
We study lepton-flavor violating slepton production and decay at a future
e^+e^- linear collider in context with the seesaw mechanism in mSUGRA post-LEP
benchmark scenarios. The present knowledge in the neutrino sector as well as
improved future measurements are taken into account. We calculate the signal
cross-sections \sigma(e^{+/-}e^- -> l_{\beta}^{+/-} l_{\alpha}^-
\tilde{\chi}_b^0 \tilde{\chi}_a^0); l_{\delta}=e, \mu, \tau; \alpha =|= \beta
and estimate the main background processes. Furthermore, we investigate the
correlations of these signals with the corresponding lepton-flavor violating
rare decays l_{\alpha} -> l_{\beta} \gamma. It is shown that these correlations
are relatively weakly affected by uncertainties in the neutrino data, but very
sensitive to the model parameters. Hence, they are particularly suited for
probing the origin of lepton-flavor violation.Comment: 31 pages, 10 figures, version published in Phys. Rev.
Virtual Effects of Split SUSY in Higgs Productions at Linear Colliders
In split supersymmetry the gauginos and higgsinos are the only supersymmetric
particles possibly accessible at foreseeable colliders like the CERN Large
Hadron Collider (LHC) and the International Linear Collider (ILC). In order to
account for the cosmic dark matter measured by WMAP, these gauginos and
higgsinos are stringently constrained and could be explored at the colliders
through their direct productions and/or virtual effects in some processes. The
clean environment and high luminosity of the ILC render the virtual effects of
percent level meaningful in unraveling the new physics effects. In this work we
assume split supersymmetry and calculate the virtual effects of the
WMAP-allowed gauginos and higgsinos in Higgs productions e+e- -> Z h and e+e-
-> \nu_e \bar_\nu_e h through WW fusion at the ILC. We find that the production
cross section of e+e- -> Zh can be altered by a few percent in some part of the
WMAP-allowed parameter space, while the correction to the WW-fusion process
e+e- -> \nu_e \bar_\nu_e h is below 1%. Such virtual effects are correlated
with the cross sections of chargino pair productions and can offer
complementary information in probing split supersymmetry at the colliders.Comment: more discussions added (7 pages, 10 figs
Higgs boson production in photon-photon collision at ILC: a comparative study in different little Higgs models
We study the process \gamma\gamma->h->bb_bar at ILC as a probe of different
little Higgs models, including the simplest little Higgs model (SLH), the
littlest Higgs model (LH), and two types of littlest Higgs models with T-parity
(LHT-I, LHT-II). Compared with the Standard Model (SM) prediction, the
production rate is found to be sizably altered in these little Higgs models
and, more interestingly, different models give different predictions. We find
that the production rate can be possibly enhanced only in the LHT-II for some
part of the parameter space, while in all other cases the rate is suppressed.
The suppression can be 10% in the LH and as much as 60% in both the SLH and the
LHT-I/LHT-II. The severe suppression in the SLH happens for a large \tan\beta
and a small m_h, in which the new decay mode h->\eta\eta (\eta is a light
pseudo-scalar) is dominant; while for the LHT-I/LHT-II the large suppression
occurs when f and m_h are both small so that the new decay mode h->A_H A_H is
dominant. Therefore, the precision measurement of such a production process at
the ILC will allow for a test of these models and even distinguish between
different scenarios.Comment: Version in JHEP (h-g-g & h-gamma-gamma expressions added
Efficient exploration of unknown indoor environments using a team of mobile robots
Whenever multiple robots have to solve a common task, they need to coordinate their actions to carry out the task efficiently and to avoid interferences between individual robots. This is especially the case when considering the problem of exploring an unknown environment with a team of mobile robots. To achieve efficient terrain coverage with the sensors of the robots, one first needs to identify unknown areas in the environment. Second, one has to assign target locations to the individual robots so that they gather new and relevant information about the environment with their sensors. This assignment should lead to a distribution of the robots over the environment in a way that they avoid redundant work and do not interfere with each other by, for example, blocking their paths. In this paper, we address the problem of efficiently coordinating a large team of mobile robots. To better distribute the robots over the environment and to avoid redundant work, we take into account the type of place a potential target is located in (e.g., a corridor or a room). This knowledge allows us to improve the distribution of robots over the environment compared to approaches lacking this capability. To autonomously determine the type of a place, we apply a classifier learned using the AdaBoost algorithm. The resulting classifier takes laser range data as input and is able to classify the current location with high accuracy. We additionally use a hidden Markov model to consider the spatial dependencies between nearby locations. Our approach to incorporate the information about the type of places in the assignment process has been implemented and tested in different environments. The experiments illustrate that our system effectively distributes the robots over the environment and allows them to accomplish their mission faster compared to approaches that ignore the place labels
