BAT According to Climatic Neutrality of Production of Steel Products

The purpose of this article is to estimate the best available technologies for values of the following technological numbers: fuel, ecological, depreciation, greenhouse and their sums. All these numbers have power dimension: t of conditional fuel/unit of production that allows to put them. The fuel technological number characterizes power consumption of production. The technological ecological number transfers a payment of the enterprise for environmental pollution to power units. The technological depreciation number transfers depreciation charges from rubles to power units. The technological greenhouse number translates a payment of the enterprise for emissions of greenhouse gases in power units. Technological numbers have through character – from extraction of raw materials before receiving finished goods. The best available technologies are characterized by the smallest sum of all technological numbers. Keywords: through power-ecological analysis, power ecological capacity of production of steel products, technological fuel ecological greenhouse number, best available technologies, climatic neutralit

Pharmacists' mental health during the SARS-CoV-2 pandemic in Italy

OBJECTIVE: The year 2020 was characterized by the outbreak of a new pandemic caused by a novel coronavirus named SARSCoV- 2. To face the pandemic, many countries worldwide imposed general lockdowns, closing all non-essential businesses. As primary care services, pharmacies had to remain open, thus putting pharmacy staff at significant risk of viral infection and overwork. This study aimed to assess the mental health of Italian Pharmacists, considering demographic and occupational characteristics, lifestyle, and habits, during the SARS-CoV-2 outbreak and the subsequent lockdown period (March-May 2020). MATERIALS AND METHODS: A web-based survey was created using Google® Forms to collect data from March 30, 2020, to June 1, 2020. The questionnaire consisted of three sections investigating: (1) demographic and occupational variables, (2) lifestyle and habits variables, (3) psychological distress and perceived well-being. RESULTS: A total of 401 participants completed the questionnaire. Older workers and those with more work experience reported more psychological stress. Older and female workers, who felt lonely at home and reported psychological stress, perceived poor well-being. CONCLUSIONS: Our findings demonstrate that the Sars-CoV-2 outbreak and subsequent lockdown rules affected pharmacists' mental health and that it is important to put in place preventive measures against the occurrence of mental disorders among them

Comprehensive Energy Conservation Assessment

Изложена методика анализа энергозатрат по сумме сквозных технологических топливных, экологических и парниковых чисел. Эта сумма характеризует энергоемкость, экологический и климатический ущерб производства технологического продукта. Экологический ущерб и эмиссия парниковых газов выражены в энергетических единицах. Это дает возможность сопоставлять ранее определенную энергоемкость продукции рассматриваемых производств с ущербом от выбросов вредных и парниковых газов.It describes the methodology for analyzing energy costs by the sum of through-process fuel, environmental and greenhouse numbers. This amount characterizes the energy intensity, ecological and climatic damage to the production of a technological product. Environmental damage and greenhouse gas emissions are expressed in energy units. This makes it possible to compare the previously defined energy intensity of the products of the considered industries with damage from emissions of harmful and greenhouse gases

PROCESS FUEL NUMBER DURING ORE MINING

This paper considers the solution to the problem of assessing the energy intensity of processes in ferrous metallurgy using technological fuel numbers. It has been shown that the use in quarrying of more powerful equipment reduces the energy intensity of ore extraction.В работе рассмотрено решение задачи оценки энергоемкости процессов в черной металлургии с использованием технологических топливных чисел. Показано, что применение в карьерных работах более мощного оборудования уменьшает энергоемкость добычи руды

Развитие острой почечной недостаточности у ребенка с генерализованной формой иерсиниозной инфекции

Yersinia infection continues to be a significant problem in infectology due to the prevalence, polymorphism of clinical manifestations, difficulties in laboratory diagnosis, often severe and complicated course of the disease, and the possibility of adverse outcomes.The article presents a clinical case of a generalized form of yersinia infection with the development of acute renal failure in a 10-year-old child.Иерсиниозная инфекция продолжает оставаться значимой проблемой инфектологии в связи с распространенностью, полиморфизмом клинических проявлений, трудностями лабораторной диагностики, нередко тяжелым и осложненным течением заболевания, возможностью неблагоприятных исходов.В статье представлен клинический случай генерализованной формы иерсиниозной инфекции с развитием острой почечной недостаточности у ребенка 10 лет

