On the evolution of the entropy and pressure profiles in X-ray luminous galaxy clusters at z > 0.4

Galaxy clusters are the most recent products of hierarchical accretion over cosmological scales. The gas accreted from the cosmic field is thermalized inside the cluster halo. Gas entropy and pressure are expected to have a self-similar behaviour with their radial distribution following a power law and a generalized Navarro-Frenk-White profile, respectively. This has been shown also in many different hydrodynamical simulations. We derive the spatially-resolved thermodynamical properties of 47 X-ray galaxy clusters observed with Chandra in the redshift range 0.4 < z < 1.2, the largest sample investigated so far in this redshift range with X-rays spectroscopy, with a particular care in reconstructing the gas entropy and pressure radial profiles. We search for deviation from the self-similar behaviour and look for possible evolution with redshift. The entropy and pressure profiles lie very close to the baseline prediction from gravitational structure formation. We show that these profiles deviate from the baseline prediction as function of redshift, in particular at z > 0.75, where, in the central regions, we observe higher values of the entropy (by a factor of 2.2) and systematically lower estimates (by a factor of 2.5) of the pressure. The effective polytropic index, which retains informations about the thermal distribution of the gas, shows a slight linear positive evolution with the redshift and the concentration of the dark matter distribution. A prevalence of non-cool-core, disturbed systems, as we observe at higher redshifts, can explain such behaviours.Comment: 14 pages, 18 figures, accepted for publication by A&

CAR T-Cell Therapies in Italy: Patient Access Barriers and Recommendations for Health System Solutions

CAR T-cell therapy has emerged as a potentially transformative immunotherapy for certain B-cell malignancies including relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Unhindered and appropriate access for eligible patients is essential to enable optimal outcomes and depends on effective interplay of stakeholders and processes along the patient’s therapeutic journey. In Italy, CAR T-cell therapies have been awarded innovation status by the Italian Medicines Agency (AIFA) and were integrated into routine patient care under specific criteria. However, our analysis indicates that fewer than one in five DLBCL patients eligible under the EMA authorization, or around one in three DLBCL patients eligible under the AIFA criteria, received treatment with a licensed CAR T-cell therapy product in 2020. This publication describes key patient access barriers to CAR T-cell therapies in Italy and provides recommendations on potential solutions at the health system level

Checklist for anesthesiological process: analysis of risks

Several methods are reported in the literature to analyze medically undesirable events during hospital care. Each method has several limitations, so no one has been defined as the standard tool to be able to detect failure during a medical process. The aim of this study was to compare an anesthesiological perioperative checklist with traditional Regional Incident Reporting (RIR) form in detecting and describing failures

Fragrance materials (FMs) affect the larval development of the copepod Acartia tonsa: An emerging issue for marine ecosystems

Fragrance materials (FMs) are used in a variety of detergents and cosmetics, including household and personal care products. Despite their widespread use and the growing evidence of their occurrence in surface waters worldwide, very little is known about their toxicity towards marine species, including a key component of the marine food webs such as copepods. Thus, we investigated the toxicity of six of the more long-lasting and stable commercial fragrances, including Amyl Salicylate (AMY), Oranger Crystals (ORA), Hexyl Salicylate (HEX), Ambrofix (AMB), Peonile (PEO), and Benzyl Salicylate (BZS), to assess their ability to impair the larval development of the calanoid copepod Acartia tonsa. FMs inhibited the development of A. tonsa significantly at concentrations by far lower than the effect-concentrations reported in the literature for aquatic species. The more toxic FMs were HEX (EC50 = 57 ng L−1), AMY (EC50 = 131 ng L−1) and ORA (EC50 = 766 ng L−1), while the other three compounds exerted toxic effects at concentrations higher than 1000 ng L−1 (LOEC at 1000 ng L−1 for PEO and BZS, and at 10,000 ng L−1 for AMB). Early life-stage mortality was unaffected by FMs at all the tested concentrations. A comparison with water concentrations of FMs reported in the literature confirmed that FMs, especially HEX and AMY, may act as contaminants of potential concern in many aquatic habitats, including urban areas and remote and polar environments

Vertebral artery dissection in term pregnancy after cervical spine manipulation: a case report and review the literature

Background: Vertebral artery dissection is an uncommon, but potentially fatal, vascular event. This case aimed to describe the pathogenesis and clinical presentation of vertebral artery dissection in a term pregnant patient. Moreover, we focused on the differential diagnosis, reviewing the available evidence. Case presentation: A 39-year-old Caucasian woman presented at 38&nbsp;+&nbsp;4&nbsp;weeks of gestation with a short-term history of vertigo, nausea, and vomiting. Symptoms appeared a few days after cervical spine manipulation by an osteopathic specialist. Urgent magnetic resonance imaging of the head was obtained and revealed an ischemic lesion of the right posterolateral portion of the brain bulb. A subsequent computed tomography angiographic scan of the head and neck showed a right vertebral artery dissection. Based on the correlation of the neurological manifestations and imaging findings, a diagnosis of vertebral artery dissection was established. The patient started low-dose acetylsalicylic acid and prophylactic enoxaparin following an urgent cesarean section. Conclusion: Vertebral artery dissection is a rare but potential cause of neurologic impairments in pregnancy and during the postpartum period. It should be considered in the differential diagnosis for women who present with headache and/or vertigo. Women with a history of migraines, hypertension, or autoimmune disorders in pregnancy are at higher risk, as well as following cervical spine manipulations. Prompt diagnosis and management of vertebral artery dissection are essential to ensure favorable outcomes