The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
The transcription factor Snail is a master regulator of cellular identity and epithelial-to-mesenchymal transition (EMT) directly repressing a broad repertoire of epithelial genes. How chromatin modifiers instrumental to its activity are recruited to Snail-specific binding sites is unclear. Here we report that the long non-coding RNA (lncRNA) HOTAIR (for HOX Transcript Antisense Intergenic RNA) mediates a physical interaction between Snail and enhancer of zeste homolog 2 (EZH2), an enzymatic subunit of the polycomb-repressive complex 2 and the main writer of chromatin-repressive marks. The Snail-repressive activity, here monitored on genes with a pivotal function in epithelial and hepatic morphogenesis, differentiation and cell-type identity, depends on the formation of a tripartite Snail/HOTAIR/EZH2 complex. These results demonstrate an lncRNA-mediated mechanism by which a transcriptional factor conveys a general chromatin modifier to specific genes, thereby allowing the execution of hepatocyte transdifferentiation; moreover, they highlight HOTAIR as a crucial player in the Snail-mediated EMT.Oncogene advance online publication, 25 July 2016; doi:10.1038/onc.2016.260
SEOM clinical guideline for the management of cutaneous melanoma (2020)
Melanoma affects about 6000 patients a year in Spain. A group of medical oncologists from Spanish Society of Medical Oncology (SEOM) and Spanish Multidisciplinary Melanoma Group (GEM) has designed these guidelines to homogenize the management of these patients. The diagnosis must be histological and determination of BRAF status has to be performed in patients with stage ≥ III. Stage I-III resectable melanomas will be treated surgically. In patients with stage III melanoma, adjuvant treatment with immunotherapy or targeted therapy is also recommended. Patients with unresectable or metastatic melanoma will receive treatment with immunotherapy or targeted therapy, the optimal sequence of these treatments remains unclear. Brain metastases require a separate consideration, since, in addition to systemic treatment, they may require local treatment. Patients must be followed up closely to receive or change treatment as soon as their previous clinical condition changes, since multiple therapeutic options are available
The Maximal Inverse Seesaw from Operator and Oscillating Asymmetric Sneutrino Dark Matter
The maximal supersymmetric inverse seesaw mechanism (MSIS)
provides a natural way to relate asymmetric dark matter (ADM) with neutrino
physics. In this paper we point out that, MSIS is a natural outcome if one
dynamically realizes the inverse seesaw mechanism in the next-to minimal
supersymmetric standard model (NMSSM) via the dimension-five operator
, with the NMSSM singlet developing TeV scale VEV; it
slightly violates lepton number due to the suppression by the fundamental scale
, thus preserving maximally. The resulting sneutrino is a
distinguishable ADM candidate, oscillating and favored to have weak scale mass.
A fairly large annihilating cross section of such a heavy ADM is available due
to the presence of singlet.Comment: journal versio
A Comparative Study of Efficient Initialization Methods for the K-Means Clustering Algorithm
K-means is undoubtedly the most widely used partitional clustering algorithm.
Unfortunately, due to its gradient descent nature, this algorithm is highly
sensitive to the initial placement of the cluster centers. Numerous
initialization methods have been proposed to address this problem. In this
paper, we first present an overview of these methods with an emphasis on their
computational efficiency. We then compare eight commonly used linear time
complexity initialization methods on a large and diverse collection of data
sets using various performance criteria. Finally, we analyze the experimental
results using non-parametric statistical tests and provide recommendations for
practitioners. We demonstrate that popular initialization methods often perform
poorly and that there are in fact strong alternatives to these methods.Comment: 17 pages, 1 figure, 7 table
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