bRing: An observatory dedicated to monitoring the β\beta Pictoris b Hill sphere transit

Aims. We describe the design and first light observations from the $\beta$ Pictoris b Ring ("bRing") project. The primary goal is to detect photometric variability from the young star $\beta$ Pictoris due to circumplanetary material surrounding the directly imaged young extrasolar gas giant planet \bpb. Methods. Over a nine month period centred on September 2017, the Hill sphere of the planet will cross in front of the star, providing a unique opportunity to directly probe the circumplanetary environment of a directly imaged planet through photometric and spectroscopic variations. We have built and installed the first of two bRing monitoring stations (one in South Africa and the other in Australia) that will measure the flux of $\beta$ Pictoris, with a photometric precision of $0.5\%$ over 5 minutes. Each station uses two wide field cameras to cover the declination of the star at all elevations. Detection of photometric fluctuations will trigger spectroscopic observations with large aperture telescopes in order to determine the gas and dust composition in a system at the end of the planet-forming era. Results. The first three months of operation demonstrate that bRing can obtain better than 0.5\% photometry on $\beta$ Pictoris in five minutes and is sensitive to nightly trends enabling the detection of any transiting material within the Hill sphere of the exoplanet

Data calibration for the MASCARA and bRing instruments

Aims: MASCARA and bRing are photometric surveys designed to detect variability caused by exoplanets in stars with $m_V < 8.4$. Such variability signals are typically small and require an accurate calibration algorithm, tailored to the survey, in order to be detected. This paper presents the methods developed to calibrate the raw photometry of the MASCARA and bRing stations and characterizes the performance of the methods and instruments. Methods: For the primary calibration a modified version of the coarse decorrelation algorithm is used, which corrects for the extinction due to the earth's atmosphere, the camera transmission, and intrapixel variations. Residual trends are removed from the light curves of individual stars using empirical secondary calibration methods. In order to optimize these methods, as well as characterize the performance of the instruments, transit signals were injected in the data. Results: After optimal calibration an RMS scatter of 10 mmag at $m_V \sim 7.5$ is achieved in the light curves. By injecting transit signals with periods between one and five days in the MASCARA data obtained by the La Palma station over the course of one year, we demonstrate that MASCARA La Palma is able to recover 84.0, 60.5 and 20.7% of signals with depths of 2, 1 and 0.5% respectively, with a strong dependency on the observed declination, recovering 65.4% of all transit signals at $\delta > 0^\circ$ versus 35.8% at $\delta < 0^\circ$. Using the full three years of data obtained by MASCARA La Palma to date, similar recovery rates are extended to periods up to ten days. We derive a preliminary occurrence rate for hot Jupiters around A-stars of ${>} 0.4 \%$, knowing that many hot Jupiters are still overlooked. In the era of TESS, MASCARA and bRing will provide an interesting synergy for finding long-period (${>} 13.5$ days) transiting gas-giant planets around the brightest stars.Comment: 18 pages, 17 figures, accepted for publication in A&

Results from the Mars Phoenix Lander Robotic Arm experiment

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95618/1/jgre2693.pd

MutLα heterodimers modify the molecular phenotype of Friedreich ataxia

This article has been made available through the Brunel Open Access Publishing Fund.Background: Friedreich ataxia (FRDA), the most common autosomal recessive ataxia disorder, is caused by a dynamic GAA repeat expansion mutation within intron 1 of FXN gene, resulting in down-regulation of frataxin expression. Studies of cell and mouse models have revealed a role for the mismatch repair (MMR) MutS-heterodimer complexes and the PMS2 component of the MutLα complex in the dynamics of intergenerational and somatic GAA repeat expansions: MSH2, MSH3 and MSH6 promote GAA repeat expansions, while PMS2 inhibits GAA repeat expansions. Methodology/Principal Findings: To determine the potential role of the other component of the MutLα complex, MLH1, in GAA repeat instability in FRDA, we have analyzed intergenerational and somatic GAA repeat expansions from FXN transgenic mice that have been crossed with Mlh1 deficient mice. We find that loss of Mlh1 activity reduces both intergenerational and somatic GAA repeat expansions. However, we also find that loss of either Mlh1 or Pms2 reduces FXN transcription, suggesting different mechanisms of action for Mlh1 and Pms2 on GAA repeat expansion dynamics and regulation of FXN transcription. Conclusions/Significance: Both MutLα components, PMS2 and MLH1, have now been shown to modify the molecular phenotype of FRDA. We propose that upregulation of MLH1 or PMS2 could be potential FRDA therapeutic approaches to increase FXN transcription. © 2014 Ezzatizadeh et al.This article has been made available through the Brunel Open Access Publishing Fund

