Transient Addressing for Related Processes: Improved Firewalling by Using IPV6 and Multiple Addresses per Host

Traditionally, hosts have tended to assign relatively few network addresses to an interface for extended periods. Encouraged by the new abundance of addressing possibilities provided by IPv6, we propose a new method, called Transient Addressing for Related Processes (TARP), whereby hosts temporarily employ and subsequently discard IPv6 addresses in servicing a client host's network requests. The method provides certain security advantages and neatly finesses some well-known firewall problems caused by dynamic port negotiation used in a variety of application protocols. A prototype implementation exists as a small set of kame/BSD kernel enhancements and allows socket programmers and applications nearly transparent access to TARP addressing's advantages

Identifying metabolic pathways for production of extracellular polymeric substances by the diatom Fragilariopsis cylindrus inhabiting sea ice

Diatoms are significant primary producers in sea ice, an ephemeral habitat with steep vertical gradients of temperature and salinity characterizing the ice matrix environment. To cope with the variable and challenging conditions, sea ice diatoms produce polysaccharide-rich extracellular polymeric substances (EPS) that play important roles in adhesion, cell protection, ligand binding and as organic carbon sources. Significant differences in EPS concentrations and chemical composition corresponding to temperature and salinity gradients were present in sea ice from the Weddell Sea and Eastern Antarctic regions of the Southern Ocean. To reconstruct the first metabolic pathway for EPS production in diatoms, we exposed Fragilariopsis cylindrus, a key bi-polar diatom species, to simulated sea ice formation. Transcriptome profiling under varying conditions of EPS production identified a significant number of genes and divergent alleles. Their complex differential expression patterns under simulated sea ice formation was aligned with physiological and biochemical properties of the cells, and with field measurements of sea ice EPS characteristics. Thus, the molecular complexity of the EPS pathway suggests metabolic plasticity in F. cylindrus is required to cope with the challenging conditions of the highly variable and extreme sea ice habitat

Source identification and distribution reveals the potential of the geochemical Antarctic sea ice proxy IPSO25

The presence of a di-unsaturated highly branched isoprenoid (HBI) lipid biomarker (diene II) in Southern Ocean sediments has previously been proposed as a proxy measure of palaeo Antarctic sea ice. Here we show that a source of diene II is the sympagic diatom Berkeleya adeliensis Medlin. Furthermore, the propensity for B. adeliensis to flourish in platelet ice is reflected by an offshore downward gradient in diene II concentration in >100 surface sediments from Antarctic coastal and near-coastal environments. Since platelet ice formation is strongly associated with super-cooled freshwater inflow, we further hypothesize that sedimentary diene II provides a potentially sensitive proxy indicator of landfast sea ice influenced by meltwater discharge from nearby glaciers and ice shelves, and re-examination of some previous diene II downcore records supports this hypothesis. The term IPSO25-Ice Proxy for the Southern Ocean with 25 carbon atoms-is proposed as a proxy name for diene II

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis

Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms (MPNs) are incompletely understood. We aimed to generate a comprehensive map of the stroma in MPNs/MFs on a single-cell level in murine models and patient samples. Our analysis revealed two distinct mesenchymal stromal cell (MSC) subsets as pro-fibrotic cells. MSCs were functionally reprogrammed in a stage-dependent manner with loss of their progenitor status and initiation of differentiation in the pre-fibrotic and acquisition of a pro-fibrotic and inflammatory phenotype in the fibrotic stage. The expression of the alarmin complex S100A8/S100A9 in MSC marked disease progression toward the fibrotic phase in murine models and in patient stroma and plasma. Tasquinimod, a small-molecule inhibiting S100A8/S100A9 signaling, significantly ameliorated the MPN phenotype and fibrosis in JAK2V617F-mutated murine models, highlighting that S100A8/S100A9 is an attractive therapeutic target in MPNs.Leimkühler and colleagues demonstrate that mesenchymal stromal progenitor cells are fibro

Design of experimental device for testing of subcooled flow boilling

The article presents the principle and function of the Hypervapotron and the current work progress on the realisation of the experimental loop. Hypervapotron is a heat exchanger operating in a two-phase flow regime, in which the latent heat of the water/steam phase transformation is used, which enables the transfer of large heat fluxes (up to tens of MW/m(2)). For this reason, it appears to be very promising for use in fusion reactors. The article describes the steps leading to the final design of the experimental loop selection of suitable mesh parameters in the Star-CCM+ code, geometry and used materials of the single elements of the heating system using electromagnetic induction. The effort of the experimental loop and the flow study in the Hypervapotron in general, is dimensional and material optimization of the geometry is suitable for a wide range of applications for which the benefits of subcooled boiling and Hypervapotron geometry can be applied

Transient Addressing for Related Processes: Improved Firewalling by Using IPV6 and Multiple Addresses per Host

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