High or low? Comparing high and low-variability phonetic training in adult and child second language learners

Background High talker variability (i.e., multiple voices in the input) has been found effective in training nonnative phonetic contrasts in adults. A small number of studies suggest that children also benefit from high-variability phonetic training with some evidence that they show greater learning (more plasticity) than adults given matched input, although results are mixed. However, no study has directly compared the effectiveness of high versus low talker variability in children. Methods Native Greek-speaking eight-year-olds (N = 52), and adults (N = 41) were exposed to the English /i/-/ɪ/ contrast in 10 training sessions through a computerized word-learning game. Pre- and post-training tests examined discrimination of the contrast as well as lexical learning. Participants were randomly assigned to high (four talkers) or low (one talker) variability training conditions. Results Both age groups improved during training, and both improved more while trained with a single talker. Results of a three-interval oddity discrimination test did not show the predicted benefit of high-variability training in either age group. Instead, children showed an effect in the reverse direction—i.e., reliably greater improvements in discrimination following single talker training, even for untrained generalization items, although the result is qualified by (accidental) differences between participant groups at pre-test. Adults showed a numeric advantage for high-variability but were inconsistent with respect to voice and word novelty. In addition, no effect of variability was found for lexical learning. There was no evidence of greater plasticity for phonetic learning in child learners. Discussion This paper adds to the handful of studies demonstrating that, like adults, child learners can improve their discrimination of a phonetic contrast via computerized training. There was no evidence of a benefit of training with multiple talkers, either for discrimination or word learning. The results also do not support the findings of greater plasticity in child learners found in a previous paper (Giannakopoulou, Uther & Ylinen, 2013a). We discuss these results in terms of various differences between training and test tasks used in the current work compared with previous literature

Star formation in the giant HII regions of M101

The molecular components of three giant HII regions (NGC 5461, NGC 5462, NGC 5471) in the galaxy M101 are investigated with new observations from the James Clerk Maxwell Telescope, the NRAO 12-meter, and the Owens Valley millimeter array. Of the three HII regions, only NGC 5461 had previously been detected in CO emission. We calculate preliminary values for the molecular mass of the GMCs in NGC 5461 by assuming a CO-to-H_2 factor (X factor) and then compare these values with the virial masses. We conclude that the data in this paper demonstrate for the first time that the value of X may decrease in regions with intense star formation. The molecular mass for the association of clouds in NGC 5461 is approximately 3x10^7 Mo and is accompanied by 1-2 times as much atomic mass. The observed CO emission in NGC 5461 is an order of magnitude stronger than in NGC 5462, while it was not possible to detect molecular gas toward NGC 5471 with the JCMT. An even larger ratio of atomic to molecular gas in NGC 5471 was observed, which might be attributed to efficient conversion of molecular to atomic gas. The masses of the individual clouds in NGC 5461, which are gravitationally bound, cover a range of (2-8) x 10^5 Mo, comparable with the masses of Galactic giant molecular clouds (GMCs). Higher star forming efficiencies, and not massive clouds, appear to be the prerequisite for the formation of the large number of stars whose radiation is required to produce the giant HII regions in M101.Comment: 32 pages, 5 figures, accepted for publication in the Astrophysical Journa

Large-Area Mapping at 850 Microns. I. Optimum Image Reconstruction from Chop Measurements

We present results on the optimum reconstruction of chop data taken using the Submillimeter Common-User Bolometer Array on the James Clerk Maxwell Telescope. Using an artificial data set with known noise properties, we analyze three techniques for constructing images of the sky from the chop data: Emerson Fourier deconvolution, matrix inversion, and maximum entropy reconstruction. We conclude that a matrix inversion formulation via an iterative procedure produces the best image reconstructions. We apply the three reconstruction techniques to produce maps of the calibration point source CRL 618 and the ? Ophiuchi A core at 850 ?m and use Wiener filtering to remove the high-frequency noise component from the matrix inversion method

Plasticity in second language (L2) learning : perception of L2 phonemes by native Greek speakers of English