Magnetic Flux Transport by turbulent reconnection in astrophysical flows

The role of MHD turbulence in astrophysical environments is still highly debated. An important question that permeates this debate is the transport of magnetic flux. This is particularly important, for instance, in the context of star formation. When clouds collapse gravitationally to form stars, there must be some magnetic flux transport. otherwise the new born stars would have magnetic fields several orders of magnitude larger than the observed ones. Also, the magnetic flux that is dragged in the late stages of the formation of a star can remove all the rotational support from the accretion disk that grows around the protostar. The efficiency of the mechanism which is often invoked to allow the transport of magnetic fields in the different stages of star formation, namely, the ambipolar diffusion, has been lately put in check. We here discuss an alternative mechanism for magnetic flux transport which is based on turbulent fast magnetic reconnection. We review recent results obtained from 3D MHD numerical simulations that indicate that this mechanism is very efficient for decoupling and transport magnetic flux from the inner denser regions to the outskirts of collapsing clouds in the different stages of star formation. We also discuss this mechanism in the context of dynamo processes and speculate that it can play a role both in the solar dynamo and in accretion disk dynamo processes.Comment: 10 pages, 2 figures, review submitted to Physica Script

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate. Here, we identify the molecular basis of the use-dependent and voltage-independent inhibitory effect of neurosteroids on NMDAR responses. The site of action is located at the extracellular vestibule of the receptor's ion channel pore and is accessible after receptor activation. Mutations in the extracellular vestibule in the SYTANLAAF motif disrupt the inhibitory effect of negatively charged steroids. In contrast, positively charged steroids inhibit mutated NMDAR responses in a voltage-dependent manner. These results, in combination with molecular modeling, characterize structure details of the open configuration of the NMDAR channel. Our results provide a unique opportunity for the development of new therapeutic neurosteroid-based ligands to treat diseases associated with dysfunction of the glutamate system

Brain architecture in the terrestrial hermit crab Coenobita clypeatus (Anomura, Coenobitidae), a crustacean with a good aerial sense of smell

<p>Abstract</p> <p>Background</p> <p>During the evolutionary radiation of Crustacea, several lineages in this taxon convergently succeeded in meeting the physiological challenges connected to establishing a fully terrestrial life style. These physiological adaptations include the need for sensory organs of terrestrial species to function in air rather than in water. Previous behavioral and neuroethological studies have provided solid evidence that the land hermit crabs (Coenobitidae, Anomura) are a group of crustaceans that have evolved a good sense of aerial olfaction during the conquest of land. We wanted to study the central olfactory processing areas in the brains of these organisms and to that end analyzed the brain of <it>Coenobita clypeatus </it>(Herbst, 1791; Anomura, Coenobitidae), a fully terrestrial tropical hermit crab, by immunohistochemistry against synaptic proteins, serotonin, FMRFamide-related peptides, and glutamine synthetase.</p> <p>Results</p> <p>The primary olfactory centers in this species dominate the brain and are composed of many elongate olfactory glomeruli. The secondary olfactory centers that receive an input from olfactory projection neurons are almost equally large as the olfactory lobes and are organized into parallel neuropil lamellae. The architecture of the optic neuropils and those areas associated with antenna two suggest that <it>C. clypeatus </it>has visual and mechanosensory skills that are comparable to those of marine Crustacea.</p> <p>Conclusion</p> <p>In parallel to previous behavioral findings of a good sense of aerial olfaction in C. clypeatus, our results indicate that in fact their central olfactory pathway is most prominent, indicating that olfaction is a major sensory modality that these brains process. Interestingly, the secondary olfactory neuropils of insects, the mushroom bodies, also display a layered structure (vertical and medial lobes), superficially similar to the lamellae in the secondary olfactory centers of <it>C. clypeatus</it>. More detailed analyses with additional markers will be necessary to explore the question if these similarities have evolved convergently with the establishment of superb aerial olfactory abilities or if this design goes back to a shared principle in the common ancestor of Crustacea and Hexapoda.</p

Risk for Clostridium difficile Infection after Radical Cystectomy for Bladder Cancer: Analysis of a Contemporary Series

Introduction This study seeks to evaluate the incidence and associated risk factors of Clostridium difficile infection (CDI) in patients undergoing radical cystectomy (RC) for bladder cancer. Methods We retrospectively reviewed a single institution׳s bladder cancer database including all patients who underwent RC between 2010 and 2013. CDI was diagnosed by detection of Clostridium difficile toxin B gene using polymerase chain reaction–based stool assay in patients with clinically significant diarrhea within 90 days of the index operation. A multivariable logistic regression model was used to identify demographics and perioperative factors associated with developing CDI. Results Of the 552 patients who underwent RC, postoperative CDI occurred in 49 patients (8.8%) with a median time to diagnosis after RC of 7 days (interquartile range: 5–19). Of the 122 readmissions for postoperative complications, 10% (n = 12) were related to CDI; 2 patients died of sepsis directly related to severe CDI. On multivariate logistic regression, the use of chronic antacid therapy (odds ratio = 1.9, 95% CI: 1.02–3.68, P = 0.04) and antibiotic exposure greater than 7 days (odds ratio = 2.2, 95% CI: 1.11–4.44, P = 0.02) were independently associated with developing CDI. The use of preoperative antibiotics for positive findings on urine culture within 30 days before surgery was not statistically significantly associated with development of CDI (P = 0.06). Conclusions The development of CDI occurs in 8.8% of patients undergoing RC. Our study demonstrates that use of chronic antacid therapy and long duration of antimicrobial exposure are associated with development of CDI. Efforts focusing on minimizing antibiotic exposure in patients undergoing RC are needed, and perioperative antimicrobial prophylaxis guidelines should be followed