The role of preclinical models in creatine transporter deficiency: Neurobiological mechanisms, biomarkers and therapeutic development

Creatine (Cr) Transporter Deficiency (CTD) is an X-linked metabolic disorder, mostly caused by missense mutations in the SLC6A8 gene and presenting with intellectual disability, autistic behavior, and epilepsy. There is no effective treatment for CTD and patients need lifelong assistance. Thus, the research of novel intervention strategies is a major scientific challenge. Animal models are an excellent tool to dissect the disease pathogenetic mechanisms and drive the preclinical development of therapeutics. This review illustrates the current knowledge about Cr metabolism and CTD clinical aspects, with a focus on mainstay diagnostic and therapeutic options. Then, we discuss the rodent models of CTD characterized in the last decade, comparing the phenotypes expressed within clinically relevant domains and the timeline of symptom development. This analysis highlights that animals with the ubiquitous deletion/mutation of SLC6A8 genes well recapitulate the early onset and the complex pathological phenotype of the human condition. Thus, they should represent the preferred model for preclinical efficacy studies. On the other hand, brain-and cell-specific conditional mutants are ideal for understanding the basis of CTD at a cellular and molecular level. Finally, we explain how CTD models might provide novel insight about the pathogenesis of other disorders, including cancer

Práticas de letramento para alunos da Educação de Jovens e Adultos Interventiva

Trabalho de Conclusão de Curso (especialização)—Universidade de Brasília, Ministério da Educação, Coordenação de Formação Continuada de Professores, Secretaria de Estado de Educação do Distrito Federal, Especialização em Letramento e Práticas Interdisciplinares nos Anos Finais, 2015.O objetivo do presente estudo é identificar e analisar as práticas de letramento para alunos da Educação de Jovens e Adultos Interventiva em uma escola pública do Distrito Federal. A EJA interventiva é um programa da Secretaria de Estado de Educação que tem como objetivo o atendimento dos jovens e adultos com deficiência intelectual. Para tanto, realizou-se uma pesquisa de campo, com elementos qualitativos com seis alunos com idades entre 17 e 37 anos. As técnicas utilizadas para a realização desse trabalho compreenderam a observação participante e entrevistas. Evidenciou-se por meio das observações e entrevistas, a importância do processo de letramento para a vida escolar e social desses alunos. Para analisar os dados obtidos foi utilizada a técnica de análise de conteúdo, onde foram criadas categorias. Os resultaram mostraram que o letramento dos alunos da EJA Interventiva colabora para uma vida social mais ativa e independente. Porém, algumas práticas realizadas mostram várias fragilidades deste processo, que necessita de adequações e reflexões que extrapolam a sala de aula, buscando por meio da escolarização, a inclusão desse aluno no contexto social em que vivemos e de sua emancipação

X-ray analysis of JWST's first galaxy cluster lens SMACS J0723.3-7327

SMACS~J0723.3-7327 is the first galaxy cluster lens observed by JWST. Based on the ERO data from JWST, several groups have reported the results on strong lensing analysis and mass distribution of this cluster. However, limited by the angular coverage of the JWST data, the strong lensing models only cover the central region. X-ray analysis on the hot ICM is necessary to obtain a more complete constraint on the mass distribution in this very massive cluster. In this work, we aim to perform a comprehensive X-ray analysis of J0723 to obtain accurate ICM hydrostatic mass measurements, using the X-ray data from SRG/eROSITA and Chandra X-ray observatories. By comparing the hydrostatic mass profile with the strong lensing model, we aim to provide the most reliable constraint on the distribution of mass up to R500. Thanks to the eROSITA all-sky survey and Chandra data, which provide high S/N and high angular resolution respectively, we are able to constrain the ICM gas density profile and temperature profile with good accuracy both in the core and to the outskirts. With the density and temperature profiles, we compute the hydrostatic mass profile, which is then projected along the line of sight to compare with the mass distribution obtained from the recent strong lensing analysis based on JWST data. We also deproject the strong lensing mass distribution using the hydrostatic mass profile we obtained in this work. The X-ray results obtained from eROSITA and Chandra agree very well with each other. The hydrostatic mass profiles we measured in this work, both projected and deprojected, are in good agreement with recent strong lensing results based on JWST data, at all radii. We also find that the radial acceleration relation in J0723 is inconsistent with the RAR for spiral galaxies, implying that the latter is not a universal property of gravity across all mass scales.Comment: Accepted for publication in A&