206 research outputs found
La gestión de la motivación organizacional con el enfoque de la teorÃa de Herzberg : Un estudio empÃrico
Esta investigación trata sobre la gestión de los factores que inciden en el nivel de satisfacción o insatisfacción en el empleo para una muestra de trabajadores del gran La Plata. En el presente trabajo se toma como referencia la teorÃa de los factores motivadores e higiénicos de Frederick Herzberg.
El estudio formal de la satisfacción en el trabajo no es tema nuevo, durante décadas se pensó que los factores fÃsicos del ambiente de trabajo eran las principales variables que causaban la satisfacción de los trabajadores.
Años después, los estudios de Elthon Mayo en la Western Electric, en Hawthorne Illinois, revelarÃan que si bien los factores fÃsicos influÃan sobre la satisfacción de los trabajadores, los factores sociales tenÃan una influencian mucho mayor, no sólo en la satisfacción sino también en la productividad.
Casi 30 años después, los hallazgos de Herzberg, advertÃan que los principales factores que influÃan en la satisfacción laboral radicaban en factores intrÃnsecos del trabajo como el sentimiento de logro, el recibir reconocimiento, y el desempeñar un puesto que resultase significativo para el individuo. Estas ideas recibieron una gran aceptación, quizás por su simplicidad, y porque ponÃan al alcance de los directivos de las empresas y de los gerentes de Recursos Humanos, el diseñar puestos de trabajo que fueran significativos para el trabajador.
Existen varias teorÃas sobre la motivación del hombre en el trabajo, las cuales plantean distintos factores a tener en cuenta para aumentar la satisfacción laboral. ¿Cuáles son esos factores hoy? El mundo cambió y las necesidades de la gente también han cambiado; por lo tanto las necesidades que los trabajadores van a buscar satisfacer en el trabajo son distintas a las que tenÃan tiempo atrás. A través de una investigación empÃrica, se estudió como es la gestión de los factores motivacionales de Herzberg en los trabajadores del gran La Plata.Facultad de Ciencias Económica
Screening for developmental disorders in 3- and 4-year-old italian children: a preliminary study
BACKGROUND:
The "Osserviamo" project, coordinated by the Municipality of Rome and the Department of Pediatrics and Child Neuropsychiatry of Sapienza University, aimed to validate an Italian version of the Ages and Stages Questionnaire-3 and to collect, for the first time in Italy, data on developmental disorders in a sample of 4,000 children aged 3 and 4 years. The present paper presents the preliminary results of the "Osserviamo" project.
METHODS:
600 parents of children between 39 and 50 months of age (divided in two age stages: 42 and 48 months) were contacted from 15 kindergarden schools.
RESULTS:
23.35% of the whole sample scored in the risk range of at least one developmental area of the Ages and Stages Questionnaire-3rd Edition (ASQ-3) and 7.78% scored in the clinical range. Specifically, 23.97% of the children in the 42-month age stage scored in the risk range and 5.79% scored in the clinical range. Males scored lower than females in the fine motor skills and personal-social development domains. Moreover, 22.79% of the children in the 48-month age stage scored in the risk range, while 9.55% scored in the clinical range. Males scored lower than females in fine motor skills.
CONCLUSION:
Italian validation of the ASQ-3 and recruitment of all 4,000 participants will allow these data on the distribution of developmental disorders to be extended to the general Italian pediatric population. One main limitation of the study is the lack of clinical confirmation of the data yielded by the screening programme, which the authors aim to obtain in later stages of the study
Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®)
Bacterial prostatitis (BP) is a common condition accounting responsible for about 5-10% of all prostatitis cases; chronic bacterial prostatitis (CBP) classified as type II, are less common but is a condition that significantly hampers the quality of life, (QoL) because not only is it a physical condition but also a psychological distress. Commonly patients are treated with antibiotics alone, and in particular fluoroquinolones are suggested by the European Urology guidelines. This approach, although recommended, may not be enough. Thus, a multimodal approach to the prolonged antibiotic therapy may be helpful.210 patients affected by chronic bacterial prostatitis were enrolled in the study. All patients were positive to Meares-Stamey test and symptoms duration was > 3 months. The purpose of the study was to evaluate the efficacy of a long lasting therapy with a fluoroquinolone in association with a nutraceutical supplement (prulifloxacin 600 mg for 21 days and an