Understanding the process of language acquisition is a challenge that many researchers spanning different disciplines (e.g. linguistics, psychology, neuroscience) have grappled with for centuries. One which has in recent years attracted a lot of attention has been in the area of non-native phoneme acquisition. Speech sounds that contain multiple phonetic cues are often difficult for foreign-language learners, especially if certain cues are weighted differently in the foreign and native languages. Greek adult and child speakers of English were studied to determine which cues (duration or spectral) they were using to make discrimination and identification judgments for an English vowel contrast pair. To this end, two forms of identification and discrimination tasks were used: natural (unedited) stimuli and another ‘modified’ vowel duration stimuli which were edited so that there were no duration differences between the vowels. Results show the Greek speakers were particularly impaired when they were unable to use the duration cue as compared to the native English speakers. Similar results were also obtained in control experiments where there was no orthographic representation or where the stimuli were cross-spliced to modify the phonetic neighborhood. Further experiments used high-variability training sessions to enhance vowel perception. Following training, performance improved for both Greek adult and child groups as revealed by post training tests. However the improvements were most pronounced for the child Greek speaker group. A further study examined the effect of different orthographic cues that might affect rhyme and homophony judgment. The results of that study showed that Greek speakers were in general more affected by orthography and regularity (particularly of the vowel) in making these judgments. This would suggest that Greek speakers were more sensitive to irrelevant orthographic cues, mirroring the results in the auditory modality where they focused on irrelevant acoustic cues. The results are discussed in terms of current theories of language acquisition, with particular reference to acquisition of non-native phonemes.EThOS - Electronic Theses Online ServiceSchool of Social Sciences, Brunel UniversityGBUnited Kingdo

Parallel and serial mediation analysis between pain, anxiety, depression, fatigue and nausea, vomiting and retching within a randomised controlled trial in patients with breast and prostate cancer

Objective Cancer treatment is a particularly stressful period for the patient. The reasons vary and include fear of treatment outcome as well as treatment induced side effects. The patient frequently experiences simultaneously various side effects resulting in a diminishing of the patient's health-related quality of life (HRQoL). The study provides evidence on the co-occurrence and inter-relations between pain, anxiety, depression and fatigue in patients with breast and prostate cancer. Design This paper presents a secondary analysis of the data from a randomised control trial designed to test the effectiveness of guided imagery and progressive muscle relaxation on pain, fatigue, anxiety and depression. Non-parametric bootstrapping analyses were used to test the mediational model of anxiety, fatigue and depression as parallel mediators of the relationship between pain and HRQoL. Setting The study was undertaken at the home setting. Participants In total 208 patients were included in the study (assigned equally in two groups), referred at the outpatient clinics of the three participating cancer care centres. Results The three mediators fully mediate the relationship between pain and HRQoL indirect effect (IE overall =-0.3839, 95% CI: Lower limit (LL)=-0.5073 to upper limit (UL)=-0.2825) indicating that patients with increased pain are likely to have higher levels of anxiety, fatigue and depression. Gender significantly moderated the mediational effect of Fatigue Index of Moderated Mediation (IMM=-0.2867 SE=0.1526, LL=-0.6127, UL=-0.0226) but did not moderate mediational effect of anxiety (IMM=-0.0709, SE=0.1414, LL=-0.3459, UL=+0.2089). The results show that the three mediators in a serial causal order fully mediate the relationship between pain and HRQoL (IE overall =-0.384, 95% CI: LL=-0.51 to UL=-0.284) and the ratio of the overall indirect effect to the total effect is 0.8315 (95% CI: LL=0.5683 to UL=1.1718). Conclusion This work provides evidence that targeting fatigue, anxiety and depression may have a meaningful effect on pain as a related symptom and potentially have a positive impact on HRQoL of patients with breast and prostate cancer.</p

Ground State Properties and Optical Conductivity of the Transition Metal Oxide Sr2VO4{\rm Sr_{2}VO_{4}}