RUSSIAN ENERGY DEVELOPMENT FORECASTS

Представлены результаты сравнительного анализа энергетики СССР и России по некоторым показателям энергоэффективности, воздействию на экономику, устойчивое развитие. Приведены данные об Энергетических правилах (ЭП), законодательстве стран ЕС, ориентированных на конечного потребителя энергии и повышение энергоэффективности. Сформулированы предложения по совершенствованию российского энергетического законодательства.The results of a comparative analysis of the energy industry of the USSR and Russia on some indicators of energy efficiency, impact on the economy, sustainable development are presented. The data on the Energy Rules (EP), the legislation of the EU countries, focused on the final consumer of energy and improving energy efficiency. The proposals on improving the Russian energy legislation are formulated

The diacylglycerol kinase α/Atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness

Diacylglycerol kinase α (DGKα), by phosphorylating diacylglycerol into phosphatidic acid, provides a key signal driving cell migration and matrix invasion. We previously demonstrated that in epithelial cells activation of DGKα activity promotes cytoskeletal remodeling and matrix invasion by recruiting atypical PKC at ruffling sites and by promoting RCP-mediated recycling of α5β1 integrin to the tip of pseudopods. In here we investigate the signaling pathway by which DGKα mediates SDF-1α-induced matrix invasion of MDA-MB-231 invasive breast carcinoma cells. Indeed we showed that, following SDF-1α stimulation, DGKα is activated and localized at cell protrusion, thus promoting their elongation and mediating SDF-1α induced MMP-9 metalloproteinase secretion and matrix invasion. Phosphatidic acid generated by DGKα promotes localization at cell protrusions of atypical PKCs which play an essential role downstream of DGKα by promoting Rac-mediated protrusion elongation and localized recruitment of β1 integrin and MMP-9. We finally demonstrate that activation of DGKα, atypical PKCs signaling and β1 integrin are all essential for MDA-MB-231 invasiveness. These data indicates the existence of a SDF-1α induced DGKα - atypical PKC - β1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells

Текстурные и КТ-признаки в дифференциальном диагнозе гиперваскулярных нейроэндокринных опухолей поджелудочной железы и метастазов почечно-клеточного рака: диагностическая модель