association of Serenoa repens 320 mg, Lactobacillus Sporogens 200 mg, Arbutin 100 mg for 30 days). Patients were randomized in two groups (A and B) receiving respectively antibiotic alone and an association of antibiotic plus supplement.Biological recurrence at 2 months in Group A was observed in 21 patients (27.6%) and in Group B in 6 patients (7.8%). Uropathogens found at the first follow-up were for the majority Gram - (E. coli and Enterobacter spp.). A statistically significant difference was found at the time of the follow-up between Group A and B in the NIH-CPSI questionnaire score, symptoms evidence and serum PSA.Broad band, short-lasting antibiotic therapy in association with a nutritional supplement (serenoa repens, lactobacillus sporogens and arbutin) show better control and recurrence rate on patients affected by chronic bacterial prostatitits in comparison with antibiotic treatment alone.NCT02130713Date of trial Registration: 30/04/2014
Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation
Inhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor which has collagen and collagen domain containing proteins as ligands. LAIR-1 is broadly expressed on immune cells and has a large availability of ligands in both circulation and tissues, implicating a need for tight regulation of this interaction. In the current study, we sought to examine the regulation and function of LAIR-1 on monocyte, dendritic cell (DC) and macrophage subtypes, using different in vitro models. We found that LAIR-1 is highly expressed on intermediate monocytes as well as on plasmacytoid DCs. LAIR-1 is also expressed on skin immune cells, mainly on tissue CD14(+) cells, macrophages and CD1c(+) DCs. In vitro, monocyte and type-2 conventional DC stimulation leads to LAIR-1 upregulation, which may reflect the importance of LAIR-1 as negative regulator under inflammatory conditions. Indeed, we demonstrate that LAIR-1 ligation on monocytes inhibits toll like receptor (TLR)4 and Interferon (IFN)-alpha- induced signals. Furthermore, LAIR-1 is downregulated on GM-CSF and IFN-gamma monocyte-derived macrophages and monocyte-derived DCs. In addition, LAIR-1 triggering during monocyte derived-DC differentiation results in significant phenotypic changes, as well as a different response to TLR4 and IFN-alpha stimulation. This indicates a role for LAIR-1 in skewing DC function, which impacts the cytokine expression profile of these cells. In conclusion, we demonstrate that LAIR-1 is consistently upregulated on monocytes and DC during the inflammatory phase of the immune response and tends to restore its expression during the resolution phase. Under inflammatory conditions, LAIR-1 has an inhibitory function, pointing toward to a potential intervention opportunity targeting LAIR-1 in inflammatory conditions
Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®)
Background: Bacterial prostatitis (BP) is a common condition accounting responsible for about 5-10% of all prostatitis
cases; chronic bacterial prostatitis (CBP) classified as type II, are less common but is a condition that significantly hampers
the quality of life, (QoL) because not only is it a physical condition but also a psychological distress. Commonly patients
are treated with antibiotics alone, and in particular fluoroquinolones are suggested by the European Urology guidelines.
This approach, although recommended, may not be enough. Thus, a multimodal approach to the prolonged antibiotic
therapy may be helpful.
Methods: 210 patients affected by chronic bacterial prostatitis were enrolled in the study. All patients were positive to
Meares-Stamey test and symptoms duration was > 3 months. The purpose of the study was to evaluate the efficacy of a
long lasting therapy with a fluoroquinolone in association with a nutraceutical supplement (prulifloxacin 600 mg for
21 days and an association of Serenoa repens 320 mg, Lactobacillus Sporogens 200 mg, Arbutin 100 mg for 30 days).
Patients were randomized in two groups (A and B) receiving respectively antibiotic alone and an association of antibiotic
plus supplement.
Results: Biological recurrence at 2 months in Group A was observed in 21 patients (27.6%) and in Group B in 6 patients
(7.8%). Uropathogens found at the first follow-up were for the majority Gram – (E. coli and Enterobacter spp.). A statistically
significant difference was found at the time of the follow-up between Group A and B in the NIH-CPSI questionnaire score,
symptoms evidence and serum PSA.
Conclusions: Broad band, short-lasting antibiotic therapy in association with a nutritional supplement (serenoa repens,
lactobacillus sporogens and arbutin) show better control and recurrence rate on patients affected by chronic bacterial
prostatitits in comparison with antibiotic treatment alone.