Combining first-principles calculations with a technique for many-body problems, we investigate properties of the transition metal oxide ${\rm Sr_{2}VO_{4}}$ from the microscopic point of view. By using the local density approximation (LDA), the high-energy band structure is obtained, while screened Coulomb interactions are derived from the constrained LDA and the GW method. The renormalization of the kinetic energy is determined from the GW method. By these downfolding procedures, an effective Hamiltonian at low energies is derived. Applying the path integral renormalization group method to this Hamiltonian, we obtain ground state properties such as the magnetic and orbital orders. Obtained results are consistent with experiments within available data. We find that ${\rm Sr_{2}VO_{4}}$ is close to the metal-insulator transition. Furthermore, because of the coexistence and competition of ferromagnetic and antiferromgnetic exchange interactions in this system, an antiferromagnetic and orbital-ordered state with a nontrivial and large unit cell structure is predicted in the ground state. The calculated optical conductivity shows characteristic shoulder structure in agreement with the experimental results. This suggests an orbital selective reduction of the Mott gap.Comment: 38pages, 22figure

Genetics of Myasthenia Gravis: A Case-Control Association Study in the Hellenic Population

Myasthenia gravis (MG) is an heterogeneous autoimmune disease characterized by the production of autoantibodies against proteins of the postsynaptic membrane, in the neuromuscular junction. The contribution of genetic factors to MG susceptibility has been evaluated through family and twin studies however, the precise genetic background of the disease remains elusive. We conducted a case-control association study in 101 unrelated MG patients of Hellenic origin and 101 healthy volunteers in order to assess the involvement of common genetic variants in susceptibility to MG. We focused on three candidate genes which have been clearly associated with several autoimmune diseases, aiming to investigate their potential implication in MG pathogenesis. These are interferon regulatory factor 5 (IRF-5), TNFα-induced protein 3 (TNFAIP3), also known as A20, and interleukin-10 (IL-10), key molecules in the regulation of immune function. A statistical trend of association (P=0.068) between IL-10 promoter single nucleotide polymorphisms (SNPs) and the subgroups of early and late-onset MG patients was revealed. No statistically significant differences were observed in the rest of the variants examined. As far as we are aware, this is the first worldwide attempt to address the possible association between IRF-5 and TNFAIP3 common genetic variants and the genetic basis of MG

Herschel / HIFI observations of CO, H2O and NH3 in Mon R2

Context. Mon R2 is the only ultracompact HII region (UCHII) where the associated photon-dominated region (PDR) can be resolved with Herschel. Due to its brightness and proximity, it is the best source to investigate the chemistry and physics of highly UV-irradiated PDRs. Aims. Our goal is to estimate the abundance of H2O and NH3 in this region and investigate their origin. Methods. We present new observations obtained with HIFI and the IRAM-30m telescope. Using a large velocity gradient approach, we model the line intensities and derive an average abundance of H2O and NH3 across the region. Finally, we model the line profiles with a non-local radiative transfer model and compare these results with the abundance predicted by the Meudon PDR code. Results. The variations of the line profiles and intensities indicate complex geometrical and kinematical patterns. The H2O lines present a strong absorption at the ambient velocity and emission in high velocity wings towards the HII region. The spatial distribution of the o-H2^18O line shows that the its emission arises in the PDR surrounding the HII region. By modeling the o-H2^18O emission we derive a mean abundance of o-H2O of ~10^-8 relative to H2. The ortho-H2O abundance is however larger, ~1x10^-7, in the high velocity wings. Possible explanations for this larger abundance include an expanding hot PDR and/or an outflow. Ammonia seems to be present only in the envelope with an average abundance of ~2x10^-9 relative to H2. Conclusions. The Meudon PDR code can account for the measured water abundance in the high velocity gas as long as we assume that it originates from a <1 mag hot expanding layer of the PDR, i.e. that the outflow has only a minor contribution to this emission. To explain the abundances in the rest of the cloud the molecular freeze out and grain surface chemistry would need to be included.Comment: 12 pages, 7 figures, 3 tables. Accepted for publication in A&A. Abstract shortened. Updated references, language editing applied in v