Objective: to develop a diagnostic model that includes CT and radiomic features for the differential diagnosis of pancreatic neuroendocrine tumors (PNETs) G1 and G2 and pancreatic renal cell carcinoma (RCC) metastases.Material and Methods. 78 patients with 79 hypervascular PNETs and 17 patients with 24 pancreatic RCC metastases who underwent pancreatic resection and histological verification were selected in the study. All the patients underwent preoperative contrast enhanced CT (CECT). We assessed tumor attenuation, composition (cystic/solid), homogeneity (homogeneous/heterogeneous), calcification and presence of the main pancreatic duct (MPD) dilation. We calculated lesion-to-parenchyma contrast (LPC), relative tumor enhancement ratio (RTE) and extracted 52 texture features for arterial phase of CECT. Qualitative and texture features were compared between PNETs and pancreatic RCC metastasis. The selection of predictors for the logistic model was carried out in 2 successive stages: 1) selection of predictors based on one-factor logistic models, the selection criterion was p < 0.2; 2) selection of predictors using L2 regularization (LASSO regression after standardization of independent variables). The selected predictors were included in a logistic regression model without interactions, the coefficients of which were estimated using the maximum likelihood method with a penalty of 0.8.Results. There was no difference in composition, homogeneity (homogeneous/heterogeneous) and presence of the MPD dilation between groups. We did not find calcification in pancreatic RCC metastasis, in contrast to the PNETs (9% contained calcifications). After selection, the LCR, CONVENTIONAL_HUmin, GLCM_Correlation, NGLDM_Coarseness were included in the final diagnostic model, which showed a sensitivity and specificity of 95.8%; 62% in the prediction of pancreatic RCC metastases.Conclusion. The diagnostic model developed on the basis of texture and CT-features has high sensitivity (95.8%) with moderate specificity (62%), which allows it to be used in complex diagnostic cases to determine the patient's treatment tactics.Цель исследования: разработать диагностическую модель, включающую КТ-характеристики и показатели радиомики для дифференциальной диагностики нейроэндокринных опухолей поджелудочной железы (ПНЭО) G1 и G2 и метастазов почечно-клеточного рака (ПКР).Материал и методы. В исследование были отобраны 78 пациентов с 79 гиперваскулярными ПНЭО и 17 пациентов с 24 метастазами ПКР, которым была выполнена резекция поджелудочной железы с гистологической верификацией. Всем пациентам перед операцией была проведена КТ с контрастным усилением. Мы оценивали плотность опухоли, структуру (кистозная/солидная), гомогенность (гомогенная/гетерогенная), кальцификацию и наличие расширения главного протока поджелудочной железы (ГПП). Мы рассчитали отношение плотности опухоли к плотности паренхимы (LPC) и относительный коэффициент контрастирования опухоли (RTE) и вычислили 52 текстурных показателя для артериальной фазы КТ-исследования. Качественные и текстурные характеристики сравнивали между ПНЭО и метастазами ПКР. Отбор предикторов в логистическую модели осуществлялся в 2 последовательных этапа: 1) отбор предикторов на основе однофакторных логистических моделей, критерием отбора служило p < 0.2; 2) отбор предикторов с помощью L2-регуляризации (LASSO-регрессия после стандартизации независимых переменных). Отобранные предикторы включались в логистическую регрессионную модель без взаимодействий, коэффициенты которой рассчитывались с использованием метода максимального праводоподобия со штрафом 0,8.Результаты. Не было различий в структуре, гомогенности (гомогенные/гетерогенные) и наличии дилатации ГПП между группами. Мы не обнаружили кальцификации при метастазах ПКР, в отличие от ПНЭО. После отбора LCR, CONVENTIONAL_HUmin, GLCM_Correlation, NGLDM_Coarseness были включены в окончательную диагностическую модель, которая показала чувствительность и специфичность 95.8%; 62% в прогнозировании метастазов ПКР.Заключение. Разработанная на основании текстурных и КТ-признаков диагностическая модель обладает высокой чувствительностью (95.8%) при умеренной специфичности (62%), что позволяет использовать ее при сложных диагностических случаях для определения тактики лечения пациента

ERS statement: A core outcome set for clinical trials evaluating the management of COPD exacerbations

Clinical trials evaluating the management of acute exacerbations of COPD assess heterogeneous outcomes, often omitting those that are clinically relevant or more important to patients. We have developed a core outcome set, a consensus-based minimum set of important outcomes that we recommend are evaluated in all future clinical trials on exacerbations management, to improve their quality and comparability. COPD exacerbations outcomes were identified through methodological systematic reviews and qualitative interviews with 86 patients from 11 countries globally. The most critical outcomes were prioritised for inclusion in the core outcome set through a two-round Delphi survey completed by 1063 participants (256 patients, 488 health professionals and 319 clinical academics) from 88 countries in five continents. Two global, multi-stakeholder, virtual consensus meetings were conducted to 1) finalise the core outcome set and 2) prioritise a single measurement instrument to be used for evaluating each of the prioritised outcomes. Consensus was informed by rigorous methodological systematic reviews. The views of patients with COPD were accounted for at all stages of the project. Survival, treatment success, breathlessness, quality of life, activities of daily living, the need for a higher level of care, arterial blood gases, disease progression, future exacerbations and hospital admissions, treatment safety and adherence were all included in the core outcome set. Focused methodological research was recommended to further validate and optimise some of the selected measurement instruments. The panel did not consider the prioritised set of outcomes and associated measurement instruments to be burdensome for patients and health professionals to use