Trial registration: NCT02130713
Date of trial Registration: 30/04/201
Hyperhomocysteinemia as an early predictor of erectile dysfunction: International index of erectile function (IIEF) and penile doppler ultrasound correlation with plasma levels of homocysteine
Erectile dysfunction (ED) is inability to achieve and maintain an erection to permit satisfactory sexual activity. Homocysteine (Hcys) is a sulfur-containing amino acid synthesized from the essential amino acid methionine. Experimental models have elucidated the role of hyperhomocysteinemia (HHcys) as a strong and independent predictor for atherosclerosis progression and impaired cavernosal perfusion. The aim of this study is to investigate the serum levels of Hcys in our cohort of patients with ED, to compare these values with these of control population and to examine Hcys as a predictive marker for those patients who are beginning to complain mild-moderate ED. A total of 431 patients were enrolled in the study. The whole cohort was asked to complete the International Index of Erectile Function (IIEF) questionnaire. The study population was divided in 3 main groups: Group A: 145 patients with no ED serving as a control group; Group B: 145 patients with mild or mild-moderate ED; Group C: 141 patients with moderate or severe ED. Each participant underwent blood analysis. All patients underwent baseline and dynamic penile Doppler ultrasonography. We found in our cohort mean Hcys plasma concentrations significantly higher than the cut-off point in both groups B and C (18.6 ± 4.7 and 28.38 ± 7.8, respectively). Mean IIEF score was 27.9 ± 1.39, 19.5 ± 2.6, and 11.1 ± 2.5 for groups A, B, and C, respectively (P < 0.0001). In the penile Doppler ultrasonography studies, a high significant inverse correlation was detected between the mean values of the 10th minute's peak-systolic velocity (PSV) and Hcys levels for the groups B and C. This establishes a dose-dependent association between Hcys and ED. Furthermore, we showed that Hcys was an earlier predictor of ED than Doppler studies, as the Hcys increase was present in patients with mild ED even before abnormal Doppler values
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification
Stem cells & developmental biolog
Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis
Dupilumab, a mAb targeting IL-4 receptor alpha (IL-4Rα), markedly improves disease severity in patients with atopic dermatitis. However, the effect of IL-4Rα blockade on dynamics of circulating skin-homing T cells, which are crucial players in the pathologic mechanism of atopic dermatitis, has not been studied yet. In addition, it remains unknown whether dupilumab treatment induces long-lasting T- and B-cell polarization. Therefore, we studied the short- and long-term effects of dupilumab treatment on IL-4Rα expression and T-cell cytokine production within total and skin-homing (cutaneous lymphocyte antigen+/CCR4+) subpopulations in patients with moderate-to-severe atopic dermatitis. Dupilumab treatment completely blocked IL-4Rα expression and signal transducer and activator of transcription 6 phosphorylation in CD19+ B cells and CD4+ T cells within 2 hours of administration and through week 52. Although no change in the proportion of skin-homing T-cell subsets was found, dupilumab treatment significantly decreased the percentage of proliferating (Ki67+) and T helper type 2 and T helper type 22 cytokine-producing skin-homing CD4+ T cells at week 4. No evidence of general T helper type cell skewing following a year of dupilumab treatment was found. In summary, dupilumab treatment rapidly and stably inhibited IL-4Rα, which was accompanied by a strong early functional immunological effect specifically on skin-homing T cells without affecting overall T helper type cell skewing in the long term
Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation
Inhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor which has collagen and collagen domain containing proteins as ligands. LAIR-1 is broadly expressed on immune cells and has a large availability of ligands in both circulation and tissues, implicating a need for tight regulation of this interaction. In the current study, we sought to examine the regulation and function of LAIR-1 on monocyte, dendritic cell (DC) and macrophage subtypes, using different in vitro models. We found that LAIR-1 is highly expressed on intermediate monocytes as well as on plasmacytoid DCs. LAIR-1 is also expressed on skin immune cells, mainly on tissue CD14+ cells, macrophages and CD1c+ DCs. In vitro, monocyte and type-2 conventional DC stimulation leads to LAIR-1 upregulation, which may reflect the importance of LAIR-1 as negative regulator under inflammatory conditions. Indeed, we demonstrate that LAIR-1 ligation on monocytes inhibits toll like receptor (TLR)4 and Interferon (IFN)-α- induced signals. Furthermore, LAIR-1 is downregulated on GM-CSF and IFN-γ monocyte-derived macrophages and monocyte-derived DCs. In addition, LAIR-1 triggering during monocyte derived-DC differentiation results in significant phenotypic changes, as well as a different response to TLR4 and IFN-α stimulation. This indicates a role for LAIR-1 in skewing DC function, which impacts the cytokine expression profile of these cells. In conclusion, we demonstrate that LAIR-1 is consistently upregulated on monocytes and DC during the inflammatory phase of the immune response and tends to restore its expression during the resolution phase. Under inflammatory conditions, LAIR-1 has an inhibitory function, pointing toward to a potential intervention opportunity targeting LAIR-1 in inflammatory conditions
Primary Metastatic Neuroendocrine Small Cell Bladder Cancer: A Case Report and Literature Review
Small cell carcinoma of the urinary bladder (SCCUB) is a rare
variant of neuroendocrine nonepithelial tumor. Clinically,
SCCUB appears like a flat or ulcerated lesion and microscopically
can cause microvascular invasion and necrosis. Small
cell cancer, rarely found in the urogenital tract in a primitive
form, usually coexists with urothelial bladder cancers. It has
an incidence of 0.35–0.7% of all bladder neoplasms and survival
at 5 years is estimated to be around 8%. A 60-year-old
man who was a smoker was referred to our department with
episodes of gross hematuria and pain in the lumbar region.
After an extensive transurethral resection of the bladder, including
of the muscular layer, the diagnosis of small cell carcinoma
of the bladder was made. The neoplastic cells were
positive with immunohistochemical staining for chromogranin
A, paranuclear reactivity to cytokeratin and neuronspecific
enolase. A total-body CT scan revealed lymph node
involvement and hepatic, adrenal and lung metastases. Be-
cause of the advanced stage it was decided to avoid radical
cystectomy and perform chemotherapy. The patient underwent
two different cycles of cisplatin chemotherapy following
international recommendations, but unfortunately without
any response. After palliative therapy, the patient died in
January 2010
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